Predicting the human in vivo performance of different oral capsule shell types using a novel in vitro dynamic gastric model

International Journal of Pharmaceutics

Volumn 419, Issue 1-2, 2011, Pages 192-199

  Vardakou, M ^a   Mercuri, A ^a   Naylor, T A ^b   Rizzo, D ^a   Butler, J M ^b   Connolly, P C ^b   Wickham, M S J ^c   Faulks, R M ^a  

^a INSTITUTE OF FOOD RESEARCH   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c LEATHERHEAD FOOD RESEARCH   (United Kingdom)

Author keywords

Dissolution; Dynamic simulation; Gastrointestinal transit; In vitro models; Oral drug delivery

Indexed keywords

GELATIN; GELLAN; HYDROXYPROPYLMETHYLCELLULOSE; PARACETAMOL;

ARTICLE; BIOLOGICAL MODEL; DIET RESTRICTION; DIFFUSION COEFFICIENT; DIGESTION; DRUG CAPSULE; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; DYNAMIC GASTRIC MODEL; FEEDING; GAMMA SCINTIGRAPHY; GASTROINTESTINAL TRANSIT; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INTESTINE TRANSIT TIME; ORAL CAPSULE SHELL; PRIORITY JOURNAL; RUPTURE; STOMACH EMPTYING; STOMACH MUCOSA; TABLET DISINTEGRATION;

ACETAMINOPHEN; ADMINISTRATION, ORAL; CAPSULES; CARRAGEENAN; EXCIPIENTS; FASTING; FOOD-DRUG INTERACTIONS; HUMANS; METHYLCELLULOSE; MODELS, BIOLOGICAL; POLYSACCHARIDES, BACTERIAL; RADIONUCLIDE IMAGING; SOLUBILITY;

EID: 80053576484     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.07.046     Document Type: Article

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