Human epidermal growth factor receptor signaling in acute lung injury

American Journal of Respiratory Cell and Molecular Biology

Volumn 47, Issue 4, 2012, Pages 395-404

  Finigan, James H ^a,b   Downey, Gregory P ^a,b,c   Kern, Jeffrey A ^a,b  

^a DEPARTMENT OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

Acute lung injury; Alveolar epithelial cell; Human epidermal growth factor receptor; Inflammation

Indexed keywords

ADAM PROTEIN; ADAM17 PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEINASE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ACUTE LUNG INJURY; EPITHELIUM CELL; INFLAMMATION; INTRACELLULAR SIGNALING; LIGAND BINDING; LUNG ALVEOLUS EPITHELIUM; LUNG DEVELOPMENT; MEMBRANE PERMEABILITY; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RECEPTOR BINDING; REVIEW; SIGNAL TRANSDUCTION; TISSUE REPAIR;

ACUTE LUNG INJURY; ADAM PROTEINS; ANIMALS; EPIDERMAL GROWTH FACTOR; HUMANS; PERMEABILITY; RECEPTOR, EPIDERMAL GROWTH FACTOR; RESPIRATORY MUCOSA; SIGNAL TRANSDUCTION;

EID: 84866985450     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2012-0100TR     Document Type: Review

References (148)

1. Rubenfeld GD, Caldwell E, Peabody E, Weaver J, Martin DP, Neff M, Stern EJ, Hudson LD. Incidence and outcomes of acute lung injury. N Engl J Med 2005;353:1685-1693. (Pubitemid 41464707)
2. Zemans RL, Colgan SP, Downey GP. Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury. Am J Respir Cell Mol Biol 2009;40:519-535.
3. Finigan JH, Boueiz A, Wilkinson E, Damico R, Skirball J, Pae HH, Damarla M, Hasan E, Pearse DB, Reddy SP, et al. Activated protein C protects against ventilator-induced pulmonary capillary leak. Am J Physiol Lung Cell Mol Physiol 2009;296:L1002-L1011.
4. Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med 2000;342:1334-1349. (Pubitemid 30408719)
5. Wiener-Kronish JP, Albertine KH, Matthay MA. Differential responses of the endothelial and epithelial barriers of the lung in sheep to Escherichia coli endotoxin. J Clin Invest 1991;88:864-875.
6. Capelozzi VL. What have anatomic and pathologic studies taught us about acute lung injury and acute respiratory distress syndrome? Curr Opin Crit Care 2008;14:56-63.
7. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, Legall JR, Morris A, Spragg R. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 1994;149:818-824. (Pubitemid 24082248)
8. Bachofen M, Weibel ER. Alterations of the gas exchange apparatus in adult respiratory insufficiency associated with septicemia. Am Rev Respir Dis 1977;116:589-615. (Pubitemid 8206000)
9. Bachofen M, Weibel ER. Structural alterations of lung parenchyma in the adult respiratory distress syndrome. Clin Chest Med 1982;3:35-56. (Pubitemid 12062058)
10. Matthay MA. Function of the alveolar epithelial barrier under pathologic conditions. Chest 1994;105:67S-74S. (Pubitemid 24085342)
11. Inoue S, Michel RP, Hogg JC. Zonulae occludentes in alveolar epithelium and capillary endothelium of dog lungs studies with the freeze-fracture technique. J Ultrastruct Res 1976;56:215-225.
12. Gorin AB, Stewart PA. Differential permeability of endothelial and epithelial barriers to albumin flux. J Appl Physiol 1979;47:1315-1324. (Pubitemid 10168979)
13. Wheeler AP, Bernard GR. Treating patients with severe sepsis. N Engl J Med 1999;340:207-214. (Pubitemid 29063218)
14. Modelska K, Pittet JF, Folkesson HG, Courtney Broaddus V, Matthay MA. Acid-induced lung injury: protective effect of anti-interleukin-8 pretreatment on alveolar epithelial barrier function in rabbits. Am J Respir Crit Care Med 1999;160:1450-1456.
15. Pittet JF, Wiener-Kronish JP, Serikov V, Matthay MA. Resistance of the alveolar epithelium to injury from septic shock in sheep. Am J Respir Crit Care Med 1995;151:1093-1100.
16. Gonzalez-Mariscal L, Betanzos A, Nava P, Jaramillo BE. Tight junction proteins. Prog Biophys Mol Biol 2003;81:1-44. (Pubitemid 35436609)
17. Nagafuchi A. Molecular architecture of adherens junctions. Curr Opin Cell Biol 2001;13:600-603. (Pubitemid 32817019)
18. Geiser T, Jarreau PH, Atabai K, Matthay MA. Interleukin-1beta augments in vitro alveolar epithelial repair. Am J Physiol Lung Cell Mol Physiol 2000;279:L1184-L1190. (Pubitemid 32009504)
19. Zemans RL, Briones N, Campbell M, McClendon J, Young SK, Suzuki T, Yang IV, De Langhe S, Reynolds SD, Mason RJ, et al. Neutrophil transmigration triggers repair of the lung epithelium via beta-catenin signaling. Proc Natl Acad Sci USA 2011;108:15990-15995.
20. Rock JR, Barkauskas CE, Cronce MJ, Xue Y, Harris JR, Liang J, Noble PW, Hogan BL. Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition. Proc Natl Acad Sci USA 2011;108:E1475-E1483.
21. Kumar PA, Hu Y, Yamamoto Y, Hoe NB, Wei TS, Mu D, Sun Y, Joo LS, Dagher R, Zielonka EM, et al. Distal airway stem cells yield alveoli in vitro and during lung regeneration following H1N1 influenza infection. Cell 2011;147:525-538.
22. Uhal BD. Cell cycle kinetics in the alveolar epithelium. Am J Physiol 1997;272:L1031-L1045.
23. Adamson IY, Bowden DH. The type 2 cell as progenitor of alveolar epithelial regeneration: a cytodynamic study in mice after exposure to oxygen. Lab Invest 1974;30:35-42.
24. Scotton CJ, Chambers RC. Molecular targets in pulmonary fibrosis: the myofibroblast in focus. Chest 2007;132:1311-1321. (Pubitemid 47621009)
25. Adamson IY, Young L, Bowden DH. Relationship of alveolar epithelial injury and repair to the induction of pulmonary fibrosis. Am J Pathol 1988;130:377-383. (Pubitemid 18076372)
26. Bitterman PB. Pathogenesis of fibrosis in acute lung injury. Am J Med 1992;92:39S-43S.
27. Adamson IY, Hedgecock C, Bowden DH. Epithelial cell-fibroblast interactions in lung injury and repair. Am J Pathol 1990;137:385-392. (Pubitemid 20232999)
28. Kasper M, Haroske G. Alterations in the alveolar epithelium after injury leading to pulmonary fibrosis. Histol Histopathol 1996;11:463-483. (Pubitemid 26135211)
29. Morishima Y, Nomura A, Uchida Y, Noguchi Y, Sakamoto T, Ishii Y, Goto Y, Masuyama K, Zhang MJ, Hirano K, et al. Triggering the induction of myofibroblast and fibrogenesis by airway epithelial shedding. Am J Respir Cell Mol Biol 2001;24:1-11. (Pubitemid 32097502)
30. Sisson TH, Mendez M, Choi K, Subbotina N, Courey A, Cunningham A, Dave A, Engelhardt JF, Liu X, White ES, et al. Targeted injury of type II alveolar epithelial cells induces pulmonary fibrosis. Am J Respir Crit Care Med 2010;181:254-263.
31. Kern JA, Robinson RA, Gazdar A, Torney L, Weiner DB. Mechanisms of p185HER2 expression in human non-small cell lung cancer cell lines. Am J Respir Cell Mol Biol 1992;6:359-363.
32. Slamon DJ, Godolphin W, Jones LA, Holt JA, Wong SG, Keith DE, Levin WJ, Stuart SG, Udove J, Ullrich A, et al. Studies of the HER- 2/neu proto-oncogene in human breast and ovarian cancer. Science 1989;244:707-712. (Pubitemid 19147683)
33. Loi S, de Azambuja E, Pugliano L, Sotiriou C, Piccart MJ. Her2-overexpressing breast cancer: time for the cure with less chemotherapy? Curr Opin Oncol 2011;23:547-558.
34. Carr LL, Finigan JH, Kern JA. Evaluation and treatment of patients with non-small cell lung cancer. Med Clin North Am 2011;95:1041-1054.
35. Jorissen RN, Walker F, Pouliot N, Garrett TP, Ward CW, Burgess AW. Epidermal growth factor receptor: mechanisms of activation and signalling. Exp Cell Res 2003;284:31-53. (Pubitemid 36331965)
36. Privalsky ML, Sealy L, Bishop JM, McGrath JP, Levinson AD. The product of the avian erythroblastosis virus erbb locus is a glycoprotein. Cell 1983;32:1257-1267.
37. Hayman MJ, Ramsay GM, Savin K, Kitchener G, Graf T, Beug H. Identification and characterization of the avian erythroblastosis virus erbB gene product as a membrane glycoprotein. Cell 1983;32:579-588. (Pubitemid 13127827)
38. Hayman MJ, Beug H. Identification of a form of the avian erythroblastosis virus erb-B gene product at the cell surface. Nature 1984; 309:460-462. (Pubitemid 14102452)
39. Yarden Y, Sliwkowski MX. Untangling the erbB signalling network. Nat Rev Mol Cell Biol 2001;2:127-137. (Pubitemid 33674041)
40. Burden S, Yarden Y. Neuregulins and their receptors: a versatile signaling module in organogenesis and oncogenesis. Neuron 1997;18: 847-855. (Pubitemid 27274603)
41. Klapper LN, Glathe S, Vaisman N, Hynes NE, Andrews GC, Sela M, Yarden Y. The erbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factors. Proc Natl Acad Sci USA 1999;96:4995-5000.
42. Guy PM, Platko JV, Cantley LC, Cerione RA, Carraway KL. III Insect cell-expressed p180erbb3 possesses an impaired tyrosine kinase activity. Proc Natl Acad Sci USA 1994;91:8132-8136.
43. Finigan JH, Faress JA, Wilkinson E, Mishra RS, Nethery DE, Wyler D, Shatat M, Ware LB, Matthay MA, Mason R, et al. Neuregulin-1- human epidermal receptor-2 signaling is a central regulator of pulmonary epithelial permeability and acute lung injury. J Biol Chem 2011;286:10660-10670.
44. Vermeer PD, Einwalter LA, Moninger TO, Rokhlina T, Kern JA, Zabner J, Welsh MJ. Segregation of receptor and ligand regulates activation of epithelial growth factor receptor. Nature 2003;422:322-326. (Pubitemid 36378360)
45. Sidhaye VK, Chau E, Breysse PN, King LS. Septin-2 mediates airway epithelial barrier function in physiologic and pathologic conditions. Am J Respir Cell Mol Biol 2011;45:120-126.
46. Luttrell LM, Della Rocca GJ, van Biesen T, Luttrell DK, Lefkowitz RJ. Gbetagamma subunits mediate src-dependent phosphorylation of the epidermal growth factor receptor: a scaffold for G protein-coupled receptor-mediated ras activation. J Biol Chem 1997;272:4637-4644. (Pubitemid 27086335)
47. Olayioye MA, Graus-Porta D, Beerli RR, Rohrer J, Gay B, Hynes NE. ErbB-1 and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner. Mol Cell Biol 1998;18:5042-5051. (Pubitemid 28388087)
48. Elenius K, Choi CJ, Paul S, Santiestevan E, Nishi E, Klagsbrun M. Characterization of a naturally occurring erbb4 isoform that does not bind or activate phosphatidyl inositol 3-kinase. Oncogene 1999;18:2607-2615. (Pubitemid 29216683)
49. Kainulainen V, Sundvall M, Maatta JA, Santiestevan E, Klagsbrun M, Elenius K. A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis. J Biol Chem 2000;275:8641-8649. (Pubitemid 30180214)
50. Buonanno A, Fischbach GD. Neuregulin and ErbB receptor signaling pathways in the nervous system. Curr Opin Neurobiol 2001;11:287-296. (Pubitemid 32524093)
51. Falls DL. Neuregulins: functions, forms, and signaling strategies. Exp Cell Res 2003;284:14-30. (Pubitemid 36335807)
52. Beers MF, Morrisey EE. The three r's of lung health and disease: repair, remodeling, and regeneration. J Clin Invest 2011;121:2065-2073.
53. Morrisey EE, Hogan BL. Preparing for the first breath: genetic and cellular mechanisms in lung development. Dev Cell 2010;18:8-23.
54. Plopper CG, St George JA, Read LC, Nishio SJ, Weir AJ, Edwards L, Tarantal AF, Pinkerton KE, Merritt TA, Whitsett JA, et al. Acceleration of alveolar type II cell differentiation in fetal rhesus monkey lung by administration of EGF. Am J Physiol 1992;262:L313-L321.
55. Yasui S, Nagai A, Oohira A, Iwashita M, Konno K. Effects of anti-mouse EGF antiserum on prenatal lung development in fetal mice. Pediatr Pulmonol 1993;15:251-256.
56. Seth R, Shum L, Wu F, Wuenschell C, Hall FL, Slavkin HC, Warburton D. Role of epidermal growth factor expression in early mouse embryo lung branching morphogenesis in culture: antisense oligodeoxynucleotide inhibitory strategy. Dev Biol 1993;158:555-559. (Pubitemid 23243912)
57. Miettinen PJ, Berger JE, Meneses J, Phung Y, Pedersen RA, Werb Z, Derynck R. Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature 1995;376:337-341.
58. Warburton D, Seth R, Shum L, Horcher PG, Hall FL, Werb Z, Slavkin HC. Epigenetic role of epidermal growth factor expression and signalling in embryonic mouse lung morphogenesis. Dev Biol 1992;149: 123-133.
59. Catterton WZ, Escobedo MB, Sexson WR, Gray ME, Sundell HW, Stahlman MT. Effect of epidermal growth factor on lung maturation in fetal rabbits. Pediatr Res 1979;13:104-108. (Pubitemid 9106018)
60. Sundell HW, Gray ME, Serenius FS, Escobedo MB, Stahlman MT. Effects of epidermal growth factor on lung maturation in fetal lambs. Am J Pathol 1980;100:707-726.
61. Holmes WE, Sliwkowski MX, Akita RW, Henzel WJ, Lee J, Park JW, Yansura D, Abadi N, Raab H, Lewis GD, et al. Identification of heregulin, a specific activator of p185erbb2. Science 1992;256:1205-1210.
62. Chang H, Riese DJ II, Gilbert W, Stern DF, McMahan UJ. Ligands for ErbB-family receptors encoded by a neuregulin-like gene. Nature 1997;387:509-512. (Pubitemid 27235469)
63. Patel NV, Acarregui MJ, Snyder JM, Klein JM, Sliwkowski MX, Kern JA. Neuregulin-1 and human epidermal growth factor receptors 2 and 3 play a role in human lung development in vitro. Am J Respir Cell Mol Biol 2000;22:432-440. (Pubitemid 30343342)
64. Vermeer PD, Panko L, Karp P, Lee JH, Zabner J. Differentiation of human airway epithelia is dependent on erbB2. Am J Physiol Lung Cell Mol Physiol 2006;291:L175-L180. (Pubitemid 44148101)
65. Liu J, Nethery D, Kern JA. Neuregulin-1 induces branching morphogenesis in the developing lung through a p13k signal pathway. Exp Lung Res 2004;30:465-478. (Pubitemid 39096095)
66. Zscheppang K, Liu W, Volpe MV, Nielsen HC, Dammann CE. ErbB4 regulates fetal surfactant phospholipid synthesis in primary fetal rat type II cells. Am J Physiol Lung Cell Mol Physiol 2007;293:L429-L435. (Pubitemid 47205023)
67. Purevdorj E, Zscheppang K, Hoymann HG, Braun A, von Mayersbach D, Brinkhaus MJ, Schmiedl A, Dammann CE. ErbB4 deletion leads to changes in lung function and structure similar to bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol 2008;294:L516-L522. (Pubitemid 351468851)
68. Zscheppang K, Dork T, Schmiedl A, Jones FE, Dammann CE. Neuregulin receptor ErbB4 functions as a transcriptional cofactor for the expression of surfactant protein b in the fetal lung. Am J Respir Cell Mol Biol 2011;45:761-767.
69. Stoll S, Garner W, Elder J. Heparin-binding ligands mediate autocrine epidermal growth factor receptor activation in skin organ culture. J Clin Invest 1997;100:1271-1281. (Pubitemid 27386314)
70. Egan LJ, de Lecea A, Lehrman ED, Myhre GM, Eckmann L, Kagnoff MF. Nuclear factor-kappa b activation promotes restitution of wounded intestinal epithelial monolayers. Am J Physiol Cell Physiol 2003;285:C1028-C1035. (Pubitemid 37296279)
71. Zieske JD, Takahashi H, Hutcheon AE, Dalbone AC. Activation of epidermal growth factor receptor during corneal epithelial migration. Invest Ophthalmol Vis Sci 2000;41:1346-1355. (Pubitemid 30261856)
72. Nakamura Y, Sotozono C, Kinoshita S. The epidermal growth factor receptor (EGFR): role in corneal wound healing and homeostasis. Exp Eye Res 2001;72:511-517. (Pubitemid 32977221)
73. Yin J, Yu FS. Erk1/2 mediate wounding- and G-protein-coupled receptor ligands-induced EGFR activation via regulating ADAM17 and HB-EGF shedding. Invest Ophthalmol Vis Sci 2009;50:132-139.
74. Crosby LM, Waters CM. Epithelial repair mechanisms in the lung. Am J Physiol Lung Cell Mol Physiol 2010;298:L715-L731.
75. Chesnutt AN, Kheradmand F, Folkesson HG, Alberts M, Matthay MA. Soluble transforming growth factor-alpha is present in the pulmonary edema fluid of patients with acute lung injury. Chest 1997;111:652-656. (Pubitemid 27132941)
76. Ryan RM, Mineo-Kuhn MM, Kramer CM, Finkelstein JN. Growth factors alter neonatal type II alveolar epithelial cell proliferation. Am J Physiol 1994;266:L17-L22.
77. Leslie CC, McCormick-Shannon K, Shannon JM, Garrick B, Damm D, Abraham JA, Mason RJ. Heparin-binding EGF-like growth factor is a mitogen for rat alveolar type II cells. Am J Respir Cell Mol Biol 1997;16:379-387. (Pubitemid 127497463)
78. Kheradmand F, Folkesson HG, Shum L, Derynk R, Pytela R, Matthay MA. Transforming growth factor-alpha enhances alveolar epithelial cell repair in a new in vitro model. Am J Physiol 1994;267:L728-L738.
79. Bajaj-Elliott M, Poulsom R, Pender SL, Wathen NC, MacDonald TT. Interactions between stromal cell-derived keratinocyte growth factor and epithelial transforming growth factor in immune-mediated crypt cell hyperplasia. J Clin Invest 1998;102:1473-1480. (Pubitemid 28492213)
80. Atabai K, Ishigaki M, Geiser T, Ueki I, Matthay MA, Ware LB. Keratinocyte growth factor can enhance alveolar epithelial repair by non-mitogenic mechanisms. Am J Physiol Lung Cell Mol Physiol 2002;283:L163-L169. (Pubitemid 34764553)
81. Dlugosz AA, Cheng C, Denning MF, Dempsey PJ, Coffey RJ Jr, Yuspa SH. Keratinocyte growth factor receptor ligands induce transforming growth factor alpha expression and activate the epidermal growth factor receptor signaling pathway in cultured epidermal keratinocytes. Cell Growth Differ 1994;5:1283-1292. (Pubitemid 24381516)
82. Puddicombe SM, Polosa R, Richter A, Krishna MT, Howarth PH, Holgate ST, Davies DE. Involvement of the epidermal growth factor receptor in epithelial repair in asthma. FASEB J 2000;14:1362-1374. (Pubitemid 30439745)
83. Savla U, Waters CM. Mechanical strain inhibits repair of airway epithelium in vitro. Am J Physiol 1998;274:L883-L892.
84. Shiomi T, Tschumperlin DJ, Park JA, Sunnarborg SW, Horiuchi K, Blobel CP, Drazen JM. Tace/adam17 mediates mechanotransduction in murine tracheal epithelial cells. Am J Respir Cell Mol Biol (In press)
85. Liu J, Kern JA. Neuregulin-1 activates the JAK-STAT pathway and regulates lung epithelial cell proliferation. Am J Respir Cell Mol Biol 2002;27:306-313. (Pubitemid 34979288)
86. Ganter MT, Roux J, Miyazawa B, Howard M, Frank JA, Su G, Sheppard D, Violette SM, Weinreb PH, Horan GS, et al. Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms. Circ Res 2008;102:804-812. (Pubitemid 351521585)
87. Ortiz LA, Dutreil M, Fattman C, Pandey AC, Torres G, Go K, Phinney DG. Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury. Proc Natl Acad Sci USA 2007;104:11002-11007. (Pubitemid 47175216)
88. Gasse P, Mary C, Guenon I, Noulin N, Charron S, Schnyder-Candrian S, Schnyder B, Akira S, Quesniaux VF, Lagente V, et al. Il-1R1/MYD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice. J Clin Invest 2007;117:3786-3799. (Pubitemid 350224089)
89. Hoshino T, Okamoto M, Sakazaki Y, Kato S, Young HA, Aizawa H. Role of proinflammatory cytokine IL-18 and IL-1{beta} in bleomycin-induced lung injury in humans and mice. Am J Respir Cell Mol Biol 2009;41:661-670.
90. Mato N, Fujii M, Hakamata Y, Kobayashi E, Sato A, Hayakawa M, Ohto-Ozaki H, Bando M, Ohno S, Tominaga S, et al. Interleukin-1 receptor-related protein st2 suppresses the initial stage of bleomycin-induced lung injury. Eur Respir J 2009;33:1415-1428.
91. Park WY, Goodman RB, Steinberg KP, Ruzinski JT, Radella F II, Park DR, Pugin J, Skerrett SJ, Hudson LD, Martin TR. Cytokine balance in the lungs of patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 2001;164:1896-1903. (Pubitemid 33152327)
92. Siler TM, Swierkosz JE, Hyers TM, Fowler AA, Webster RO. Immunoreactive interleukin-1 in bronchoalveolar lavage fluid of high-risk patients and patients with the adult respiratory distress syndrome. Exp Lung Res 1989;15:881-894. (Pubitemid 20061102)
93. Pugin J, Ricou B, Steinberg KP, Suter PM, Martin TR. Proinflammatory activity in bronchoalveolar lavage fluids from patients with ARDS, a prominent role for interleukin-1. Am J Respir Crit Care Med 1996;153:1850-1856. (Pubitemid 26187910)
94. Geiser T, Atabai K, Jarreau PH, Ware LB, Pugin J, Matthay MA. Pulmonary edema fluid from patients with acute lung injury augments in vitro alveolar epithelial repair by an il-1beta-dependent mechanism. Am J Respir Crit Care Med 2001;163:1384-1388. (Pubitemid 32506603)
95. Bierman A, Yerrapureddy A, Reddy NM, Hassoun PM, Reddy SP. Epidermal growth factor receptor (EGFR) regulates mechanical ventilation-induced lung injury in mice. Transl Res 2008;152:265-272.
96. Correa-Meyer E, Pesce L, Guerrero C, Sznajder JI. Cyclic stretch activates ERK1/2 via G proteins and EGFR in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 2002;282:L883-L891. (Pubitemid 34654602)
97. Hardie WD, Davidson C, Ikegami M, Leikauf GD, Le Cras TD, Prestridge A, Whitsett JA, Korfhagen TR. EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 2008;294:L1217-L1225.
98. Ishii Y, Fujimoto S, Fukuda T. Gefitinib prevents bleomycin-induced lung fibrosis in mice. Am J Respir Crit Care Med 2006;174:550-556. (Pubitemid 44330548)
99. Suzuki H, Aoshiba K, Yokohori N, Nagai A. Epidermal growth factor receptor tyrosine kinase inhibition augments a murine model of pulmonary fibrosis. Cancer Res 2003;63:5054-5059. (Pubitemid 37025129)
100. Min JH, Lee HY, Lim H, Ahn MJ, Park K, Chung MP, Lee KS. Drug-induced interstitial lung disease in tyrosine kinase inhibitor therapy for non-small cell lung cancer: a review on current insight. Cancer Chemother Pharmacol 2011;68:1099-1109.
101. Nethery DE, Moore BB, Minowada G, Carroll J, Faress JA, Kern JA. Expression of mutant human epidermal receptor 3 attenuates lung fibrosis and improves survival in mice. J Appl Physiol 2005;99:298-307. (Pubitemid 40934495)
102. Faress JA, Nethery DE, Kern EF, Eisenberg R, Jacono FJ, Allen CL, Kern JA. Bleomycin-induced pulmonary fibrosis is attenuated by a monoclonal antibody targeting HER2. J Appl Physiol 2007;103:2077-2083. (Pubitemid 350232393)
103. Finigan JH, Mishra R, Vasu VT, Silveira LJ, Nethery DE, Standiford TJ, Burnham EL, Moss M, Kern JA. BAL neuregulin-1 is elevated in acute lung injury and correlates with inflammation. Eur Respir J (In press)
104. Seals DF, Courtneidge SA. The ADAMs family of metalloproteases: multidomain proteins with multiple functions. Genes Dev 2003;17:7-30. (Pubitemid 36062504)
105. Black RA, Rauch CT, Kozlosky CJ, Peschon JJ, Slack JL, Wolfson MF, Castner BJ, Stocking KL, Reddy P, Srinivasan S, et al. A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. Nature 1997;385:729-733. (Pubitemid 27098094)
106. Peschon JJ, Slack JL, Reddy P, Stocking KL, Sunnarborg SW, Lee DC, Russell WE, Castner BJ, Johnson RS, Fitzner JN, et al. An essential role for ectodomain shedding in mammalian development. Science 1998;282:1281-1284. (Pubitemid 28524483)
107. Sibilia M, Wagner EF. Strain-dependent epithelial defects in mice lacking the EGF receptor. Science 1995;269:234-238.
108. Threadgill DW, Dlugosz AA, Hansen LA, Tennenbaum T, Lichti U, Yee D, LaMantia C, Mourton T, Herrup K, Harris RC, et al. Targeted disruption of mouse egf receptor: effect of genetic background on mutant phenotype. Science 1995;269:230-234.
109. Luetteke NC, Lee DC, Palmiter RD, Brinster RL, Sandgren EP. Regulation of fat and muscle development by transforming growth factor alpha in transgenic mice and in cultured cells. Cell Growth Differ 1993;4:203-213.
110. Mann GB, Fowler KJ, Gabriel A, Nice EC, Williams RL, Dunn AR. Mice with a null mutation of the TGF alpha gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation. Cell 1993;73:249-261. (Pubitemid 23123305)
111. Jackson LF, Qiu TH, Sunnarborg SW, Chang A, Zhang C, Patterson C, Lee DC. Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling. EMBO J 2003;22:2704-2716. (Pubitemid 36712367)
112. Iwamoto R, Yamazaki S, Asakura M, Takashima S, Hasuwa H, Miyado K, Adachi S, Kitakaze M, Hashimoto K, Raab G, et al. Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function. Proc Natl Acad Sci USA 2003;100:3221-3226. (Pubitemid 36356564)
113. Sternlicht MD, Sunnarborg SW, Kouros-Mehr H, Yu Y, Lee DC, Werb Z. Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin. Development 2005;132:3923-3933. (Pubitemid 41410256)
114. Sahin U, Weskamp G, Kelly K, Zhou HM, Higashiyama S, Peschon J, Hartmann D, Saftig P, Blobel CP. Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands. J Cell Biol 2004;164:769-779. (Pubitemid 38282960)
115. Blobel CP. ADAMs: key components in EGFR signalling and development. Nat Rev Mol Cell Biol 2005;6:32-43. (Pubitemid 40064897)
116. Ohtsu H, Dempsey PJ, Eguchi S. ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors. Am J Physiol Cell Physiol 2006;291:C1-C10.
117. Charbonneau M, Harper K, Grondin F, Pelmus M, McDonald PP, Dubois CM. Hypoxia-inducible factor mediates hypoxic and tumor necrosis factor alpha-induced increases in tumor necrosis factor-alpha converting enzyme/ADAM17 expression by synovial cells. J Biol Chem 2007;282:33714-33724. (Pubitemid 350159521)
118. Colon AL, Menchen LA, Hurtado O, De Cristobal J, Lizasoain I, Leza JC, Lorenzo P, Moro MA. Implication of TNF-alpha convertase (TACE/ADAM17) in inducible nitric oxide synthase expression and inflammation in an experimental model of colitis. Cytokine 2001;16:220-226. (Pubitemid 34252604)
119. Gloushankova NA. Changes in regulation of cell-cell adhesion during tumor transformation. Biochemistry (Mosc) 2008;73:742-750.
120. Borrell-Pages M, Rojo F, Albanell J, Baselga J, Arribas J. TACE is required for the activation of the EGFR by TGF-alpha in tumors. EMBO J 2003;22:1114-1124. (Pubitemid 36313595)
121. Gill SE, Huizar I, Bench EM, Sussman SW, Wang Y, Khokha R, Parks WC. Tissue inhibitor of metalloproteinases 3 regulates resolution of inflammation following acute lung injury. Am J Pathol 2010;176:64-73.
122. Walser T, Cui X, Yanagawa J, Lee JM, Heinrich E, Lee G, Sharma S, Dubinett SM. Smoking and lung cancer: the role of inflammation. Proc Am Thorac Soc 2008;5:811-815.
123. Terry S, Nie M, Matter K, Balda MS. Rho signaling and tight junction functions. Physiology (Bethesda) 2010;25:16-26.
124. Bustelo XR, Sauzeau V, Berenjeno IM. Gtp-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo. Bioessays 2007;29:356-370. (Pubitemid 46597867)
125. Arias-Romero LE, Villamar-Cruz O, Pacheco A, Kosoff R, Huang M, Muthuswamy SK, Chernoff J. A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells. Oncogene 2010;29:5839-5849.
126. Yang C, Liu Y, Lemmon MA, Kazanietz MG. Essential role for Rac in heregulin beta1 mitogenic signaling: a mechanism that involves epidermal growth factor receptor and is independent of ErbB4. Mol Cell Biol 2006;26:831-842. (Pubitemid 43146479)
127. Montero JC, Seoane S, Ocana A, Pandiella A. P-rex1 participates in neuregulin-erbb signal transduction and its expression correlates with patient outcome in breast cancer. Oncogene 2011;30:1059-1071.
128. Dise RS, Frey MR, Whitehead RH, Polk DB. Epidermal growth factor stimulates rac activation through Src and phosphatidylinositol 3-kinase to promote colonic epithelial cell migration. Am J Physiol Gastrointest Liver Physiol 2008;294:G276-G285.
129. Yin J, Lu J, Yu FS. Role of small gtpase Rho in regulating corneal epithelial wound healing. Invest Ophthalmol Vis Sci 2008;49:900-909.
130. Pittet JF, Griffiths MJ, Geiser T, Kaminski N, Dalton SL, Huang X, Brown LA, Gotwals PJ, Koteliansky VE, Matthay MA, et al. TGF-beta is a critical mediator of acute lung injury. J Clin Invest 2001;107: 1537-1544. (Pubitemid 32574640)
131. Sime PJ, Xing Z, Graham FL, Csaky KG, Gauldie J. Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung. J Clin Invest 1997;100:768-776. (Pubitemid 27371693)
132. Degryse AL, Tanjore H, Xu XC, Polosukhin VV, Jones BR, Boomershine CS, Ortiz C, Sherrill TP, McMahon FB, Gleaves LA, et al. TGFbeta signaling in lung epithelium regulates bleomycin-induced alveolar injury and fibroblast recruitment. Am J Physiol Lung Cell Mol Physiol 2011;300:L887-L897.
133. Chow A, Arteaga CL, Wang SE. When tumor suppressor TGF-beta meets the HER2 (erbB2) oncogene. J Mammary Gland Biol Neoplasia 2011;16:81-88.
134. Wang SE, Xiang B, Guix M, Olivares MG, Parker J, Chung CH, Pandiella A, Arteaga CL. Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab. Mol Cell Biol 2008;28:5605-5620.
135. Ueda Y, Wang S, Dumont N, Yi JY, Koh Y, Arteaga CL. Overexpression of HER2 (erbb2) in human breast epithelial cells unmasks transforming growth factor beta-induced cell motility. J Biol Chem 2004;279:24505-24513. (Pubitemid 38725316)
136. Northey JJ, Chmielecki J, Ngan E, Russo C, Annis MG, Muller WJ, Siegel PM. Signaling through shca is required for transforming growth factor beta- and neu/ErbB-2-induced breast cancer cell motility and invasion. Mol Cell Biol 2008;28:3162-3176. (Pubitemid 351657082)
137. Wang SE, Shin I, Wu FY, Friedman DB, Arteaga CL.HER2/neu (ErbB2) signaling to Rac1-Pak1 is temporally and spatially modulated by transforming growth factor beta. Cancer Res 2006;66:9591-9600. (Pubitemid 44623658)
138. Wang SE, Xiang B, Zent R, Quaranta V, Pozzi A, Arteaga CL. Transforming growth factor beta induces clustering of HER2 and integrins by activating Src-focal adhesion kinase and receptor association to the cytoskeleton. Cancer Res 2009;69:475-482.
139. Wang SE, Yu Y, Criswell TL, Debusk LM, Lin PC, Zent R, Johnson DH, Ren X, Arteaga CL. Oncogenic mutations regulate tumor microenvironment through induction of growth factors and angiogenic mediators. Oncogene 2010;29:3335-3348.
140. Terakado M, Gon Y, Sekiyama A, Takeshita I, Kozu Y, Matsumoto K, Takahashi N, Hashimoto S. The rac1/jnk pathway is critical for EGFR-dependent barrier formation in human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 2011;300:L56-L63.
141. Chen SP, Zhou B, Willis BC, Sandoval AJ, Liebler JM, Kim KJ, Ann DK, Crandall ED, Borok Z. Effects of transdifferentiation and EGF on claudin isoform expression in alveolar epithelial cells. J Appl Physiol 2005;98:322-328. (Pubitemid 40041263)
142. Gon Y, Matsumoto K, Terakado M, Sekiyama A, Maruoka S, Takeshita I, Kozu Y, Okayama Y, Ra C, Hashimoto S. Heregulin activation of ErbB2/ErbB3 signaling potentiates the integrity of airway epithelial barrier. Exp Cell Res 2011;317:1947-1953.
143. Giri S, Poindexter KM, Sundar SN, Firestone GL. Arecoline induced disruption of expression and localization of the tight junctional protein ZO-1 is dependent on the HER 2 expression in human endometrial ishikawa cells. BMC Cell Biol 2010;11:53.
144. Hintermann E, Yang N, O'Sullivan D, Higgins JM, Quaranta V. Integrin alpha6beta4-erbB2 complex inhibits haptotaxis by up-regulating E-cadherin cell-cell junctions in keratinocytes. J Biol Chem 2005;280:8004-8015. (Pubitemid 40349698)
145. Chapman HA, Li X, Alexander JP, Brumwell A, Lorizio W, Tan K, Sonnenberg A, Wei Y, Vu TH. Integrin alpha6beta4 identifies an adult distal lung epithelial population with regenerative potential in mice. J Clin Invest 2011;121:2855-2862.
146. Guo W, Pylayeva Y, Pepe A, Yoshioka T, Muller WJ, Inghirami G, Giancotti FG. Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis. Cell 2006;126:489-502. (Pubitemid 44163602)
147. Herrlich A, Leitch V, King LS. Role of proneuregulin 1 cleavage and human epidermal growth factor receptor activation in hypertonic aquaporin induction. Proc Natl Acad Sci USA 2004;101:15799-15804. (Pubitemid 39473568)
148. Richeldi L, Costabel U, Selman M, Kim DS, Hansell DM, Nicholson AG, Brown KK, Flaherty KR, Noble PW, Raghu G, et al. Efficacy of a tyrosine kinase inhibitor in idiopathic pulmonary fibrosis. N Engl J Med 2011;365:1079-1087.