-
1
-
-
0032510109
-
Signal transduction pathways activated and required for mammary carcinogenesis in response to specific oncogenes
-
Amundadottir LT, Leder P. (1998). Signal transduction pathways activated and required for mammary carcinogenesis in response to specific oncogenes. Oncogene 16: 737-746.
-
(1998)
Oncogene
, vol.16
, pp. 737-746
-
-
Amundadottir, L.T.1
Leder, P.2
-
3
-
-
27744521323
-
Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors
-
Beeser A, Jaffer ZM, Hofmann C, Chernoff J. (2005). Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors. J Biol Chem 280: 36609-36615.
-
(2005)
J Biol Chem
, vol.280
, pp. 36609-36615
-
-
Beeser, A.1
Jaffer, Z.M.2
Hofmann, C.3
Chernoff, J.4
-
4
-
-
0038554077
-
Biology of the p21-activated kinases
-
Bokoch GM. (2003). Biology of the p21-activated kinases. Annu Rev Biochem 72: 743-781.
-
(2003)
Annu Rev Biochem
, vol.72
, pp. 743-781
-
-
Bokoch, G.M.1
-
5
-
-
41949100602
-
An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase
-
Deacon SW, Beeser A, Fukui JA, Rennefahrt UE, Myers C, Chernoff J et al. (2008). An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem Biol 15: 322-331.
-
(2008)
Chem Biol
, vol.15
, pp. 322-331
-
-
Deacon, S.W.1
Beeser, A.2
Fukui, J.A.3
Rennefahrt, U.E.4
Myers, C.5
Chernoff, J.6
-
7
-
-
0036333485
-
Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEKI-ERK complexes
-
Eblen ST, Slack JK, Weber MJ, Catling AD. (2002). Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEKI-ERK complexes. Mol Cell Biol 22: 6023-6033.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 6023-6033
-
-
Eblen, S.T.1
Slack, J.K.2
Weber, M.J.3
Catling, A.D.4
-
8
-
-
0030830220
-
Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins
-
Frost JA, Steen H, Shapiro P, Lewis T, Ahn N, Shaw PE et al. (1997). Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins. EMBO J 16: 6426-6438.
-
(1997)
EMBO J
, vol.16
, pp. 6426-6438
-
-
Frost, J.A.1
Steen, H.2
Shapiro, P.3
Lewis, T.4
Ahn, N.5
Shaw, P.E.6
-
9
-
-
0036223236
-
P21-activated kinases: Three more join the Pak
-
Jaffer ZM, Chernoff J. (2002). p21-activated kinases: three more join the Pak. Int J Biochem Cell Biol 34: 713-717.
-
(2002)
Int J Biochem Cell Biol
, vol.34
, pp. 713-717
-
-
Jaffer, Z.M.1
Chernoff, J.2
-
10
-
-
56749178863
-
Targeting Large Kinase Active Site with Rigid, Bulky Octahedral Ruthenium Complexes
-
Maksimoska J, Feng L, Harms K, Yi C, Kissil J, Marmorstein R et al. (2008). Targeting Large Kinase Active Site with Rigid, Bulky Octahedral Ruthenium Complexes. J Am Chem Soc 130:15764-15765.
-
(2008)
J Am Chem Soc
, vol.130
, pp. 15764-15765
-
-
Maksimoska, J.1
Feng, L.2
Harms, K.3
Yi, C.4
Kissil, J.5
Marmorstein, R.6
-
11
-
-
2442664118
-
Rational design and characterization of a Rac GTPase-specific small molecule inhibitor
-
Gao Y, Dickerson JB, Guo F, Zheng J, Zheng Y. (2004). Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc Natl Acad Sci USA 101: 7618-7623.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 7618-7623
-
-
Gao, Y.1
Dickerson, J.B.2
Guo, F.3
Zheng, J.4
Zheng, Y.5
-
12
-
-
0031055468
-
Construction of adenovirus vectors through Cre-lox recombination
-
Hardy S, Kitamura M, Harris-Stansil T, Dai Y, Phipps ML. (1997). Construction of adenovirus vectors through Cre-lox recombination. J Virol 71: 1842-1849.
-
(1997)
J Virol
, vol.71
, pp. 1842-1849
-
-
Hardy, S.1
Kitamura, M.2
Harris-Stansil, T.3
Dai, Y.4
Phipps, M.L.5
-
15
-
-
33646940460
-
Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients
-
Holm C, Rayala S, Jirstrom K, Stal O, Kumar R, Landberg G. (2006). Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients. J Natl Cancer Inst 98: 671-680.
-
(2006)
J Natl Cancer Inst
, vol.98
, pp. 671-680
-
-
Holm, C.1
Rayala, S.2
Jirstrom, K.3
Stal, O.4
Kumar, R.5
Landberg, G.6
-
16
-
-
63749086305
-
ErbB receptors and signaling pathways in cancer
-
Hynes NE, MacDonald G. (2009). ErbB receptors and signaling pathways in cancer. Curr Opin Cell Biol 21: 177-184.
-
(2009)
Curr Opin Cell Biol
, vol.21
, pp. 177-184
-
-
Hynes, N.E.1
MacDonald, G.2
-
17
-
-
0030030072
-
ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: Implications for breast cancer
-
Karunagaran D, Tzahar E, Beerli RR, Chen X, Graus-Porta D, Ratzkin BJ et al. (1996). ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer. EMBO J 15: 254-264.
-
(1996)
EMBO J
, vol.15
, pp. 254-264
-
-
Karunagaran, D.1
Tzahar, E.2
Beerli, R.R.3
Chen, X.4
Graus-Porta, D.5
Ratzkin, B.J.6
-
18
-
-
0029833422
-
Episomal vectors rapidly and stably produce high-titer recombinant retrovirus
-
Kinsella TM, Nolan GP. (1996). Episomal vectors rapidly and stably produce high-titer recombinant retrovirus. Hum Gene Ther 7: 1405-1413.
-
(1996)
Hum Gene Ther
, vol.7
, pp. 1405-1413
-
-
Kinsella, T.M.1
Nolan, G.P.2
-
19
-
-
41649085584
-
P21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer
-
Li Q, Mullins SR, Sloane BF, Mattingly RR. (2008). p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer. Neoplasia 10: 314-329.
-
(2008)
Neoplasia
, vol.10
, pp. 314-329
-
-
Li, Q.1
Mullins, S.R.2
Sloane, B.F.3
Mattingly, R.R.4
-
20
-
-
67649464367
-
Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development
-
Lightcap CM, Kari G, Arias-Romero LE, Chernoff J, Rodeck U, Williams JC. (2009). Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development. PLoS One 4: e6025.
-
(2009)
PLoS One
, vol.4
-
-
Lightcap, C.M.1
Kari, G.2
Arias-Romero, L.E.3
Chernoff, J.4
Rodeck, U.5
Williams, J.C.6
-
21
-
-
56749178863
-
Targeting large kinase active site with rigid, bulky octahedral ruthenium complexes
-
Maksimoska J, Feng L, Harms K, Yi C, Kissil J, Marmorstein R et al. (2008). Targeting large kinase active site with rigid, bulky octahedral ruthenium complexes. J Am Chem Soc 130: 15764-15765.
-
(2008)
J Am Chem Soc
, vol.130
, pp. 15764-15765
-
-
Maksimoska, J.1
Feng, L.2
Harms, K.3
Yi, C.4
Kissil, J.5
Marmorstein, R.6
-
22
-
-
38949200283
-
Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes
-
Mao K, Kobayashi S, Jaffer ZM, Huang Y, Volden P, Chernoff J et al. (2008). Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes. J Mol Cell Cardiol 44: 429-434.
-
(2008)
J Mol Cell Cardiol
, vol.44
, pp. 429-434
-
-
Mao, K.1
Kobayashi, S.2
Jaffer, Z.M.3
Huang, Y.4
Volden, P.5
Chernoff, J.6
-
23
-
-
0142027033
-
Cell surface receptors activate p21-activated kinase 1 via multiple Ras and PI3-kinase-dependent pathways
-
Menard RE, Mattingly RR. (2003). Cell surface receptors activate p21-activated kinase 1 via multiple Ras and PI3-kinase-dependent pathways. Cell Signal 15: 1099-1109.
-
(2003)
Cell Signal
, vol.15
, pp. 1099-1109
-
-
Menard, R.E.1
Mattingly, R.R.2
-
24
-
-
0034854417
-
ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini
-
Muthuswamy SK, Li D, Lelievre S, Bissell MJ, Brugge JS. (2001). ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini. Nat Cell Biol 3: 785-792.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 785-792
-
-
Muthuswamy, S.K.1
Li, D.2
Lelievre, S.3
Bissell, M.J.4
Brugge, J.S.5
-
25
-
-
35549012934
-
OSU03012, a celecoxib derivative, directly targets p21 activated kinase
-
Porchia LM, Guerra M, Wang YC, Zhang Y, Espinosa AV, Shinohara M et al. (2007). OSU03012, a celecoxib derivative, directly targets p21 activated kinase. Mol Pharmacol 72: 1124-1131.
-
(2007)
Mol Pharmacol
, vol.72
, pp. 1124-1131
-
-
Porchia, L.M.1
Guerra, M.2
Wang, Y.C.3
Zhang, Y.4
Espinosa, A.V.5
Shinohara, M.6
-
26
-
-
33745714519
-
Nuclear p21-activated kinase 1 in breast cancer packs off tamoxifen sensitivity
-
Rayala SK, Molli PR, Kumar R. (2006). Nuclear p21-activated kinase 1 in breast cancer packs off tamoxifen sensitivity. Cancer Res 66: 5985-5988.
-
(2006)
Cancer Res
, vol.66
, pp. 5985-5988
-
-
Rayala, S.K.1
Molli, P.R.2
Kumar, R.3
-
27
-
-
0034659739
-
Rac1 in human breast cancer: Overexpression, mutation analysis, and characterization of a new isoform, Rac1b
-
Schnelzer A, Prechtel D, Knaus U, Dehne K, Gerhard M, Graeff H et al. (2000). Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b. Oncogene 19: 3013-3020.
-
(2000)
Oncogene
, vol.19
, pp. 3013-3020
-
-
Schnelzer, A.1
Prechtel, D.2
Knaus, U.3
Dehne, K.4
Gerhard, M.5
Graeff, H.6
-
28
-
-
0026604793
-
Development of humanized bispecific antibodies reactive with cytotoxic lymphocytes and tumor cells overexpressing the HER2 protooncogene
-
Shalaby MR, Shepard HM, Presta L, Rodrigues ML, Beverley PC, Feldmann M et al. (1992). Development of humanized bispecific antibodies reactive with cytotoxic lymphocytes and tumor cells overexpressing the HER2 protooncogene. J Exp Med 175: 217-225.
-
(1992)
J Exp Med
, vol.175
, pp. 217-225
-
-
Shalaby, M.R.1
Shepard, H.M.2
Presta, L.3
Rodrigues, M.L.4
Beverley, P.C.5
Feldmann, M.6
-
29
-
-
2942652871
-
Mechanisms of tamoxifen resistance: Increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer
-
Shou J, Massarweh S, Osborne CK, Wakeling AE, Ali S, Weiss H et al. (2004). Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer. J Natl Cancer Inst 96: 926-935.
-
(2004)
J Natl Cancer Inst
, vol.96
, pp. 926-935
-
-
Shou, J.1
Massarweh, S.2
Osborne, C.K.3
Wakeling, A.E.4
Ali, S.5
Weiss, H.6
-
30
-
-
0025129726
-
Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10
-
Soule HD, Maloney TM, Wolman SR, Peterson WDJ, Brenz R, McGrath CM et al. (1990). Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10. Cancer Res 50: 6075-6086.
-
(1990)
Cancer Res
, vol.50
, pp. 6075-6086
-
-
Soule, H.D.1
Maloney, T.M.2
Wolman, S.R.3
Wdj, P.4
Brenz, R.5
McGrath, C.M.6
-
31
-
-
0037415640
-
Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis
-
Srinivasan S, Wang F, Glavas S, Ott A, Hofmann F, Aktories K et al. (2003). Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis. J Cell Biol 160: 3375-3385.
-
(2003)
J Cell Biol
, vol.160
, pp. 3375-3385
-
-
Srinivasan, S.1
Wang, F.2
Glavas, S.3
Ott, A.4
Hofmann, F.5
Aktories, K.6
-
32
-
-
0038184147
-
The activation of an extracellular signal-regulated kinase by oestradiol interferes with the effects of trastuzumab on HER2 signalling in endometrial adenocarcinoma cell lines
-
Treeck O, Diedrich K, Ortmann O. (2003). The activation of an extracellular signal-regulated kinase by oestradiol interferes with the effects of trastuzumab on HER2 signalling in endometrial adenocarcinoma cell lines. Eur J Cancer 39: 1302-1309.
-
(2003)
Eur J Cancer
, vol.39
, pp. 1302-1309
-
-
Treeck, O.1
Diedrich, K.2
Ortmann, O.3
-
33
-
-
70349484472
-
An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently
-
Viaud J, Peterson JR. (2009). An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently. Mol Cancer Ther 8: 2559-2565.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 2559-2565
-
-
Viaud, J.1
Peterson, J.R.2
-
34
-
-
33646682385
-
PAK1 hyperactivation is sufficient for mammary gland tumor formation
-
Wang RA, Zhang H, Balasenthil S, Medina D, Kumar R. (2005). PAK1 hyperactivation is sufficient for mammary gland tumor formation. Oncogene 25: 2931-2936.
-
(2005)
Oncogene
, vol.25
, pp. 2931-2936
-
-
Wang, R.A.1
Zhang, H.2
Balasenthil, S.3
Medina, D.4
Kumar, R.5
-
35
-
-
33750324597
-
HER2/ Neu (ErbB2) signaling to Rac1-Pak1 is temporally and spatially modulated by transforming growth factor beta
-
Wang SE, Shin I, Wu FY, Friedman DB, Arteaga CL. (2006). HER2/ Neu (ErbB2) signaling to Rac1-Pak1 is temporally and spatially modulated by transforming growth factor beta. Cancer Res 66: 9591-9600.
-
(2006)
Cancer Res
, vol.66
, pp. 9591-9600
-
-
Wang, S.E.1
Shin, I.2
Wu, F.Y.3
Friedman, D.B.4
Arteaga, C.L.5
-
36
-
-
77953540958
-
HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D micro-environment
-
Weigelt B, Lo AT, Park CC, Gray JW, Bissell MJ. (2009). HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D micro-environment. Breast Cancer Res Treat 122: 35-43.
-
(2009)
Breast Cancer Res Treat
, vol.122
, pp. 35-43
-
-
Weigelt, B.1
Lo, A.T.2
Park, C.C.3
Gray, J.W.4
Bissell, M.J.5
-
37
-
-
33744912774
-
Controlled activation of ErbB1/ErbB2 heterodimers promote invasion of three-dimensional organized epithelia in an ErbB1-dependent manner: Implications for progression of ErbB2-overexpressing tumors
-
Zhan L, Xiang B, Muthuswamy SK. (2006). Controlled activation of ErbB1/ErbB2 heterodimers promote invasion of three-dimensional organized epithelia in an ErbB1-dependent manner: implications for progression of ErbB2-overexpressing tumors. Cancer Res 66: 5201-5208.
-
(2006)
Cancer Res
, vol.66
, pp. 5201-5208
-
-
Zhan, L.1
Xiang, B.2
Muthuswamy, S.K.3
|