-
1
-
-
0032561206
-
Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase
-
DOI 10.1074/jbc.273.43.28238
-
Adam L, Vadlamudi R, Kondapaka SB, Chernoff J, Mendelsohn J, Kumar R. (1998). Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phospha-tidylinositol-3 kinase. J Biol Chem 273: 28238-28246. (Pubitemid 28496122)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.43
, pp. 28238-28246
-
-
Adam, L.1
Vadlamudi, R.2
Kondapaka, S.B.3
Chernoff, J.4
Mendelsohn, J.5
Kumar, R.6
-
2
-
-
0037226817
-
Heregulin is sufficient for the promotion of tumorigenicity and metastasis of breast cancer cells in vivo
-
Atlas E, Cardillo M, Mehmi I, Zahedkargaran H, Tang C, Lupu R. (2003). Heregulin is sufficient for the promotion of tumorigenicity and metastasis of breast cancer cells in vivo. Mol Cancer Res 1: 165-175. (Pubitemid 36330198)
-
(2003)
Molecular Cancer Research
, vol.1
, Issue.3
, pp. 165-175
-
-
Atlas, E.1
Cardillo, M.2
Mehmi, I.3
Zahedkargaran, H.4
Tang, C.5
Lupu, R.6
-
3
-
-
35648934623
-
Membrane translocation of P-Rex1 is mediated by G protein βγ subunits and phosphoinositide 3-kinase
-
DOI 10.1074/jbc.M701877200
-
Barber MA, Donald S, Thelen S, Anderson KE, Thelen M, Welch HC. (2007). Membrane translocation of P-Rex1 is mediated by G protein betagamma subunits and phosphoinositide 3-kinase. J Biol Chem 282: 29967-29976. (Pubitemid 350035293)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.41
, pp. 29967-29976
-
-
Barber, M.A.1
Donald, S.2
Thelen, S.3
Anderson, K.E.4
Thelen, M.5
Welch, H.C.E.6
-
4
-
-
17844372539
-
Critical update and emerging trends in epidermal growth factor receptor targeting in cancer
-
DOI 10.1200/JCO.2005.11.890
-
Baselga J, Arteaga CL. (2005). Critical update and emerging trends in epidermal growth factor receptor targeting in cancer. J Clin Oncol 23: 2445-2459. (Pubitemid 47050835)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.11
, pp. 2445-2459
-
-
Baselga, J.1
Arteaga, C.L.2
-
5
-
-
34548611498
-
Role of heregulin in human cancer
-
DOI 10.1007/s00018-007-7120-0
-
Breuleux M. (2007). Role of heregulin in human cancer. Cell Mol Life Sci 64: 2358-2377. (Pubitemid 47402579)
-
(2007)
Cellular and Molecular Life Sciences
, vol.64
, Issue.18
, pp. 2358-2377
-
-
Breuleux, M.1
-
6
-
-
0030020074
-
TrkA receptor ectodomain cleavage generates a tyrosine-phosphorylated cell-associated fragment
-
DOI 10.1083/jcb.132.3.427
-
Cabrera N, Diaz-Rodriguez E, Becker E, Martin-Zanca D, Pandiella A. (1996). TrkA receptor ectodomain cleavage generates a tyrosine-phosphorylated cell-associated fragment. J Cell Biol 132: 427-436. (Pubitemid 26053446)
-
(1996)
Journal of Cell Biology
, vol.132
, Issue.3
, pp. 427-436
-
-
Cabrera, N.1
Diaz-Rodriguez, E.2
Becker, E.3
Martin-Zanca, D.4
Pandiella, A.5
-
7
-
-
0028335209
-
The erbB3 gene product is a receptor for heregulin
-
Carraway III KL, Sliwkowski MX, Akita R, Platko JV, Guy PM, Nuijens A et al. (1994). The erbB3 gene product is a receptor for heregulin. J Biol Chem 269: 14303-14306. (Pubitemid 24191194)
-
(1994)
Journal of Biological Chemistry
, vol.269
, Issue.19
, pp. 14303-14306
-
-
Carraway III, K.L.1
Sliwkowski, M.X.2
Akita, R.3
Platko, J.V.4
Guy, P.M.5
Nuijens, A.6
John Diamonti, A.7
Vandlen, R.L.8
Cantley, L.C.9
Cerione, R.A.10
-
8
-
-
34447568389
-
Neuregulin expression modulates clinical response to trastuzumab in patients with metastatic breast cancer
-
DOI 10.1200/JCO.2006.08.6850
-
de Alava E, Ocana A, Abad M, Montero JC, Esparis-Ogando A, Rodriguez CA et al. (2007). Neuregulin expression modulates clinical response to trastuzumab in patients with metastatic breast cancer. J Clin Oncol 25: 2656-2663. (Pubitemid 47123170)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.19
, pp. 2656-2663
-
-
De Alava, E.1
Ocana, A.2
Abad, M.3
Montero, J.C.4
Esparis-Ogando, A.5
Rodriguez, C.A.6
Otero, A.P.7
Hernandez, T.8
Cruz, J.J.9
Pandiella, A.10
-
9
-
-
4143145447
-
P-Rex2, a new guanine-nucleotide exchange factor for Rac
-
DOI 10.1016/j.febslet.2004.06.096, PII S0014579304008968
-
Donald S, Hill K, Lecureuil C, Barnouin R, Krugmann S, John Coadwell W et al. (2004). P-Rex2, a new guanine-nucleotide exchange factor for Rac. FEBS Lett 572: 172-176. (Pubitemid 39092531)
-
(2004)
FEBS Letters
, vol.572
, Issue.1-3
, pp. 172-176
-
-
Donald, S.1
Hill, K.2
Lecureuil, C.3
Barnouin, R.4
Krugmann, S.5
John Coadwell, W.6
Andrews, S.R.7
Walker, S.A.8
Hawkins, P.T.9
Stephens, L.R.10
Welch, H.C.E.11
-
10
-
-
0036133133
-
Erk5 participates in neuregulin signal transduction and is constitutively active in breast cancer cells overexpressing ErbB2
-
DOI 10.1128/MCB.22.1.270-285.2002
-
Esparis-Ogando A, Diaz-Rodriguez E, Montero JC, Yuste L, Crespo P, Pandiella A. (2002). Erk5 participates in neuregulin signal transduction and is constitutively active in breast cancer cells overexpressing ErbB2. Mol Cell Biol 22: 270-285. (Pubitemid 33144274)
-
(2002)
Molecular and Cellular Biology
, vol.22
, Issue.1
, pp. 270-285
-
-
Esparis-Ogando, A.1
Diaz-Rodriguez, E.2
Montero, J.C.3
Yuste, L.4
Crespo, P.5
Pandiella, A.6
-
11
-
-
76449104021
-
Molecular predictors of response to trastuzumab and lapatinib in breast cancer
-
Esteva FJ, Yu D, Hung MC, Hortobagyi GN. (2009). Molecular predictors of response to trastuzumab and lapatinib in breast cancer. Nature Rev Clin Oncol 7: 98-107.
-
(2009)
Nature Rev Clin Oncol
, vol.7
, pp. 98-107
-
-
Esteva, F.J.1
Yu, D.2
Hung, M.C.3
Hortobagyi, G.N.4
-
12
-
-
69949170092
-
Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a
-
Fine B, Hodakoski C, Koujak S, Su T, Saal LH, Maurer M et al. (2009). Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a. Science 325: 1261-1265.
-
(2009)
Science
, vol.325
, pp. 1261-1265
-
-
Fine, B.1
Hodakoski, C.2
Koujak, S.3
Su, T.4
Saal, L.H.5
Maurer, M.6
-
13
-
-
14244269335
-
Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gβγ subunits
-
DOI 10.1074/jbc.M411262200
-
Hill K, Krugmann S, Andrews SR, Coadwell WJ, Finan P, Welch HC et al. (2005). Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits. J Biol Chem 280: 4166-4173. (Pubitemid 40288581)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.6
, pp. 4166-4173
-
-
Hill, K.1
Krugmann, S.2
Andrews, S.R.3
Coadwell, W.J.4
Finan, P.5
Welch, H.C.E.6
Hawkins, P.T.7
Stephens, L.R.8
-
14
-
-
0026659262
-
Identification of heregulin, a specific activator of p185erbB2
-
Holmes WE, Sliwkowski MX, Akita RW, Henzel WJ, Lee J, Park JW et al. (1992). Identification of heregulin, a specific activator of p185erbB2. Science 256: 1205-1210.
-
(1992)
Science
, vol.256
, pp. 1205-1210
-
-
Holmes, W.E.1
Sliwkowski, M.X.2
Akita, R.W.3
Henzel, W.J.4
Lee, J.5
Park, J.W.6
-
15
-
-
18344390418
-
ERBB receptors and cancer: The complexity of targeted inhibitors
-
DOI 10.1038/nrc1609
-
Hynes NE, Lane HA. (2005). ERBB receptors and cancer: the complexity of targeted inhibitors. Nat Rev Cancer 5: 341-354. (Pubitemid 40637826)
-
(2005)
Nature Reviews Cancer
, vol.5
, Issue.5
, pp. 341-354
-
-
Hynes, N.E.1
Lane, H.A.2
-
16
-
-
23044432652
-
Substrate specificity and recognition is conferred by the pleckstrin homology domain of the Dbl family guanine nucleotide exchange factor P-Rex2
-
DOI 10.1074/jbc.M412495200
-
Joseph RE, Norris FA. (2005). Substrate specificity and recognition is conferred by the pleckstrin homology domain of the Dbl family guanine nucleotide exchange factor P-Rex2. J Biol Chem 280: 27508-27512. (Pubitemid 41076861)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.30
, pp. 27508-27512
-
-
Joseph, R.E.1
Norris, F.A.2
-
17
-
-
0029912447
-
NDF/heregulin induces persistence of terminal end buds and adenocarcinomas in the mammary glands of transgenic mice
-
Krane IM, Leder P. (1996). NDF/heregulin induces persistence of terminal end buds and adenocarcinomas in the mammary glands of transgenic mice. Oncogene 12: 1781-1788. (Pubitemid 26146303)
-
(1996)
Oncogene
, vol.12
, Issue.8
, pp. 1781-1788
-
-
Krane, I.M.1
Leder, P.2
-
18
-
-
24944519450
-
Highly selective enrichment of phosphorylated peptides from peptide mixtures using titanium dioxide microcolumns
-
DOI 10.1074/mcp.T500007-MCP200
-
Larsen MR, Thingholm TE, Jensen ON, Roepstorff P, Jorgensen TJ. (2005). Highly selective enrichment of phosphorylated peptides from peptide mixtures using titanium dioxide microcolumns. Mol Cell Proteomics 4: 873-886. (Pubitemid 41309146)
-
(2005)
Molecular and Cellular Proteomics
, vol.4
, Issue.7
, pp. 873-886
-
-
Larsen, M.R.1
Thingholm, T.E.2
Jensen, O.N.3
Roepstorff, P.4
Jorgensen, T.J.D.5
-
20
-
-
33644855674
-
Phosphorylation of P-Rex1 by the cyclic AMP-dependent protein kinase inhibits the phosphatidylinositiol (3,4,5)-trisphosphate and Gβγ-mediated regulation of its activity
-
DOI 10.1074/jbc.M506035200
-
Mayeenuddin LH, Garrison JC. (2006). Phosphorylation of P-Rex1 by the cyclic AMP-dependent protein kinase inhibits the phosphatidy-linositiol (3,4,5)-trisphosphate and Gbetagamma-mediated regulation of its activity. J Biol Chem 281: 1921-1928. (Pubitemid 43845777)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.4
, pp. 1921-1928
-
-
Mayeenuddin, L.H.1
Garrison, J.C.2
-
21
-
-
50349085912
-
Neuregulins and cancer
-
Montero JC, Rodriguez-Barrueco R, Ocana A, Diaz-Rodriguez E, Esparis-Ogando A, Pandiella A. (2008). Neuregulins and cancer. Clin Cancer Res 14: 3237-3241.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 3237-3241
-
-
Montero, J.C.1
Rodriguez-Barrueco, R.2
Ocana, A.3
Diaz-Rodriguez, E.4
Esparis-Ogando, A.5
Pandiella, A.6
-
22
-
-
33846837213
-
The extracellular linker of pro-neuregulin-α2c is required for efficient sorting and juxtacrine function
-
DOI 10.1091/mbc.E06-06-0511
-
Montero JC, Rodriguez-Barrueco R, Yuste L, Juanes PP, Borges J, Esparis-Ogando A et al. (2007). The extracellular linker of pro-neuregulin- alpha2c is required for efficient sorting and juxtacrine function. Mol Biol Cell 18: 380-393. (Pubitemid 46213209)
-
(2007)
Molecular Biology of the Cell
, vol.18
, Issue.2
, pp. 380-393
-
-
Montero, J.C.1
Rodriguez-Barrueco, R.2
Yuste, L.3
Juanes, P.P.4
Borges, J.5
Esparis-Ogando, A.6
Pandiella, A.7
-
23
-
-
67349167687
-
Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis
-
Qin J, Xie Y, Wang B, Hoshino M, Wolff DW, Zhao J et al. (2009). Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis. Oncogene 28: 1853-1863.
-
(2009)
Oncogene
, vol.28
, pp. 1853-1863
-
-
Qin, J.1
Xie, Y.2
Wang, B.3
Hoshino, M.4
Wolff, D.W.5
Zhao, J.6
-
24
-
-
4143060469
-
P-REX2, a novel PI-3-kinase sensitive Rac exchange factor
-
DOI 10.1016/j.febslet.2004.06.097, PII S0014579304008956
-
Rosenfeldt H, Vazquez-Prado J, Gutkind JS. (2004). P-REX2, a novel PI-3-kinase sensitive Rac exchange factor. FEBS Lett 572: 167-171. (Pubitemid 39092530)
-
(2004)
FEBS Letters
, vol.572
, Issue.1-3
, pp. 167-171
-
-
Rosenfeldt, H.1
Vazquez-Prado, J.2
Gutkind, J.S.3
-
25
-
-
0024337144
-
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
-
Slamon DJ, Godolphin W, Jones LA, Holt JA, Wong SG, Keith DE et al. (1989). Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 244: 707-712. (Pubitemid 19147683)
-
(1989)
Science
, vol.244
, Issue.4905
, pp. 707-712
-
-
Slamon, D.J.1
Godolphin, W.2
Jones, L.A.3
Holt, J.A.4
Wong, S.G.5
Keith, D.E.6
Levin, W.J.7
Stuart, S.G.8
Udove, J.9
Ullrich, A.10
Press, M.F.11
-
26
-
-
0028358856
-
Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin
-
Sliwkowski MX, Schaefer G, Akita RW, Lofgren JA, Fitzpatrick VD, Nuijens A et al. (1994). Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin. J Biol Chem 269: 14661-14665.
-
(1994)
J Biol Chem
, vol.269
, pp. 14661-14665
-
-
Sliwkowski, M.X.1
Schaefer, G.2
Akita, R.W.3
Lofgren, J.A.4
Fitzpatrick, V.D.5
Nuijens, A.6
-
27
-
-
0037421965
-
Blockage of heregulin expression inhibits tumorigenicity and metastasis of breast cancer
-
DOI 10.1038/sj.onc.1206130
-
Tsai MS, Shamon-Taylor LA, Mehmi I, Tang CK, Lupu R. (2003). Blockage of heregulin expression inhibits tumorigenicity and metastasis of breast cancer. Oncogene 22: 761-768. (Pubitemid 36269290)
-
(2003)
Oncogene
, vol.22
, Issue.5
, pp. 761-768
-
-
Tsai, M.-S.1
Shamon-Taylor, L.A.2
Mehmi, I.3
Tang, C.K.4
Lupu, R.5
-
28
-
-
0037155727
-
3- and gβγ-regulated guanine-nucleotide exchange factor for Rac
-
DOI 10.1016/S0092-8674(02)00663-3
-
Welch HC, Coadwell WJ, Ellson CD, Ferguson GJ, Andrews SR, Erdjument-Bromage H et al. (2002). P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac. Cell 108: 809-821. (Pubitemid 34327532)
-
(2002)
Cell
, vol.108
, Issue.6
, pp. 809-821
-
-
Welch, H.C.E.1
Coadwell W.John2
Ellson, C.D.3
Ferguson G.John4
Andrews, S.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Hawkins, P.T.8
Stephens, L.R.9
-
29
-
-
39749195406
-
Cip1
-
DOI 10.1042/BJ20070781
-
Yang C, Klein EA, Assoian RK, Kazanietz MG. (2008). Heregulin beta1 promotes breast cancer cell proliferation through Rac/ ERK-dependent induction of cyclin D1 and p21Cip1. Biochem J 410: 167-175. (Pubitemid 351300336)
-
(2008)
Biochemical Journal
, vol.410
, Issue.1
, pp. 167-175
-
-
Yang, C.1
Klein, E.A.2
Assoian, R.K.3
Kazanietz, M.G.4
-
30
-
-
31344467784
-
Essential role for Rac in heregulin β1 mitogenic signaling: A mechanism that involves epidermal growth factor receptor and is independent of ErbB4
-
DOI 10.1128/MCB.26.3.831-842.2006
-
Yang C, Liu Y, Lemmon MA, Kazanietz MG. (2006). Essential role for Rac in heregulin beta1 mitogenic signaling: a mechanism that involves epidermal growth factor receptor and is independent of ErbB4. Mol Cell Biol 26: 831-842. (Pubitemid 43146479)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.3
, pp. 831-842
-
-
Yang, C.1
Liu, Y.2
Lemmon, M.A.3
Kazanietz, M.G.4
-
31
-
-
23044436390
-
Activation of ErbB2 by overexpression or by transmembrane neuregulin results in differential signaling and sensitivity to herceptin
-
DOI 10.1158/0008-5472.CAN-04-4023
-
Yuste L, Montero JC, Esparis-Ogando A, Pandiella A. (2005). Activation of ErbB2 by overexpression or by transmembrane neuregulin results in differential signaling and sensitivity to herceptin. Cancer Res 65: 6801-6810. (Pubitemid 41060718)
-
(2005)
Cancer Research
, vol.65
, Issue.15
, pp. 6801-6810
-
-
Yuste, L.1
Montero, J.C.2
Esparis-Ogando, A.3
Pandiella, A.4
|