메뉴 건너뛰기




Volumn 26, Issue 3, 2006, Pages 831-842

Essential role for Rac in heregulin β1 mitogenic signaling: A mechanism that involves epidermal growth factor receptor and is independent of ErbB4

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 4; MITOGEN ACTIVATED PROTEIN KINASE; NEU DIFFERENTIATION FACTOR; RAC PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; SMALL INTERFERING RNA;

EID: 31344467784     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.26.3.831-842.2006     Document Type: Article
Times cited : (68)

References (56)
  • 1
    • 0035958897 scopus 로고    scopus 로고
    • Tiam1 overexpression potentiates heregulin-induced lymphoid enhancer factor-1/beta-catenin nuclear signaling in breast cancer cells by modulating the intercellular stability
    • Adam, L., R. K. Vadlamudi, P. McCrea, and R. Kumar. 2001. Tiam1 overexpression potentiates heregulin-induced lymphoid enhancer factor-1/beta-catenin nuclear signaling in breast cancer cells by modulating the intercellular stability. J. Biol. Chem. 276:28443-28450.
    • (2001) J. Biol. Chem. , vol.276 , pp. 28443-28450
    • Adam, L.1    Vadlamudi, R.K.2    McCrea, P.3    Kumar, R.4
  • 2
    • 0032561206 scopus 로고    scopus 로고
    • Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase
    • Adam, L., R. Vadlamudi, S. B. Kondapaka, J. Chernoff, J. Mendelsohn, and R. Kumar. 1998. Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase. J. Biol. Chem. 273:28238-28246.
    • (1998) J. Biol. Chem. , vol.273 , pp. 28238-28246
    • Adam, L.1    Vadlamudi, R.2    Kondapaka, S.B.3    Chernoff, J.4    Mendelsohn, J.5    Kumar, R.6
  • 3
    • 0037226817 scopus 로고    scopus 로고
    • Heregulin is sufficient for the promotion of tumorigenicity and metastasis of breast cancer cells in vivo
    • Atlas, E., M. Cardillo, I. Mehml, H. Zahedkargaran, C. Tang, and R. Lupu. 2003. Heregulin is sufficient for the promotion of tumorigenicity and metastasis of breast cancer cells in vivo. Mol. Cancer Res. 1:165-175.
    • (2003) Mol. Cancer Res. , vol.1 , pp. 165-175
    • Atlas, E.1    Cardillo, M.2    Mehml, I.3    Zahedkargaran, H.4    Tang, C.5    Lupu, R.6
  • 4
    • 0029912203 scopus 로고    scopus 로고
    • All ErbB receptors other than the epidermal growth factor receptor are endocytosis impaired
    • Baulida, J., M. H. Kraus, M. Alimandi, P. P. Di Fiore, and G. Carpenter. 1996. All ErbB receptors other than the epidermal growth factor receptor are endocytosis impaired. J. Biol. Chem. 271:5251-5257.
    • (1996) J. Biol. Chem. , vol.271 , pp. 5251-5257
    • Baulida, J.1    Kraus, M.H.2    Alimandi, M.3    Di Fiore, P.P.4    Carpenter, G.5
  • 6
    • 0035947687 scopus 로고    scopus 로고
    • Phorbol esters and related analogs regulate the subcellular localization of beta 2-chimaerin, a non-protein kinase C phorbol ester receptor
    • Caloca, M. J., H. Wang, A. Delemos, S. Wang, and M. G. Kazanietz. 2001. Phorbol esters and related analogs regulate the subcellular localization of beta 2-chimaerin, a non-protein kinase C phorbol ester receptor. J. Biol. Chem. 276:18303-18312.
    • (2001) J. Biol. Chem. , vol.276 , pp. 18303-18312
    • Caloca, M.J.1    Wang, H.2    Delemos, A.3    Wang, S.4    Kazanietz, M.G.5
  • 8
    • 0037429722 scopus 로고    scopus 로고
    • ErbB-4: Mechanism of action and biology
    • Carpenter, G. 2003. ErbB-4: mechanism of action and biology. Exp. Cell Res. 10:66-77.
    • (2003) Exp. Cell Res. , vol.10 , pp. 66-77
    • Carpenter, G.1
  • 9
    • 0037429779 scopus 로고    scopus 로고
    • The deaf and the dumb: The biology of ErbB-2 and ErbB-3
    • Citri, A., K. B. Skaria, and Y. Yarden. 2003. The deaf and the dumb: the biology of ErbB-2 and ErbB-3. Exp. Cell Res. 10:54-65.
    • (2003) Exp. Cell Res. , vol.10 , pp. 54-65
    • Citri, A.1    Skaria, K.B.2    Yarden, Y.3
  • 10
    • 0029866079 scopus 로고    scopus 로고
    • HER4-mediated biological and biochemical properties in NIH 3T3 cells. Evidence for HER1-HER4 heterodimers
    • Cohen, B. D., J. M. Green, L. Foy, and H. P. Fell. 1996. HER4-mediated biological and biochemical properties in NIH 3T3 cells. Evidence for HER1-HER4 heterodimers. J. Biol. Chem. 271:4813-4818.
    • (1996) J. Biol. Chem. , vol.271 , pp. 4813-4818
    • Cohen, B.D.1    Green, J.M.2    Foy, L.3    Fell, H.P.4
  • 12
    • 0036333485 scopus 로고    scopus 로고
    • Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes
    • Eblen, S. T., J. K. Slack, M. J. Weber, and A. D. Catling. 2002. Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes. Mol. Cell. Biol. 22:6023-6033.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 6023-6033
    • Eblen, S.T.1    Slack, J.K.2    Weber, M.J.3    Catling, A.D.4
  • 13
    • 0037429649 scopus 로고    scopus 로고
    • Neuregulins: Functions, forms, and signaling strategies
    • Falls, D. L. 2003. Neuregulins: functions, forms, and signaling strategies. Exp. Cell Res. 284:14-30.
    • (2003) Exp. Cell Res. , vol.284 , pp. 14-30
    • Falls, D.L.1
  • 14
    • 0032575091 scopus 로고    scopus 로고
    • Inhibition of the MAP kinase cascade blocks heregulin-induced cell cycle progression in T-47D human breast cancer cells
    • Fiddes, R. J., P. W. Janes, S. P. Sivertsen, R. L. Sutherland, E. A. Musgrove, and R. J. Daly. 1998. Inhibition of the MAP kinase cascade blocks heregulin-induced cell cycle progression in T-47D human breast cancer cells. Oncogene 16:2803-2813.
    • (1998) Oncogene , vol.16 , pp. 2803-2813
    • Fiddes, R.J.1    Janes, P.W.2    Sivertsen, S.P.3    Sutherland, R.L.4    Musgrove, E.A.5    Daly, R.J.6
  • 15
    • 4744362965 scopus 로고    scopus 로고
    • Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1
    • Fleming, I. N., I. H. Batty, A. R. Prescott, A. Gray, G. S. Kular, H. Stewart, and C. P. Downes. 2004. Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1. Biochem. J. 382:857-865.
    • (2004) Biochem. J. , vol.382 , pp. 857-865
    • Fleming, I.N.1    Batty, I.H.2    Prescott, A.R.3    Gray, A.4    Kular, G.S.5    Stewart, H.6    Downes, C.P.7
  • 16
    • 0032939619 scopus 로고    scopus 로고
    • Rho GTPases are over-expressed in human tumors
    • Fritz, G., I. Just, and B. Kaina. 1999. Rho GTPases are over-expressed in human tumors. Int. J. Cancer 81:682-687.
    • (1999) Int. J. Cancer , vol.81 , pp. 682-687
    • Fritz, G.1    Just, I.2    Kaina, B.3
  • 17
    • 0031010495 scopus 로고    scopus 로고
    • Secondary dimerization between members of the epidermal growth factor receptor family
    • Gamett, D. C., G. Pearson, R. A. Cerione, and I. Friedberg. 1997. Secondary dimerization between members of the epidermal growth factor receptor family. J. Biol. Chem. 272:12052-12056.
    • (1997) J. Biol. Chem. , vol.272 , pp. 12052-12056
    • Gamett, D.C.1    Pearson, G.2    Cerione, R.A.3    Friedberg, I.4
  • 18
    • 0030944455 scopus 로고    scopus 로고
    • ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling
    • Graus-Porta, D., R. R. Beerli, J. M. Daly, and N. E. Hynes. 1997. ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling. EMBO J. 16:1647-1655.
    • (1997) EMBO J. , vol.16 , pp. 1647-1655
    • Graus-Porta, D.1    Beerli, R.R.2    Daly, J.M.3    Hynes, N.E.4
  • 19
    • 15144353776 scopus 로고    scopus 로고
    • Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav
    • Han, J., K. Luby-Phelps, B. Das, X. Shu, Y. Xia, R. D. Mosteller, U. M. Krishna, J. R. Falck, M. A. White, and D. Broek. 1998. Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. Science 279:558-560.
    • (1998) Science , vol.279 , pp. 558-560
    • Han, J.1    Luby-Phelps, K.2    Das, B.3    Shu, X.4    Xia, Y.5    Mosteller, R.D.6    Krishna, U.M.7    Falck, J.R.8    White, M.A.9    Broek, D.10
  • 20
    • 0035834663 scopus 로고    scopus 로고
    • Heregulin-dependent activation of phosphoinositide 3-kinase and Akt via the ErbB2/ErbB3 coreceptor
    • Hellyer, N. J., M. S. Kim, and J. G. Koland. 2001. Heregulin-dependent activation of phosphoinositide 3-kinase and Akt via the ErbB2/ErbB3 coreceptor. J. Biol. Chem. 276:42153-42161.
    • (2001) J. Biol. Chem. , vol.276 , pp. 42153-42161
    • Hellyer, N.J.1    Kim, M.S.2    Koland, J.G.3
  • 21
    • 0032055791 scopus 로고    scopus 로고
    • Proxy activation of protein ErbB2 by heterologous ligands implies a heterotetrameric mode of receptor tyrosine kinase interaction
    • Huang, G. C., X. Ouyang, and R. J. Epstein. 1998. Proxy activation of protein ErbB2 by heterologous ligands implies a heterotetrameric mode of receptor tyrosine kinase interaction. Biochem. J. 331:113-119.
    • (1998) Biochem. J. , vol.331 , pp. 113-119
    • Huang, G.C.1    Ouyang, X.2    Epstein, R.J.3
  • 22
    • 18344390418 scopus 로고    scopus 로고
    • ERBB receptors and cancer: The complexity of targeted inhibitors
    • Hynes, N. E., and H. A. Lane. 2005. ERBB receptors and cancer: the complexity of targeted inhibitors. Nat. Rev. Cancer 5:341-354.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 341-354
    • Hynes, N.E.1    Lane, H.A.2
  • 23
    • 1942441770 scopus 로고    scopus 로고
    • Blockade of epidermal growth factor- or heregulin-dependent ErbB2 activation with the anti-ErbB2 monoclonal antibody 2C4 has divergent downstream signaling and growth effects
    • Jackson, J. G., P. St Clair, M. X. Sliwkowski, and M. G. Brattain. 2004. Blockade of epidermal growth factor- or heregulin-dependent ErbB2 activation with the anti-ErbB2 monoclonal antibody 2C4 has divergent downstream signaling and growth effects. Cancer Res. 64:2601-2609.
    • (2004) Cancer Res. , vol.64 , pp. 2601-2609
    • Jackson, J.G.1    St. Clair, P.2    Sliwkowski, M.X.3    Brattain, M.G.4
  • 25
    • 14044273991 scopus 로고    scopus 로고
    • Vav2 as a Rac-GDP/GTP exchange factor responsible for the nectin-induced, c-Src- and Cdc42-mediated activation of Rac
    • Kawakatsu, T., H. Ogita, T. Fukuhara, T. Fukuyama, Y. Minami, K. Shimizu, and Y. Takai. 2005. Vav2 as a Rac-GDP/GTP exchange factor responsible for the nectin-induced, c-Src- and Cdc42-mediated activation of Rac. J. Biol. Chem. 280:4940-4947.
    • (2005) J. Biol. Chem. , vol.280 , pp. 4940-4947
    • Kawakatsu, T.1    Ogita, H.2    Fukuhara, T.3    Fukuyama, T.4    Minami, Y.5    Shimizu, K.6    Takai, Y.7
  • 29
    • 17444403242 scopus 로고    scopus 로고
    • Structural basis for inhibition of the epidermal growth factor receptor by cetuximab
    • Li, S., K. R. Schmitz, P. D. Jeffrey, J. J. Wiltzius, P. Russie, and K. M. Ferguson. 2005. Structural basis for inhibition of the epidermal growth factor receptor by cetuximab. Cancer Cell 7:301-311.
    • (2005) Cancer Cell , vol.7 , pp. 301-311
    • Li, S.1    Schmitz, K.R.2    Jeffrey, P.D.3    Wiltzius, J.J.4    Russie, P.5    Ferguson, K.M.6
  • 30
    • 0038375063 scopus 로고    scopus 로고
    • Inhibition of aggressiveness of metastatic mouse mammary carcinoma cells by the beta2-chimaerin GAP domain
    • Lorenzano-Menna, P., G. Skilton, F. Coluccio Leskow, D. F. Alonso, D. E. Gomez, and M. G. Kazanietz. 2003. Inhibition of aggressiveness of metastatic mouse mammary carcinoma cells by the beta2-chimaerin GAP domain. Cancer Res. 63:2284-2291.
    • (2003) Cancer Res. , vol.63 , pp. 2284-2291
    • Lorenzano-Menna, P.1    Skilton, G.2    Coluccio Leskow, F.3    Alonso, D.F.4    Gomez, D.E.5    Kazanietz, M.G.6
  • 31
    • 0028152333 scopus 로고
    • MAP kinase kinase kinase, MAP kinase kinase and MAP kinase
    • Marshall, C. J. 1994. MAP kinase kinase kinase, MAP kinase kinase and MAP kinase. Curr. Opin. Genet. Dev. 4:82-89.
    • (1994) Curr. Opin. Genet. Dev. , vol.4 , pp. 82-89
    • Marshall, C.J.1
  • 32
    • 13844256522 scopus 로고    scopus 로고
    • The docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K/Akt cell survival pathway
    • Mattoon, D. R., B. Lamothe, I. Lax, and J. Schlessinger. 2004. The docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K/Akt cell survival pathway. BMC Biol. 2:24.
    • (2004) BMC Biol. , vol.2 , pp. 24
    • Mattoon, D.R.1    Lamothe, B.2    Lax, I.3    Schlessinger, J.4
  • 33
    • 0035893560 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo
    • Moulder, S. L., F. M. Yakes, S. K. Muthuswamy, R. Bianco, J. F. Simpson, and C. L. Arteaga. 2001. Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo. Cancer Res. 61:8887-8895.
    • (2001) Cancer Res. , vol.61 , pp. 8887-8895
    • Moulder, S.L.1    Yakes, F.M.2    Muthuswamy, S.K.3    Bianco, R.4    Simpson, J.F.5    Arteaga, C.L.6
  • 34
    • 0037019186 scopus 로고    scopus 로고
    • Distinct roles for phosphoinositide 3-kinase, mitogen-activated protein kinase and p38 MAPK in mediating cell cycle progression of breast cancer cells
    • Neve, R. M., T. Holbro, and N. E. Hynes. 2002. Distinct roles for phosphoinositide 3-kinase, mitogen-activated protein kinase and p38 MAPK in mediating cell cycle progression of breast cancer cells. Oncogene 21:4567-4576.
    • (2002) Oncogene , vol.21 , pp. 4567-4576
    • Neve, R.M.1    Holbro, T.2    Hynes, N.E.3
  • 36
    • 0034600849 scopus 로고    scopus 로고
    • The ErbB signaling network: Receptor heterodimerization in development and cancer
    • Olayioye, M. A., R. M. Neve, H. A. Lane, and N. E. Hynes. 2000. The ErbB signaling network: receptor heterodimerization in development and cancer. EMBO J. 19:3159-3167.
    • (2000) EMBO J. , vol.19 , pp. 3159-3167
    • Olayioye, M.A.1    Neve, R.M.2    Lane, H.A.3    Hynes, N.E.4
  • 39
    • 0028903247 scopus 로고
    • An essential role for Rac in Ras transformation
    • Qiu, R. G., J. Chen, D. Kirn, F. McCormick, and M. Symons. 1995. An essential role for Rac in Ras transformation. Nature 374:457-459.
    • (1995) Nature , vol.374 , pp. 457-459
    • Qiu, R.G.1    Chen, J.2    Kirn, D.3    McCormick, F.4    Symons, M.5
  • 40
    • 0033777071 scopus 로고    scopus 로고
    • Determination of GTP loading on Rho
    • Ren, X. D., and M. A. Schwartz. 2000. Determination of GTP loading on Rho. Methods Enzymol. 325:264-272.
    • (2000) Methods Enzymol. , vol.325 , pp. 264-272
    • Ren, X.D.1    Schwartz, M.A.2
  • 41
    • 0029118223 scopus 로고
    • The cellular response to neuregulins is governed by complex interactions of the erbB receptor family
    • Riese, D. J., II, T. M. van Raaij, G. D. Plowman, G. C. Andrews, and D. F. Stern. 1995. The cellular response to neuregulins is governed by complex interactions of the erbB receptor family. Mol. Cell. Biol. 15:5770-5776.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 5770-5776
    • Riese II, D.J.1    Van Raaij, T.M.2    Plowman, G.D.3    Andrews, G.C.4    Stern, D.F.5
  • 43
    • 0034644539 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Schlessinger, J. 2000. Cell signaling by receptor tyrosine kinases. Cell 103: 211-225.
    • (2000) Cell , vol.103 , pp. 211-225
    • Schlessinger, J.1
  • 45
    • 0029011218 scopus 로고
    • The MAPK signaling cascade
    • Seger, R., and E. G. Krebs. 1995. The MAPK signaling cascade. FASEB J. 9:726-735.
    • (1995) FASEB J. , vol.9 , pp. 726-735
    • Seger, R.1    Krebs, E.G.2
  • 46
    • 0141668894 scopus 로고    scopus 로고
    • Rac1 function is required for Src-induced transformation. Evidence of a role for Tiam1 and Vav2 in Rac activation by Src
    • Servitja, J. M., M. J. Marinissen, A. Sodhi, X. R. Bustelo, and J. S. Gutkind. 2003. Rac1 function is required for Src-induced transformation. Evidence of a role for Tiam1 and Vav2 in Rac activation by Src. J. Biol. Chem. 278: 34339-34346.
    • (2003) J. Biol. Chem. , vol.278 , pp. 34339-34346
    • Servitja, J.M.1    Marinissen, M.J.2    Sodhi, A.3    Bustelo, X.R.4    Gutkind, J.S.5
  • 47
    • 12544256298 scopus 로고    scopus 로고
    • Adhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylation
    • Sundberg-Smith, L. J., J. T. Doherty, C. P. Mack, and J. M. Taylor. 2005. Adhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylation. J. Biol. Chem. 280:2055-2064.
    • (2005) J. Biol. Chem. , vol.280 , pp. 2055-2064
    • Sundberg-Smith, L.J.1    Doherty, J.T.2    Mack, C.P.3    Taylor, J.M.4
  • 49
    • 0037421965 scopus 로고    scopus 로고
    • Blockage of heregulin expression inhibits tumorigenicity and metastasis of breast cancer
    • Tsai, M. S., L. A. Shamon-Taylor, I. Mehmi, C. K. Tang, and R. Lupu. 2003. Blockage of heregulin expression inhibits tumorigenicity and metastasis of breast cancer. Oncogene 22:761-768.
    • (2003) Oncogene , vol.22 , pp. 761-768
    • Tsai, M.S.1    Shamon-Taylor, L.A.2    Mehmi, I.3    Tang, C.K.4    Lupu, R.5
  • 50
    • 0037376578 scopus 로고    scopus 로고
    • Roles of mitogen-activated protein kinase and phosphoinositide 3′-kinase in ErbB2/ErbB3 coreceptor-mediated heregulin signaling
    • Vijapurkar, U., M. S. Kim, and J. G. Koland. 2003. Roles of mitogen-activated protein kinase and phosphoinositide 3′-kinase in ErbB2/ErbB3 coreceptor-mediated heregulin signaling. Exp. Cell Res. 284:291-302.
    • (2003) Exp. Cell Res. , vol.284 , pp. 291-302
    • Vijapurkar, U.1    Kim, M.S.2    Koland, J.G.3
  • 51
    • 0038575385 scopus 로고    scopus 로고
    • Expression of the HER1-4 family of receptor tyrosine kinases in breast cancer
    • Witton, C. J., J. R. Reeves, J. J. Going, T. G. Cooke, and J. M. Bartlett. 2003. Expression of the HER1-4 family of receptor tyrosine kinases in breast cancer. J. Pathol. 200:290-297.
    • (2003) J. Pathol. , vol.200 , pp. 290-297
    • Witton, C.J.1    Reeves, J.R.2    Going, J.J.3    Cooke, T.G.4    Bartlett, J.M.5
  • 53
    • 21644476814 scopus 로고    scopus 로고
    • Rac-GAP-dependent inhibition of breast cancer cell proliferation by beta2-chimaerin
    • Yang, C., Y. Liu, F. Coluccio Leskow, V. M. Weaver, and M. G. Kazanietz. 2005. Rac-GAP-dependent inhibition of breast cancer cell proliferation by beta2-chimaerin. J. Biol. Chem. 280:24363-24370.
    • (2005) J. Biol. Chem. , vol.280 , pp. 24363-24370
    • Yang, C.1    Liu, Y.2    Coluccio Leskow, F.3    Weaver, V.M.4    Kazanietz, M.G.5
  • 54
    • 0034766736 scopus 로고    scopus 로고
    • Biology of HER2 and its importance in breast cancer
    • Yarden, Y. 2001. Biology of HER2 and its importance in breast cancer. Oncology 61:1-13.
    • (2001) Oncology , vol.61 , pp. 1-13
    • Yarden, Y.1
  • 56
    • 0030064531 scopus 로고    scopus 로고
    • Transformation of NIH 3T3 cells by HER3 or HER4 receptors requires the presence of HER1 or HER2
    • Zhang, K., J. Sun, N. Liu, D. Wen, D. Chang, A. Thomason, and S. K. Yoshinaga. 1996. Transformation of NIH 3T3 cells by HER3 or HER4 receptors requires the presence of HER1 or HER2. J. Biol. Chem. 271:3884-3890.
    • (1996) J. Biol. Chem. , vol.271 , pp. 3884-3890
    • Zhang, K.1    Sun, J.2    Liu, N.3    Wen, D.4    Chang, D.5    Thomason, A.6    Yoshinaga, S.K.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.