Adenovector-mediated gene transfer of active transforming growth factor- β1 induces prolonged severe fibrosis in rat lung

Journal of Clinical Investigation

Volumn 100, Issue 4, 1997, Pages 768-776

  Sime, Patricia J ^a   Xing, Zhou ^a   Graham, Frank L ^a   Csaky, Karl G ^a,b   Gauldie, Jack ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b NATIONAL EYE INSTITUTE   (United States)

Author keywords

Cytokine; Extracellular matrix; Fibrotic; Gene transfer; Pulmonary

Indexed keywords

COLLAGEN; ELASTIN; FIBRONECTIN; TRANSFORMING GROWTH FACTOR BETA1; VIRUS VECTOR;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE TRANSFER; LUNG FIBROSIS; MALE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030800795     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119590     Document Type: Article

References (38)

1. Roberts, A.B., and M.B. Sporn. 1990. The transforming growth factor-betas. In Peptide Growth Factors and Their Receptors. Handbook of Experimental Pharmacology. M. Sporn and A.B. Roberts, editors. Springer-Verlag, Heidelberg. 95:419-473.
2. Kelley, J. 1993. Transforming growth factor-β. In Cytokines of the Lung. J. Kelley, editor. Marcel Dekker Inc., New York. 101-137.
3. Derynck, R., J.A. Jarrett, E.Y. Chen, D.H. Eaton, J.R. Bell, R.K. Assoian, A.B. Roberts, M.B. Sporn, and D.V. Goeddel. 1985. Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells. Nature (Lond.). 316:701-705.
4. Wakefield, L.M., D.M. Smith, K.C. Flanders, and M.B. Sporn. 1988. Latent transforming growth factor-β from human platelets: a high molecular weight complex containing precursor sequences. J. Biol. Chem. 263:7646-7654.
5. Miyazono, K., U. Hellman, C. Wernstedt, and C.-H. Heldin. 1988. Latent high molecular weight complex of transforming growth factor β1: purification from human platelets and structural characterization. J. Biol. Chem. 263:6407-6415.
6. Lyons, R.M., J. Keski-Oja, and H.L. Moses. 1988. Proteolytic activation of latent transforming growth factor-β from fibroblast-conditioned medium. Eur. J. Biochem. 1990:1659-1665.
7. Schultz-Cherry, S., and J.E. Murphy-Ullrich. 1993. Thrombospondin causes activation of latent transforming growth factor-β secreted by endothelial cells. J. Cell Biol. 122:923-932.
8. Sato, Y., and D.B. Rifkin. 1989. Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-β-like molecule by plasmin during co-culture. J. Cell Biol. 109:309-315.
9. Hoyt, D.G., and J.S. Lazo. 1988. Alterations in pulmonary mRNA encoding procollagens, fibronectin, and transforming growth factor-β precedes bleomycin-induced pulmonary fibrosis in mice. J. Pharmacol. Exp. Ther. 246:765-771.
10. Khalil, N., R.N. O'Conner, K.C. Flanders, and H. Umruh. 1996. TGF-β1, but not TGF-β2 or TGF-β3, is differentially present in epithelial cells of advanced pulmonary fibrosis: an immunohistochemical study. Am. J. Respir. Cell Mol. Biol. 14:131-138.
11. Limper, A.H., T.V. Colby, M.S. Sanders, S. Asakura, P.C. Roche, and R.A. DeRemee. 1994. Immunohistochemical localization of transforming growth factor-β1 in the nonnecrotizing granulomas of pulmonary sarcoidosis. Am. J. Respir. Crit. Care Med. 149:197-204.
12. Broekelmann, T.J., A.H. Limper, T.V. Colby, and J.A. McDonald. 1991. Transforming growth factor β1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis. Proc. Natl. Acad. Sci. USA. 88:6642-6646.
13. Xing, Z., T. Braciak, M. Jordana, K. Croitoru, F.L. Graham, and J. Gauldie. 1994. Adenovirus-mediated cytokine gene transfer at tissue sites. Overexpression of IL-6 induces lymphocytic hyperplasia in the lung. J. Immunol. 153:4059-4069.
14. Xing, Z., Y. Ohkawara, M. Jordana, F.L. Graham, and J. Gauldie. 1996. Transfer of granulocyte-macrophage colony-stimulating factor gene to rat lung induces eosinophilia, monocytosis, and fibrotic reactions. J. Clin. Invest. 97: 1102-1110.
15. Foley, R., K. Driscoll, Y. Wan, T. Braciak, B. Howard, Z. Xing, F. Graham, and J. Gauldie. 1996. Adenoviral gene transfer of macrophage inflammatory protein-2 in rat lung. Am. J. Pathol. 149:1395-1403.
16. Brunner, A.M., H. Marquardt, A.R. Malacko, M.N. Lioubin, and A.F. Purchio. 1989. Site-directed mutagenesis of cysteine residues in the pro region of the transforming growth factor β1 precursor: expression and characterization of mutant proteins. J. Biol. Chem. 264:13660-13664.
17. Bett, A.J., W. Haddara, L. Prevec, and F.L. Graham. 1994. An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 2. Proc. Natl. Acad. Sci. USA. 91:8802-8806.
18. Pircher, R., D. A. Lawrence, and P. Jullien. 1984. Latent β-transforming growth factor in nontransformed and Kirsten sarcoma virus-transformed normal rat kidney cells, clone 49F. Cancer Res. 44:5538-5543.
19. Tsang, M.L.-S., J.A. Weatherbee, M. Dietz, T. Kitamura, and R.C Lucas. 1990. TGF-beta specifically inhibits the IL-4 dependent proliferation of multifactor dependent murine T-helper and human hematopoietic cell lines. Lymphokine Res. 9:607.
20. Stegmann, H., and K. Stalder. 1967. Determination of hydroxyproline. Clin. Chim. Acta. 18:267-273.
21. Graham, F.L., and L. Prevec. 1990. Manipulation of adenovirus vectors. In Gene Transfer and Expression Protocols. Methods in Molecular Biology. E.J. Murray and J.M. Walker, editors. Humana Press Inc., Clifton, NJ. 7:109-127.
22. Darby, I., O. Skalli, and G. Gabbiani. 1990. α-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing. Lab. Invest. 63:21-29.
23. Desmouliere, A. 1995. Factors influencing myofibroblast differentiation during wound healing and fibrosis. Cell Biol. Int. 19:471-476.
24. Myung-Shik, L., D. Gu, L. Feng, S. Curriden, M. Arnush, T. Krahl, D. Gurushanthaiah, C. Wilson, D.L. Loskutoff, H. Fox, and N. Sarvetnick. 1995. Accumulation of extracellular matrix and developmental dysregulation in the pancreas by transgenic production of transforming growth factor-β1. Am. J. Pathol. 147:42-52.
25. Sanderson, N., V. Factor, P. Nagy, J. Kopp, P. Kondaiah, L. Wakefield, A.B. Roberts, M.B. Sporn, and S.S. Thorgeirsson. 1995. Hepatic expression of mature transforming growth factor β1 in transgenic mice results in multiple tissue lesions. Proc. Natl. Acad. Sci. USA. 92:2572-2576.
26. Zhou, L., C.R. Dey, S.E. Wert, and J.A. Whitsett. 1996. Arrested lung morphogenesis in transgenic mice bearing an SP-C-TGF-beta 1 chimeric gene. Dev. Biol. 175:227-238.
27. Xing, Z., G.M. Tremblay, P.J. Sime, and J. Gauldie. 1997. Overexpression of granulocyte/macrophage colony-stimulating factor induces pulmonary granulation tissue formation and fibrosis by induction of transforming growth factor-β1 and myofibroblast accumulation. Am. J. Pathol. 150:59-66.
28. Zhang, K., M.D. Rekhter, D. Gordon, and S.H. Phan. 1994. Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis. Am. J. Pathol. 145:114-125.
29. Desmouliere, A., A. Geinoz, F. Gabbiani, and G. Gabbiani. 1993. Transforming growth factor-β1 induces α-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J. Cell Biol. 122:103-111.
30. Hildebrand, A., M. Romaris, L.M. Rasmussen, P. Heinegard, D.R. Twardzik, W.A. Border, and E. Ruoslahti. 1994. Interaction of the small interstitial proteoglycan biglycan, decorin and fibromodulin with transforming growth factor β. Biochem. J. 302:527-534.
31. Fava, R.A., and D.B. McClure. 1987. Fibronectin-associated transforming growth factor. J. Cell. Physiol. 131:184-189.
32. Piguet, P.F., M.A. Collart, G.F. Grau, Y. Kapanci, and P. Vassalli. 1989. Tumor necrosis factor α cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis. J. Exp. Med. 170:655-663.
33. Wahl, S.M., D.A. Hunt, L.M. Wakefield, N. McCartney-Francis, L.M. Wahl, A.B. Roberts, and M.B. Sporn. 1987. Transforming growth factor type β induces monocyte chemotaxis and growth factor production. Proc. Natl. Acad. Sci. USA. 84:5788-5792.
34. 125I-labeled type β transforming growth factor from human platelets. Proc. Natl. Acad. Sci. USA. 81:6757-6761.
35. Khalil, N., C. Whitman, L. Zuo, D. Danielpour, and A. Greenberg. 1993. Regulation of alveolar macrophage transforming growth factor-β secretion by corticosteroids in bleomycin-induced pulmonary inflammation in the rat. J. Clin. Invest. 92:1812-1818.
36. Roberts, A.B., M.B. Sporn, R.K. Assoian, J.M. Smith, N.S. Roche, L.M. Wakefield, U.I. Heine, L.A. Liotta, V. Falanga, J.H. Kehrl, and A.S. Fauci. 1986. Transforming growth factor type β: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc. Natl. Acad. Sci. USA. 83:4167-4171.
37. Corrin, B., D. Butcher, B.J. McAnulty, R.M. Dubois, C.M. Black, G.J. Laurent, and N.K. Harrison. 1994. Immunohistochemical localisation of transforming growth factor-β1 in the lungs of patients with systemic sclerosis, cryptogenic fibrosing alveolitis, and other lung disorders. Histopathology (Oxford). 24:145-150.
38. Khalil, N., S. Corne, C. Whitman, and H. Yacyshyn. 1996. Plasmin regulates the activation of cell-associated latent TGF-β1 secreted by rat alveolar macrophages after in vivo bleomycin injury. Am. J. Respir. Cell Mol. Biol. 15: 252-259.