TACE is required for the activation of the EGFR by TGF-α in tumors

EMBO Journal

Volumn 22, Issue 5, 2003, Pages 1114-1124

  Borrell Pagès, Maria ^a   Rojo, Federico ^a   Albanell, Joan ^b   Baselga, Josep ^a   Arribas, Joaquín ^a  

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

EGFR; Metalloproteases; Shedding; TGF

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME;

ANIMAL CELL; ARTICLE; BREAST TUMOR; CARCINOGENESIS; CELL INTERACTION; CELL MEMBRANE; CHO CELL; CONTROLLED STUDY; ENZYME ACTIVITY; GENE OVEREXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ADAM PROTEINS; AMINO ACID SEQUENCE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BREAST NEOPLASMS; CARCINOGENICITY TESTS; CHO CELLS; CRICETINAE; CULTURE MEDIA, CONDITIONED; ENDOPEPTIDASES; FEMALE; HELA CELLS; HUMANS; MATRIX METALLOPROTEINASES, MEMBRANE-ASSOCIATED; METALLOENDOPEPTIDASES; MICE; MICE, NUDE; NEOPLASMS; RECEPTOR, EPIDERMAL GROWTH FACTOR; TRANSFORMING GROWTH FACTOR ALPHA; TRANSPLANTATION, HETEROLOGOUS;

ANIMALIA; MUS MUSCULUS;

EID: 0037416187     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdg111     Document Type: Article

References (43)

1. Albanell, J. et al. (2001) Activated extracellular signal-regulated kinases: association with epidermal growth factor receptor/transforming growth factor-α expression in head and neck squamous carcinoma and inhibition by anti-epidermal growth factor receptor treatments. Cancer Res., 61, 6500-6510.
2. Albanell, J. et al. (2002) Pharmacodynamic studies of the epidermal growth factor receptor inhibitor ZD1839 in skin from cancer patients: histopathologic and molecular consequences of receptor inhibition. J. Clin. Oncol., 20, 110-124.
3. Arribas, J. and Massagué, J. (1995) Transforming growth factor α and β amyloid precursor protein share a secretory mechanism. J. Cell Biol., 128, 433-441.
4. Arribas, J. and Merlos-Suárez, A. (2002) Shedding of plasma membrane proteins. Curr. Top. Dev. Biol., in press.
5. Arribas, J., Coodly, L., Vollmer, P., Kishimoto, T.K., Rosejohn, S. and Massagué, J., (1996) Diverse cell surface protein ectodomains are shed by a system sensitive to metalloprotease inhibitors. J. Biol. Chem., 271, 11376-11382.
6. Arribas, J., López-Casillas, F. and Massagué, J. (1997) Role of the juxtamembrane domains of the transforming growth factor-α precursor and the β-amyloid precursor protein in regulated ectodomain shedding. J. Biol. Chem., 272, 17160-17165.
7. Asakura, M. et al. (2002) Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: metalloproteinase inhibitors as a new therapy. Nat. Med., 8, 35-40.
8. Baselga, J. (2001) Targeting the epidermal growth factor receptor: a clinical reality. J. Clin. Oncol., 19, 41S-44S.
9. Baselga, J., Norton, L., Masui, H., Pandiella, A., Coplan, K., Miller, W.H.J. and Mendelsohn, J. (1993) Antitumor effects of doxorubicin in combination with anti-epidermal growth factor receptor monoclonal antibodies. J. Natl Cancer Inst., 85, 1327-1233.
10. Bassi, D.E., Mahloogi, H., Al-Saleem, L., Lopez De Cicco, R., Ridge, J.A. and Klein-Szanto, A.J. (2001) Elevated furin expression in aggressive human head and neck tumors and tumor cell lines. Mol. Carcin., 224-232.
11. Bergers, G. and Coussens, L.M. (2000) Extrinsic regulators of epithelial tumor progression: metalloproteinases. Curr. Opin. Genet. Dev., 10, 120-127.
12. Black, R.A. et al. (1997) A metalloprotease disintegrin that releases tumour-necrosis factor α from cells. Nature, 385, 729-733.
13. Brachmann, R., Lindquist, P.B., Nagashima, M., Kohr, W., Lipari, T., Napier, N. and Derynck, R. (1989) Transmembrane TGF-α precursors activate EGF/TGF-α receptors. Cell, 56, 691-700.
14. Brinckerhoff, C.E. and Matrisian, L.M. (2002) Matrix metalloproteinases: a tail of a frog that became a prince. Nat. Rev., 3, 207-214.
15. Brou, C. et al. (2000) A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. Mol. Cell, 5, 207-216.
16. Coussens, L.M., Tinkle, C.L., Hanahan, D. and Werb, Z. (2000) MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell, 103, 481-490.
17. Dempsey, P.J. and Coffey, R.J. (1994) Basolateral targeting and efficient consumption of transforming growth factor-α when expressed in Madin-Darby canine kidney cells. J. Biol. Chem., 269, 7131-7136.
18. Dong, J., Opresko, L.K., Dempsey, P.J., Lauffenburger, D.A., Coffey, R.J. and Wiley, H.S. (1999) Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor. Proc. Natl Acad. Sci. USA, 96, 6235-6240.
19. Fernández-Larrea, J., Merlos-Suárez, A., Ureña, J.M., Baselga, J. and Arribas, J. (1999) A role for a PDZ protein in the early secretory pathway for the targeting of proTGF-α to the cell surface. Mol. Cell, 3, 423-433.
20. Hattori, M., Osterfield, M. and Flanagan, J.G. (2000) Regulated cleavage of a contact-mediated axon repellent. Science, 289, 1360-1365.
21. Izumi, Y. et al. (1998) A metalloprotease-disintegrin, MDC9/meltrin-γ/ADAM9 and PKCδ are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. EMBO J., 17, 7260-7272.
22. Jhappan, C., Stahle, C., Harkins, R.N., Fausto, N., Smith, G.H. and Merlino, G.T. (1990) TGF-α overexpression of in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas. Cell, 61, 1137-1146.
23. Kheradmand, F. and Werb, Z. (2002) Shedding light on sheddases: role in growth and development. BioEssays, 24, 8-12.
24. Kuo, A., Zhong, C., Lane, W.S. and Derynck, R. (2000) Transmembrane transforming growth factor-α tethers to the PDZ domain-containing, Golgi membrane-associated protein p59/GRASP55. EMBO J., 19, 6427-6429.
25. Lee, J.R., Urban, S., Garvey, C.F. and Freeman, M. (2001) Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila. Cell, 107, 161-171.
26. Massagué, J. and Pandiella, A. (1993) Membrane-anchored growth factors. Annu. Rev. Biochem., 62, 515-541.
27. Mendelsohn, J. and Baselga, J. (2000) The EGF receptor family as targets for cancer therapy, Oncogene, 19, 6550-6565.
28. Merlos-Suárez, A., Ruiz-Paz, S., Baselga, J. and Arribas, J. (2001) Metalloprotease-dependent proTGF-a ectodomain shedding in the absence of TACE. J. Biol. Chem., 276, 48510-48517.
29. Montero, J.C., Yuste, L., Diaz-Rodriguez, E., Esparis-Ogando, A. and Pandiella, A. (2000) Differential shedding of transmembrane neuregulin isoforms by the tumor necrosis factor-α-converting enzyme. Mol. Cell. Neurosci., 16, 631-648.
30. Moss, M.L. et al. (1997) Cloning of a disintegrin metalloproteinase that processes precursor tumour necrosis factor-α. Nature, 385, 733-736.
31. Peschon, J. et al. (1998) An essential role for ectodomain shedding in mammalian development. Science, 282, 1281-1284.
32. Prenzel, N., Fischer, O.M., Streit, S., Hart, S. and Ullrich, A. (2001) The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification. Endocr. Relat. Cancer, 8, 11-31.
33. Sandgren, E.P., Luetteke, N.C., Palmiter, R.D., Brinster, R.L. and Lee, D.C. (1990) Overexpression of TGF-α in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast. Cell, 61, 1121-1135.
34. Schlöndorff, J., Becherer, J.D. and Blobel, C.P. (2000) Intracellular maturation and localization of the tumour necrosis factor α convertase (TACE). Biochem. J., 347, 131-138.
35. Shi, W., Fan, H., Shum, L. and Derynck, R. (2000) The tetraspanin CD9 associates with transmembrane TGF-α and regulates TGF-α-induced EGF receptor activation and cell proliferation. J. Cell Biol., 148, 591-602.
36. Shirakabe, K., Wakatsuki, S., Kurisaki, T. and Fujisawa-Sehara, A. (2001) Roles of meltrin β/ADAM19 in the processing of neuregulin. J. Biol. Chem., 276, 9352-9358.
37. Strachan, L., Murison, J.G., Prestidge, R.L., Sleeman, M.A., Watson, J.D. and Kumble, K.D. (2001) Cloning and biological activity of epigen, a novel member of the epidermal growth factor superfamily. J. Biol. Chem., 276, 18265-18271.
38. Sunnarborg, S.W. et al. (2002) Tumor necrosis factor-α converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability. J. Biol. Chem., 277, 12838-12845.
39. Urban, S., Lee, J.R. and Freeman, M. (2001) Drosophila rhomboid-I defines a family of putative intramembrane serine proteases. Cell, 107, 173-182.
40. Weskamp, G., Cai, H., Brodie, T.A., Higashyama, S., Manova, K., Ludwig, T. and Blobel, C.P. (2002) Mice lacking the metalloprotease-disintegrin MDC9 (ADAM9) have no evident major abnormalities during development or adult life. Mol. Cell. Biol., 22, 1537-1544.
41. Wong, S.T., Winchell, L.F., McCune, B.K., Earp, H.S., Teixidó, J., Massagué, J., Herman, B. and Lee, D.C. (1989) The TGF-α precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction. Cell, 56, 495-506.
42. Yang, H., Jiang, D., Li, W., Liang, J., Gentry, L.E. and Brattain, M.G. (2000) Defective cleavage of membrane bound TGFα leads to enhanced activation of the EGF receptor in malignant cells. Oncogene, 1901-1914.
43. Yarden, Y. and Sliwkowski, M.X. (2001) Untangling the ErbB signalling network. Nat. Rev. Mol. Cell Biol., 2, 127-137.