Aggravation of experimental allergic encephalomyelitis (EAE) by administration of nitric oxide (NO) synthase inhibitors

Clinical and Experimental Immunology

Volumn 103, Issue 3, 1996, Pages 467-474

  Ruuls, S R ^a   Van Der Linden, S ^a   Sontrop, K ^a   Huitinga, I ^a   Dijkstra, C D ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Experimental allergic encephalomyelitis; Macrophages; Nitric oxide; Nitric oxide synthase inhibitors

Indexed keywords

N(G) METHYLARGININE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; MACROPHAGE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0029873759     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2249.1996.tb08304.x     Document Type: Article

References (39)

1. Sobel RA, Blanchette BW, Bhan AK et al. The immunopathology of experimental allergic encephalomyelitis: I. Quantitative analysis of inflammatory cells in situ. J Immunol 1984; 132:2392-401.
2. Polman CH, Dijkstra CD, Sminia T et al. Immunohistological analysis of macrophages in the central nervous system of Lewis rats with experimental allergic encephalomyelitis. J Neuroimmunol 1986; 11:215-22.
3. Huitinga I, Van Rooijen N, De Groot CJA et al. Suppression of experimental allergic encephalomyelitis in Lewis rats after elimination of macrophages. J Exp Med 1990; 172:1025-33.
4. Huitinga I, Damoiseaux JGMC, Döpp EA et al. Treatment with anti-CR3 antibodies ED7 and ED8 suppresses experimental allergic encephalomyelitis in Lewis rats. Eur J Immunol 1993; 23:709-15.
5. Hibbs JB, Taintor RR, Vavrin Z et al. Nitric oxide: a cytotoxic macrophage effector molecule. Biochem Biophys Res Commun 1988; 157:87-94.
6. Marletta MA, Yoon PS, Iyengar R et al. Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate. Biochem 1988; 27:8706-11.
7. Koprowski H, Zheng YM, Heber-Katz E et al. In vivo expression of inducible nitric oxide synthase in experimentally induced neurological diseases. Proc Natl Acad Sci USA 1993; 90:3024-7.
8. Lin RF, Lin T-S, Tilton RG et al. Nitric oxide localized to spinal cords of mice with experimental allergic encephalomyelitis: an electron paramagnetic resonance study. J Exp Med 1993; 178:643-8.
9. Merrill JE, Ignarro LJ, Sherman MP et al. Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide. J Immunol 1993; 151:2132-41.
10. Denham S, Rowland IJ. Inhibition of the reactive proliferation of lymphocytes by activated macrophages: the role of nitric oxide. Clin Exp Immunol 1992; 87:157-62.
11. Kubes P, Suzuki M, Granger DN. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA 1991; 88:4651-5.
12. Matthaei I, Polman CH, De Groot CJA et al. Observer agreement in the assessment of clinical signs in experimental allergic encephalomyelitis. J Neuroimmunol 1989; 11:215-22.
13. De Groot CJA, Sminia T, Dijkstra CD. Isolation and characterization of brain macrophages from the central nervous sytem of newborn and adult rats and of rats with experimental allergic encephalomyelitis. Immunobiol 1989; 179:314-27.
14. Ding AH, Nathan CF, Stuehr DJ. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J Immunol 1988; 141:2407-12.
15. Kolb H, Kiesel U, Kroncke K-D et al. Suppression of low dose streptozotocin induced diabetes in mice by administration of a nitric oxide synthase inhibitor. Life Sci 1991; 49:PL213-7.
16. Calapai G, Squadrito F, Altavilla D et al. Evidence that nitric oxide modulates drinking behaviour. Neuropharmacol 1992; 31:761-4.
17. Van Dam A-M, Bauer J, Man-A-Hing WKH et al. Appearance of inducible nitric oxide synthase in the rat central nervous system after rabies infection and during experimental allergic encephalomyelitis, but not after peripheral administration of endotoxin. J Neurosci Res 1995; 40:251-60.
18. Ruuls SR, Bauer J, Sontrop K et al. Reactive oxygen species are involved in the pathogenesis of experimental allergic encephalomyelitis. J Neuroimmunol 1995; 56:207-17.
19. Dijkstra CD, Döpp EA, Joling P et al. The heterogeneity of mononuclear phagocytes in lymphoid tissue: distinct macrophage subpopulations in the rat recognized by monoclonal antibodies ED1, ED2 and ED3. Immunology 1985; 54:589-99.
20. Rees DD, Palmer RMJ, Schulz R et al. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Brit J Pharmacol 1990; 101:746-52.
21. Gross SS, Stuehr DJ, Alsaka K et al. Macrophage and endothelial cell nitric oxide synthesis: cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine. Biochem Biophys Res Commun 1990; 170:96-103.
22. Mulligan MS, Moncada S, Ward PA. Protective effects of inhibitors of nitric oxide synthase in immune complex-induced vasculitis. Brit J Pharmacol 1992; 107:1159-62.
23. Squadrito F, Calapai G, Altavilla D et al. Central serotinergic system involvement in the anorexia induced by NG-nitro-L-arginine, an inhibitor of nitric oxide synthase. Eur J Pharmacol 1994; 255:51-55.
24. MacMicking JD, Willenborg DO, Weidemann MJ et al. Elevated secretion of reactive nitrogen and oxygen intermediates in hyperacute experimental autoimmune encephalomyelitis: enhancement by the soluble products of encephalitogenic T cells. J Exp Med 1992; 176:303-7.
25. McCartney-Francis N, Allen JB, Mizel DE et al. Suppression of arthritis by an inhibitor of nitric oxide synthase. J Exp Med 1993; 178:749-54.
26. Weinberg JB, Granger DL, Pisetsky DS et al. The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production in MR1-1pr/1pr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine. J Exp Med 1994; 179:651-60.
27. Al-Ramadi BK, Meissler JJ, Huang D et al. Immunosuppression induced by nitric oxide and its inhibition by interleukin-4. Eur J Immunol 1992; 22:2249-54.
28. Nussler AK, Billiar TR. Inflammation, immunoregulation, and inducible nitric oxide synthase. J Leukocyte Biol 1993; 54:171-8.
29. Habrecht BG, Billiar TR, Stadler J et al. Inhibition of nitric oxide synthesis during endotoxemia promotes intrahepatic thrombosis and an oxygen radical-mediated hepatic injury. J Leukocyte Biol 1992; 52:390-4.
30. Peterson DA, Peterson DC, Archer S et al. The non-specificity of specific nitric oxide synthase inhibitors. Biochem Biophys Res Commun 1992; 187:797-801.
31. Hartung H-P, Jung S, Stoll G et al. Inflammatory mediators in demyelinating disorders of the CNS and PNS. J Neuroimmunol 1992; 40:197-210.
32. Jessup W, Dean RT. The antioxidant properties of an inhibitor of nitric oxide synthase. Free Rad Med Biol 1993; 14:447-8.
33. Bluthe R-M, Sparber S, Dantzer R. Modulation of the behavioural effects of interleukin-1 in mice by nitric oxide. Neuroreporl 1992; 3:207-9.
34. Persoons JHA, Schonnagel K, Tildens FJH et al. Alveolar macrophages autoregulate IL-1 and IL-6 production by endogenous nitric oxide. Am J Resp Cell Mol; in press.
35. Bauer J, Berkenbosh F, Van Dam A-M et al. Demonstration of interleukin-1beta in Lewis rat brain during experimental allergic encephalomyelitis by immunocytochemistry at the light and ultrastructural level. J Neuroimmunol 1993; 48:13-22.
36. Dinarello CA. Biology of interleukm-1. FASEB J 1988; 2:108-15.
37. Zielasek J, Jung S, Gold R et al. Administration of nitric oxide synthase inhibitors in experimental autoimmune neuritis and experimental autoimmune encephalomyelitis. J Neuroimmunol 1995; 58:81-88.
38. Misho TP, Moore WM, Kasten TP et al. Selective inhibition of the inducible nitric oxide synthase by aminoguanidine. Eur J Pharmacol 1993; 233:119-25.
39. Cross AH, Misko TP, Lin RF et al. Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental allergic encephalomyelitis in SJL mice. J Clin Invest 1994; 193:2684-90.