Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B

Nature

Volumn 423, Issue 6941, 2003, Pages 773-777

  Van Montfort, Rob L M ^a   Congreve, Miles ^a   Tisi, Dominic ^a   Carr, Robin ^a   Jhoti, Harren ^a  

^a ASTEX PHARMACEUTICALS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CRYSTAL STRUCTURE; INSULIN; OXIDATION; REDOX REACTIONS; SIGNAL PROCESSING;

SIGNAL TRANSDUCTION;

ENZYMES;

GLUTATHIONE; INSULIN RECEPTOR; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE 1B; SULFENAMIDE DERIVATIVE; SULFENIC ACID DERIVATIVE; SULFINIC ACID DERIVATIVE; SULFONIC ACID DERIVATIVE; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

MEDICINE;

ARTICLE; CRYSTAL STRUCTURE; DIABETES MELLITUS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HYPERTENSION; MALIGNANT NEOPLASTIC DISEASE; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION;

AMIDES; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; GLUTATHIONE; MODELS, MOLECULAR; OXIDATION-REDUCTION; PROTEIN CONFORMATION; PROTEIN-TYROSINE-PHOSPHATASE; SULFENIC ACIDS; SULFINIC ACIDS; SULFONIC ACIDS;

EID: 0038749600     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01681     Document Type: Article

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