Matrix metalloproteinase inhibition prevents oxidative stress-associated blood-brain barrier disruption after transient focal cerebral ischemia

Journal of Cerebral Blood Flow and Metabolism

Volumn 21, Issue 12, 2001, Pages 1393-1400

  Gasche, Yvan ^a,b   Copin, Jean Christophe ^a,b   Sugawara, Taku ^a   Fujimura, Miki ^a   Chan, Pak H ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

Blood brain barrier; Metalloproteinases; Oxidative stress; Stroke; Vasogenic edema

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; GELATINASE; MATRIX METALLOPROTEINASE; SUPEROXIDE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN EDEMA; BRAIN ISCHEMIA; BRAIN PROTECTION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME DEFICIENCY; ENZYME INHIBITION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; REPERFUSION INJURY; STROKE;

EID: 0035194622     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-200112000-00003     Document Type: Article

References (42)

1. Reduction of tissue plasminogen activator-induced hemorrhage and brain injury by free radical spin trapping after embolic focal cerebral ischemia in rats
2. Protection against blood-brain barrier disruption in focal cerebral ischemia by the type IV phosphodiesterase inhibitor BBB022: A quantitative study
3. Critical evaluation of the use of hydroethidine as a measure of superoxide anion radical
4. Superoxide production in rat hippocampal neurons: Selective imaging with hydroethidine
5. Oxygen radicals in focal cerebral ischemia
6. Neuroprotective role of CuZn-superoxide dismutase in ischemic brain damage
7. Redox regulation of nuclear factor kappa B: Therapeutic potential for attenuating inflammatory responses
8. The rtPA (alteplase) 0- to 6-hour acute stroke trial. Part 1: (A0276g) results of a double-blind, placebo-controlled, multicenter study. Thrombolytic therapy in acute ischemic stroke study investigators
9. The neuronal microenvironment: A comparative view
10. Brain edema
11. Early appearance of activated matrix metalloproteinase-9 after focal cerebral ischemia in mice: A possible role in blood-brain barrier dysfunction
12. Cytokines regulate gelatinase A and B (matrix metalloproteinase 2 and 9) activity in cultured rat astrocytes
13. Increased production of gelatinase B (matrix metalloproteinase-9) and interleukin-6 by activated rat microglia in culture
14. NAD(P)H oxidase: Role in cardiovascular biology and disease
15. Microvascular basal lamina antigens disappear during cerebral ischemia and reperfusion
16. Oxidant signaling in vascular cell growth, death, and survival: A review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling
17. Quantitative zymography: Detection of picogram quantities of gelatinases
18. Reduction of CuZn-superoxide dismutase activity exacerbates neuronal cell injury and edema formation after transient focal cerebral ischemia
19. Interferon-beta inhibits activated leukocyte migration through human brain microvascular endothelial cell monolayer
20. Overexpression of copper and zinc superoxide dismutase in transgenic mice prevents the induction and activation of matrix metalloproteinases after cold injury-induced brain trauma
21. Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency
22. Tissue plasminogen activator for acute ischemic stroke
23. Active and tissue inhibitor of matrix metalloproteinase-free gelatinase B accumulates within human microvascular endothelial vesicles
24. Matrix metalloproteinase-9/gelatinase B is required for process outgrowth by oligodendrocytes
25. Differential expression of matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase genes in the mouse central nervous system in normal and inflammatory states
26. Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro
27. Motor neurons in Cu/Zn superoxide dismutase deficient mice develop normally but exhibit enhanced cell death after axonal injury
28. Matrix metalloproteinase expression increases after cerebral focal ischemia in rats: Inhibition of matrix metalloproteinase-9 reduces infarct size
29. Proteolytic cascade enzymes increase in focal cerebral ischemia in rat
30. Matrix metalloproteinases and TIMPs are associated with blood-brain barrier opening after reperfusion in rat brain
31. Computational sequence analysis of matrix metalloproteinases
32. Antioxidant and redox regulation of gene transcription
33. Molecular sieving characteristics of cultured endothelial monolayer
34. Human skin fibroblast pro-collagenase: Mechanisms of activation by organomercurials and trypsin
35. The stoichiometric activation of human skin fibroblast pro-collagenase by factors present in human skin and rat uterus
36. The cysteine switch: A principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family
37. Effects of oxygen radicals on cerebral arterioles
38. Oxidative autoactivation of latent collagenase by human neutrophils
39. Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia
40. Molecular architecture of basement membranes
41. Zymographic measurement of gelatinase activity in brain tissue after detergent extraction and affinity-support purification
42. Measurement of endothelial cell free radical generation: Evidence for a central mechanism of free radical injury in postischemic tissue