메뉴 건너뛰기




Volumn 108, Issue 34, 2011, Pages 14330-14335

S-nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by β-amyloid peptide

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; CYCLIN DEPENDENT KINASE 5; CYSTEINE; NITRIC OXIDE; THIOL GROUP;

EID: 80052150240     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1105172108     Document Type: Article
Times cited : (160)

References (49)
  • 2
    • 0027978170 scopus 로고
    • p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5
    • DOI 10.1038/371419a0
    • Tsai LH, Delalle I, Caviness VS, Jr., Chae T, Harlow E (1994) p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. Nature 371:419-423. (Pubitemid 24302556)
    • (1994) Nature , vol.371 , Issue.6496 , pp. 419-423
    • Teai, L.-H.1    Delalle, I.2    Cavness Jr., V.S.3    Chae, T.4    Harlow, E.5
  • 3
    • 0028858467 scopus 로고
    • An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator
    • Tang D, et al. (1995) An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator. J Biol Chem 270:26897-26903.
    • (1995) J Biol Chem , vol.270 , pp. 26897-26903
    • Tang, D.1
  • 5
    • 0042329506 scopus 로고    scopus 로고
    • Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration
    • DOI 10.1016/S0092-8674(03)00605-6
    • Xie Z, Sanada K, Samuels BA, Shih H, Tsai LH (2003) Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration. Cell 114:469-482. (Pubitemid 37100995)
    • (2003) Cell , vol.114 , Issue.4 , pp. 469-482
    • Xie, Z.1    Sanada, K.2    Samuels, B.A.3    Shih, H.4    Tsai, L.-H.5
  • 8
    • 17744368458 scopus 로고    scopus 로고
    • Deregulation of Cdk5 in a mouse model of ALS: Toxicity alleviated by perikaryal neurofilament inclusions
    • DOI 10.1016/S0896-6273(01)00268-9
    • Nguyen MD, Larivière RC, Julien JP (2001) Deregulation of Cdk5 in a mouse model of ALS: Toxicity alleviated by perikaryal neurofilament inclusions. Neuron 30:135-147. (Pubitemid 32441682)
    • (2001) Neuron , vol.30 , Issue.1 , pp. 135-147
    • Nguyen, M.D.1    Lariviere, R.C.2    Julien, J.-P.3
  • 11
    • 54049089271 scopus 로고    scopus 로고
    • Dopaminergic and glutamatergic signaling crosstalk in Huntington's disease neurodegeneration: The role of p25/cyclin-dependent kinase 5
    • Paoletti P, et al. (2008) Dopaminergic and glutamatergic signaling crosstalk in Huntington's disease neurodegeneration: The role of p25/cyclin-dependent kinase 5. J Neurosci 28:10090-10101.
    • (2008) J Neurosci , vol.28 , pp. 10090-10101
    • Paoletti, P.1
  • 12
    • 0034682414 scopus 로고    scopus 로고
    • Neurotoxicity induces cleavage of p35 to p25 by calpain
    • Lee MS, et al. (2000) Neurotoxicity induces cleavage of p35 to p25 by calpain. Nature 405:360-364.
    • (2000) Nature , vol.405 , pp. 360-364
    • Lee, M.S.1
  • 13
    • 0037373079 scopus 로고    scopus 로고
    • Up-regulation of cDK5/p35 by oxidative stress in human neuroblastoma IMR-32 cells
    • DOI 10.1002/jcb.10391
    • Strocchi P, Pession A, Dozza B (2003) Up-regulation of cDK5/p35 by oxidative stress in human neuroblastoma IMR-32 cells. J Cell Biochem 88:758-765. (Pubitemid 36258825)
    • (2003) Journal of Cellular Biochemistry , vol.88 , Issue.4 , pp. 758-765
    • Strocchi, P.1    Pession, A.2    Dozza, B.3
  • 14
    • 2342466091 scopus 로고    scopus 로고
    • Oxidative stress promotes tau dephosphorylation in neuronal cells: The roles of cdk5 and PP1
    • DOI 10.1016/j.freeradbiomed.2004.03.007, PII S0891584904002199
    • Zambrano CA, Egaña JT, Núñez MT, Maccioni RB, González-Billault C (2004) Oxidative stress promotes tau dephosphorylation in neuronal cells: The roles of cdk5 and PP1. Free Radic Biol Med 36:1393-1402. (Pubitemid 38596799)
    • (2004) Free Radical Biology and Medicine , vol.36 , Issue.11 , pp. 1393-1402
    • Zambrano, C.A.1    Egana, J.T.2    Nunez, M.T.3    Maccioni, R.B.4    Gonzalez-Billault, C.5
  • 15
    • 25644456097 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease
    • DOI 10.1523/JNEUROSCI.2868-05.2005
    • Kitazawa M, Oddo S, Yamasaki TR, Green KN, LaFerla FM (2005) Lipopolysaccharideinduced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease. J Neurosci 25:8843-8853. (Pubitemid 41384452)
    • (2005) Journal of Neuroscience , vol.25 , Issue.39 , pp. 8843-8853
    • Kitazawa, M.1    Oddo, S.2    Yamasaki, T.R.3    Green, K.N.4    LaFerla, F.M.5
  • 17
    • 28744449248 scopus 로고    scopus 로고
    • Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory
    • Fischer A, Sananbenesi F, Pang PT, Lu B, Tsai LH (2005) Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory. Neuron 48:825-838.
    • (2005) Neuron , vol.48 , pp. 825-838
    • Fischer, A.1    Sananbenesi, F.2    Pang, P.T.3    Lu, B.4    Tsai, L.H.5
  • 18
    • 36148975760 scopus 로고    scopus 로고
    • Emerging roles of S-nitrosylation in protein misfolding and neurodegenerative diseases
    • DOI 10.1089/ars.2007.1858
    • Nakamura T, Lipton SA (2008) Emerging roles of S-nitrosylation in protein misfolding and neurodegenerative diseases. Antioxid Redox Signal 10:87-101. (Pubitemid 350115990)
    • (2008) Antioxidants and Redox Signaling , vol.10 , Issue.1 , pp. 87-101
    • Nakamura, T.1    Lipton, S.A.2
  • 20
    • 64249133725 scopus 로고    scopus 로고
    • S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury
    • Cho DH, et al. (2009) S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury. Science 324:102-105.
    • (2009) Science , vol.324 , pp. 102-105
    • Cho, D.H.1
  • 21
    • 48249132446 scopus 로고    scopus 로고
    • Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cyclin-dependent kinase 5 complexes
    • Asada A, et al. (2008) Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cyclin-dependent kinase 5 complexes. J Neurochem 106:1325-1336.
    • (2008) J Neurochem , vol.106 , pp. 1325-1336
    • Asada, A.1
  • 23
    • 78049351867 scopus 로고    scopus 로고
    • S-nitrosylation of cyclin-dependent kinase 5 (cdk5) regulates its kinase activity and dendrite growth during neuronal development
    • Zhang P, et al. (2010) S-nitrosylation of cyclin-dependent kinase 5 (cdk5) regulates its kinase activity and dendrite growth during neuronal development. J Neurosci 30: 14366-14370.
    • (2010) J Neurosci , vol.30 , pp. 14366-14370
    • Zhang, P.1
  • 24
    • 59649128916 scopus 로고    scopus 로고
    • Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death
    • Tian B, Yang Q, Mao Z (2009) Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death. Nat Cell Biol 11:211-218.
    • (2009) Nat Cell Biol , vol.11 , pp. 211-218
    • Tian, B.1    Yang, Q.2    Mao, Z.3
  • 25
    • 0030956929 scopus 로고    scopus 로고
    • (S)NO signals: Translocation, regulation, and a consensus motif
    • DOI 10.1016/S0896-6273(00)80310-4
    • Stamler JS, Toone EJ, Lipton SA, Sucher NJ (1997) (S)NO signals: Translocation, regulation, and a consensus motif. Neuron 18:691-696. (Pubitemid 27232781)
    • (1997) Neuron , vol.18 , Issue.5 , pp. 691-696
    • Stamler, J.S.1    Toone, E.J.2    Lipton, S.A.3    Sucher, N.J.4
  • 26
    • 73649121243 scopus 로고    scopus 로고
    • Structural analysis of cysteine S-nitrosylation: A modified acid-based motif and the emerging role of trans-nitrosylation
    • Marino SM, Gladyshev VN (2010) Structural analysis of cysteine S-nitrosylation: A modified acid-based motif and the emerging role of trans-nitrosylation. J Mol Biol 395:844-859.
    • (2010) J Mol Biol , vol.395 , pp. 844-859
    • Marino, S.M.1    Gladyshev, V.N.2
  • 28
    • 0141542665 scopus 로고    scopus 로고
    • Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors
    • DOI 10.1038/nn1119
    • Wang J, Liu S, Fu Y, Wang JH, Lu Y (2003) Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors. Nat Neurosci 6:1039-1047. (Pubitemid 37186195)
    • (2003) Nature Neuroscience , vol.6 , Issue.10 , pp. 1039-1047
    • Wang, J.1    Liu, S.2    Fu, Y.3    Wang, J.H.4    Lu, Y.5
  • 31
    • 1542328910 scopus 로고    scopus 로고
    • Cdk5, a therapeutic target for Alzheimer's disease?
    • Tsai LH, Lee MS, Cruz J (2004) Cdk5, a therapeutic target for Alzheimer's disease? Biochim Biophys Acta 1697:137-142.
    • (2004) Biochim Biophys Acta , vol.1697 , pp. 137-142
    • Tsai, L.H.1    Lee, M.S.2    Cruz, J.3
  • 32
    • 33947314641 scopus 로고    scopus 로고
    • Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway
    • DOI 10.1523/JNEUROSCI.4970-06.2007
    • Shankar GM, et al. (2007) Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci 27:2866-2875. (Pubitemid 46438992)
    • (2007) Journal of Neuroscience , vol.27 , Issue.11 , pp. 2866-2875
    • Shankar, G.M.1    Bloodgood, B.L.2    Townsend, M.3    Walsh, D.M.4    Selkoe, D.J.5    Sabatini, B.L.6
  • 33
    • 0033816844 scopus 로고    scopus 로고
    • Beta-amyloid neurotoxicity is mediated by a glutamate-triggered excitotoxic cascade in rat nucleus basalis
    • Harkany T, et al. (2000) beta-amyloid neurotoxicity is mediated by a glutamate-triggered excitotoxic cascade in rat nucleus basalis. Eur J Neurosci 12:2735-2745.
    • (2000) Eur J Neurosci , vol.12 , pp. 2735-2745
    • Harkany, T.1
  • 34
    • 77955855654 scopus 로고    scopus 로고
    • Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses
    • Xia P, Chen HSV, Zhang D, Lipton SA (2010) Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses. J Neurosci 30:11246-11250.
    • (2010) J Neurosci , vol.30 , pp. 11246-11250
    • Xia, P.1    Chen, H.S.V.2    Zhang, D.3    Lipton, S.A.4
  • 35
    • 33645095476 scopus 로고    scopus 로고
    • Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond
    • Lipton SA (2006) Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond. Nat Rev Drug Discov 5:160-170.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 160-170
    • Lipton, S.A.1
  • 36
    • 0032888131 scopus 로고    scopus 로고
    • Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease
    • Lue LF, et al. (1999) Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am J Pathol 155:853-862.
    • (1999) Am J Pathol , vol.155 , pp. 853-862
    • Lue, L.F.1
  • 37
    • 0032590054 scopus 로고    scopus 로고
    • Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
    • McLean CA, et al. (1999) Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. Ann Neurol 46:860-866.
    • (1999) Ann Neurol , vol.46 , pp. 860-866
    • McLean, C.A.1
  • 38
    • 0025987048 scopus 로고
    • Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
    • Terry RD, et al. (1991) Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment. Ann Neurol 30:572-580.
    • (1991) Ann Neurol , vol.30 , pp. 572-580
    • Terry, R.D.1
  • 39
    • 77955480840 scopus 로고    scopus 로고
    • Transnitrosylation of XIAP regulates caspase-dependent neuronal cell death
    • Nakamura T, et al. (2010) Transnitrosylation of XIAP regulates caspase-dependent neuronal cell death. Mol Cell 39:184-195.
    • (2010) Mol Cell , vol.39 , pp. 184-195
    • Nakamura, T.1
  • 42
    • 33644818614 scopus 로고    scopus 로고
    • Thioredoxin catalyzes the S-nitrosation of the caspase-3 active site cysteine
    • Mitchell DA, Marletta MA (2005) Thioredoxin catalyzes the S-nitrosation of the caspase-3 active site cysteine. Nat Chem Biol 1:154-158.
    • (2005) Nat Chem Biol , vol.1 , pp. 154-158
    • Mitchell, D.A.1    Marletta, M.A.2
  • 45
    • 66449090794 scopus 로고    scopus 로고
    • Specific role of neuronal nitric-oxide synthase when tethered to the plasma membrane calcium pump in regulating the beta-adrenergic signal in the myocardium
    • Mohamed TM, et al. (2009) Specific role of neuronal nitric-oxide synthase when tethered to the plasma membrane calcium pump in regulating the beta-adrenergic signal in the myocardium. J Biol Chem 284:12091-12098.
    • (2009) J Biol Chem , vol.284 , pp. 12091-12098
    • Mohamed, T.M.1
  • 46
    • 77954187920 scopus 로고    scopus 로고
    • Membrane association facilitates degradation and cleavage of the cyclin-dependent kinase 5 activators p35 and p39
    • Minegishi S, et al. (2010) Membrane association facilitates degradation and cleavage of the cyclin-dependent kinase 5 activators p35 and p39. Biochemistry 49: 5482-5493.
    • (2010) Biochemistry , vol.49 , pp. 5482-5493
    • Minegishi, S.1
  • 47
    • 0030903814 scopus 로고    scopus 로고
    • Dendritic spine density and LTP induction in cultured hippocampal slices
    • Collin C, Miyaguchi K, Segal M (1997) Dendritic spine density and LTP induction in cultured hippocampal slices. J Neurophysiol 77:1614-1623. (Pubitemid 27137052)
    • (1997) Journal of Neurophysiology , vol.77 , Issue.3 , pp. 1614-1623
    • Collin, C.1    Miyaguchi, K.2    Segal, M.3
  • 48
    • 33845899093 scopus 로고    scopus 로고
    • Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism
    • Fu WY, et al. (2007) Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. Nat Neurosci 10:67-76.
    • (2007) Nat Neurosci , vol.10 , pp. 67-76
    • Fu, W.Y.1
  • 49
    • 0027757042 scopus 로고
    • Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5
    • DOI 10.1016/0014-5793(93)80849-P
    • Baumann K, Mandelkow EM, Biernat J, Piwnica-Worms H, Mandelkow E (1993) Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5. FEBS Lett 336:417-424. (Pubitemid 24036992)
    • (1993) FEBS Letters , vol.336 , Issue.3 , pp. 417-424
    • Baumann, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.