Cytokine induction of inducible nitric oxide synthase in an oligodendrocyte cell line: Role of p38 mitogen-activated protein kinase activation

Journal of Neurochemistry

Volumn 72, Issue 2, 1999, Pages 472-478

  Bhat, Narayan R ^a   Zhang, Peisheng ^a   Bhat, Aruna N ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Cytokines; Inducible nitric oxide synthase; Nitric oxide; Oligodendrocyte; p38 mitogen activated protein kinase

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CYTOKINE; GAMMA INTERFERON; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; RECOMBINANT INTERLEUKIN 1; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME INDUCTION; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; STEM CELL;

ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL LINE; CULTURE MEDIA; CYTOKINES; CYTOTOXINS; ENZYME ACTIVATION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; IMIDAZOLES; INTERFERON TYPE II; INTERLEUKIN-1; MITOGEN-ACTIVATED PROTEIN KINASES; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; OLIGODENDROGLIA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PYRIDINES; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032900218     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1999.0720472.x     Document Type: Article

References (40)

1. Andrews T., Zhang P., and Bhat N. R. (1998) TNFα potentiates IFNγ-induced cell death in oligodendrocyte progenitors. J. Neurosci. Res. (in press).
2. Bagasra O., Michaels F. H., Zheng Y. M., Borroski L. E., Spitsin S. V., Fu Z. F., Tawadros R., and Koprowski H. (1995) Activation of the inducible form of nitric oxide synthase in the brains of patients with multiple sclerosis. Proc. Natl. Acad. Sci. USA 92, 12041-12045.
3. Bhat N. R. and Zhang P. (1996) Activation of mitogen-activated protein kinases in oligodendrocytes. J. Neurochem. 66, 1986-1994.
4. Bhat N. R., Zhang P., Lee J. C., and Hogan E. L. (1998) Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulated inducible nitric oxide synthase and tumor necrosis factor-α gene expression in endotoxin-stimulated primary glial cultures. J. Neurosci. 18, 1633-1641.
5. Bolaños J. P., Almeida A., Stewart V., Peuchen S., Land J. M., Clark J. B., and Heales S. J. R. (1997) Nitric oxide-mediated mitochondrial damage in the brain: mechanisms and implications for neurodegenerative diseases. J. Neurochem. 68, 2227-2240.
6. Brosnan C. F., Lee S. C., and Liu J. (1998) Regulation of inducible nitric oxide synthase expression in human glia: implications for inflammatory central nervous system diseases. Biochem. Soc. Trans. 25, 679-683.
7. Chen C. Y. A. and Shyu A. B. (1995) AU-rich elements: characterization and importance in mRNA degradation. Trends Biochem. Sci. 20, 465-470.
8. Cohen P. (1997) The search for physiological substrates of MAP and SAP kinases in mammalian cells. Trends Cell Biol. 7, 353-361.
9. Coyle P. K. (1996) The neuroimmunology of multiple sclerosis. Adv. Neuroimmunol. 6, 143-154.
10. Da Silva J., Pierrat B., Mary J.-L., and Lesslauer W. (1997) Blockade of p38 mitogen-activated protein kinase pathway inhibits inducible nitric oxide synthase expression in mouse astrocytes. J. Biol. Chem. 272, 28373-28380.
11. Dawson V. L. and Dawson T. M. (1996) Nitric oxide in neuronal degeneration. Proc. Soc. Exp. Biol. Med. 211, 33-40.
12. Flynn A. and Proud C. G. (1996) The role of eIF4 in cell proliferation. Cancer Surv. 27, 293-310.
13. Fukunaga R. and Hunter T. (1997) MNKI, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. EMBO J. 16, 1921-1933.
14. Galea E., Reis D. J., and Feinstein D. L. (1994) Cloning and expression of inducible nitric oxide synthase from rat astrocytes. J. Neurosci. Res. 266, 3172-3177.
15. Kamijo R., Harada H., Matsuyama T., Bosland M., Gerecitano J., Shapiro D., Le J., Koh S. I., Kimura T., Green S. J., Mak T. W., Taniguchi T., and Vilcek J. (1994) Requirement for transcription factor IRF-1 in NO synthase induction in macrophages. Science 263, 1612-1615.
16. Kopnisky K. L., Sumners C., and Chandler L. J. (1997) Cytokine- and endotoxin-induced nitric oxide synthase in rat astroglial cultures: differential modulation by angiotensin II. J. Neurochem. 68, 935-944.
17. Koprowski H., Zheng Y. M., Heber-Katz E., Fraser N., Rorke L., Fu Z. F., Hanlon C., and Dietzchold B. (1993) In vivo expression of nitric oxide synthase in experimentally induced neurological diseases. Proc. Natl. Acad. Sci. USA 90, 3024-3027.
18. Kreutzberg G. W. (1996) Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 19, 312-318.
19. Larsen C. M., Wadt K. A. W., Juhl L. F., Andersen H. U., Karlesen A. E., Su M. S. S., Seedorf K., Shapiro L., Dinarello C. A., and Mandruppoulsen T. (1998) J. Biol. Chem. 273, 15294-15300.
20. Ledeen R. W. and Chakraborty G. (1998) Cytokines, signal transduction, and inflammatory demyelination: review and hypothesis. Neurochem. Res. 23, 277-289.
21. Lin T., Kong X., Haystead T. A. J., Pause A., Belsham G., Sonenberg N., and Lawrence J. C. (1994) PHAS-I as a link between mitogen-activated protein kinase and translation initiation. Science 260, 653-656.
22. Lowenstein C. J., Alley E. W., Rava I. P., Snowman A. M., Snyder S. H., Russell S. W., and Murphy W. J. (1993) Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon y and lipopolysaccharide. Proc. Natl. Acad. Sci. USA 90, 9730-9734.
23. Merrill J. E. and Benveniste E. N. (1996) Cytokines in inflammatory brain lesions: helpful and harmful. Trends Neurosci. 19, 331-338.
24. Merrill J. E. and Jonakait G. M. (1995) Interactions of the nervous system and immune system development, normal brain homeostasis and disease. FASEB J. 9, 611-618.
25. Merrill J. E., Murphy S. P., Mitrovic B., Mackenzie-Graham A., Dopp J. C., Ding M., Griscavage J., Ignarro L. J., and Lowenstein C. J. (1997) Inducible nitric oxide synthase and nitric oxide production by oligodendrocytes. J. Neurosci. Res. 48, 372-384.
26. Mitrovic B., Ignarro L. J., Vinters H. V., Akers M.-A., Schmid I., Uittenbogaart C., and Merrill J. E. (1995) Nitric oxide induces necrotic but not apoptotic cell death in oligodendrocytes. Neuroscience 65, 531-539.
27. Mohr S., McCormick T. S., and Lapetina E. G. (1998) Macrophages resistant to endogenously generated nitric oxide-mediated apoptosis are hypersensitive to exogenously added nitric oxide donors: dichotomous apoptotic response independent of caspase 3 and reversal by the mitogen-activated protein kinase kinase (MEK) inhibitor PD 098059. Proc. Natl. Acad. Sci. USA 95, 5045-5050.
28. Mosmann T. (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65, 55-63.
29. Mucke L. and Eddleston M. (1993) Astrocytes in infectious and immune-mediated diseases of the central nervous system. FASEB J. 7, 1226-1232.
30. Murphy S., Simmons L. A., Garcia A., Feinstein D. L., Galea E., Reis D. J., Minc-Golomb D., and Schwartz J. P. (1993) Synthesis of nitric oxide in glial cells. Trends Neurosci. 16, 323-328.
31. Navikas V. and Link H. (1996) Cytokines and the pathogenesis of multiple sclerosis. J. Neurosci. Res. 45, 322-333.
32. Park S. K. and Murphy S. (1996) Nitric oxide synthase type II mRNA stability is translation- and transcription-dependent. J. Neurochem. 67, 1766-1769.
33. Parkinson J. F., Mitrovic B., and Merrill J. E. (1997) The role of nitric oxide in multiple sclerosis. J. Mol. Med. 75, 174-186.
34. Pause A., Belsham G. J., Gingra A., Donze O., Lin T., Lawrence J. C., and Sonenberg N. (1994) Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function. Nature 371, 762-767.
35. Perry V. H., Andersson P. B., and Gordon S. (1993) Macrophages and inflammation in the central nervous system. Trends Neurosci. 16, 268-273.
36. Raine C. S. (1995) Multiple sclerosis: TNF revisited, with promise. Nat. Med. 1, 211-214.
37. Stuehr D. J. and Nathan C. F. (1989) Nitric oxide: a macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. J. Exp. Med. 169, 1543-1555.
38. Waskiewicz A. J., Flynn A., Proud C. G., and Cooper J. A. (1997) Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. EMBO J. 16, 1909-1920.
39. Xie Q. W., Wishnan R., and Nathan C. (1993) Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon-γ and bacterial lipopolysaccharide. J. Exp. Med. 177, 1779-1784.
40. Zhang P., Miller B. S., Rosenzweig S. A., and Bhat N. R. (1996) Activation of c-Jun N-terminal kinase/stress-activated protein kinase in primary glial cultures. J. Neurosci. Res. 46, 114-121.