Nitric oxide acutely inhibits neuronal energy production

Journal of Neuroscience

Volumn 19, Issue 1, 1999, Pages 147-158

  Brorson, James R ^a   Schumacker, Paul T ^a   Zhang, He ^a,b  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Glycolysis; Ischemia; Mitochondria; Nitric oxide; Peroxynitrite; Poly (ADP ribose) polymerase

Indexed keywords

3 NITROPROPIONIC ACID; ADENOSINE TRIPHOSPHATE; IODOACETIC ACID; NITRIC OXIDE; NITRIC OXIDE DONOR; PYRUVIC ACID; RHODAMINE 123; ROTENONE;

ANIMAL CELL; ARTICLE; BRAIN MITOCHONDRION; CONTROLLED STUDY; EMBRYO; GLYCOLYSIS; HIPPOCAMPUS; MITOCHONDRIAL RESPIRATION; NERVE CELL MEMBRANE STEADY POTENTIAL; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0032911944     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-01-00147.1999     Document Type: Article

References (38)

1. Akaike T, Yoshida M, Miyamoto Y, Sato K, Kohno M, Sasamoto K, Miyazaki K, Ueda S, Maesa H (1993) Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/NO through a radical reaction. Biochemistry 32:827-832.
2. Albin RL, Greenamyre JT (1992) Alternative excitotoxic hypotheses. Neurology 42:733-738.
3. Almeida A, Heales SJR, Bolarios JP, Medina JM (1998) Glutamate neurotoxicity is associated with nitric oxide-mediated mitochondrial dysfunction and glutathione depletion. Brain Res 790:209-216.
4. Beal MF (1995) Aging, energy, and oxidative stress in neurodegenerative diseases. Ann Neurol 38:357-366.
5. Beal MF, Ferrante RJ, Browne SE, Matthews RT, Kowall NW, Brown RH (1997) Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis. Ann Neurol 42:646-654.
6. Bindokas VP, Jordan J, Lee CC, Miller RJ (1996) Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine. J Neurosci 16:1324-1336.
7. Bolanos JP, Heales SJR, Land JM. Clark JB (1995) Effect of peroxynitrite on the mitochondrial respiratory chain: differential susceptibility of neurones and astrocytes in primary culture. J Neurochem 64:1965-1972.
8. Bolanos JP, Almeida A, Medina JM (1998) Nitric oxide mediates brain mitochondrial damage during perinatal anoxia. Brain Res 787:117-122.
9. Bonfoco E, Krainc D, Ankarcrona M, Nicotera P, Lipton SA (1995) Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/ superoxide in cortical cell cultures. Proc Natl Acad Sci USA 92:7162-7166.
10. i, homeostasis contributes to the toxicity of nitric oxide in cultured hippocampal neurons. J Neurochem 69:1882-1889.
11. 2+ homeostasis in hippocampal neurons. J Neurochem 68:95-105.
12. 2+ homeostasis. J Neurochem 66:403-411.
13. Butler AR, Flitney FW, Williams DLH (1995) NO, nitrosonium ions, nitroxide ions, nitrosothiols, and iron nitrosyls in biology: a chemist's perspective. Trends Pharmacol Sci 16:18-22.
14. Cassina A, Radi R (1996) Differential inhibitory action of nitric oxide and peroxynitrite on mitochondrial electron transport. Arch Biochem Biophys 328:309-316.
15. 2+ -dependent changes in the mitochondrial energetics in single dissociated mouse sensory neurons. Biochem J 283:41-50.
16. Erecinska M, Nelson D, Vanderkooi JM (1995) Effects of NO-generating compounds on synaptosomal energy metabolism. J Neurochem 65:2699-2705.
17. Goldberg MP, Choi DW (1993) Combined oxygen and glucose deprivation in cortical cell culture: calcium-dependent and calcium-independent mechanisms of neuronal injury. J Neurosci 13:3510-3524.
18. Goldberg MP, Weiss JW, Pham PC, Choi DW (1987) N-methyl-D-aspartate receptors mediate hypoxic neuronal injury in cortical cultures. J Pharmacol Exp Ther 243:784-791.
19. Good PF, Werner P, Hsu A, Olanow CW, Perl DP (1996) Evidence for neuronal oxidative damage in Alzheimer's disease. Am J Pathol 149:21-28.
20. Gross SS, Wolin MS (1995) Nitric oxide: pathophysiological mechanisms. Annu Rev Physiol 57:737-769.
21. Iadecola C (1997) Bright and dark sides of nitric oxide in ischemic brain injury. Trends Neurosci 20:132-139.
22. Kraig RP, Petito CK, Plum F, Pulsinelli WA (1987) Hydrogen ions kill brain at concentrations reached in ischemia. J Cereb Blood Flow Metab 7:379-386.
23. Lipton SA, Choi Y-B, Pan Z-H, Lei SZ, Chen H-SV, Sucher NJ, Loscalzo J, Singel DJ, Stamler JS (1993) A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature 364:626-632.
24. Lizasoain U, Moro MA, Knowles RG, Darley-Usmar V, Moncada S (1996) Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose. Biochem J 314:877-880.
25. Malinski T, Bailey F, Zhang ZG, Chopp M (1993a) Nitric oxide measured by a porphyrinic microsensor in rat brain after transient middle cerebral artery occlusion. J Cereb Blood Flow Metab 13:355-358.
26. Malinski T, Taha Z, Grunfeld S, Patton S, Kapturczak M, Tomboulian P (1993b) Diffusion of nitric oxide in the aorta wall monitored in situ by porphyrinic microsensors. Biochem Biophys Res Commun 193:1076-1082.
27. Molina y Vedia L, McDonald B, Reep B, Brune B, DiSilvio M, Billiar TR, Lapetina EG (1992) Nitric oxide-induced 5-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation. J Biol Chem 267:24929-24932.
28. Nguyen T, Brunson D, Crespi CL, Penman BW, Wishnok JS, Tannenbaum SR (1992) DNA damage and mutation in human cells exposed to nitric oxide in vitro. Proc Natl Acad Sci USA 89:3030-3034.
29. Pang Z, Geddes JW (1997) Mechanisms of cell death induced by the mitochondrial toxin 3-nitropropionic acid: acute excitotoxic necrosis and delayed apoptosis. J Neurosci 17:3064-3073.
30. Radi R, Rodriguez M, Castro L, Telleri R (1994) Inhibition of mitochondrial electron transport by peroxynitrite. Arch Biochem Biophys 308:89-95.
31. Sabri MI, Ochs S (1971) Inhibition of glyceraldehyde-3-phosphate dehydrogenase in mammalian nerve by iodoacetic acid. J Neurochem 18:1509-1514.
32. Siesjö BK (1978) Brain energy metabolism. New York: Wiley.
33. Siesjö BK, Wieloch T (1985) Cerebral metabolism in ischaemia: neurochemical basis for therapy. Br J Anaesth 57:47-62.
34. Stadler J, Billiar TR, Curran RD, Stuehr DJ, Ochoa JB, Simmons RL (1991) Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes. Am J Physiol 260:C910-C916.
35. Tombaugh GC, Sapolsky RM (1990) Mechanistic distinctions between excitotoxic and acidotic hippocampal damage in an in vitro model of ischemia. J Cereb Blood Flow Metab 10:527-535.
36. Tominaga T, Sato S, Ohnishi T, Ohnishi ST (1994) Electron paramagnetic resonance (EPR) detection of nitric oxide produced during fore-brain ischemia of the rat. J Cereb Blood Flow Metab 14:715-722.
37. Williams RJ, Maus M, Stella N, Glowinski J, Premont J (1996) Reduced glucose metabolism enhances the glutamate-evoked release of arachidonic acid from striatal neurons. Neuroscience 74:461-468.
38. Zhang J, Dawson VL, Dawson TM, Snyder SH (1994) Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity. Science 263:687-689.