메뉴 건너뛰기




Volumn 52, Issue 3, 2012, Pages 389-405

PI3K keeps the balance between metabolism and cancer

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84864554955     PISSN: 22124926     EISSN: None     Source Type: Book Series    
DOI: 10.1016/j.jbior.2012.04.002     Document Type: Review
Times cited : (43)

References (147)
  • 1
  • 3
    • 15644362968 scopus 로고    scopus 로고
    • Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity
    • Arcaro A., Volinia S., Zvelebil M.J., Stein R., Watton S.J., Layton M.J., et al. Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity. J Biol Chem 1998, 273:33082-33090.
    • (1998) J Biol Chem , vol.273 , pp. 33082-33090
    • Arcaro, A.1    Volinia, S.2    Zvelebil, M.J.3    Stein, R.4    Watton, S.J.5    Layton, M.J.6
  • 4
    • 31944444234 scopus 로고    scopus 로고
    • Cancer-specific mutations in PIK3CA are oncogenic in vivo
    • Bader A.G., Kang S., Vogt P.K. Cancer-specific mutations in PIK3CA are oncogenic in vivo. Proc Natl Acad Sci U S A 2006, 103:1475-1479.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 1475-1479
    • Bader, A.G.1    Kang, S.2    Vogt, P.K.3
  • 5
    • 68749119758 scopus 로고    scopus 로고
    • Epidermal growth factor stimulates translocation of the class II phosphoinositide 3-kinase PI3K-C2beta to the nucleus
    • Banfic H., Visnjic D., Mise N., Balakrishnan S., Deplano S., Korchev Y.E., et al. Epidermal growth factor stimulates translocation of the class II phosphoinositide 3-kinase PI3K-C2beta to the nucleus. Biochem J 2009, 422:53-60.
    • (2009) Biochem J , vol.422 , pp. 53-60
    • Banfic, H.1    Visnjic, D.2    Mise, N.3    Balakrishnan, S.4    Deplano, S.5    Korchev, Y.E.6
  • 6
    • 33644775504 scopus 로고    scopus 로고
    • Phosphatidylinositol 4-phosphatase type II is an erythropoietin-responsive gene
    • Barnache S., Le Scolan E., Kosmider O., Denis N., Moreau-Gachelin F. Phosphatidylinositol 4-phosphatase type II is an erythropoietin-responsive gene. Oncogene 2006, 25:1420-1423.
    • (2006) Oncogene , vol.25 , pp. 1420-1423
    • Barnache, S.1    Le Scolan, E.2    Kosmider, O.3    Denis, N.4    Moreau-Gachelin, F.5
  • 7
    • 0141839103 scopus 로고    scopus 로고
    • Novel concepts in insulin regulation of hepatic gluconeogenesis
    • Barthel A., Schmoll D. Novel concepts in insulin regulation of hepatic gluconeogenesis. Am J Physiol Endocrinol Metab 2003, 285:E685-E692.
    • (2003) Am J Physiol Endocrinol Metab , vol.285
    • Barthel, A.1    Schmoll, D.2
  • 8
    • 80054811005 scopus 로고    scopus 로고
    • PI3Kgamma within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance
    • Becattini B., Marone R., Zani F., Arsenijevic D., Seydoux J., Montani J.P., et al. PI3Kgamma within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance. Proc Natl Acad Sci U S A 2011, 108:E854-E863.
    • (2011) Proc Natl Acad Sci U S A , vol.108
    • Becattini, B.1    Marone, R.2    Zani, F.3    Arsenijevic, D.4    Seydoux, J.5    Montani, J.P.6
  • 9
    • 77953116995 scopus 로고    scopus 로고
    • Insulin - carcinogen or mitogen? Preclinical and clinical evidence from prostate, breast, pancreatic, and colorectal cancer research
    • Call R., Grimsley M., Cadwallader L., Cialone L., Hill M., Hreish V., et al. Insulin - carcinogen or mitogen? Preclinical and clinical evidence from prostate, breast, pancreatic, and colorectal cancer research. Postgrad Med 2010, 122:158-165.
    • (2010) Postgrad Med , vol.122 , pp. 158-165
    • Call, R.1    Grimsley, M.2    Cadwallader, L.3    Cialone, L.4    Hill, M.5    Hreish, V.6
  • 10
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley L.C. The phosphoinositide 3-kinase pathway. Science 2002, 296:1655-1657.
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 11
    • 84555191770 scopus 로고    scopus 로고
    • CAL-101: a phosphatidylinositol-3-kinase p110-delta inhibitor for the treatment of lymphoid malignancies
    • Castillo J.J., Furman M., Winer E.S. CAL-101: a phosphatidylinositol-3-kinase p110-delta inhibitor for the treatment of lymphoid malignancies. Expert Opin Investig Drugs 2012, 21:15-22.
    • (2012) Expert Opin Investig Drugs , vol.21 , pp. 15-22
    • Castillo, J.J.1    Furman, M.2    Winer, E.S.3
  • 12
    • 0032559272 scopus 로고    scopus 로고
    • Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study
    • Chan J.M., Stampfer M.J., Giovannucci E., Gann P.H., Ma J., Wilkinson P., et al. Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study. Science 1998, 279:563-566.
    • (1998) Science , vol.279 , pp. 563-566
    • Chan, J.M.1    Stampfer, M.J.2    Giovannucci, E.3    Gann, P.H.4    Ma, J.5    Wilkinson, P.6
  • 14
    • 55649084906 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development
    • Ciraolo E., Iezzi M., Marone R., Marengo S., Curcio C., Costa C., et al. Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development. Sci Signal 2008, 1:ra3.
    • (2008) Sci Signal , vol.1
    • Ciraolo, E.1    Iezzi, M.2    Marone, R.3    Marengo, S.4    Curcio, C.5    Costa, C.6
  • 16
    • 0036684497 scopus 로고    scopus 로고
    • Hepatocyte growth factor activates phosphoinositide 3-kinase C2 beta in renal brush-border plasma membranes
    • Crljen V., Volinia S., Banfic H. Hepatocyte growth factor activates phosphoinositide 3-kinase C2 beta in renal brush-border plasma membranes. Biochem J 2002, 365:791-799.
    • (2002) Biochem J , vol.365 , pp. 791-799
    • Crljen, V.1    Volinia, S.2    Banfic, H.3
  • 17
    • 68449094325 scopus 로고    scopus 로고
    • The influence of glucose-lowering therapies on cancer risk in type 2 diabetes
    • Currie C.J., Poole C.D., Gale E.A. The influence of glucose-lowering therapies on cancer risk in type 2 diabetes. Diabetologia 2009, 52:1766-1777.
    • (2009) Diabetologia , vol.52 , pp. 1766-1777
    • Currie, C.J.1    Poole, C.D.2    Gale, E.A.3
  • 19
    • 0029978202 scopus 로고    scopus 로고
    • The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase
    • Damen J.E., Liu L., Rosten P., Humphries R.K., Jefferson A.B., Majerus P.W., et al. The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase. Proc Natl Acad Sci U S A 1996, 93:1689-1693.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 1689-1693
    • Damen, J.E.1    Liu, L.2    Rosten, P.3    Humphries, R.K.4    Jefferson, A.B.5    Majerus, P.W.6
  • 20
    • 0035930577 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase C2alpha contains a nuclear localization sequence and associates with nuclear speckles
    • Didichenko S.A., Thelen M. Phosphatidylinositol 3-kinase C2alpha contains a nuclear localization sequence and associates with nuclear speckles. J Biol Chem 2001, 276:48135-48142.
    • (2001) J Biol Chem , vol.276 , pp. 48135-48142
    • Didichenko, S.A.1    Thelen, M.2
  • 21
    • 0034697119 scopus 로고    scopus 로고
    • The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles
    • Domin J., Gaidarov I., Smith M.E., Keen J.H., Waterfield M.D. The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles. J Biol Chem 2000, 275:11943-11950.
    • (2000) J Biol Chem , vol.275 , pp. 11943-11950
    • Domin, J.1    Gaidarov, I.2    Smith, M.E.3    Keen, J.H.4    Waterfield, M.D.5
  • 22
    • 0030884527 scopus 로고    scopus 로고
    • Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor Wortmannin
    • Domin J., Pages F., Volinia S., Rittenhouse S.E., Zvelebil M.J., Stein R.C., et al. Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor Wortmannin. Biochem J 1997, 326(Pt 1):139-147.
    • (1997) Biochem J , vol.326 , Issue.PART 1 , pp. 139-147
    • Domin, J.1    Pages, F.2    Volinia, S.3    Rittenhouse, S.E.4    Zvelebil, M.J.5    Stein, R.C.6
  • 23
    • 79952997159 scopus 로고    scopus 로고
    • Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells
    • Dominguez V., Raimondi C., Somanath S., Bugliani M., Loder M.K., Edling C.E., et al. Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells. J Biol Chem 2011, 286:4216-4225.
    • (2011) J Biol Chem , vol.286 , pp. 4216-4225
    • Dominguez, V.1    Raimondi, C.2    Somanath, S.3    Bugliani, M.4    Loder, M.K.5    Edling, C.E.6
  • 25
    • 42049089732 scopus 로고    scopus 로고
    • Down-regulation of class II phosphoinositide 3-kinase alpha expression below a critical threshold induces apoptotic cell death
    • Elis W., Triantafellow E., Wolters N.M., Sian K.R., Caponigro G., Borawski J., et al. Down-regulation of class II phosphoinositide 3-kinase alpha expression below a critical threshold induces apoptotic cell death. Mol Cancer Res 2008, 6:614-623.
    • (2008) Mol Cancer Res , vol.6 , pp. 614-623
    • Elis, W.1    Triantafellow, E.2    Wolters, N.M.3    Sian, K.R.4    Caponigro, G.5    Borawski, J.6
  • 26
    • 0042316755 scopus 로고    scopus 로고
    • PTEN: one gene, many syndromes
    • Eng C. PTEN: one gene, many syndromes. Hum Mutat 2003, 22:183-198.
    • (2003) Hum Mutat , vol.22 , pp. 183-198
    • Eng, C.1
  • 27
    • 34247141906 scopus 로고    scopus 로고
    • Role of class II phosphoinositide 3-kinase in cell signalling
    • Falasca M., Maffucci T. Role of class II phosphoinositide 3-kinase in cell signalling. Biochem Soc Trans 2007, 35:211-214.
    • (2007) Biochem Soc Trans , vol.35 , pp. 211-214
    • Falasca, M.1    Maffucci, T.2
  • 28
    • 72049110528 scopus 로고    scopus 로고
    • Rethinking phosphatidylinositol 3-monophosphate
    • Falasca M., Maffucci T. Rethinking phosphatidylinositol 3-monophosphate. Biochim Biophys Acta 2009, 1793:1795-1803.
    • (2009) Biochim Biophys Acta , vol.1793 , pp. 1795-1803
    • Falasca, M.1    Maffucci, T.2
  • 29
    • 27144450970 scopus 로고    scopus 로고
    • Insulin-sensitive protein kinases (atypical protein kinase C and protein kinase B/Akt): actions and defects in obesity and type II diabetes
    • Farese R.V., Sajan M.P., Standaert M.L. Insulin-sensitive protein kinases (atypical protein kinase C and protein kinase B/Akt): actions and defects in obesity and type II diabetes. Exp Biol Med (Maywood) 2005, 230:593-605.
    • (2005) Exp Biol Med (Maywood) , vol.230 , pp. 593-605
    • Farese, R.V.1    Sajan, M.P.2    Standaert, M.L.3
  • 30
    • 34547663520 scopus 로고    scopus 로고
    • Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes
    • Farese R.V., Sajan M.P., Yang H., Li P., Mastorides S., Gower W.R., et al. Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes. J Clin Invest 2007, 117:2289-2301.
    • (2007) J Clin Invest , vol.117 , pp. 2289-2301
    • Farese, R.V.1    Sajan, M.P.2    Yang, H.3    Li, P.4    Mastorides, S.5    Gower, W.R.6
  • 31
    • 78650675585 scopus 로고    scopus 로고
    • Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers
    • Fedele C.G., Ooms L.M., Ho M., Vieusseux J., O'Toole S.A., Millar E.K., et al. Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers. Proc Natl Acad Sci U S A 2010, 107:22231-22236.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 22231-22236
    • Fedele, C.G.1    Ooms, L.M.2    Ho, M.3    Vieusseux, J.4    O'Toole, S.A.5    Millar, E.K.6
  • 33
    • 52449106253 scopus 로고    scopus 로고
    • The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-t hieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer
    • Folkes A.J., Ahmadi K., Alderton W.K., Alix S., Baker S.J., Box G., et al. The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-t hieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer. J Med Chem 2008, 51:5522-5532.
    • (2008) J Med Chem , vol.51 , pp. 5522-5532
    • Folkes, A.J.1    Ahmadi, K.2    Alderton, W.K.3    Alix, S.4    Baker, S.J.5    Box, G.6
  • 34
    • 84863726264 scopus 로고    scopus 로고
    • P37delta is a new isoform of PI3K p110delta that increases cell proliferation and is overexpressed in tumors
    • Fransson S., Uv A., Eriksson H., Andersson M.K., Wettergren Y., Bergo M., et al. p37delta is a new isoform of PI3K p110delta that increases cell proliferation and is overexpressed in tumors. Oncogene 2011.
    • (2011) Oncogene
    • Fransson, S.1    Uv, A.2    Eriksson, H.3    Andersson, M.K.4    Wettergren, Y.5    Bergo, M.6
  • 35
    • 21344475048 scopus 로고    scopus 로고
    • Impact of the liver-specific expression of SHIP2 (SH2-containing inositol 5'-phosphatase 2) on insulin signaling and glucose metabolism in mice
    • Fukui K., Wada T., Kagawa S., Nagira K., Ikubo M., Ishihara H., et al. Impact of the liver-specific expression of SHIP2 (SH2-containing inositol 5'-phosphatase 2) on insulin signaling and glucose metabolism in mice. Diabetes 2005, 54:1958-1967.
    • (2005) Diabetes , vol.54 , pp. 1958-1967
    • Fukui, K.1    Wada, T.2    Kagawa, S.3    Nagira, K.4    Ikubo, M.5    Ishihara, H.6
  • 36
    • 84863721726 scopus 로고    scopus 로고
    • Inhibiting PI3K reduces mammary tumor growth and induces hyperglycemia in a mouse model of insulin resistance and hyperinsulinemia
    • Gallagher E.J., Fierz Y., Vijayakumar A., Haddad N., Yakar S., Leroith D. Inhibiting PI3K reduces mammary tumor growth and induces hyperglycemia in a mouse model of insulin resistance and hyperinsulinemia. Oncogene 2011.
    • (2011) Oncogene
    • Gallagher, E.J.1    Fierz, Y.2    Vijayakumar, A.3    Haddad, N.4    Yakar, S.5    Leroith, D.6
  • 38
    • 39149123820 scopus 로고    scopus 로고
    • A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity
    • Garlich J.R., De P., Dey N., Su J.D., Peng X., Miller A., et al. A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity. Cancer Res 2008, 68:206-215.
    • (2008) Cancer Res , vol.68 , pp. 206-215
    • Garlich, J.R.1    De, P.2    Dey, N.3    Su, J.D.4    Peng, X.5    Miller, A.6
  • 39
    • 67651148274 scopus 로고    scopus 로고
    • Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling
    • Gewinner C., Wang Z.C., Richardson A., Teruya-Feldstein J., Etemadmoghadam D., Bowtell D., et al. Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling. Cancer Cell 2009, 16:115-125.
    • (2009) Cancer Cell , vol.16 , pp. 115-125
    • Gewinner, C.1    Wang, Z.C.2    Richardson, A.3    Teruya-Feldstein, J.4    Etemadmoghadam, D.5    Bowtell, D.6
  • 40
    • 77949873730 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase gamma inhibition ameliorates inflammation and tumor growth in a model of colitis-associated cancer
    • Gonzalez-Garcia A., Sanchez-Ruiz J., Flores J.M., Carrera A.C. Phosphatidylinositol 3-kinase gamma inhibition ameliorates inflammation and tumor growth in a model of colitis-associated cancer. Gastroenterology 2010, 138:1374-1383.
    • (2010) Gastroenterology , vol.138 , pp. 1374-1383
    • Gonzalez-Garcia, A.1    Sanchez-Ruiz, J.2    Flores, J.M.3    Carrera, A.C.4
  • 41
    • 79960684273 scopus 로고    scopus 로고
    • A sensitized RNA interference screen identifies a novel role for the PI3K p110gamma isoform in medulloblastoma cell proliferation and chemoresistance
    • Guerreiro A.S., Fattet S., Kulesza D.W., Atamer A., Elsing A.N., Shalaby T., et al. A sensitized RNA interference screen identifies a novel role for the PI3K p110gamma isoform in medulloblastoma cell proliferation and chemoresistance. Mol Cancer Res 2011, 9:925-935.
    • (2011) Mol Cancer Res , vol.9 , pp. 925-935
    • Guerreiro, A.S.1    Fattet, S.2    Kulesza, D.W.3    Atamer, A.4    Elsing, A.N.5    Shalaby, T.6
  • 42
    • 46149106818 scopus 로고    scopus 로고
    • The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma
    • Guillermet-Guibert J., Bjorklof K., Salpekar A., Gonella C., Ramadani F., Bilancio A., et al. The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma. Proc Natl Acad Sci U S A 2008, 105:8292-8297.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 8292-8297
    • Guillermet-Guibert, J.1    Bjorklof, K.2    Salpekar, A.3    Gonella, C.4    Ramadani, F.5    Bilancio, A.6
  • 43
    • 0030777104 scopus 로고    scopus 로고
    • Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma
    • Guldberg P., thor Straten P., Birck A., Ahrenkiel V., Kirkin A.F., Zeuthen J. Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma. Cancer Res 1997, 57:3660-3663.
    • (1997) Cancer Res , vol.57 , pp. 3660-3663
    • Guldberg, P.1    thor Straten, P.2    Birck, A.3    Ahrenkiel, V.4    Kirkin, A.F.5    Zeuthen, J.6
  • 44
    • 70149087158 scopus 로고    scopus 로고
    • High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia
    • Gutierrez A., Sanda T., Grebliunaite R., Carracedo A., Salmena L., Ahn Y., et al. High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia. Blood 2009, 114:647-650.
    • (2009) Blood , vol.114 , pp. 647-650
    • Gutierrez, A.1    Sanda, T.2    Grebliunaite, R.3    Carracedo, A.4    Salmena, L.5    Ahn, Y.6
  • 45
    • 0034131260 scopus 로고    scopus 로고
    • Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay
    • Han S.Y., Kato H., Kato S., Suzuki T., Shibata H., Ishii S., et al. Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay. Cancer Res 2000, 60:3147-3151.
    • (2000) Cancer Res , vol.60 , pp. 3147-3151
    • Han, S.Y.1    Kato, H.2    Kato, S.3    Suzuki, T.4    Shibata, H.5    Ishii, S.6
  • 46
    • 41149156431 scopus 로고    scopus 로고
    • Genome-wide DNA copy number analysis in pancreatic cancer using high-density single nucleotide polymorphism arrays
    • Harada T., Chelala C., Bhakta V., Chaplin T., Caulee K., Baril P., et al. Genome-wide DNA copy number analysis in pancreatic cancer using high-density single nucleotide polymorphism arrays. Oncogene 2008, 27:1951-1960.
    • (2008) Oncogene , vol.27 , pp. 1951-1960
    • Harada, T.1    Chelala, C.2    Bhakta, V.3    Chaplin, T.4    Caulee, K.5    Baril, P.6
  • 47
    • 78649707989 scopus 로고    scopus 로고
    • Frequent gastrointestinal polyps and colorectal adenocarcinomas in a prospective series of PTEN mutation carriers
    • Heald B., Mester J., Rybicki L., Orloff M.S., Burke C.A., Eng C. Frequent gastrointestinal polyps and colorectal adenocarcinomas in a prospective series of PTEN mutation carriers. Gastroenterology 2010, 139:1927-1933.
    • (2010) Gastroenterology , vol.139 , pp. 1927-1933
    • Heald, B.1    Mester, J.2    Rybicki, L.3    Orloff, M.S.4    Burke, C.A.5    Eng, C.6
  • 49
    • 34547895443 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinases as a common platform for multi-hormone signaling
    • Hirsch E., Costa C., Ciraolo E. Phosphoinositide 3-kinases as a common platform for multi-hormone signaling. J Endocrinol 2007, 194:243-256.
    • (2007) J Endocrinol , vol.194 , pp. 243-256
    • Hirsch, E.1    Costa, C.2    Ciraolo, E.3
  • 50
    • 0031560922 scopus 로고    scopus 로고
    • Identification of four novel human phosphoinositide 3-kinases defines a multi-isoform subfamily
    • Ho L.K., Liu D., Rozycka M., Brown R.A., Fry M.J. Identification of four novel human phosphoinositide 3-kinases defines a multi-isoform subfamily. Biochem Biophys Res Commun 1997, 235:130-137.
    • (1997) Biochem Biophys Res Commun , vol.235 , pp. 130-137
    • Ho, L.K.1    Liu, D.2    Rozycka, M.3    Brown, R.A.4    Fry, M.J.5
  • 51
    • 80053345977 scopus 로고    scopus 로고
    • The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia
    • Hoellenriegel J., Meadows S.A., Sivina M., Wierda W.G., Kantarjian H., Keating M.J., et al. The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia. Blood 2011, 118:3603-3612.
    • (2011) Blood , vol.118 , pp. 3603-3612
    • Hoellenriegel, J.1    Meadows, S.A.2    Sivina, M.3    Wierda, W.G.4    Kantarjian, H.5    Keating, M.J.6
  • 52
    • 66149173789 scopus 로고    scopus 로고
    • The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo
    • Huse J.T., Brennan C., Hambardzumyan D., Wee B., Pena J., Rouhanifard S.H., et al. The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo. Genes Dev 2009, 23:1327-1337.
    • (2009) Genes Dev , vol.23 , pp. 1327-1337
    • Huse, J.T.1    Brennan, C.2    Hambardzumyan, D.3    Wee, B.4    Pena, J.5    Rouhanifard, S.H.6
  • 53
    • 4444223702 scopus 로고    scopus 로고
    • Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling
    • Ihle N.T., Williams R., Chow S., Chew W., Berggren M.I., Paine-Murrieta G., et al. Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling. Mol Cancer Ther 2004, 3:763-772.
    • (2004) Mol Cancer Ther , vol.3 , pp. 763-772
    • Ihle, N.T.1    Williams, R.2    Chow, S.3    Chew, W.4    Berggren, M.I.5    Paine-Murrieta, G.6
  • 54
    • 20944450964 scopus 로고    scopus 로고
    • The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane
    • Ivetac I., Munday A.D., Kisseleva M.V., Zhang X.M., Luff S., Tiganis T., et al. The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane. Mol Biol Cell 2005, 16:2218-2233.
    • (2005) Mol Biol Cell , vol.16 , pp. 2218-2233
    • Ivetac, I.1    Munday, A.D.2    Kisseleva, M.V.3    Zhang, X.M.4    Luff, S.5    Tiganis, T.6
  • 55
    • 49649087385 scopus 로고    scopus 로고
    • Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis
    • Jia S., Liu Z., Zhang S., Liu P., Zhang L., Lee S.H., et al. Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis. Nature 2008, 454:776-779.
    • (2008) Nature , vol.454 , pp. 776-779
    • Jia, S.1    Liu, Z.2    Zhang, S.3    Liu, P.4    Zhang, L.5    Lee, S.H.6
  • 56
    • 44149127993 scopus 로고    scopus 로고
    • The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila
    • Juhasz G., Hill J.H., Yan Y., Sass M., Baehrecke E.H., Backer J.M., et al. The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila. J Cell Biol 2008, 181:655-666.
    • (2008) J Cell Biol , vol.181 , pp. 655-666
    • Juhasz, G.1    Hill, J.H.2    Yan, Y.3    Sass, M.4    Baehrecke, E.H.5    Backer, J.M.6
  • 57
    • 64749108996 scopus 로고    scopus 로고
    • Tumours with PI3K activation are resistant to dietary restriction
    • Kalaany N.Y., Sabatini D.M. Tumours with PI3K activation are resistant to dietary restriction. Nature 2009, 458:725-731.
    • (2009) Nature , vol.458 , pp. 725-731
    • Kalaany, N.Y.1    Sabatini, D.M.2
  • 58
    • 31944448780 scopus 로고    scopus 로고
    • Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase
    • Kang S., Denley A., Vanhaesebroeck B., Vogt P.K. Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase. Proc Natl Acad Sci U S A 2006, 103:1289-1294.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 1289-1294
    • Kang, S.1    Denley, A.2    Vanhaesebroeck, B.3    Vogt, P.K.4
  • 59
    • 33646383684 scopus 로고    scopus 로고
    • A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling
    • Knight Z.A., Gonzalez B., Feldman M.E., Zunder E.R., Goldenberg D.D., Williams O., et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell 2006, 125:733-747.
    • (2006) Cell , vol.125 , pp. 733-747
    • Knight, Z.A.1    Gonzalez, B.2    Feldman, M.E.3    Zunder, E.R.4    Goldenberg, D.D.5    Williams, O.6
  • 60
    • 79955012753 scopus 로고    scopus 로고
    • Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance
    • Kobayashi N., Ueki K., Okazaki Y., Iwane A., Kubota N., Ohsugi M., et al. Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance. Proc Natl Acad Sci U S A 2011, 108:5753-5758.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 5753-5758
    • Kobayashi, N.1    Ueki, K.2    Okazaki, Y.3    Iwane, A.4    Kubota, N.5    Ohsugi, M.6
  • 61
    • 77956356660 scopus 로고    scopus 로고
    • ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor identified using the JFCR39 drug discovery system
    • Kong D.X., Yamori T. ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor identified using the JFCR39 drug discovery system. Acta Pharmacol Sin 2010, 31:1189-1197.
    • (2010) Acta Pharmacol Sin , vol.31 , pp. 1189-1197
    • Kong, D.X.1    Yamori, T.2
  • 62
    • 78649338141 scopus 로고    scopus 로고
    • Autophagy and the integrated stress response
    • Kroemer G., Marino G., Levine B. Autophagy and the integrated stress response. Mol Cell 2010, 40:280-293.
    • (2010) Mol Cell , vol.40 , pp. 280-293
    • Kroemer, G.1    Marino, G.2    Levine, B.3
  • 63
    • 9344259718 scopus 로고    scopus 로고
    • Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors
    • Kwon J., Lee S.R., Yang K.S., Ahn Y., Kim Y.J., Stadtman E.R., et al. Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors. Proc Natl Acad Sci U S A 2004, 101:16419-16424.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 16419-16424
    • Kwon, J.1    Lee, S.R.2    Yang, K.S.3    Ahn, Y.4    Kim, Y.J.5    Stadtman, E.R.6
  • 65
    • 0033615538 scopus 로고    scopus 로고
    • Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association
    • Lee J.O., Yang H., Georgescu M.M., Di Cristofano A., Maehama T., Shi Y., et al. Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell 1999, 99:323-334.
    • (1999) Cell , vol.99 , pp. 323-334
    • Lee, J.O.1    Yang, H.2    Georgescu, M.M.3    Di Cristofano, A.4    Maehama, T.5    Shi, Y.6
  • 66
    • 20044388328 scopus 로고    scopus 로고
    • PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas
    • Lee J.W., Soung Y.H., Kim S.Y., Lee H.W., Park W.S., Nam S.W., et al. PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas. Oncogene 2005, 24:1477-1480.
    • (2005) Oncogene , vol.24 , pp. 1477-1480
    • Lee, J.W.1    Soung, Y.H.2    Kim, S.Y.3    Lee, H.W.4    Park, W.S.5    Nam, S.W.6
  • 67
    • 0030936323 scopus 로고    scopus 로고
    • PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
    • Li J., Yen C., Liaw D., Podsypanina K., Bose S., Wang S.I., et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997, 275:1943-1947.
    • (1997) Science , vol.275 , pp. 1943-1947
    • Li, J.1    Yen, C.2    Liaw, D.3    Podsypanina, K.4    Bose, S.5    Wang, S.I.6
  • 68
    • 0037192852 scopus 로고    scopus 로고
    • AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival
    • Li Y., Dowbenko D., Lasky L.A. AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival. J Biol Chem 2002, 277:11352-11361.
    • (2002) J Biol Chem , vol.277 , pp. 11352-11361
    • Li, Y.1    Dowbenko, D.2    Lasky, L.A.3
  • 69
    • 0031004088 scopus 로고    scopus 로고
    • Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
    • Liaw D., Marsh D.J., Li J., Dahia P.L., Wang S.I., Zheng Z., et al. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat Genet 1997, 16:64-67.
    • (1997) Nat Genet , vol.16 , pp. 64-67
    • Liaw, D.1    Marsh, D.J.2    Li, J.3    Dahia, P.L.4    Wang, S.I.5    Zheng, Z.6
  • 70
    • 65549088020 scopus 로고    scopus 로고
    • Frequent mutations and amplifications of the PIK3CA gene in pituitary tumors
    • Lin Y., Jiang X., Shen Y., Li M., Ma H., Xing M., et al. Frequent mutations and amplifications of the PIK3CA gene in pituitary tumors. Endocr Relat Cancer 2009, 16:301-310.
    • (2009) Endocr Relat Cancer , vol.16 , pp. 301-310
    • Lin, Y.1    Jiang, X.2    Shen, Y.3    Li, M.4    Ma, H.5    Xing, M.6
  • 71
    • 68249093818 scopus 로고    scopus 로고
    • Targeting the phosphoinositide 3-kinase pathway in cancer
    • Liu P., Cheng H., Roberts T.M., Zhao J.J. Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov 2009, 8:627-644.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 627-644
    • Liu, P.1    Cheng, H.2    Roberts, T.M.3    Zhao, J.J.4
  • 72
    • 0033119739 scopus 로고    scopus 로고
    • SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival
    • Liu Q., Sasaki T., Kozieradzki I., Wakeham A., Itie A., Dumont D.J., et al. SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival. Genes Dev 1999, 13:786-791.
    • (1999) Genes Dev , vol.13 , pp. 786-791
    • Liu, Q.1    Sasaki, T.2    Kozieradzki, I.3    Wakeham, A.4    Itie, A.5    Dumont, D.J.6
  • 73
    • 68649105674 scopus 로고    scopus 로고
    • Inactivation of SHIP1 in T-cell acute lymphoblastic leukemia due to mutation and extensive alternative splicing
    • Lo T.C., Barnhill L.M., Kim Y., Nakae E.A., Yu A.L., Diccianni M.B. Inactivation of SHIP1 in T-cell acute lymphoblastic leukemia due to mutation and extensive alternative splicing. Leuk Res 2009, 33:1562-1566.
    • (2009) Leuk Res , vol.33 , pp. 1562-1566
    • Lo, T.C.1    Barnhill, L.M.2    Kim, Y.3    Nakae, E.A.4    Yu, A.L.5    Diccianni, M.B.6
  • 75
    • 83255193930 scopus 로고    scopus 로고
    • The catalytic phosphoinositol 3-kinase isoform p110delta is required for glioma cell migration and invasion
    • Luk S.K., Piekorz R.P., Nurnberg B., Tony To S.S. The catalytic phosphoinositol 3-kinase isoform p110delta is required for glioma cell migration and invasion. Eur J Cancer 2012, 48:149-157.
    • (2012) Eur J Cancer , vol.48 , pp. 149-157
    • Luk, S.K.1    Piekorz, R.P.2    Nurnberg, B.3    Tony To, S.S.4
  • 76
    • 0037269497 scopus 로고    scopus 로고
    • Possible dominant-negative mutation of the SHIP gene in acute myeloid leukemia
    • Luo J.M., Yoshida H., Komura S., Ohishi N., Pan L., Shigeno K., et al. Possible dominant-negative mutation of the SHIP gene in acute myeloid leukemia. Leukemia 2003, 17:1-8.
    • (2003) Leukemia , vol.17 , pp. 1-8
    • Luo, J.M.1    Yoshida, H.2    Komura, S.3    Ohishi, N.4    Pan, L.5    Shigeno, K.6
  • 77
    • 39149097499 scopus 로고    scopus 로고
    • PI(3,4,5)P3 and PI(3,4)P2 levels correlate with PKB/Akt phosphorylation at Thr308 and Ser473, respectively; PI(3,4)P2 levels determine PKB activity
    • Ma K., Cheung S.M., Marshall A.J., Duronio V. PI(3,4,5)P3 and PI(3,4)P2 levels correlate with PKB/Akt phosphorylation at Thr308 and Ser473, respectively; PI(3,4)P2 levels determine PKB activity. Cell Signal 2008, 20:684-694.
    • (2008) Cell Signal , vol.20 , pp. 684-694
    • Ma, K.1    Cheung, S.M.2    Marshall, A.J.3    Duronio, V.4
  • 79
    • 51049109033 scopus 로고    scopus 로고
    • Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
    • Maira S.M., Stauffer F., Brueggen J., Furet P., Schnell C., Fritsch C., et al. Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol Cancer Ther 2008, 7:1851-1863.
    • (2008) Mol Cancer Ther , vol.7 , pp. 1851-1863
    • Maira, S.M.1    Stauffer, F.2    Brueggen, J.3    Furet, P.4    Schnell, C.5    Fritsch, C.6
  • 80
    • 77950944395 scopus 로고    scopus 로고
    • Macrophages, innate immunity and cancer: balance, tolerance, and diversity
    • Mantovani A., Sica A. Macrophages, innate immunity and cancer: balance, tolerance, and diversity. Curr Opin Immunol 2010, 22:231-237.
    • (2010) Curr Opin Immunol , vol.22 , pp. 231-237
    • Mantovani, A.1    Sica, A.2
  • 81
    • 77953849832 scopus 로고    scopus 로고
    • Ammonia: a diffusible factor released by proliferating cells that induces autophagy
    • Marino G., Kroemer G. Ammonia: a diffusible factor released by proliferating cells that induces autophagy. Sci Signal 2010, 3:pe19.
    • (2010) Sci Signal , vol.3
    • Marino, G.1    Kroemer, G.2
  • 82
    • 79958742163 scopus 로고    scopus 로고
    • PI3Kgamma mediates Kaposi's sarcoma-associated herpesvirus vGPCR-induced sarcomagenesis
    • Martin D., Galisteo R., Molinolo A.A., Wetzker R., Hirsch E., Gutkind J.S. PI3Kgamma mediates Kaposi's sarcoma-associated herpesvirus vGPCR-induced sarcomagenesis. Cancer Cell 2011, 19:805-813.
    • (2011) Cancer Cell , vol.19 , pp. 805-813
    • Martin, D.1    Galisteo, R.2    Molinolo, A.A.3    Wetzker, R.4    Hirsch, E.5    Gutkind, J.S.6
  • 83
    • 0142217895 scopus 로고    scopus 로고
    • PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity
    • Matsumoto M., Ogawa W., Akimoto K., Inoue H., Miyake K., Furukawa K., et al. PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity. J Clin Invest 2003, 112:935-944.
    • (2003) J Clin Invest , vol.112 , pp. 935-944
    • Matsumoto, M.1    Ogawa, W.2    Akimoto, K.3    Inoue, H.4    Miyake, K.5    Furukawa, K.6
  • 84
    • 0035949588 scopus 로고    scopus 로고
    • A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
    • Mayo L.D., Donner D.B. A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus. Proc Natl Acad Sci U S A 2001, 98:11598-11603.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 11598-11603
    • Mayo, L.D.1    Donner, D.B.2
  • 85
    • 79958047958 scopus 로고    scopus 로고
    • Class II phosphoinositide 3-kinase C2alpha: what we learned so far
    • Mazza S., Maffucci T. Class II phosphoinositide 3-kinase C2alpha: what we learned so far. Int J Biochem Mol Biol 2011, 2:168-182.
    • (2011) Int J Biochem Mol Biol , vol.2 , pp. 168-182
    • Mazza, S.1    Maffucci, T.2
  • 86
    • 0034643331 scopus 로고    scopus 로고
    • AFX-like forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
    • Medema R.H., Kops G.J., Bos J.L., Burgering B.M. AFX-like forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 2000, 404:782-787.
    • (2000) Nature , vol.404 , pp. 782-787
    • Medema, R.H.1    Kops, G.J.2    Bos, J.L.3    Burgering, B.M.4
  • 87
    • 0026710682 scopus 로고
    • Insulin receptor expression and function in human breast cancer cell lines
    • Milazzo G., Giorgino F., Damante G., Sung C., Stampfer M.R., Vigneri R., et al. Insulin receptor expression and function in human breast cancer cell lines. Cancer Res 1992, 52:3924-3930.
    • (1992) Cancer Res , vol.52 , pp. 3924-3930
    • Milazzo, G.1    Giorgino, F.2    Damante, G.3    Sung, C.4    Stampfer, M.R.5    Vigneri, R.6
  • 89
    • 24944536147 scopus 로고    scopus 로고
    • Comparison of phosphatidylinositol-3-kinase signalling within a panel of human colorectal cancer cell lines with mutant or wild-type PIK3CA
    • Morrow C.J., Gray A., Dive C. Comparison of phosphatidylinositol-3-kinase signalling within a panel of human colorectal cancer cell lines with mutant or wild-type PIK3CA. FEBS Lett 2005, 579:5123-5128.
    • (2005) FEBS Lett , vol.579 , pp. 5123-5128
    • Morrow, C.J.1    Gray, A.2    Dive, C.3
  • 90
    • 0033616619 scopus 로고    scopus 로고
    • The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol
    • Munday A.D., Norris F.A., Caldwell K.K., Brown S., Majerus P.W., Mitchell C.A. The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol. Proc Natl Acad Sci U S A 1999, 96:3640-3645.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 3640-3645
    • Munday, A.D.1    Norris, F.A.2    Caldwell, K.K.3    Brown, S.4    Majerus, P.W.5    Mitchell, C.A.6
  • 91
    • 0036161583 scopus 로고    scopus 로고
    • Electrostatic control of the membrane targeting of C2 domains
    • Murray D., Honig B. Electrostatic control of the membrane targeting of C2 domains. Mol Cell 2002, 9:145-154.
    • (2002) Mol Cell , vol.9 , pp. 145-154
    • Murray, D.1    Honig, B.2
  • 92
    • 34447650761 scopus 로고    scopus 로고
    • High resolution genomic analysis of sporadic breast cancer using array-based comparative genomic hybridization
    • Naylor T.L., Greshock J., Wang Y., Colligon T., Yu Q.C., Clemmer V., et al. High resolution genomic analysis of sporadic breast cancer using array-based comparative genomic hybridization. Breast Cancer Res 2005, 7:R1186-R1198.
    • (2005) Breast Cancer Res , vol.7
    • Naylor, T.L.1    Greshock, J.2    Wang, Y.3    Colligon, T.4    Yu, Q.C.5    Clemmer, V.6
  • 93
    • 0028289708 scopus 로고
    • Hydrolysis of phosphatidylinositol 3,4-bisphosphate by inositol polyphosphate 4-phosphatase isolated by affinity elution chromatography
    • Norris F.A., Majerus P.W. Hydrolysis of phosphatidylinositol 3,4-bisphosphate by inositol polyphosphate 4-phosphatase isolated by affinity elution chromatography. J Biol Chem 1994, 269:8716-8720.
    • (1994) J Biol Chem , vol.269 , pp. 8716-8720
    • Norris, F.A.1    Majerus, P.W.2
  • 94
    • 0035950222 scopus 로고    scopus 로고
    • A null mutation in inositol polyphosphate 4-phosphatase type I causes selective neuronal loss in weeble mutant mice
    • Nystuen A., Legare M.E., Shultz L.D., Frankel W.N. A null mutation in inositol polyphosphate 4-phosphatase type I causes selective neuronal loss in weeble mutant mice. Neuron 2001, 32:203-212.
    • (2001) Neuron , vol.32 , pp. 203-212
    • Nystuen, A.1    Legare, M.E.2    Shultz, L.D.3    Frankel, W.N.4
  • 95
    • 0034194152 scopus 로고    scopus 로고
    • Phosphoinositide signaling and the regulation of membrane trafficking in yeast
    • Odorizzi G., Babst M., Emr S.D. Phosphoinositide signaling and the regulation of membrane trafficking in yeast. Trends Biochem Sci 2000, 25:229-235.
    • (2000) Trends Biochem Sci , vol.25 , pp. 229-235
    • Odorizzi, G.1    Babst, M.2    Emr, S.D.3
  • 96
    • 0742269398 scopus 로고    scopus 로고
    • Inhibition of the PI3K-Akt signaling pathway enhances the sensitivity of Fas-mediated apoptosis in human gastric carcinoma cell line, MKN-45
    • Osaki M., Kase S., Adachi K., Takeda A., Hashimoto K., Ito H. Inhibition of the PI3K-Akt signaling pathway enhances the sensitivity of Fas-mediated apoptosis in human gastric carcinoma cell line, MKN-45. J Cancer Res Clin Oncol 2004, 130:8-14.
    • (2004) J Cancer Res Clin Oncol , vol.130 , pp. 8-14
    • Osaki, M.1    Kase, S.2    Adachi, K.3    Takeda, A.4    Hashimoto, K.5    Ito, H.6
  • 97
    • 0032800850 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: evidence for a second mechanism of IGF-I signaling
    • Pandini G., Vigneri R., Costantino A., Frasca F., Ippolito A., Fujita-Yamaguchi Y., et al. Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: evidence for a second mechanism of IGF-I signaling. Clin Cancer Res 1999, 5:1935-1944.
    • (1999) Clin Cancer Res , vol.5 , pp. 1935-1944
    • Pandini, G.1    Vigneri, R.2    Costantino, A.3    Frasca, F.4    Ippolito, A.5    Fujita-Yamaguchi, Y.6
  • 99
    • 13244265590 scopus 로고    scopus 로고
    • Frequent genetic and biochemical alterations of the PI3-K/AKT/PTEN pathway in head and neck squamous cell carcinoma
    • Pedrero J.M., Carracedo D.G., Pinto C.M., Zapatero A.H., Rodrigo J.P., Nieto C.S., et al. Frequent genetic and biochemical alterations of the PI3-K/AKT/PTEN pathway in head and neck squamous cell carcinoma. Int J Cancer 2005, 114:242-248.
    • (2005) Int J Cancer , vol.114 , pp. 242-248
    • Pedrero, J.M.1    Carracedo, D.G.2    Pinto, C.M.3    Zapatero, A.H.4    Rodrigo, J.P.5    Nieto, C.S.6
  • 100
    • 57449108541 scopus 로고    scopus 로고
    • High expression of obesity-linked phosphatase SHIP2 in invasive breast cancer correlates with reduced disease-free survival
    • Prasad N.K., Tandon M., Handa A., Moore G.E., Babbs C.F., Snyder P.W., et al. High expression of obesity-linked phosphatase SHIP2 in invasive breast cancer correlates with reduced disease-free survival. Tumour Biol 2008, 29:330-341.
    • (2008) Tumour Biol , vol.29 , pp. 330-341
    • Prasad, N.K.1    Tandon, M.2    Handa, A.3    Moore, G.E.4    Babbs, C.F.5    Snyder, P.W.6
  • 101
    • 58849102128 scopus 로고    scopus 로고
    • A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN
    • Rahdar M., Inoue T., Meyer T., Zhang J., Vazquez F., Devreotes P.N. A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN. Proc Natl Acad Sci U S A 2009, 106:480-485.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 480-485
    • Rahdar, M.1    Inoue, T.2    Meyer, T.3    Zhang, J.4    Vazquez, F.5    Devreotes, P.N.6
  • 102
    • 79956348919 scopus 로고    scopus 로고
    • Metabolic syndrome and the risk of breast cancer in postmenopausal women
    • Rosato V., Bosetti C., Talamini R., Levi F., Montella M., Giacosa A., et al. Metabolic syndrome and the risk of breast cancer in postmenopausal women. Ann Oncol 2011, 22:2687-2692.
    • (2011) Ann Oncol , vol.22 , pp. 2687-2692
    • Rosato, V.1    Bosetti, C.2    Talamini, R.3    Levi, F.4    Montella, M.5    Giacosa, A.6
  • 103
    • 80052665281 scopus 로고    scopus 로고
    • Metabolic syndrome and pancreatic cancer risk: a case-control study in Italy and meta-analysis
    • Rosato V., Tavani A., Bosetti C., Pelucchi C., Talamini R., Polesel J., et al. Metabolic syndrome and pancreatic cancer risk: a case-control study in Italy and meta-analysis. Metabolism 2011, 60:1372-1378.
    • (2011) Metabolism , vol.60 , pp. 1372-1378
    • Rosato, V.1    Tavani, A.2    Bosetti, C.3    Pelucchi, C.4    Talamini, R.5    Polesel, J.6
  • 104
    • 0032534892 scopus 로고    scopus 로고
    • CDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12
    • Rozycka M., Lu Y.J., Brown R.A., Lau M.R., Shipley J.M., Fry M.J. cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12. Genomics 1998, 54:569-574.
    • (1998) Genomics , vol.54 , pp. 569-574
    • Rozycka, M.1    Lu, Y.J.2    Brown, R.A.3    Lau, M.R.4    Shipley, J.M.5    Fry, M.J.6
  • 106
    • 34250687198 scopus 로고    scopus 로고
    • Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity
    • Saal L.H., Johansson P., Holm K., Gruvberger-Saal S.K., She Q.B., Maurer M., et al. Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity. Proc Natl Acad Sci U S A 2007, 104:7564-7569.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 7564-7569
    • Saal, L.H.1    Johansson, P.2    Holm, K.3    Gruvberger-Saal, S.K.4    She, Q.B.5    Maurer, M.6
  • 107
    • 43049128529 scopus 로고    scopus 로고
    • Tenets of PTEN tumor suppression
    • Salmena L., Carracedo A., Pandolfi P.P. Tenets of PTEN tumor suppression. Cell 2008, 133:403-414.
    • (2008) Cell , vol.133 , pp. 403-414
    • Salmena, L.1    Carracedo, A.2    Pandolfi, P.P.3
  • 109
    • 11144358645 scopus 로고    scopus 로고
    • High frequency of mutations of the PIK3CA gene in human cancers
    • Samuels Y., Wang Z., Bardelli A., Silliman N., Ptak J., Szabo S., et al. High frequency of mutations of the PIK3CA gene in human cancers. Science 2004, 304:554.
    • (2004) Science , vol.304 , pp. 554
    • Samuels, Y.1    Wang, Z.2    Bardelli, A.3    Silliman, N.4    Ptak, J.5    Szabo, S.6
  • 110
    • 4344602002 scopus 로고    scopus 로고
    • The biology and clinical relevance of the PTEN tumor suppressor pathway
    • Sansal I., Sellers W.R. The biology and clinical relevance of the PTEN tumor suppressor pathway. J Clin Oncol 2004, 22:2954-2963.
    • (2004) J Clin Oncol , vol.22 , pp. 2954-2963
    • Sansal, I.1    Sellers, W.R.2
  • 111
    • 62449302407 scopus 로고    scopus 로고
    • PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies
    • Sartore-Bianchi A., Martini M., Molinari F., Veronese S., Nichelatti M., Artale S., et al. PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies. Cancer Res 2009, 69:1851-1857.
    • (2009) Cancer Res , vol.69 , pp. 1851-1857
    • Sartore-Bianchi, A.1    Martini, M.2    Molinari, F.3    Veronese, S.4    Nichelatti, M.5    Artale, S.6
  • 112
    • 79958696667 scopus 로고    scopus 로고
    • Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kgamma, a single convergent point promoting tumor inflammation and progression
    • Schmid M.C., Avraamides C.J., Dippold H.C., Franco I., Foubert P., Ellies L.G., et al. Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kgamma, a single convergent point promoting tumor inflammation and progression. Cancer Cell 2011, 19:715-727.
    • (2011) Cancer Cell , vol.19 , pp. 715-727
    • Schmid, M.C.1    Avraamides, C.J.2    Dippold, H.C.3    Franco, I.4    Foubert, P.5    Ellies, L.G.6
  • 113
    • 51849111524 scopus 로고    scopus 로고
    • NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations
    • Serra V., Markman B., Scaltriti M., Eichhorn P.J., Valero V., Guzman M., et al. NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations. Cancer Res 2008, 68:8022-8030.
    • (2008) Cancer Res , vol.68 , pp. 8022-8030
    • Serra, V.1    Markman, B.2    Scaltriti, M.3    Eichhorn, P.J.4    Valero, V.5    Guzman, M.6
  • 116
    • 33947141370 scopus 로고    scopus 로고
    • Biochemical characterization of the type I inositol polyphosphate 4-phosphatase C2 domain
    • Shearn C.T., Norris F.A. Biochemical characterization of the type I inositol polyphosphate 4-phosphatase C2 domain. Biochem Biophys Res Commun 2007, 356:255-259.
    • (2007) Biochem Biophys Res Commun , vol.356 , pp. 255-259
    • Shearn, C.T.1    Norris, F.A.2
  • 117
    • 13244252424 scopus 로고    scopus 로고
    • Mechanisms regulating phosphoinositide 3-kinase signalling in insulin-sensitive tissues
    • Shepherd P.R. Mechanisms regulating phosphoinositide 3-kinase signalling in insulin-sensitive tissues. Acta Physiol Scand 2005, 183:3-12.
    • (2005) Acta Physiol Scand , vol.183 , pp. 3-12
    • Shepherd, P.R.1
  • 118
    • 25444476447 scopus 로고    scopus 로고
    • Polyphosphoinositides are derived from ether-linked inositol glycerophospholipids in rat brain
    • Shin S.H., Kim J.S., Kim H.R., Lim J.K., Choi B.K., Yeo Y.K. Polyphosphoinositides are derived from ether-linked inositol glycerophospholipids in rat brain. J Biochem Mol Biol 2005, 38:360-365.
    • (2005) J Biochem Mol Biol , vol.38 , pp. 360-365
    • Shin, S.H.1    Kim, J.S.2    Kim, H.R.3    Lim, J.K.4    Choi, B.K.5    Yeo, Y.K.6
  • 119
    • 20044364159 scopus 로고    scopus 로고
    • Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity
    • Sleeman M.W., Wortley K.E., Lai K.M., Gowen L.C., Kintner J., Kline W.O., et al. Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity. Nat Med 2005, 11:199-205.
    • (2005) Nat Med , vol.11 , pp. 199-205
    • Sleeman, M.W.1    Wortley, K.E.2    Lai, K.M.3    Gowen, L.C.4    Kintner, J.5    Kline, W.O.6
  • 121
    • 22544444889 scopus 로고    scopus 로고
    • Essential role for the p110delta isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia
    • Sujobert P., Bardet V., Cornillet-Lefebvre P., Hayflick J.S., Prie N., Verdier F., et al. Essential role for the p110delta isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia. Blood 2005, 106:1063-1066.
    • (2005) Blood , vol.106 , pp. 1063-1066
    • Sujobert, P.1    Bardet, V.2    Cornillet-Lefebvre, P.3    Hayflick, J.S.4    Prie, N.5    Verdier, F.6
  • 122
    • 80455140538 scopus 로고    scopus 로고
    • Discovery of a potent, selective, and orally available class I phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) kinase inhibitor (GDC-0980) for the treatment of cancer
    • Sutherlin D.P., Bao L., Berry M., Castanedo G., Chuckowree I., Dotson J., et al. Discovery of a potent, selective, and orally available class I phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) kinase inhibitor (GDC-0980) for the treatment of cancer. J Med Chem 2011, 54:7579-7587.
    • (2011) J Med Chem , vol.54 , pp. 7579-7587
    • Sutherlin, D.P.1    Bao, L.2    Berry, M.3    Castanedo, G.4    Chuckowree, I.5    Dotson, J.6
  • 123
    • 70350057467 scopus 로고    scopus 로고
    • Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2
    • Suwa A., Yamamoto T., Sawada A., Minoura K., Hosogai N., Tahara A., et al. Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2. Br J Pharmacol 2009, 158:879-887.
    • (2009) Br J Pharmacol , vol.158 , pp. 879-887
    • Suwa, A.1    Yamamoto, T.2    Sawada, A.3    Minoura, K.4    Hosogai, N.5    Tahara, A.6
  • 124
    • 61449258534 scopus 로고    scopus 로고
    • Critical role of bad phosphorylation by Akt in cytostatic resistance of human bladder cancer cells
    • Szanto A., Bognar Z., Szigeti A., Szabo A., Farkas L., Gallyas F. Critical role of bad phosphorylation by Akt in cytostatic resistance of human bladder cancer cells. Anticancer Res 2009, 29:159-164.
    • (2009) Anticancer Res , vol.29 , pp. 159-164
    • Szanto, A.1    Bognar, Z.2    Szigeti, A.3    Szabo, A.4    Farkas, L.5    Gallyas, F.6
  • 125
    • 33244464562 scopus 로고    scopus 로고
    • Critical nodes in signalling pathways: insights into insulin action
    • Taniguchi C.M., Emanuelli B., Kahn C.R. Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 2006, 7:85-96.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 85-96
    • Taniguchi, C.M.1    Emanuelli, B.2    Kahn, C.R.3
  • 126
    • 33646148946 scopus 로고    scopus 로고
    • Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta
    • Taniguchi C.M., Kondo T., Sajan M., Luo J., Bronson R., Asano T., et al. Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta. Cell Metab 2006, 3:343-353.
    • (2006) Cell Metab , vol.3 , pp. 343-353
    • Taniguchi, C.M.1    Kondo, T.2    Sajan, M.3    Luo, J.4    Bronson, R.5    Asano, T.6
  • 127
    • 80054700538 scopus 로고    scopus 로고
    • Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs
    • Tay Y., Kats L., Salmena L., Weiss D., Tan S.M., Ala U., et al. Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell 2011, 147:344-357.
    • (2011) Cell , vol.147 , pp. 344-357
    • Tay, Y.1    Kats, L.2    Salmena, L.3    Weiss, D.4    Tan, S.M.5    Ala, U.6
  • 128
    • 33745310789 scopus 로고    scopus 로고
    • Are class II phosphoinositide 3-kinases potential targets for anticancer therapies?
    • Traer C.J., Foster F.M., Abraham S.M., Fry M.J. Are class II phosphoinositide 3-kinases potential targets for anticancer therapies?. Bull Cancer 2006, 93:E53-E58.
    • (2006) Bull Cancer , vol.93
    • Traer, C.J.1    Foster, F.M.2    Abraham, S.M.3    Fry, M.J.4
  • 129
  • 130
    • 33748999833 scopus 로고    scopus 로고
    • Hyperplasia and carcinomas in PTEN-deficient mice and reduced PTEN protein in human bladder cancer patients
    • Tsuruta H., Kishimoto H., Sasaki T., Horie Y., Natsui M., Shibata Y., et al. Hyperplasia and carcinomas in PTEN-deficient mice and reduced PTEN protein in human bladder cancer patients. Cancer Res 2006, 66:8389-8396.
    • (2006) Cancer Res , vol.66 , pp. 8389-8396
    • Tsuruta, H.1    Kishimoto, H.2    Sasaki, T.3    Horie, Y.4    Natsui, M.5    Shibata, Y.6
  • 131
    • 0035496903 scopus 로고    scopus 로고
    • Embryonic and hematopoietic stem cells express a novel SH2-containing inositol 5'-phosphatase isoform that partners with the Grb2 adapter protein
    • Tu Z., Ninos J.M., Ma Z., Wang J.W., Lemos M.P., Desponts C., et al. Embryonic and hematopoietic stem cells express a novel SH2-containing inositol 5'-phosphatase isoform that partners with the Grb2 adapter protein. Blood 2001, 98:2028-2038.
    • (2001) Blood , vol.98 , pp. 2028-2038
    • Tu, Z.1    Ninos, J.M.2    Ma, Z.3    Wang, J.W.4    Lemos, M.P.5    Desponts, C.6
  • 132
    • 0032476036 scopus 로고    scopus 로고
    • The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 phosphatidylinositol 3-kinase and the class II PI3K-C2alpha
    • Turner S.J., Domin J., Waterfield M.D., Ward S.G., Westwick J. The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 phosphatidylinositol 3-kinase and the class II PI3K-C2alpha. J Biol Chem 1998, 273:25987-25995.
    • (1998) J Biol Chem , vol.273 , pp. 25987-25995
    • Turner, S.J.1    Domin, J.2    Waterfield, M.D.3    Ward, S.G.4    Westwick, J.5
  • 135
    • 33749431713 scopus 로고    scopus 로고
    • The mTOR pathway in the control of protein synthesis
    • Wang X., Proud C.G. The mTOR pathway in the control of protein synthesis. Physiology (Bethesda) 2006, 21:362-369.
    • (2006) Physiology (Bethesda) , vol.21 , pp. 362-369
    • Wang, X.1    Proud, C.G.2
  • 137
    • 79960747094 scopus 로고    scopus 로고
    • Metabolic syndrome increases the risk of primary liver cancer in the United States: a study in the SEER-Medicare database
    • Welzel T.M., Graubard B.I., Zeuzem S., El-Serag H.B., Davila J.A., McGlynn K.A. Metabolic syndrome increases the risk of primary liver cancer in the United States: a study in the SEER-Medicare database. Hepatology 2011, 54:463-471.
    • (2011) Hepatology , vol.54 , pp. 463-471
    • Welzel, T.M.1    Graubard, B.I.2    Zeuzem, S.3    El-Serag, H.B.4    Davila, J.A.5    McGlynn, K.A.6
  • 139
    • 75149155674 scopus 로고    scopus 로고
    • Insulin-like growth factor-I regulates the liver microenvironment in obese mice and promotes liver metastasis
    • Wu Y., Brodt P., Sun H., Mejia W., Novosyadlyy R., Nunez N., et al. Insulin-like growth factor-I regulates the liver microenvironment in obese mice and promotes liver metastasis. Cancer Res 2010, 70:57-67.
    • (2010) Cancer Res , vol.70 , pp. 57-67
    • Wu, Y.1    Brodt, P.2    Sun, H.3    Mejia, W.4    Novosyadlyy, R.5    Nunez, N.6
  • 140
    • 0042090507 scopus 로고    scopus 로고
    • Reduced circulating insulin-like growth factor I levels delay the onset of chemically and genetically induced mammary tumors
    • Wu Y., Cui K., Miyoshi K., Hennighausen L., Green J.E., Setser J., et al. Reduced circulating insulin-like growth factor I levels delay the onset of chemically and genetically induced mammary tumors. Cancer Res 2003, 63:4384-4388.
    • (2003) Cancer Res , vol.63 , pp. 4384-4388
    • Wu, Y.1    Cui, K.2    Miyoshi, K.3    Hennighausen, L.4    Green, J.E.5    Setser, J.6
  • 141
    • 0036173548 scopus 로고    scopus 로고
    • Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis
    • Wu Y., Yakar S., Zhao L., Hennighausen L., LeRoith D. Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis. Cancer Res 2002, 62:1030-1035.
    • (2002) Cancer Res , vol.62 , pp. 1030-1035
    • Wu, Y.1    Yakar, S.2    Zhao, L.3    Hennighausen, L.4    LeRoith, D.5
  • 143
    • 77951879658 scopus 로고    scopus 로고
    • Inhibition of cancer cell proliferation and metastasis by insulin receptor downregulation
    • Zhang H., Fagan D.H., Zeng X., Freeman K.T., Sachdev D., Yee D. Inhibition of cancer cell proliferation and metastasis by insulin receptor downregulation. Oncogene 2010, 29:2517-2527.
    • (2010) Oncogene , vol.29 , pp. 2517-2527
    • Zhang, H.1    Fagan, D.H.2    Zeng, X.3    Freeman, K.T.4    Sachdev, D.5    Yee, D.6
  • 144
    • 29444449785 scopus 로고    scopus 로고
    • The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells
    • Zhao J.J., Liu Z., Wang L., Shin E., Loda M.F., Roberts T.M. The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells. Proc Natl Acad Sci U S A 2005, 102:18443-18448.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 18443-18448
    • Zhao, J.J.1    Liu, Z.2    Wang, L.3    Shin, E.4    Loda, M.F.5    Roberts, T.M.6
  • 145
    • 77951884299 scopus 로고    scopus 로고
    • Hot-spot mutations in p110alpha of phosphatidylinositol 3-kinase (pI3K): differential interactions with the regulatory subunit p85 and with RAS.
    • Zhao L., Vogt P.K. Hot-spot mutations in p110alpha of phosphatidylinositol 3-kinase (pI3K): differential interactions with the regulatory subunit p85 and with RAS. Cell Cycle 2010, 9:596-600.
    • (2010) Cell Cycle , vol.9 , pp. 596-600
    • Zhao, L.1    Vogt, P.K.2
  • 146
    • 36048963331 scopus 로고    scopus 로고
    • Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance
    • Zhou J., Wulfkuhle J., Zhang H., Gu P., Yang Y., Deng J., et al. Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance. Proc Natl Acad Sci U S A 2007, 104:16158-16163.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 16158-16163
    • Zhou, J.1    Wulfkuhle, J.2    Zhang, H.3    Gu, P.4    Yang, Y.5    Deng, J.6
  • 147
    • 2942525073 scopus 로고    scopus 로고
    • Identification of Flk-1 target genes in vasculogenesis: Pim-1 is required for endothelial and mural cell differentiation in vitro
    • Zippo A., De Robertis A., Bardelli M., Galvagni F., Oliviero S. Identification of Flk-1 target genes in vasculogenesis: Pim-1 is required for endothelial and mural cell differentiation in vitro. Blood 2004, 103:4536-4544.
    • (2004) Blood , vol.103 , pp. 4536-4544
    • Zippo, A.1    De Robertis, A.2    Bardelli, M.3    Galvagni, F.4    Oliviero, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.