-
1
-
-
0036434431
-
Insulin regulation of glucose uptake: A complex interplay of intracellular signalling pathways
-
Khan AH, Pessin JE: Insulin regulation of glucose uptake: a complex interplay of intracellular signalling pathways. Diabetologia 45:1475-1483, 2002
-
(2002)
Diabetologia
, vol.45
, pp. 1475-1483
-
-
Khan, A.H.1
Pessin, J.E.2
-
2
-
-
0035856949
-
Insulin signalling and the regulation of glucose and lipid metabolism
-
Saltiel AR, Kahn CR: Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414:799-806, 2001
-
(2001)
Nature
, vol.414
, pp. 799-806
-
-
Saltiel, A.R.1
Kahn, C.R.2
-
3
-
-
0036710280
-
IRS proteins and the common path to diabetes
-
White MF: IRS proteins and the common path to diabetes. Am J Physiol Endocrinol Metab 283:E413-E422, 2002
-
(2002)
Am J Physiol Endocrinol Metab
, vol.283
-
-
White, M.F.1
-
4
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
Cantley LC: The phosphoinositide 3-kinase pathway. Science 296:1655-1657, 2002
-
(2002)
Science
, vol.296
, pp. 1655-1657
-
-
Cantley, L.C.1
-
5
-
-
0032143284
-
Phosphoinositide 3-kinase: The key switch mechanism in insulin signalling
-
Shepherd PR, Withers DJ, Siddle K: Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling. Biochem J 333:471-490, 1998
-
(1998)
Biochem J
, vol.333
, pp. 471-490
-
-
Shepherd, P.R.1
Withers, D.J.2
Siddle, K.3
-
6
-
-
0036143774
-
Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival
-
Ueki K, Fruman DA, Brachmann SM, Tseng Y-H, Cantley LC, Kahn CR: Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival. Mol Cell Biol 22:965-977, 2002
-
(2002)
Mol Cell Biol
, vol.22
, pp. 965-977
-
-
Ueki, K.1
Fruman, D.A.2
Brachmann, S.M.3
Tseng, Y.-H.4
Cantley, L.C.5
Kahn, C.R.6
-
7
-
-
0030799706
-
Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B
-
Stokoe D, Stephens LR, Copeland T, Gaffney PRJ, Reese CB, Painter GF, Holmes AB, McCormick F, Hawkins PT: Dual role of phosphatidylinositol-3,4,5- trisphosphate in the activation of protein kinase B. Science 277:567-570, 1997
-
(1997)
Science
, vol.277
, pp. 567-570
-
-
Stokoe, D.1
Stephens, L.R.2
Copeland, T.3
Gaffney, P.R.J.4
Reese, C.B.5
Painter, G.F.6
Holmes, A.B.7
McCormick, F.8
Hawkins, P.T.9
-
8
-
-
3543017307
-
Intracellular delivery of phosphatidylinositol (3,4,5)-trisphosphate causes incorporation of glucose transporter 4 into the plasma membrane of muscle and fat cells without increasing glucose uptake
-
Sweeney G, Garg RR, Ceddia RB, Li D, Ishiki M, Somwar R, Foster LJ, Neilsen PO, Prestwich GD, Rudich A, Klip A: Intracellular delivery of phosphatidylinositol (3,4,5)-trisphosphate causes incorporation of glucose transporter 4 into the plasma membrane of muscle and fat cells without increasing glucose uptake. J Biol Chem 279:32233-32242, 2004
-
(2004)
J Biol Chem
, vol.279
, pp. 32233-32242
-
-
Sweeney, G.1
Garg, R.R.2
Ceddia, R.B.3
Li, D.4
Ishiki, M.5
Somwar, R.6
Foster, L.J.7
Neilsen, P.O.8
Prestwich, G.D.9
Rudich, A.10
Klip, A.11
-
9
-
-
0242468741
-
Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change
-
Milburn CC, Deak M, Kelly SM, Price NC, Alessi DR, Van Aalten DM: Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change. Biochem J 375:531-538, 2003
-
(2003)
Biochem J
, vol.375
, pp. 531-538
-
-
Milburn, C.C.1
Deak, M.2
Kelly, S.M.3
Price, N.C.4
Alessi, D.R.5
Van Aalten, D.M.6
-
10
-
-
1542328927
-
Structure, regulation and function of PKB/AKT: A major therapeutic target
-
Hanada M, Feng J, Hemmings BA: Structure, regulation and function of PKB/AKT: a major therapeutic target. Biochim Biophys Acta 1697:3-16, 2004
-
(2004)
Biochim Biophys Acta
, vol.1697
, pp. 3-16
-
-
Hanada, M.1
Feng, J.2
Hemmings, B.A.3
-
11
-
-
0031590449
-
Identification of a second SH2-domain-containing protein closely related to the phosphatidylinositol polyphosphate 5-phosphatase SHIP
-
Pesesse X, Deleu S, De Smedt F, Drayer L, Erneux C: Identification of a second SH2-domain-containing protein closely related to the phosphatidylinositol polyphosphate 5-phosphatase SHIP. Biochem Biophys Res Commun 239:697-700, 1997
-
(1997)
Biochem Biophys Res Commun
, vol.239
, pp. 697-700
-
-
Pesesse, X.1
Deleu, S.2
De Smedt, F.3
Drayer, L.4
Erneux, C.5
-
12
-
-
0033600185
-
Molecular cloning of rat SH2-containing inositol phosphatase 2 (SHIP2) and its role in the regulation of insulin signaling
-
Ishihara H, Sasaoka T, Hori H, Wada T, Hirai H, Haruta T, Langlois WJ, Kobayashi M: Molecular cloning of rat SH2-containing inositol phosphatase 2 (SHIP2) and its role in the regulation of insulin signaling. Biochem Biophys Res Commun 260:265-272, 1999
-
(1999)
Biochem Biophys Res Commun
, vol.260
, pp. 265-272
-
-
Ishihara, H.1
Sasaoka, T.2
Hori, H.3
Wada, T.4
Hirai, H.5
Haruta, T.6
Langlois, W.J.7
Kobayashi, M.8
-
13
-
-
0035804251
-
The lipid phosphatase SHIP2 controls insulin sensitivity
-
Clément S, Krause U, Desmedt F, Tanti J-F, Behrends J, Pesesse X, Sasaki T, Penninger J, Doherty M, Malaisse W, Dumont JE, Le Marchand-Brustel Y, Erneux C, Hue L, Schurmans S: The lipid phosphatase SHIP2 controls insulin sensitivity. Nature 409:92-97, 2001
-
(2001)
Nature
, vol.409
, pp. 92-97
-
-
Clément, S.1
Krause, U.2
Desmedt, F.3
Tanti, J.-F.4
Behrends, J.5
Pesesse, X.6
Sasaki, T.7
Penninger, J.8
Doherty, M.9
Malaisse, W.10
Dumont, J.E.11
Le Marchand-Brustel, Y.12
Erneux, C.13
Hue, L.14
Schurmans, S.15
-
14
-
-
3042820621
-
Polymorphisms in type II SH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome
-
Kaisaki PJ, Delépine M, Woon PY, Sebag-Montefiore L, Wilder SP, Menzel S, Vionnet N, Marion E, Riveline J-P, Charpentier G, Schurmans S, Levy JC, Lathrop M, Farrall M, Gauguier D: Polymorphisms in type II SH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome. Diabetes 53:1900-1904, 2004
-
(2004)
Diabetes
, vol.53
, pp. 1900-1904
-
-
Kaisaki, P.J.1
Delépine, M.2
Woon, P.Y.3
Sebag-Montefiore, L.4
Wilder, S.P.5
Menzel, S.6
Vionnet, N.7
Marion, E.8
Riveline, J.-P.9
Charpentier, G.10
Schurmans, S.11
Levy, J.C.12
Lathrop, M.13
Farrall, M.14
Gauguier, D.15
-
15
-
-
0036300603
-
The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man
-
Marion E, Kaisaki PJ, Pouillon V, Gueydan C, Levy JC, Bodson A, Krzentowski G, Daubresse JC, Mockel J, Behrends J, Servais G, Szpirer C, Kruys V, Gauguier D, Schurmans S: The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man. Diabetes 51:2012-2017, 2002
-
(2002)
Diabetes
, vol.51
, pp. 2012-2017
-
-
Marion, E.1
Kaisaki, P.J.2
Pouillon, V.3
Gueydan, C.4
Levy, J.C.5
Bodson, A.6
Krzentowski, G.7
Daubresse, J.C.8
Mockel, J.9
Behrends, J.10
Servais, G.11
Szpirer, C.12
Kruys, V.13
Gauguier, D.14
Schurmans, S.15
-
16
-
-
0032561507
-
The SH2 domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity
-
Pesesse X, Moreau C, Drayer AL, Woscholski R, Parker P, Erneux C: The SH2 domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity. FEBS Lett 437:301-303, 1998
-
(1998)
FEBS Lett
, vol.437
, pp. 301-303
-
-
Pesesse, X.1
Moreau, C.2
Drayer, A.L.3
Woscholski, R.4
Parker, P.5
Erneux, C.6
-
17
-
-
0037702455
-
The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5-phosphatases
-
Backers K, Blero D, Paternotte N, Zhang J, Erneux C: The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5-phosphatases. Adv Enzyme Regul 43:15-28, 2003
-
(2003)
Adv Enzyme Regul
, vol.43
, pp. 15-28
-
-
Backers, K.1
Blero, D.2
Paternotte, N.3
Zhang, J.4
Erneux, C.5
-
18
-
-
0035135318
-
Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5′-phosphatase catalytic activity
-
Wada T, Sasaoka T, Funaki M, Hori H, Murakami S, Ishiki M, Haruta T, Asano T, Ogawa W, Ishihara H, Kobayashi M: Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5′-phosphatase catalytic activity. Mol Cell Biol 21:163-1646, 2001
-
(2001)
Mol Cell Biol
, vol.21
, pp. 163-1646
-
-
Wada, T.1
Sasaoka, T.2
Funaki, M.3
Hori, H.4
Murakami, S.5
Ishiki, M.6
Haruta, T.7
Asano, T.8
Ogawa, W.9
Ishihara, H.10
Kobayashi, M.11
-
19
-
-
0034775501
-
SH2-containing inositol phosphatase 2 negatively regulates insulin-induced glycogen synthesis in L6 myotubes
-
Sasaoka T, Hori H, Wada T, Ishiki M, Haruta T, Ishihara H, Kobayashi M: SH2-containing inositol phosphatase 2 negatively regulates insulin-induced glycogen synthesis in L6 myotubes. Diabetologia 44:1258-1267, 2001
-
(2001)
Diabetologia
, vol.44
, pp. 1258-1267
-
-
Sasaoka, T.1
Hori, H.2
Wada, T.3
Ishiki, M.4
Haruta, T.5
Ishihara, H.6
Kobayashi, M.7
-
20
-
-
2442553111
-
SH2-containing inositol phosphatase 2 predominantly regulates Akt2, and not Akt1, phosphorylation at the plasma membrane in response to insulin in 3T3-L1 adipocytes
-
Sasaoka T, Wada T, Fukui K, Murakami S, Ishihara H, Suzuki R, Tobe K, Kadowaki T, Kobayashi M: SH2-containing inositol phosphatase 2 predominantly regulates Akt2, and not Akt1, phosphorylation at the plasma membrane in response to insulin in 3T3-L1 adipocytes. J Biol Chem 279:14835-14843, 2004
-
(2004)
J Biol Chem
, vol.279
, pp. 14835-14843
-
-
Sasaoka, T.1
Wada, T.2
Fukui, K.3
Murakami, S.4
Ishihara, H.5
Suzuki, R.6
Tobe, K.7
Kadowaki, T.8
Kobayashi, M.9
-
21
-
-
0036329397
-
Association of SH2-containing inositol phosphatase 2 with the insulin resistance of diabetic db/db mice
-
Hori H, Sasaoka T, Ishihara H, Wada T, Murakami S, Ishiki M, Kobayashi M: Association of SH2-containing inositol phosphatase 2 with the insulin resistance of diabetic db/db mice. Diabetes 51:2387-2394, 2002
-
(2002)
Diabetes
, vol.51
, pp. 2387-2394
-
-
Hori, H.1
Sasaoka, T.2
Ishihara, H.3
Wada, T.4
Murakami, S.5
Ishiki, M.6
Kobayashi, M.7
-
22
-
-
3042687456
-
Impact of Src homology 2-containing inositol 5′-phosphatase 2 on the regulation of insulin signaling leading to protein synthesis in 3T3-L1 adipocytes cultured with excess amino acids
-
Murakami S, Sasaoka T, Wada T, Fukui K, Nagira K, Ishihara H, Usui I, Kobayashi M: Impact of Src homology 2-containing inositol 5′-phosphatase 2 on the regulation of insulin signaling leading to protein synthesis in 3T3-L1 adipocytes cultured with excess amino acids. Endocrinology 145:3215-3223, 2004
-
(2004)
Endocrinology
, vol.145
, pp. 3215-3223
-
-
Murakami, S.1
Sasaoka, T.2
Wada, T.3
Fukui, K.4
Nagira, K.5
Ishihara, H.6
Usui, I.7
Kobayashi, M.8
-
23
-
-
0033636523
-
Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
-
Michael MD, Kulkarni RN, Postic C, Previs SF, Shulman GI, Magnuson MA, Kahn CR: Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell 6:87-97, 2000
-
(2000)
Mol Cell
, vol.6
, pp. 87-97
-
-
Michael, M.D.1
Kulkarni, R.N.2
Postic, C.3
Previs, S.F.4
Shulman, G.I.5
Magnuson, M.A.6
Kahn, C.R.7
-
24
-
-
0034687208
-
Diabetes: The importance of the liver
-
Rutter GA: Diabetes: the importance of the liver. Curr Biol 10:R736-R738, 2000
-
(2000)
Curr Biol
, vol.10
-
-
Rutter, G.A.1
-
25
-
-
0034873371
-
Insulin-regulated gene expression
-
O'Brien RM, Streeper RS, Ayala JE, Stadelmaier BT, Hornbuckle LA: Insulin-regulated gene expression. Biochem Soc Trans 29:552-558, 2001
-
(2001)
Biochem Soc Trans
, vol.29
, pp. 552-558
-
-
O'Brien, R.M.1
Streeper, R.S.2
Ayala, J.E.3
Stadelmaier, B.T.4
Hornbuckle, L.A.5
-
26
-
-
0033755408
-
Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory β-cell hyperplasia
-
Kubota N, Tobe K, Terauchi Y, Eto K, Yamauchi T, Suzuki R, Tsubamoto Y, Komeda K, Nakano R, Miki H, Satoh S, Sekihara H, Sciacchitano S, Lesniak M, Aizawa S, Nagai R, Kimura S, Akanuma Y, Taylor SI, Kadowaki T: Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory β-cell hyperplasia. Diabetes 49:1880-1889, 2000
-
(2000)
Diabetes
, vol.49
, pp. 1880-1889
-
-
Kubota, N.1
Tobe, K.2
Terauchi, Y.3
Eto, K.4
Yamauchi, T.5
Suzuki, R.6
Tsubamoto, Y.7
Komeda, K.8
Nakano, R.9
Miki, H.10
Satoh, S.11
Sekihara, H.12
Sciacchitano, S.13
Lesniak, M.14
Aizawa, S.15
Nagai, R.16
Kimura, S.17
Akanuma, Y.18
Taylor, S.I.19
Kadowaki, T.20
more..
-
27
-
-
0031982799
-
Liver microsomal glucose-6-phosphatase is competitively inhibited by the lipid products of phosphatidylinositol 3-kinase
-
Mithieux G, Daniele N, Payrastre B, Zitoun C: Liver microsomal glucose-6-phosphatase is competitively inhibited by the lipid products of phosphatidylinositol 3-kinase. J Biol Chem 273:17-19, 1998
-
(1998)
J Biol Chem
, vol.273
, pp. 17-19
-
-
Mithieux, G.1
Daniele, N.2
Payrastre, B.3
Zitoun, C.4
-
28
-
-
0035368548
-
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ)
-
Cho H, Mu J, Kim JK, Thorvaldsen JL, Chu Q, Crenshaw EB 3rd, Kaestner KH, Bartolomei MS, Shulman GI, Birnbaum MJ: Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ). Science 292:1728-1731, 2001
-
(2001)
Science
, vol.292
, pp. 1728-1731
-
-
Cho, H.1
Mu, J.2
Kim, J.K.3
Thorvaldsen, J.L.4
Chu, Q.5
Crenshaw III, E.B.6
Kaestner, K.H.7
Bartolomei, M.S.8
Shulman, G.I.9
Birnbaum, M.J.10
-
29
-
-
0141839103
-
Novel concepts in insulin regulation of hepatic gluconeogenesis
-
Barthel A, Schmoll D: Novel concepts in insulin regulation of hepatic gluconeogenesis. Am J Physiol Endocrinol Metab 285:E685-E692, 2003
-
(2003)
Am J Physiol Endocrinol Metab
, vol.285
-
-
Barthel, A.1
Schmoll, D.2
-
30
-
-
0036260017
-
Role of the insulin receptor substrate 1 and phosphatidylinositol 3-kinase signaling pathway in insulin-induced expression of sterol regulatory element-binding protein 1c and glucokinase genes in rat hepatocytes
-
Matsumoto M, Ogawa W, Teshigawara K, Inoue H, Miyake K, Sakaue H, Kasuga M: Role of the insulin receptor substrate 1 and phosphatidylinositol 3-kinase signaling pathway in insulin-induced expression of sterol regulatory element-binding protein 1c and glucokinase genes in rat hepatocytes. Diabetes 51:1672-1680, 2002
-
(2002)
Diabetes
, vol.51
, pp. 1672-1680
-
-
Matsumoto, M.1
Ogawa, W.2
Teshigawara, K.3
Inoue, H.4
Miyake, K.5
Sakaue, H.6
Kasuga, M.7
-
31
-
-
0027247998
-
The regulation of gene expression by insulin is differentially impaired in the liver of the genetically obese-hyperglycemic Wistar fatty rat
-
Noguchi T, Matsuda T, Tomari Y, Yamada K, Imai E, Wang Z, Ikeda H, Tanaka T: The regulation of gene expression by insulin is differentially impaired in the liver of the genetically obese-hyperglycemic Wistar fatty rat. FEBS Lett 328:145-148, 1993
-
(1993)
FEBS Lett
, vol.328
, pp. 145-148
-
-
Noguchi, T.1
Matsuda, T.2
Tomari, Y.3
Yamada, K.4
Imai, E.5
Wang, Z.6
Ikeda, H.7
Tanaka, T.8
-
32
-
-
0029797604
-
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a
-
Shimano H, Horton JD, Hammer RE, Shimomura I, Brown MS, Goldstein JL: Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. J Clin Invest 98:1575-1584, 1996
-
(1996)
J Clin Invest
, vol.98
, pp. 1575-1584
-
-
Shimano, H.1
Horton, J.D.2
Hammer, R.E.3
Shimomura, I.4
Brown, M.S.5
Goldstein, J.L.6
-
33
-
-
0022214778
-
Rat hepatic cytosolic phosphoenolpyruvate carboxykinase (GTP): Structures of the protein, messenger RNA, and gene
-
Beale EG, Chrapkiewicz NB, Scoble HA, Metz RJ, Quick DP, Noble RL, Donelson JE, Biemann K, Granner DK: Rat hepatic cytosolic phosphoenolpyruvate carboxykinase (GTP): structures of the protein, messenger RNA, and gene. J Biol Chem 260:10748-10760, 1985
-
(1985)
J Biol Chem
, vol.260
, pp. 10748-10760
-
-
Beale, E.G.1
Chrapkiewicz, N.B.2
Scoble, H.A.3
Metz, R.J.4
Quick, D.P.5
Noble, R.L.6
Donelson, J.E.7
Biemann, K.8
Granner, D.K.9
-
34
-
-
0029816847
-
Expression and distribution of glucose-6-phosphatase catalytic subunit messenger RNA and its changes in the diabetic state
-
Shingu R, Nakajima H, Horikawa Y, Hamaguchi T, Yamasaki T, Miyagawa J, Namba M, Hanafusa T, Matsuzawa Y: Expression and distribution of glucose-6-phosphatase catalytic subunit messenger RNA and its changes in the diabetic state. Res Commun Mol Pathol Pharmacol 93:13-24, 1996
-
(1996)
Res Commun Mol Pathol Pharmacol
, vol.93
, pp. 13-24
-
-
Shingu, R.1
Nakajima, H.2
Horikawa, Y.3
Hamaguchi, T.4
Yamasaki, T.5
Miyagawa, J.6
Namba, M.7
Hanafusa, T.8
Matsuzawa, Y.9
-
35
-
-
0036853886
-
Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver
-
Miyake K, Ogawa W, Matsumoto M, Nakamura T, Sakaue H, Kasuga M: Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver. J Clin Invest 110:1483-1491, 2002
-
(2002)
J Clin Invest
, vol.110
, pp. 1483-1491
-
-
Miyake, K.1
Ogawa, W.2
Matsumoto, M.3
Nakamura, T.4
Sakaue, H.5
Kasuga, M.6
-
36
-
-
0026906987
-
Adenovirus-mediated in vivo gene transfer and expression in normal rat liver
-
Jaffe HA, Danel C, Longenecker G, Metzger M, Setoguchi Y, Rosenfeld MA, Gant TW, Thorgeirsson SS, Stratford-Perricaudet LD, Perricaudet M, Pavirani A, Lecocq JP, Crystal RG: Adenovirus-mediated in vivo gene transfer and expression in normal rat liver. Nat Genet 1:372-378, 1992
-
(1992)
Nat Genet
, vol.1
, pp. 372-378
-
-
Jaffe, H.A.1
Danel, C.2
Longenecker, G.3
Metzger, M.4
Setoguchi, Y.5
Rosenfeld, M.A.6
Gant, T.W.7
Thorgeirsson, S.S.8
Stratford-Perricaudet, L.D.9
Perricaudet, M.10
Pavirani, A.11
Lecocq, J.P.12
Crystal, R.G.13
-
37
-
-
0029804116
-
Mechanism of activation of protein kinase B by insulin and IGF-1
-
Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P, Hemmings BA: Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 15:6541-6551, 1996
-
(1996)
EMBO J
, vol.15
, pp. 6541-6551
-
-
Alessi, D.R.1
Andjelkovic, M.2
Caudwell, B.3
Cron, P.4
Morrice, N.5
Cohen, P.6
Hemmings, B.A.7
-
38
-
-
15644381754
-
Role of translocation in the activation and function of protein kinase B
-
Andjelkovic M, Alessi DR, Meier R, Fernandez A, Lamb NJC, Frech M, Cron P, Cohen P, Lucocq JM, Hemmings BA: Role of translocation in the activation and function of protein kinase B. J Biol Chem 272:31515-31524, 1997
-
(1997)
J Biol Chem
, vol.272
, pp. 31515-31524
-
-
Andjelkovic, M.1
Alessi, D.R.2
Meier, R.3
Fernandez, A.4
Lamb, N.J.C.5
Frech, M.6
Cron, P.7
Cohen, P.8
Lucocq, J.M.9
Hemmings, B.A.10
-
39
-
-
0033956846
-
The db/db mouse, a model for diabetic dyslipidemia: Molecular characterization and effects of Western diet feeding
-
Kobayashi K, Forte TM, Taniguchi S, Ishida BY, Oka K, Chan L: The db/db mouse, a model for diabetic dyslipidemia: molecular characterization and effects of Western diet feeding. Metabolism 49:22-31, 2000
-
(2000)
Metabolism
, vol.49
, pp. 22-31
-
-
Kobayashi, K.1
Forte, T.M.2
Taniguchi, S.3
Ishida, B.Y.4
Oka, K.5
Chan, L.6
-
41
-
-
20044364159
-
Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity
-
Sleeman MW, Wortley KE, Lai KM, Gowen LC, Kintner J, Kline WO, Garcia K, Stitt TN, Yancopoulos GD, Wiegand SJ, Glass DJ: Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity. Nat Med 11:199-205, 2005
-
(2005)
Nat Med
, vol.11
, pp. 199-205
-
-
Sleeman, M.W.1
Wortley, K.E.2
Lai, K.M.3
Gowen, L.C.4
Kintner, J.5
Kline, W.O.6
Garcia, K.7
Stitt, T.N.8
Yancopoulos, G.D.9
Wiegand, S.J.10
Glass, D.J.11
-
42
-
-
0032577699
-
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
-
Maehama T, Dixon JE: The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 273:13375-13378, 1998
-
(1998)
J Biol Chem
, vol.273
, pp. 13375-13378
-
-
Maehama, T.1
Dixon, J.E.2
-
43
-
-
10744222107
-
Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity
-
Stiles B, Wang Y, Stahl A, Bassilian S, Lee WP, Kim YJ, Sherwin R, Devaskar S, Lesche R, Magnuson MA, Wu H: Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity. Proc Natl Acad Sci U S A 101:2082-2087, 2004
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 2082-2087
-
-
Stiles, B.1
Wang, Y.2
Stahl, A.3
Bassilian, S.4
Lee, W.P.5
Kim, Y.J.6
Sherwin, R.7
Devaskar, S.8
Lesche, R.9
Magnuson, M.A.10
Wu, H.11
-
44
-
-
0036231778
-
Specific inhibition of PTEN expression reverses hyperglycemic in diabetic mice
-
Butler M, McKay RA, Popoff IJ, Gaarde WA, Witchell D, Murray SF, Dean NM, Bhanot S, Monia BP: Specific inhibition of PTEN expression reverses hyperglycemic in diabetic mice. Diabetes 51:1028-1034, 2002
-
(2002)
Diabetes
, vol.51
, pp. 1028-1034
-
-
Butler, M.1
McKay, R.A.2
Popoff, I.J.3
Gaarde, W.A.4
Witchell, D.5
Murray, S.F.6
Dean, N.M.7
Bhanot, S.8
Monia, B.P.9
-
45
-
-
0035787576
-
Cell-specific roles of glucokinase in glucose homeostasis
-
Postic C, Shiota M, Magnuson MA: Cell-specific roles of glucokinase in glucose homeostasis. Recent Prog Horm Res 56:195-217, 2001
-
(2001)
Recent Prog Horm Res
, vol.56
, pp. 195-217
-
-
Postic, C.1
Shiota, M.2
Magnuson, M.A.3
-
46
-
-
0141704191
-
Overexpression of sterol regulatory element-binding protein-la in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver
-
Horton JD, Shimomura I, Ikemoto S, Bashmakov Y, Hammer RE: Overexpression of sterol regulatory element-binding protein-la in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver. J Biol Chem 278:36652-36660, 2003
-
(2003)
J Biol Chem
, vol.278
, pp. 36652-36660
-
-
Horton, J.D.1
Shimomura, I.2
Ikemoto, S.3
Bashmakov, Y.4
Hammer, R.E.5
-
47
-
-
4644311421
-
Hepatic insulin resistance precedes the development of diabetes in a model of intrauterine growth retardation
-
Vuguin P, Raab E, Liu B, Barzilai N, Simmons R: Hepatic insulin resistance precedes the development of diabetes in a model of intrauterine growth retardation. Diabetes 53:2617-2622, 2004
-
(2004)
Diabetes
, vol.53
, pp. 2617-2622
-
-
Vuguin, P.1
Raab, E.2
Liu, B.3
Barzilai, N.4
Simmons, R.5
-
48
-
-
0033636780
-
Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice
-
Shimomura I, Matsuda M, Hammer RE, Bashmakov Y, Brown MS, Goldstein JL: Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol Cell 6:77-86, 2000
-
(2000)
Mol Cell
, vol.6
, pp. 77-86
-
-
Shimomura, I.1
Matsuda, M.2
Hammer, R.E.3
Bashmakov, Y.4
Brown, M.S.5
Goldstein, J.L.6
-
49
-
-
0030856736
-
Metabolic impact of adenovirus-mediated overexpression of the glucose-6-phosphatase catalytic subunit in hepatocytes
-
Seoane J, Trinh K, O'Doherty RM, Gómez-Foix AM, Lange AJ, Newgard CB, Guinovart JJ: Metabolic impact of adenovirus-mediated overexpression of the glucose-6-phosphatase catalytic subunit in hepatocytes. J Biol Chem 272:26972-26977, 1997
-
(1997)
J Biol Chem
, vol.272
, pp. 26972-26977
-
-
Seoane, J.1
Trinh, K.2
O'Doherty, R.M.3
Gómez-Foix, A.M.4
Lange, A.J.5
Newgard, C.B.6
Guinovart, J.J.7
-
50
-
-
0037189517
-
Phosphoenolpyruvate carboxykinase overexpression selectively attenuates insulin signaling and hepatic insulin sensitivity in transgenic mice
-
Sun Y, Liu S, Ferguson S, Wang L, Klepcyk P, Yun JS, Friedman JE: Phosphoenolpyruvate carboxykinase overexpression selectively attenuates insulin signaling and hepatic insulin sensitivity in transgenic mice. J Biol Chem 277:23301-23307, 2002
-
(2002)
J Biol Chem
, vol.277
, pp. 23301-23307
-
-
Sun, Y.1
Liu, S.2
Ferguson, S.3
Wang, L.4
Klepcyk, P.5
Yun, J.S.6
Friedman, J.E.7
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