Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy

Science Translational Medicine

Volumn 4, Issue 124, 2012, Pages

  Lee, Changhan ^a   Raffaghello, Lizzia ^b   Brandhorst, Sebastian ^a,c   Safdie, Fernando M ^a   Bianchi, Giovanna ^b   Martin Montalvo, Alejandro ^d   Pistoia, Vito ^b   Wei, Min ^a   Hwang, Saewon ^a   Merlino, Annalisa ^a   Emionite, Laura ^e   De Cabo, Rafael ^d   Longo, Valter D ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b G GASLINI INSTITUTE   (Italy)

^c UNIVERSITY OF DUISBURG ESSEN   (Germany)

^d NATIONAL INSTITUTE ON AGING   (United States)

^e UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CISPLATIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; GLUCOSE; GROWTH FACTOR; INITIATION FACTOR 2ALPHA; PROTEIN KINASE B; S6 KINASE; SOMATOMEDIN C; TOXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CANCER INHIBITION; CANCER MORTALITY; CANCER SURVIVAL; CELL DEATH; CELL PROLIFERATION; CHEMOSENSITIVITY; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DIET RESTRICTION; DNA DAMAGE; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG MEGADOSE; DRUG SENSITIVITY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; FOOD DRUG INTERACTION; GENE EXPRESSION; GLIOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MELANOMA; METASTASIS POTENTIAL; MONOTHERAPY; MOUSE; MULTIPLE CYCLE TREATMENT; NEUROBLASTOMA; NONHUMAN; ONCOGENE; ONCOGENE EEF1G; ONCOGENE IRS2; ONCOGENE PRLR; ONCOGENE RAS2; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; RISK REDUCTION; SACCHAROMYCES CEREVISIAE; STRESS; TRANSLATION REGULATION; YEAST CELL; ANIMAL; BODY WEIGHT; DRUG SCREENING; NEOPLASM; NUDE MOUSE; PHYSIOLOGY; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; BODY WEIGHT; CELL LINE, TUMOR; FASTING; FEMALE; HUMANS; MICE; MICE, NUDE; NEOPLASMS; NEUROBLASTOMA; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84863229916     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3003293     Document Type: Article

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