-
1
-
-
70350504453
-
The DNA-damage response in human biology and disease
-
Jackson SP, Bartek J. The DNA-damage response in human biology and disease. Nature 2009; 461: 1071-8.
-
(2009)
Nature
, vol.461
, pp. 1071-1078
-
-
Jackson, S.P.1
Bartek, J.2
-
2
-
-
78649336706
-
The DNA damage response: making it safe to play with knives
-
Ciccia A, Elledge SJ. The DNA damage response: making it safe to play with knives. Mol Cell 2010; 40: 179-204.
-
(2010)
Mol Cell
, vol.40
, pp. 179-204
-
-
Ciccia, A.1
Elledge, S.J.2
-
3
-
-
84861526824
-
Checkpoint control and cancer
-
doi: 10.1038/onc.2011.451. [Epub ahead of print].
-
Medema RH, Macurek L. Checkpoint control and cancer. Oncogene 2011; doi: 10.1038/onc.2011.451. [Epub ahead of print].
-
(2011)
Oncogene
-
-
Medema, R.H.1
Macurek, L.2
-
4
-
-
33847737716
-
DNA damage checkpoints: from initiation to recovery or adaptation
-
Bartek J, Lukas J. DNA damage checkpoints: from initiation to recovery or adaptation. Curr Opin Cell Biol 2007; 19: 238-45.
-
(2007)
Curr Opin Cell Biol
, vol.19
, pp. 238-245
-
-
Bartek, J.1
Lukas, J.2
-
5
-
-
79952235291
-
Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications
-
Polo SE, Jackson SP. Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. Genes Dev 2011; 25: 409-33.
-
(2011)
Genes Dev
, vol.25
, pp. 409-433
-
-
Polo, S.E.1
Jackson, S.P.2
-
6
-
-
81055155450
-
Regulatory networks integrating cell cycle control with DNA damage checkpoints and double-strand break repair
-
Langerak P, Russell P. Regulatory networks integrating cell cycle control with DNA damage checkpoints and double-strand break repair. Philos Trans R Soc Lond B Biol Sci 2011; 366: 3562-71.
-
(2011)
Philos Trans R Soc Lond B Biol Sci
, vol.366
, pp. 3562-3571
-
-
Langerak, P.1
Russell, P.2
-
7
-
-
33344476097
-
DNA damage checkpoints in mammals
-
Niida H, Nakanishi M. DNA damage checkpoints in mammals. Mutagenesis 2006; 21: 3-9.
-
(2006)
Mutagenesis
, vol.21
, pp. 3-9
-
-
Niida, H.1
Nakanishi, M.2
-
8
-
-
7744243520
-
The DNA damage response: sensing and signaling
-
McGowan CH, Russell P. The DNA damage response: sensing and signaling. Curr Opin Cell Biol 2004; 16: 629-33.
-
(2004)
Curr Opin Cell Biol
, vol.16
, pp. 629-633
-
-
McGowan, C.H.1
Russell, P.2
-
9
-
-
77958191599
-
ATM activation by oxidative stress
-
Guo Z, Kozlov S, Lavin MF, Person MD, Paull TT. ATM activation by oxidative stress. Science 2010; 330: 517-21.
-
(2010)
Science
, vol.330
, pp. 517-521
-
-
Guo, Z.1
Kozlov, S.2
Lavin, M.F.3
Person, M.D.4
Paull, T.T.5
-
10
-
-
0035983264
-
Checking in on Cds1 (Chk2): a checkpoint kinase and tumor suppressor
-
McGowan CH. Checking in on Cds1 (Chk2): a checkpoint kinase and tumor suppressor. BioEssays 2002; 24: 502-11.
-
(2002)
BioEssays
, vol.24
, pp. 502-511
-
-
McGowan, C.H.1
-
11
-
-
0034818446
-
Post-translational modifications and activation of p53 by genotoxic stresses
-
Appella E, Anderson CW. Post-translational modifications and activation of p53 by genotoxic stresses. Eur J Biochem 2001; 268: 2764-72.
-
(2001)
Eur J Biochem
, vol.268
, pp. 2764-2772
-
-
Appella, E.1
Anderson, C.W.2
-
13
-
-
79952454660
-
ATR: a master conductor of cellular responses to DNA replication stress
-
Flynn RL, Zou L. ATR: a master conductor of cellular responses to DNA replication stress. Trends Biochem Sci 2011; 36: 133-40.
-
(2011)
Trends Biochem Sci
, vol.36
, pp. 133-140
-
-
Flynn, R.L.1
Zou, L.2
-
14
-
-
47749141560
-
ATR: an essential regulator of genome integrity
-
Cimprich KA, Cortez D. ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol 2008; 9: 616-27.
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 616-627
-
-
Cimprich, K.A.1
Cortez, D.2
-
15
-
-
79957690359
-
ATR signalling: more than meeting at the fork
-
Nam EA, Cortez D. ATR signalling: more than meeting at the fork. Biochem J 2011; 436: 527-36.
-
(2011)
Biochem J
, vol.436
, pp. 527-536
-
-
Nam, E.A.1
Cortez, D.2
-
16
-
-
0034967556
-
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
-
Zhao H, Piwnica-Worms H. ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol Cell Biol 2001; 21: 4129-39.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 4129-4139
-
-
Zhao, H.1
Piwnica-Worms, H.2
-
17
-
-
1642546298
-
Regulation of Chk1 kinase by autoinhibition and ATR-mediated phosphorylation
-
Katsuragi Y, Sagata N. Regulation of Chk1 kinase by autoinhibition and ATR-mediated phosphorylation. Mol Biol Cell 2004; 15: 1680-9.
-
(2004)
Mol Biol Cell
, vol.15
, pp. 1680-1689
-
-
Katsuragi, Y.1
Sagata, N.2
-
18
-
-
67649253108
-
Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity
-
Walker M, Black EJ, Oehler V, Gillespie DA, Scott MT. Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity. Oncogene 2009; 28: 2314-23.
-
(2009)
Oncogene
, vol.28
, pp. 2314-2323
-
-
Walker, M.1
Black, E.J.2
Oehler, V.3
Gillespie, D.A.4
Scott, M.T.5
-
19
-
-
0042242580
-
Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345
-
Jiang K, Pereira E, Maxfield M, Russell B, Goudelock DM, Sanchez Y. Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345. J Biol Chem 2003; 278: 25207-17.
-
(2003)
J Biol Chem
, vol.278
, pp. 25207-25217
-
-
Jiang, K.1
Pereira, E.2
Maxfield, M.3
Russell, B.4
Goudelock, D.M.5
Sanchez, Y.6
-
20
-
-
2342584830
-
Cdc25A regulation: to destroy or not to destroy-is that the only question?
-
Neely KE, Piwnica-Worms H. Cdc25A regulation: to destroy or not to destroy-is that the only question? Cell Cycle 2003; 2: 455-7.
-
(2003)
Cell Cycle
, vol.2
, pp. 455-457
-
-
Neely, K.E.1
Piwnica-Worms, H.2
-
21
-
-
34250865564
-
CDC25 phosphatases in cancer cells: key players? Good targets?
-
Boutros R, Lobjois V, Ducommun B. CDC25 phosphatases in cancer cells: key players? Good targets? Nat Rev Cancer 2007; 7: 495-507.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 495-507
-
-
Boutros, R.1
Lobjois, V.2
Ducommun, B.3
-
22
-
-
0036901957
-
Cyclin dependent kinases and cell cycle control (nobel lecture)
-
Nurse P. Cyclin dependent kinases and cell cycle control (nobel lecture). ChemBioChem 2002; 3: 596-603.
-
(2002)
ChemBioChem
, vol.3
, pp. 596-603
-
-
Nurse, P.1
-
23
-
-
0037096158
-
From Cdc2 to Cdk1: when did the cell cycle kinase join its cyclin partner?
-
Doree M, Hunt T. From Cdc2 to Cdk1: when did the cell cycle kinase join its cyclin partner? J Cell Sci 2002; 115: 2461-4.
-
(2002)
J Cell Sci
, vol.115
, pp. 2461-2464
-
-
Doree, M.1
Hunt, T.2
-
24
-
-
0035235736
-
Mitotic kinases as regulators of cell division and its checkpoints
-
Nigg EA. Mitotic kinases as regulators of cell division and its checkpoints. Nat Rev Mol Cell Biol 2001; 2: 21-32.
-
(2001)
Nat Rev Mol Cell Biol
, vol.2
, pp. 21-32
-
-
Nigg, E.A.1
-
25
-
-
65349102972
-
The decision to enter mitosis: feedback and redundancy in the mitotic entry network
-
Lindqvist A, Rodriguez-Bravo V, Medema RH. The decision to enter mitosis: feedback and redundancy in the mitotic entry network. J Cell Biol 2009; 185: 193-202.
-
(2009)
J Cell Biol
, vol.185
, pp. 193-202
-
-
Lindqvist, A.1
Rodriguez-Bravo, V.2
Medema, R.H.3
-
26
-
-
41149094512
-
Regulation of DNA repair throughout the cell cycle
-
Branzei D, Foiani M. Regulation of DNA repair throughout the cell cycle. Nat Rev Mol Cell Biol 2008; 9: 297-308.
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 297-308
-
-
Branzei, D.1
Foiani, M.2
-
27
-
-
0037567268
-
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
-
Zou L, Elledge SJ. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 2003; 300: 1542-8.
-
(2003)
Science
, vol.300
, pp. 1542-1548
-
-
Zou, L.1
Elledge, S.J.2
-
28
-
-
0345564858
-
Replication protein A-mediated recruitment and activation of Rad17 complexes
-
Zou L, Liu D, Elledge SJ. Replication protein A-mediated recruitment and activation of Rad17 complexes. Proc Natl Acad Sci USA 2003; 100: 13827-32.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 13827-13832
-
-
Zou, L.1
Liu, D.2
Elledge, S.J.3
-
29
-
-
4243156107
-
Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5′ recessed DNA
-
Ellison V, Stillman B. Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5′ recessed DNA. PLoS Biol 2003; 1: E33.
-
(2003)
PLoS Biol
, vol.1
-
-
Ellison, V.1
Stillman, B.2
-
30
-
-
34948889415
-
The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR
-
Lee J, Kumagai A, Dunphy WG. The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR. J Biol Chem 2007; 282: 28036-44.
-
(2007)
J Biol Chem
, vol.282
, pp. 28036-28044
-
-
Lee, J.1
Kumagai, A.2
Dunphy, W.G.3
-
31
-
-
34250705797
-
The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1
-
Delacroix S, Wagner JM, Kobayashi M, Yamamoto K, Karnitz LM. The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1. Genes Dev 2007; 21: 1472-7.
-
(2007)
Genes Dev
, vol.21
, pp. 1472-1477
-
-
Delacroix, S.1
Wagner, J.M.2
Kobayashi, M.3
Yamamoto, K.4
Karnitz, L.M.5
-
33
-
-
0033634679
-
Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts
-
Kumagai A, Dunphy WG. Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. Mol Cell 2000; 6: 839-49.
-
(2000)
Mol Cell
, vol.6
, pp. 839-849
-
-
Kumagai, A.1
Dunphy, W.G.2
-
34
-
-
3242878502
-
Claspin, a regulator of Chk1 in DNA replication stress pathway
-
Chini CC, Chen J. Claspin, a regulator of Chk1 in DNA replication stress pathway. DNA Repair 2004; 3: 1033-7.
-
(2004)
DNA Repair
, vol.3
, pp. 1033-1037
-
-
Chini, C.C.1
Chen, J.2
-
35
-
-
9644275421
-
Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1
-
Kumagai A, Kim SM, Dunphy WG. Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1. J Biol Chem 2004; 279: 49599-608.
-
(2004)
J Biol Chem
, vol.279
, pp. 49599-49608
-
-
Kumagai, A.1
Kim, S.M.2
Dunphy, W.G.3
-
36
-
-
77950368489
-
Differences in the DNA replication of unicellular eukaryotes and metazoans: known unknowns
-
Errico A, Costanzo V. Differences in the DNA replication of unicellular eukaryotes and metazoans: known unknowns. EMBO Rep 2010; 11: 270-8.
-
(2010)
EMBO Rep
, vol.11
, pp. 270-278
-
-
Errico, A.1
Costanzo, V.2
-
37
-
-
77952764443
-
Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress
-
Kemp MG, Akan Z, Yilmaz S et al. Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress. J Biol Chem 2010; 285: 16562-71.
-
(2010)
J Biol Chem
, vol.285
, pp. 16562-16571
-
-
Kemp, M.G.1
Akan, Z.2
Yilmaz, S.3
-
38
-
-
77955849465
-
14-3-3gamma mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage
-
Kasahara K, Goto H, Enomoto M, Tomono Y, Kiyono T, Inagaki M. 14-3-3gamma mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage. EMBO J 2010; 29: 2802-12.
-
(2010)
EMBO J
, vol.29
, pp. 2802-2812
-
-
Kasahara, K.1
Goto, H.2
Enomoto, M.3
Tomono, Y.4
Kiyono, T.5
Inagaki, M.6
-
39
-
-
33646117239
-
Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks
-
Bekker-Jensen S, Lukas C, Kitagawa R et al. Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. J Cell Biol 2006; 173: 195-206.
-
(2006)
J Cell Biol
, vol.173
, pp. 195-206
-
-
Bekker-Jensen, S.1
Lukas, C.2
Kitagawa, R.3
-
40
-
-
68249125947
-
14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response
-
Mohammad DH, Yaffe MB. 14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response. DNA Repair 2009; 8: 1009-17.
-
(2009)
DNA Repair
, vol.8
, pp. 1009-1017
-
-
Mohammad, D.H.1
Yaffe, M.B.2
-
41
-
-
0031948093
-
C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding
-
Peng CY, Graves PR, Ogg S et al. C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding. Cell Growth Differ 1998; 9: 197-208.
-
(1998)
Cell Growth Differ
, vol.9
, pp. 197-208
-
-
Peng, C.Y.1
Graves, P.R.2
Ogg, S.3
-
42
-
-
0035799557
-
Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase
-
Bulavin DV, Higashimoto Y, Popoff IJ et al. Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase. Nature 2001; 411: 102-7.
-
(2001)
Nature
, vol.411
, pp. 102-107
-
-
Bulavin, D.V.1
Higashimoto, Y.2
Popoff, I.J.3
-
43
-
-
33751160547
-
CHK1 phosphorylates CDC25B during the cell cycle in the absence of DNA damage
-
Schmitt E, Boutros R, Froment C, Monsarrat B, Ducommun B, Dozier C. CHK1 phosphorylates CDC25B during the cell cycle in the absence of DNA damage. J Cell Sci 2006; 119: 4269-75.
-
(2006)
J Cell Sci
, vol.119
, pp. 4269-4275
-
-
Schmitt, E.1
Boutros, R.2
Froment, C.3
Monsarrat, B.4
Ducommun, B.5
Dozier, C.6
-
44
-
-
15044365805
-
Normal cell cycle and checkpoint responses in mice and cells lacking Cdc25B and Cdc25C protein phosphatases
-
Ferguson AM, White LS, Donovan PJ, Piwnica-Worms H. Normal cell cycle and checkpoint responses in mice and cells lacking Cdc25B and Cdc25C protein phosphatases. Mol Cell Biol 2005; 25: 2853-60.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 2853-2860
-
-
Ferguson, A.M.1
White, L.S.2
Donovan, P.J.3
Piwnica-Worms, H.4
-
45
-
-
0036544855
-
Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation
-
Lincoln AJ, Wickramasinghe D, Stein P et al. Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation. Nat Genet 2002; 30: 446-9.
-
(2002)
Nat Genet
, vol.30
, pp. 446-449
-
-
Lincoln, A.J.1
Wickramasinghe, D.2
Stein, P.3
-
46
-
-
0034997233
-
Absence of apparent phenotype in mice lacking Cdc25C protein phosphatase
-
Chen MS, Hurov J, White LS, Woodford-Thomas T, Piwnica-Worms H. Absence of apparent phenotype in mice lacking Cdc25C protein phosphatase. Mol Cell Biol 2001; 21: 3853-61.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3853-3861
-
-
Chen, M.S.1
Hurov, J.2
White, L.S.3
Woodford-Thomas, T.4
Piwnica-Worms, H.5
-
47
-
-
34547107624
-
Hemizygous disruption of Cdc25A inhibits cellular transformation and mammary tumorigenesis in mice
-
Ray D, Terao Y, Nimbalkar D et al. Hemizygous disruption of Cdc25A inhibits cellular transformation and mammary tumorigenesis in mice. Cancer Res 2007; 67: 6605-11.
-
(2007)
Cancer Res
, vol.67
, pp. 6605-6611
-
-
Ray, D.1
Terao, Y.2
Nimbalkar, D.3
-
48
-
-
0034102337
-
ATR disruption leads to chromosomal fragmentation and early embryonic lethality
-
Brown EJ, Baltimore D. ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev 2000; 14: 397-402.
-
(2000)
Genes Dev
, vol.14
, pp. 397-402
-
-
Brown, E.J.1
Baltimore, D.2
-
49
-
-
0034177408
-
Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice
-
de Klein A, Muijtjens M, van Os R et al. Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice. Curr Biol 2000; 10: 479-82.
-
(2000)
Curr Biol
, vol.10
, pp. 479-482
-
-
de Klein, A.1
Muijtjens, M.2
van Os, R.3
-
50
-
-
0034659341
-
Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice
-
Takai H, Tominaga K, Motoyama N et al. Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice. Genes Dev 2000; 14: 1439-47.
-
(2000)
Genes Dev
, vol.14
, pp. 1439-1447
-
-
Takai, H.1
Tominaga, K.2
Motoyama, N.3
-
51
-
-
17644432403
-
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
-
Liu Q, Guntuku S, Cui XS et al. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev 2000; 14: 1448-59.
-
(2000)
Genes Dev
, vol.14
, pp. 1448-1459
-
-
Liu, Q.1
Guntuku, S.2
Cui, X.S.3
-
52
-
-
0142027900
-
Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding
-
Chen MS, Ryan CE, Piwnica-Worms H. Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding. Mol Cell Biol 2003; 23: 7488-97.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 7488-7497
-
-
Chen, M.S.1
Ryan, C.E.2
Piwnica-Worms, H.3
-
53
-
-
33749626550
-
Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit
-
Leung-Pineda V, Ryan CE, Piwnica-Worms H. Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit. Mol Cell Biol 2006; 26: 7529-38.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 7529-7538
-
-
Leung-Pineda, V.1
Ryan, C.E.2
Piwnica-Worms, H.3
-
54
-
-
18844405191
-
PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints
-
Lu X, Nannenga B, Donehower LA. PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints. Genes Dev 2005; 19: 1162-74.
-
(2005)
Genes Dev
, vol.19
, pp. 1162-1174
-
-
Lu, X.1
Nannenga, B.2
Donehower, L.A.3
-
55
-
-
0347361537
-
SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase
-
Jin J, Shirogane T, Xu L et al. SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. Genes Dev 2003; 17: 3062-74.
-
(2003)
Genes Dev
, vol.17
, pp. 3062-3074
-
-
Jin, J.1
Shirogane, T.2
Xu, L.3
-
56
-
-
1842486794
-
Cdc25A phosphatase: combinatorial phosphorylation, ubiquitylation and proteolysis
-
Busino L, Chiesa M, Draetta GF, Donzelli M. Cdc25A phosphatase: combinatorial phosphorylation, ubiquitylation and proteolysis. Oncogene 2004; 23: 2050-6.
-
(2004)
Oncogene
, vol.23
, pp. 2050-2056
-
-
Busino, L.1
Chiesa, M.2
Draetta, G.F.3
Donzelli, M.4
-
57
-
-
70349652574
-
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint
-
Melixetian M, Klein DK, Sorensen CS, Helin K. NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint. Nat Cell Biol 2009; 11: 1247-53.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 1247-1253
-
-
Melixetian, M.1
Klein, D.K.2
Sorensen, C.S.3
Helin, K.4
-
58
-
-
77953479905
-
Casein kinase 1 functions as both penultimate and ultimate kinase in regulating Cdc25A destruction
-
Honaker Y, Piwnica-Worms H. Casein kinase 1 functions as both penultimate and ultimate kinase in regulating Cdc25A destruction. Oncogene 2010; 29: 3324-34.
-
(2010)
Oncogene
, vol.29
, pp. 3324-3334
-
-
Honaker, Y.1
Piwnica-Worms, H.2
-
59
-
-
20244388673
-
Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage
-
Syljuasen RG, Sorensen CS, Hansen LT et al. Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage. Mol Cell Biol 2005; 25: 3553-62.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 3553-3562
-
-
Syljuasen, R.G.1
Sorensen, C.S.2
Hansen, L.T.3
-
60
-
-
34250010317
-
Chk1 regulates the density of active replication origins during the vertebrate S phase
-
Maya-Mendoza A, Petermann E, Gillespie DA, Caldecott KW, Jackson DA. Chk1 regulates the density of active replication origins during the vertebrate S phase. EMBO J 2007; 26: 2719-31.
-
(2007)
EMBO J
, vol.26
, pp. 2719-2731
-
-
Maya-Mendoza, A.1
Petermann, E.2
Gillespie, D.A.3
Caldecott, K.W.4
Jackson, D.A.5
-
61
-
-
4444345565
-
Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase
-
Kramer A, Mailand N, Lukas C et al. Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase. Nat Cell Biol 2004; 6: 884-91.
-
(2004)
Nat Cell Biol
, vol.6
, pp. 884-891
-
-
Kramer, A.1
Mailand, N.2
Lukas, C.3
-
62
-
-
71749099636
-
Novel positive feedback loop between Cdk1 and Chk1 in the nucleus during G2/M transition
-
Enomoto M, Goto H, Tomono Y et al. Novel positive feedback loop between Cdk1 and Chk1 in the nucleus during G2/M transition. J Biol Chem 2009; 284: 34223-30.
-
(2009)
J Biol Chem
, vol.284
, pp. 34223-34230
-
-
Enomoto, M.1
Goto, H.2
Tomono, Y.3
-
63
-
-
79960290323
-
Nuclear Chk1 prevents premature mitotic entry
-
Matsuyama M, Goto H, Kasahara K et al. Nuclear Chk1 prevents premature mitotic entry. J Cell Sci 2011; 124: 2113-9.
-
(2011)
J Cell Sci
, vol.124
, pp. 2113-2119
-
-
Matsuyama, M.1
Goto, H.2
Kasahara, K.3
-
64
-
-
0012966157
-
Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A
-
Sorensen CS, Syljuasen RG, Falck J et al. Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. Cancer Cell 2003; 3: 247-58.
-
(2003)
Cancer Cell
, vol.3
, pp. 247-258
-
-
Sorensen, C.S.1
Syljuasen, R.G.2
Falck, J.3
-
65
-
-
38649118240
-
Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression
-
Shimada M, Niida H, Zineldeen DH et al. Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression. Cell 2008; 132: 221-32.
-
(2008)
Cell
, vol.132
, pp. 221-232
-
-
Shimada, M.1
Niida, H.2
Zineldeen, D.H.3
-
66
-
-
51349144633
-
Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery
-
Macurek L, Lindqvist A, Lim D et al. Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery. Nature 2008; 455: 119-23.
-
(2008)
Nature
, vol.455
, pp. 119-123
-
-
Macurek, L.1
Lindqvist, A.2
Lim, D.3
-
67
-
-
46249084662
-
Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry
-
Seki A, Coppinger JA, Jang CY, Yates JR, Fang G. Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry. Science 2008; 320: 1655-8.
-
(2008)
Science
, vol.320
, pp. 1655-1658
-
-
Seki, A.1
Coppinger, J.A.2
Jang, C.Y.3
Yates, J.R.4
Fang, G.5
-
68
-
-
33645800984
-
Regulation of mitotic function of Chk1 through phosphorylation at novel sites by cyclin-dependent kinase 1 (Cdk1)
-
Shiromizu T, Goto H, Tomono Y et al. Regulation of mitotic function of Chk1 through phosphorylation at novel sites by cyclin-dependent kinase 1 (Cdk1). Genes Cells 2006; 11: 477-85.
-
(2006)
Genes Cells
, vol.11
, pp. 477-485
-
-
Shiromizu, T.1
Goto, H.2
Tomono, Y.3
-
69
-
-
33746429958
-
Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress
-
Mailand N, Bekker-Jensen S, Bartek J, Lukas J. Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. Mol Cell 2006; 23: 307-18.
-
(2006)
Mol Cell
, vol.23
, pp. 307-318
-
-
Mailand, N.1
Bekker-Jensen, S.2
Bartek, J.3
Lukas, J.4
-
70
-
-
33746413746
-
SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response
-
Peschiaroli A, Dorrello NV, Guardavaccaro D et al. SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response. Mol Cell 2006; 23: 319-29.
-
(2006)
Mol Cell
, vol.23
, pp. 319-329
-
-
Peschiaroli, A.1
Dorrello, N.V.2
Guardavaccaro, D.3
-
71
-
-
84859708296
-
P90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferation
-
doi: 10.1091/mbc.E11-10-0883. [Epub ahead of print].
-
Li P, Goto H, Kasahara K et al. P90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferation. Mol Biol Cell 2012; doi: 10.1091/mbc.E11-10-0883. [Epub ahead of print].
-
(2012)
Mol Biol Cell
-
-
Li, P.1
Goto, H.2
Kasahara, K.3
-
72
-
-
0030867582
-
Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25
-
Sanchez Y, Wong C, Thoma RS et al. Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science 1997; 277: 1497-501.
-
(1997)
Science
, vol.277
, pp. 1497-1501
-
-
Sanchez, Y.1
Wong, C.2
Thoma, R.S.3
-
73
-
-
3142552523
-
Chk1 is haploinsufficient for multiple functions critical to tumor suppression
-
Lam MH, Liu Q, Elledge SJ, Rosen JM. Chk1 is haploinsufficient for multiple functions critical to tumor suppression. Cancer Cell 2004; 6: 45-59.
-
(2004)
Cancer Cell
, vol.6
, pp. 45-59
-
-
Lam, M.H.1
Liu, Q.2
Elledge, S.J.3
Rosen, J.M.4
-
74
-
-
79651470785
-
Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics
-
Ma CX, Janetka JW, Piwnica-Worms H. Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics. Trends Mol Med 2011; 17: 88-96.
-
(2011)
Trends Mol Med
, vol.17
, pp. 88-96
-
-
Ma, C.X.1
Janetka, J.W.2
Piwnica-Worms, H.3
-
75
-
-
79960580428
-
Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells
-
Raab M, Kappel S, Kramer A et al. Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells. Nat Commun 2011; 2: 395.
-
(2011)
Nat Commun
, vol.2
, pp. 395
-
-
Raab, M.1
Kappel, S.2
Kramer, A.3
-
76
-
-
33748331308
-
The mighty mouse: genetically engineered mouse models in cancer drug development
-
Sharpless NE, Depinho RA. The mighty mouse: genetically engineered mouse models in cancer drug development. Nat Rev Drug Discov 2006; 5: 741-54.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 741-754
-
-
Sharpless, N.E.1
Depinho, R.A.2
-
77
-
-
0037169361
-
Cancer modeling in the modern era: progress and challenges
-
Van Dyke T, Jacks T. Cancer modeling in the modern era: progress and challenges. Cell 2002; 108: 135-44.
-
(2002)
Cell
, vol.108
, pp. 135-144
-
-
Van Dyke, T.1
Jacks, T.2
-
78
-
-
55849147330
-
Polo-like kinase 1 is essential for early embryonic development and tumor suppression
-
Lu LY, Wood JL, Minter-Dykhouse K et al. Polo-like kinase 1 is essential for early embryonic development and tumor suppression. Mol Cell Biol 2008; 28: 6870-6.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 6870-6876
-
-
Lu, L.Y.1
Wood, J.L.2
Minter-Dykhouse, K.3
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