Regulation of mitotic function of Chk1 through phosphorylation at novel sites by cyclin-dependent kinase 1 (Cdk1)

Genes to Cells

Volumn 11, Issue 5, 2006, Pages 477-485

  Shiromizu, Takashi ^a   Goto, Hidemasa ^a,b   Tomono, Yasuko ^c   Bartek, Jiri ^d   Totsukawa, Go ^b,f   Inoko, Akihito ^a   Nakanishi, Makoto ^e   Matsumura, Fumio ^b   Inagaki, Masaki ^a  

^a AICHI CANCER CENTER HOSPITAL   (Japan)

^b RUTGERS UNIVERSITY   (United States)

^c Shigei Medical Research Institute   (Japan)

^d DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^e NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

^f MITSUBISHI KAGAKU INSTITUTE OF LIFE SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BUTYROLACTONE; CHECKPOINT KINASE 1; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; NOCODAZOLE; PHOSPHOPEPTIDE; SERINE; SMALL INTERFERING RNA;

ANAPHASE; ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; IONIZING RADIATION; METAPHASE; MITOSIS; NONHUMAN; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; ULTRAVIOLET RADIATION;

AMINO ACID SEQUENCE; ANIMALS; CDC2 PROTEIN KINASE; CHO CELLS; CRICETINAE; HELA CELLS; HUMANS; IMMUNOBLOTTING; MITOSIS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; NOCODAZOLE; PHOSPHORYLATION; PROTEIN KINASES; RADIATION, IONIZING; RECOMBINANT PROTEINS; SERINE; TRANSFECTION; ULTRAVIOLET RAYS;

ANIMALIA;

EID: 33645800984     PISSN: 13569597     EISSN: 13652443     Source Type: Journal    
DOI: 10.1111/j.1365-2443.2006.00955.x     Document Type: Article

References (32)

1. Abraham, R.T. (2001) Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 15, 2177-2196.
2. Bartek, J. & Lukas, J. (2003) Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell 3, 421-429.
3. Boyle, W.J., van der Geer, P. & Hunter, T. (1991) Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates. Meth ods Enzymol. 201, 110-149.
4. Bulavin, D.V., Higashimoto, Y., Demidenko, Z.N., et al. (2003) Dual phosphorylation controls Cdc25 phosphatases and mitotic entry. Nature Cell Biol. 5, 545-551.
5. Chang, L. & Karin, M. (2001) Mammalian MAP kinase signalling cascades. Nature 410, 37-40.
6. Doree, M. & Hunt, T. (2002) From Cdc2 to Cdk1: When did the cell cycle kinase join its cyclin partner? J. Cell Sci. 115, 2461-2464.
7. Hartwell, L.H. & Weinert, T.A. (1989) Checkpoints: Controls that ensure the order of cell cycle events. Science 246, 629-634.
8. Hirota, T., Kunitoku, N., Sasayama, T., et al. (2003) Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. Cell 114, 585-598.
9. Huang, X., Tran, T., Zhang, L., Hatcher, R. & Zhang, P. (2005) DNA damage-induced mitotic catastrophe is mediated by the Chk1-dependent mitotic exit DNA damage checkpoint. Proc. Natl. Acad. Sci. USA 102, 1065-1070.
10. Jiang, K., Pereira, E., Maxfield, M., Russell, B., Goudelock, D.M. & Sanchez, Y. (2003) Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345. J. Biol. Chem. 278, 25207-25217.
11. Kaneko, Y.S., Watanabe, N., Morisaki, H., et al. (1999) Cell-cycle-dependent and ATM-independent expression of human Chk1 kinase. Oncogene 18, 3673-3681.
12. Kastan, M.B. & Bartek, J. (2004) Cell-cycle checkpoints and cancer. Nature 432, 316-323.
13. Kawajiri, A. & Inagaki, M. (2004) Approaches to study phosphorylation of intermediate filament proteins using site-specific and phosphorylation state-specific antibodies. Methods Cell Biol. 78, 353-371.
14. Kitagawa, M., Okabe, T., Ogino, H., et al. (1993) Butyrolactone I, a selective inhibitor of cdk2 and cdc2 kinase. Oncogene 8, 2425-2432.
15. Landry, J., Lambert, H., Zhou, M., et al. (1992) Human HSP27 is phosphorylated at serines 78 and 82 by heat shock and mitogen-activated kinases that recognize the same amino acid motif as S6 kinase II. J. Biol. Chem. 267, 794-803.
16. Lee, J.C., Kassis, S., Kumar, S., Badger, A. & Adams, J.L. (1999) p38 mitogen-activated protein kinase inhibitors - mechanisms and therapeutic potentials. Pharmacol. Ther. 82, 389-397.
17. Matsusaka, T. & Pines, J. (2004) Chfr acts with the p38 stress kinases to block entry to mitosis in mammalian cells. J. Cell Biol. 166, 507-516.
18. Miyata, Y. & Nishida, E. (1999) Distantly related cousins of MAP kinase: Biochemical properties and possible physiological functions. Biochem. Biophys. Res. Commun. 266, 291-295.
19. Neely, K.E. & Piwnica-Worms, H. (2003) Cdc25A regulation: To destroy or not to destroy - is that the only question? Cell Cycle 2, 455-457.
20. Ng, C.P., Lee, H.C., Ho, C.W., et al. (2004) Differential mode of regulation of the checkpoint kinases CHK1 and CHK2 by their regulatory domains. J. Biol. Chem. 279, 8808-8819.
21. Nishizawa, K., Yano, T., Shibata, M., et al. (1991) Specific localization of phosphointermediate filament protein in the constricted area of dividing cells. J. Biol. Chem. 266, 3074-3079.
22. Nurse, P. (2002) Cyclin dependent kinases and cell cycle control (nobel lecture). Chembiochem. 3, 596-603.
23. Rhind, N. & Russell, P. (2000) Chk1 and Cds1: Linchpins of the DNA damage and replication checkpoint pathways. J. Cell Sci. 113, 3889-3896.
24. Rouse, J., Cohen, P., Trigon, S., et al. (1994) A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell 78, 1027-1037.
25. Shiloh, Y. (2003) ATM and related protein kinases: Safeguarding genome integrity. Nature Rev. Cancer 3, 155-168.
26. Takenaka, K., Moriguchi, T. & Nishida, E. (1998) Activation of the protein kinase p38 in the spindle assembly checkpoint and mitotic arrest. Science 280, 599-602.
27. Tsujimura, K., Ogawara, M., Takeuchi, Y., Imajoh-Ohmi, S., Ha, M.H. & Inagaki, M. (1994) Visualization and function of vimentin phosphorylation by cdc2 kinase during mitosis. J. Biol. Chem. 269, 31097-31106.
28. Tsvetkov, L., Xu, X., Li, J. & Stern, D.F. (2003) Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody. J. Biol. Chem. 278, 8468-8475.
29. Watanabe, N., Broome, M. & Hunter, T. (1995) Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle. EMBO J. 14, 1878-1891.
30. Yano, T., Taura, C., Shibata, M., et al. (1991) A monoclonal antibody to the phosphorylated form of glial fibrillary acidic protein: Application to a non-radioactive method for measuring protein kinase activities. Biochem. Biophys. Res. Commun. 175, 1144 -1151.
31. Zhao, H. & Piwnica-Worms, H. (2001) ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol. Cell. Biol. 21, 4129-4139.
32. Zhou, B.B. & Elledge, S.J. (2000) The DNA damage response: Putting checkpoints in perspective. Nature 408, 433-439.