메뉴 건너뛰기




Volumn 23, Issue 8, 2012, Pages 1582-1592

P90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferation

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; ATR PROTEIN; BI D1870; CHECKPOINT KINASE 1; MK 2206; PROTEIN; PROTEIN P90; PROTEIN SERINE THREONINE KINASE INHIBITOR; S6 KINASE; UNCLASSIFIED DRUG;

EID: 84859708296     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E11-10-0883     Document Type: Article
Times cited : (42)

References (55)
  • 1
    • 52449095361 scopus 로고    scopus 로고
    • The RSK family of kinases: Emerging roles in cellular signalling
    • Anjum R, Blenis J (2008). The RSK family of kinases: emerging roles in cellular signalling. Nat Rev Mol Cell Biol 9, 747-758.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 747-758
    • Anjum, R.1    Blenis, J.2
  • 2
    • 36949005417 scopus 로고    scopus 로고
    • DNA damage signalling guards against activated oncogenes and tumour progression
    • DOI 10.1038/sj.onc.1210881, PII 1210881
    • Bartek J, Bartkova J, Lukas J (2007). DNA damage signalling guards against activated oncogenes and tumour progression. Oncogene 26, 7773-7779. (Pubitemid 350242463)
    • (2007) Oncogene , vol.26 , Issue.56 , pp. 7773-7779
    • Bartek, J.1    Bartkova, J.2    Lukas, J.3
  • 4
    • 0032698075 scopus 로고    scopus 로고
    • Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
    • Bonni A, Brunet A, West AE, Datta SR, Takasu MA, Greenberg ME (1999). Cell survival promoted by the Ras-MAPK signaling pathway by transcription- dependent and -independent mechanisms. Science 286, 1358-1362.
    • (1999) Science , vol.286 , pp. 1358-1362
    • Bonni, A.1    Brunet, A.2    West, A.E.3    Datta, S.R.4    Takasu, M.A.5    Greenberg, M.E.6
  • 5
    • 41149094512 scopus 로고    scopus 로고
    • Regulation of DNA repair throughout the cell cycle
    • DOI 10.1038/nrm2351, PII NRM2351
    • Branzei D, Foiani M (2008). Regulation of DNA repair throughout the cell cycle. Nature Rev 9, 297-308. (Pubitemid 351430844)
    • (2008) Nature Reviews Molecular Cell Biology , vol.9 , Issue.4 , pp. 297-308
    • Branzei, D.1    Foiani, M.2
  • 6
    • 79952435349 scopus 로고    scopus 로고
    • Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases
    • Cargnello M, Roux PP (2011). Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Microbiol Mol Biol Rev 75, 50-83.
    • (2011) Microbiol Mol Biol Rev , vol.75 , pp. 50-83
    • Cargnello, M.1    Roux, P.P.2
  • 7
    • 78649336706 scopus 로고    scopus 로고
    • The DNA damage response: Making it safe to play with knives
    • Ciccia A, Elledge SJ (2010). The DNA damage response: making it safe to play with knives. Mol Cell 40, 179-204.
    • (2010) Mol Cell , vol.40 , pp. 179-204
    • Ciccia, A.1    Elledge, S.J.2
  • 8
    • 47749141560 scopus 로고    scopus 로고
    • ATR: An essential regulator of genome integrity
    • DOI 10.1038/nrm2450, PII NRM2450
    • Cimprich KA, Cortez D (2008). ATR: an essential regulator of genome integrity. Nature Rev 9, 616-627. (Pubitemid 352032926)
    • (2008) Nature Reviews Molecular Cell Biology , vol.9 , Issue.8 , pp. 616-627
    • Cimprich, K.A.1    Cortez, D.2
  • 9
    • 67749122122 scopus 로고    scopus 로고
    • Targeting PI3K signalling in cancer: Opportunities, challenges and limitations
    • Engelman JA (2009). Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev Cancer 9, 550-562.
    • (2009) Nat Rev Cancer , vol.9 , pp. 550-562
    • Engelman, J.A.1
  • 10
    • 71749099636 scopus 로고    scopus 로고
    • Novel positive feedback loop between Cdk1 and Chk1 in the nucleus during G2/M transition
    • Enomoto M, Goto H, Tomono Y, Kasahara K, Tsujimura K, Kiyono T, Inagaki M (2009). Novel positive feedback loop between Cdk1 and Chk1 in the nucleus during G2/M transition. J Biol Chem 284, 34223-34230.
    • (2009) J Biol Chem , vol.284 , pp. 34223-34230
    • Enomoto, M.1    Goto, H.2    Tomono, Y.3    Kasahara, K.4    Tsujimura, K.5    Kiyono, T.6    Inagaki, M.7
  • 11
    • 79952454660 scopus 로고    scopus 로고
    • ATR: A master conductor of cellular responses to DNA replication stress
    • Flynn RL, Zou L (2011). ATR: a master conductor of cellular responses to DNA replication stress. Trends Biochem Sci 36, 133-140.
    • (2011) Trends Biochem Sci , vol.36 , pp. 133-140
    • Flynn, R.L.1    Zou, L.2
  • 12
    • 38449123339 scopus 로고    scopus 로고
    • Production of a site- and phosphorylation state-specific antibody
    • Goto H, Inagaki M (2007). Production of a site- and phosphorylation state-specific antibody. Nature Protoc 2, 2574-2581.
    • (2007) Nature Protoc , vol.2 , pp. 2574-2581
    • Goto, H.1    Inagaki, M.2
  • 13
    • 40449120350 scopus 로고    scopus 로고
    • An oncogene-induced DNA damage model for cancer development
    • DOI 10.1126/science.1140735
    • Halazonetis TD, Gorgoulis VG, Bartek J (2008). An oncogene-induced DNA damage model for cancer development. Science 319, 1352-1355. (Pubitemid 351354863)
    • (2008) Science , vol.319 , Issue.5868 , pp. 1352-1355
    • Halazonetis, T.D.1    Gorgoulis, V.G.2    Bartek, J.3
  • 14
    • 0035437146 scopus 로고    scopus 로고
    • DNA damage-induced cell-cycle arrest of hematopoietic cells is overridden by activation of the PI-3 kinase/Akt signaling pathway
    • Henry MK, Lynch JT, Eapen AK, Quelle FW (2001). DNA damage-induced cell-cycle arrest of hematopoietic cells is overridden by activation of the PI-3 kinase/Akt signaling pathway. Blood 98, 834-841.
    • (2001) Blood , vol.98 , pp. 834-841
    • Henry, M.K.1    Lynch, J.T.2    Eapen, A.K.3    Quelle, F.W.4
  • 15
    • 79952790040 scopus 로고    scopus 로고
    • Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein
    • Ibi M et al. (2011). Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein. J Cell Sci 124, 857-864.
    • (2011) J Cell Sci , vol.124 , pp. 857-864
    • Ibi, M.1
  • 17
    • 70350504453 scopus 로고    scopus 로고
    • The DNA-damage response in human biology and disease
    • Jackson SP, Bartek J (2009). The DNA-damage response in human biology and disease. Nature 461, 1071-1078.
    • (2009) Nature , vol.461 , pp. 1071-1078
    • Jackson, S.P.1    Bartek, J.2
  • 18
    • 30344463835 scopus 로고    scopus 로고
    • ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
    • DOI 10.1038/ncb1337, PII N1337
    • Jazayeri A, Falck J, Lukas C, Bartek J, Smith GC, Lukas J, Jackson SP (2006). ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat Cell Biol 8, 37-45. (Pubitemid 43064795)
    • (2006) Nature Cell Biology , vol.8 , Issue.1 , pp. 37-45
    • Jazayeri, A.1    Falck, J.2    Lukas, C.3    Bartek, J.4    Smith, G.C.M.5    Lukas, J.6    Jackson, S.P.7
  • 19
    • 0042242580 scopus 로고    scopus 로고
    • Regulation of Chk1 Includes Chromatin Association and 14-3-3 Binding following Phosphorylation on Ser-345
    • DOI 10.1074/jbc.M300070200
    • Jiang K, Pereira E, Maxfield M, Russell B, Goudelock DM, Sanchez Y (2003). Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345. J Biol Chem 278, 25207-25217. (Pubitemid 37548685)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.27 , pp. 25207-25217
    • Jiang, K.1    Pereira, E.2    Maxfield, M.3    Russell, B.4    Goudelock, D.M.5    Sanchez, Y.6
  • 20
    • 77955849465 scopus 로고    scopus 로고
    • 14-3-3gamma mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage
    • Kasahara K, Goto H, Enomoto M, Tomono Y, Kiyono T, Inagaki M (2010). 14-3-3gamma mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage. EMBO J 29, 2802-2812.
    • (2010) EMBO J , vol.29 , pp. 2802-2812
    • Kasahara, K.1    Goto, H.2    Enomoto, M.3    Tomono, Y.4    Kiyono, T.5    Inagaki, M.6
  • 21
    • 4644241295 scopus 로고    scopus 로고
    • Inhibition of Chk1 by activated PKB/Akt
    • King FW, Skeen J, Hay N, Shtivelman E (2004). Inhibition of Chk1 by activated PKB/Akt. Cell Cycle 3, 634-637. (Pubitemid 40278209)
    • (2004) Cell Cycle , vol.3 , Issue.5 , pp. 634-637
    • King, F.W.1    Skeen, J.2    Hay, N.3    Shtivelman, E.4
  • 23
    • 33847688584 scopus 로고    scopus 로고
    • Label-free kinase profiling using phosphate affinity polyacrylamide gel electrophoresis
    • DOI 10.1074/mcp.T600044-MCP200
    • Kinoshita-Kikuta E, Aoki Y, Kinoshita E, Koike T (2007). Label-free kinase profiling using phosphate affinity polyacrylamide gel electrophoresis. Mol Cell Proteomics 6, 356-366. (Pubitemid 46359522)
    • (2007) Molecular and Cellular Proteomics , vol.6 , Issue.2 , pp. 356-366
    • Kinoshita-Kikuta, E.1    Aoki, Y.2    Kinoshita, E.3    Koike, T.4
  • 25
    • 77949430065 scopus 로고    scopus 로고
    • The Akt/PKB family of protein kinases: A review of small molecule inhibitors and progress towards target validation: A 2009 update
    • Lindsley CW (2010). The Akt/PKB family of protein kinases: a review of small molecule inhibitors and progress towards target validation: a 2009 update. Curr Top Med Chem 10, 458-477.
    • (2010) Curr Top Med Chem , vol.10 , pp. 458-477
    • Lindsley, C.W.1
  • 26
    • 79651470785 scopus 로고    scopus 로고
    • Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics
    • Ma CX, Janetka JW, Piwnica-Worms H (2011). Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics. Trends Mol Med 17, 88-96.
    • (2011) Trends Mol Med , vol.17 , pp. 88-96
    • Ma, C.X.1    Janetka, J.W.2    Piwnica-Worms, H.3
  • 28
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB Signaling: Navigating Downstream
    • DOI 10.1016/j.cell.2007.06.009, PII S0092867407007751
    • Manning BD, Cantley LC (2007). AKT/PKB signaling: navigating downstream. Cell 129, 1261-1274. (Pubitemid 46962095)
    • (2007) Cell , vol.129 , Issue.7 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 30
    • 7744243520 scopus 로고    scopus 로고
    • The DNA damage response: Sensing and signaling
    • DOI 10.1016/j.ceb.2004.09.005, PII S0955067404001413
    • McGowan CH, Russell P (2004). The DNA damage response: sensing and signaling. Curr Opin Cell Biol 16, 629-633. (Pubitemid 39463112)
    • (2004) Current Opinion in Cell Biology , vol.16 , Issue.6 , pp. 629-633
    • McGowan, C.H.1    Russell, P.2
  • 31
    • 77949681661 scopus 로고    scopus 로고
    • Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor
    • Meuillet EJ et al. (2010). Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor. Mol Cancer Ther 9, 706-717.
    • (2010) Mol Cancer Ther , vol.9 , pp. 706-717
    • Meuillet, E.J.1
  • 32
    • 0037376173 scopus 로고    scopus 로고
    • Divide and conquer: Nucleotide excision repair battles cancer and ageing
    • DOI 10.1016/S0955-0674(03)00018-8
    • Mitchell JR, Hoeijmakers JH, Niedernhofer LJ (2003). Divide and conquer: nucleotide excision repair battles cancer and ageing. Curr Opin Cell Biol 15, 232-240. (Pubitemid 36332199)
    • (2003) Current Opinion in Cell Biology , vol.15 , Issue.2 , pp. 232-240
    • Mitchell, J.R.1    Hoeijmakers, J.H.J.2    Niedernhofer, L.J.3
  • 33
    • 78751697353 scopus 로고    scopus 로고
    • Nek10 mediates G2/M cell cycle arrest and MEK autoactivation in response to UV irradiation
    • Moniz LS, Stambolic V (2011). Nek10 mediates G2/M cell cycle arrest and MEK autoactivation in response to UV irradiation. Mol Cell Biol 31, 30-42.
    • (2011) Mol Cell Biol , vol.31 , pp. 30-42
    • Moniz, L.S.1    Stambolic, V.2
  • 34
    • 33344476097 scopus 로고    scopus 로고
    • DNA damage checkpoints in mammals
    • DOI 10.1093/mutage/gei063
    • Niida H, Nakanishi M (2006). DNA damage checkpoints in mammals. Mutagenesis 21, 3-9. (Pubitemid 43288730)
    • (2006) Mutagenesis , vol.21 , Issue.1 , pp. 3-9
    • Niida, H.1    Nakanishi, M.2
  • 35
    • 51849135030 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase signaling overrides a G2 phase arrest checkpoint and promotes aberrant cell cycling and death of hematopoietic cells after DNA damage
    • Nimbalkar D, Quelle FW (2008). Phosphoinositide 3-kinase signaling overrides a G2 phase arrest checkpoint and promotes aberrant cell cycling and death of hematopoietic cells after DNA damage. Cell Cycle 7, 2877-2885.
    • (2008) Cell Cycle , vol.7 , pp. 2877-2885
    • Nimbalkar, D.1    Quelle, F.W.2
  • 36
    • 33747792064 scopus 로고    scopus 로고
    • MAPK signalling: ERK5 versus ERK1/2
    • DOI 10.1038/sj.embor.7400755, PII 7400755
    • Nishimoto S, Nishida E (2006). MAPK signalling: ERK5 versus ERK1/2. EMBO Rep 7, 782-786. (Pubitemid 44275395)
    • (2006) EMBO Reports , vol.7 , Issue.8 , pp. 782-786
    • Nishimoto, S.1    Nishida, E.2
  • 38
    • 79952235291 scopus 로고    scopus 로고
    • Dynamics of DNA damage response proteins at DNA breaks: A focus on protein modifications
    • Polo SE, Jackson SP (2011). Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. Genes Dev 25, 409-433.
    • (2011) Genes Dev , vol.25 , pp. 409-433
    • Polo, S.E.1    Jackson, S.P.2
  • 39
    • 0033529549 scopus 로고    scopus 로고
    • Generation of constitutively active p90 ribosomal S6 kinase in vivo. Implications for the mitogen-activated protein kinase-activated protein kinase family
    • Poteet-Smith CE, Smith JA, Lannigan DA, Freed TA, Sturgill TW (1999). Generation of constitutively active p90 ribosomal S6 kinase in vivo. Implications for the mitogen-activated protein kinase-activated protein kinase family. J Biol Chem 274, 22135-22138.
    • (1999) J Biol Chem , vol.274 , pp. 22135-22138
    • Poteet-Smith, C.E.1    Smith, J.A.2    Lannigan, D.A.3    Freed, T.A.4    Sturgill, T.W.5
  • 41
    • 63749131243 scopus 로고    scopus 로고
    • Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2
    • Reinhardt HC, Yaffe MB (2009). Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2. Curr Opin Cell Biol 21, 245-255.
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 245-255
    • Reinhardt, H.C.1    Yaffe, M.B.2
  • 42
    • 3943107573 scopus 로고    scopus 로고
    • Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
    • DOI 10.1146/annurev.biochem.73.011303.073723
    • Sancar A, Lindsey-Boltz LA, Unsal-Kacmaz K, Linn S (2004). Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem 73, 39-85. (Pubitemid 39050363)
    • (2004) Annual Review of Biochemistry , vol.73 , pp. 39-85
    • Sancar, A.1    Lindsey-Boltz, L.A.2    Unsal-Kacmaz, K.3    Linn, S.4
  • 43
    • 0030867582 scopus 로고    scopus 로고
    • Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25
    • DOI 10.1126/science.277.5331.1497
    • Sanchez Y, Wong C, Thoma RS, Richman R, Wu Z, Piwnica-Worms H, Elledge SJ (1997). Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science 277, 1497-1501. (Pubitemid 27449236)
    • (1997) Science , vol.277 , Issue.5331 , pp. 1497-1501
    • Sanchez, Y.1    Wong, C.2    Thoma, R.S.3    Richman, R.4    Wu, Z.5    Piwnica-Worms, H.6    Elledge, S.J.7
  • 47
    • 0037018847 scopus 로고    scopus 로고
    • A role for PI 3-kinase and PKB activity in the G2/M phase of the cell cycle
    • DOI 10.1016/S0960-9822(02)00843-6, PII S0960982202008436
    • Shtivelman E, Sussman J, Stokoe D (2002). A role for PI 3-kinase and PKB activity in the G2/M phase of the cell cycle. Curr Biol 12, 919-924. (Pubitemid 34689227)
    • (2002) Current Biology , vol.12 , Issue.11 , pp. 919-924
    • Shtivelman, E.1    Sussman, J.2    Stokoe, D.3
  • 48
    • 0033520937 scopus 로고    scopus 로고
    • RSK blocks bad-mediated cell death via a protein kinase C-dependent pathway
    • Tan Y, Ruan H, Demeter MR, Comb MJ (1999). p90(RSK) blocks bad-mediated cell death via a protein kinase C-dependent pathway. J Biol Chem 274, 34859-34867. (Pubitemid 129509532)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.49 , pp. 34859-34867
    • Tan, Y.1    Ruan, H.2    Demeter, M.R.3    Comb, M.J.4
  • 49
    • 77954937159 scopus 로고    scopus 로고
    • Akt activation emulates Chk1 inhibition and Bcl2 overexpression and abrogates G2 cell cycle checkpoint by inhibiting BRCA1 foci
    • Tonic I, Yu WN, Park Y, Chen CC, Hay N (2010). Akt activation emulates Chk1 inhibition and Bcl2 overexpression and abrogates G2 cell cycle checkpoint by inhibiting BRCA1 foci. J Biol Chem 285, 23790-23798.
    • (2010) J Biol Chem , vol.285 , pp. 23790-23798
    • Tonic, I.1    Yu, W.N.2    Park, Y.3    Chen, C.C.4    Hay, N.5
  • 50
    • 0037031828 scopus 로고    scopus 로고
    • Signal transduction from N-cadherin increases Bcl-2. Regulation of the phosphatidylinositol 3-kinase/Akt pathway by homophilic adhesion and actin cytoskeletal organization
    • DOI 10.1074/jbc.M200300200
    • Tran NL, Adams DG, Vaillancourt RR, Heimark RL (2002). Signal transduction from N-cadherin increases Bcl-2. Regulation of the phosphatidylinositol 3-kinase/Akt pathway by homophilic adhesion and actin cytoskeletal organization. J Biol Chem 277, 32905-32914. (Pubitemid 34984804)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.36 , pp. 32905-32914
    • Tran, N.L.1    Adams, D.G.2    Vaillancourt, R.R.3    Heimark, R.L.4
  • 51
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase-AKT pathway in human cancer
    • Vivanco I, Sawyers CL (2002). The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2, 489-501. (Pubitemid 37328931)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.7 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 52
    • 67649253108 scopus 로고    scopus 로고
    • Chk1 Cterminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity
    • Walker M, Black EJ, Oehler V, Gillespie DA, Scott MT (2009). Chk1 Cterminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity. Oncogene 28, 2314-2323.
    • (2009) Oncogene , vol.28 , pp. 2314-2323
    • Walker, M.1    Black, E.J.2    Oehler, V.3    Gillespie, D.A.4    Scott, M.T.5
  • 55
    • 0034967556 scopus 로고    scopus 로고
    • ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
    • DOI 10.1128/MCB.21.13.4129-4139.2001
    • Zhao H, Piwnica-Worms H (2001). ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol Cell Biol 21, 4129-4139. (Pubitemid 32565295)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.13 , pp. 4129-4139
    • Zhao, H.1    Piwnica-Worms, H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.