메뉴 건너뛰기




Volumn 1, Issue 1, 2012, Pages

Targeted in situ gene correction of dysfunctional APOE alleles to produce atheroprotective plasma ApoE3 protein

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; APOLIPOPROTEIN E; APOLIPOPROTEIN E3; ENDONUCLEASE; OLIGONUCLEOTIDE; PLASMID DNA; SINGLE STRANDED DNA;

EID: 84862272272     PISSN: None     EISSN: 20900597     Source Type: Journal    
DOI: 10.1155/2012/148796     Document Type: Review
Times cited : (9)

References (153)
  • 2
    • 17644412023 scopus 로고    scopus 로고
    • Mechanisms of disease: Inflammation, atherosclerosis, and coronary artery disease
    • Hansson G. K., Mechanisms of disease: inflammation, atherosclerosis, and coronary artery disease The New England Journal of Medicine 2005 352 16 1685 1626
    • (2005) The New England Journal of Medicine , vol.352 , Issue.16 , pp. 1685-1626
    • Hansson, G.K.1
  • 3
    • 69749115691 scopus 로고    scopus 로고
    • Enhancing cardiovascular disease risk reduction: Raising high-density lipoprotein levels
    • Hausenloy D. J., Yellon D. M., Enhancing cardiovascular disease risk reduction: raising high-density lipoprotein levels Current Opinion in Cardiology 2009 24 5 473 482
    • (2009) Current Opinion in Cardiology , vol.24 , Issue.5 , pp. 473-482
    • Hausenloy, D.J.1    Yellon, D.M.2
  • 4
    • 14944381287 scopus 로고    scopus 로고
    • HDL as a target in the treatment of atherosclerotic cardiovascular disease
    • DOI 10.1038/nrd1658
    • Linsel-Nitschke P., Tall A. R., HDL as a target in the treatment of atherosclerotic cardiovascular disease Nature Reviews Drug Discovery 2005 4 3 193 205 (Pubitemid 40372554)
    • (2005) Nature Reviews Drug Discovery , vol.4 , Issue.3 , pp. 193-205
    • Linsel-Nitschke, P.1    Tall, A.R.2
  • 5
    • 79952514300 scopus 로고    scopus 로고
    • Ezetimibe, cardiovascular risk and atherogenic dyslipidaemia
    • Rizzo M., Rini G. B., Ezetimibe, cardiovascular risk and atherogenic dyslipidaemia Archives of Medical Science 2011 7 1 5 7
    • (2011) Archives of Medical Science , vol.7 , Issue.1 , pp. 5-7
    • Rizzo, M.1    Rini, G.B.2
  • 6
    • 37349106003 scopus 로고    scopus 로고
    • Human cholesterol metabolism and therapeutic molecules
    • DOI 10.1113/expphysiol.2007.035147
    • Charlton-Menys V., Durrington P. N., Human cholesterol metabolism and therapeutic molecules Experimental Physiology 2008 93 1 27 42 (Pubitemid 350293976)
    • (2008) Experimental Physiology , vol.93 , Issue.1 , pp. 27-42
    • Charlton-Menys, V.1    Durrington, P.N.2
  • 7
    • 69849109122 scopus 로고    scopus 로고
    • Update on strategies to increase HDL quantity and function
    • Duffy D., Rader D. J., Update on strategies to increase HDL quantity and function Nature Reviews 2009 6 7 455 463
    • (2009) Nature Reviews , vol.6 , Issue.7 , pp. 455-463
    • Duffy, D.1    Rader, D.J.2
  • 8
    • 79952008123 scopus 로고    scopus 로고
    • Apolipoprotein A-I therapy: Promise, challenges, and disappointment
    • Davidson M. H., Apolipoprotein A-I therapy: promise, challenges, and disappointment Journal of the American College of Cardiology 2011 57 9 1120 1121
    • (2011) Journal of the American College of Cardiology , vol.57 , Issue.9 , pp. 1120-1121
    • Davidson, M.H.1
  • 9
    • 79955476272 scopus 로고    scopus 로고
    • Novel HDL-directed pharmacotherapeutic strategies
    • deGoma E. M., Rader D. J., Novel HDL-directed pharmacotherapeutic strategies Nature Reviews Cardiology 2011 8 5 266 277
    • (2011) Nature Reviews Cardiology , vol.8 , Issue.5 , pp. 266-277
    • Degoma, E.M.1    Rader, D.J.2
  • 11
    • 78651350647 scopus 로고    scopus 로고
    • PCSK9: An emerging target for treatment of hypercholesterolemia
    • Duff C. J., Hooper N. M., PCSK9: an emerging target for treatment of hypercholesterolemia Expert Opinion on Therapeutic Targets 2011 15 2 157 168
    • (2011) Expert Opinion on Therapeutic Targets , vol.15 , Issue.2 , pp. 157-168
    • Duff, C.J.1    Hooper, N.M.2
  • 12
    • 79957923056 scopus 로고    scopus 로고
    • Unexpected roles for PCSK9 in lipid metabolism
    • Soutar A. K., Unexpected roles for PCSK9 in lipid metabolism Current Opinion in Lipidology 2011 22 3 192 196
    • (2011) Current Opinion in Lipidology , vol.22 , Issue.3 , pp. 192-196
    • Soutar, A.K.1
  • 13
    • 77956244457 scopus 로고    scopus 로고
    • Apolipoprotein A-I and its mimetics for the treatment of atherosclerosis
    • Smith J. D., Apolipoprotein A-I and its mimetics for the treatment of atherosclerosis Current Opinion in Investigational Drugs 2010 11 9 989 996
    • (2010) Current Opinion in Investigational Drugs , vol.11 , Issue.9 , pp. 989-996
    • Smith, J.D.1
  • 14
    • 33846554963 scopus 로고    scopus 로고
    • Sustained phenotypic correction in a mouse model of hypoalphalipoproteinemia with a helper-dependent adenovirus vector
    • DOI 10.1038/sj.gt.3302819, PII 3302819
    • Oka K., Belalcazar L. M., Dieker C., Nour E. A., Nuno-Gonzalez P., Paul A., Cormier S., Shin J. K., Finegold M., Chan L., Sustained phenotypic correction in a mouse model of hypoalphalipoproteinemia with a helper-dependent adenovirus vector Gene Therapy 2007 14 3 191 202 (Pubitemid 46152622)
    • (2007) Gene Therapy , vol.14 , Issue.3 , pp. 191-202
    • Oka, K.1    Belalcazar, L.M.2    Dieker, C.3    Nour, E.A.4    Nuno-Gonzalez, P.5    Paul, A.6    Cormier, S.7    Shin, J.-K.8    Finegold, M.9    Chan, L.10
  • 16
    • 20444398284 scopus 로고    scopus 로고
    • The key role of apolipoprotein e in atherosclerosis
    • DOI 10.1007/s00109-004-0631-3
    • Greenow K., Pearce N. J., Ramji D. P., The key role of apolipoprotein E in atherosclerosis Journal of Molecular Medicine 2005 83 5 329 342 (Pubitemid 41201798)
    • (2005) Journal of Molecular Medicine , vol.83 , Issue.5 , pp. 329-342
    • Greenow, K.1    Pearce, N.J.2    Ramji, D.P.3
  • 17
    • 33746311471 scopus 로고    scopus 로고
    • Apolipoprotein E structure: insights into function
    • DOI 10.1016/j.tibs.2006.06.008, PII S0968000406001708
    • Hatters D. M., Peters-Libeu C. A., Weisgraber K. H., Apolipoprotein E structure: insights into function Trends in Biochemical Sciences 2006 31 8 445 454 (Pubitemid 44108662)
    • (2006) Trends in Biochemical Sciences , vol.31 , Issue.8 , pp. 445-454
    • Hatters, D.M.1    Peters-Libeu, C.A.2    Weisgraber, K.H.3
  • 19
    • 0032743737 scopus 로고    scopus 로고
    • Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia): Questions, quandaries, and paradoxes
    • Mahley R. W., Huang Y., Rall S. C., Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia): questions, quandaries, and paradoxes Journal of Lipid Research 1999 40 11 1933 1949 (Pubitemid 29523420)
    • (1999) Journal of Lipid Research , vol.40 , Issue.11 , pp. 1933-1949
    • Mahley, R.W.1    Huang, Y.2    Rall Jr., S.C.3
  • 20
    • 15944403233 scopus 로고    scopus 로고
    • Plasma triglycerides and type III hyperlipidemia are independently associated with premature familial coronary artery disease
    • DOI 10.1016/j.jacc.2004.11.062
    • Hopkins P. N., Wu L. L., Hunt S. C., Brinton E. A., Plasma triglycerides and type III hyperlipidemia are independently associated with premature familial coronary artery disease Journal of the American College of Cardiology 2005 45 7 1003 1012 (Pubitemid 40432430)
    • (2005) Journal of the American College of Cardiology , vol.45 , Issue.7 , pp. 1003-1012
    • Hopkins, P.N.1    Wu, L.L.2    Hunt, S.C.3    Brinton, E.A.4
  • 21
    • 33644857332 scopus 로고    scopus 로고
    • Does Apolipoprotein E genotype influence the risk of ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage? Systematic review and meta-analyses of 31 studies among 5961 cases and 17 965 controls
    • DOI 10.1161/01.STR.0000199065.12908.62, PII 0000767020060200000051
    • Sudlow C., Martnez Gonzlez N. A., Kim J., Clark C., Does Apolipoprotein E genotype influence the risk of ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage? Systematic review and meta-analyses of 31 studies among 5961 cases and 17 965 controls Stroke 2006 37 2 364 370 (Pubitemid 43731988)
    • (2006) Stroke , vol.37 , Issue.2 , pp. 364-370
    • Sudlow, C.1    Martinez Gonzalez, N.A.2    Kim, J.3    Clark, C.4
  • 23
    • 3142706539 scopus 로고    scopus 로고
    • Meta-analysis: Apolipoprotein E genotypes and risk for coronary heart disease
    • Song Y., Stampfer M. J., Liu S., Meta-analysis: apolipoprotein E genotypes and risk for coronary heart disease Annals of Internal Medicine 2004 141 2 137 147 (Pubitemid 38937836)
    • (2004) Annals of Internal Medicine , vol.141 , Issue.2 , pp. 137-147
    • Song, Y.1    Stampfer, M.J.2    Liu, S.3
  • 25
    • 84855949513 scopus 로고    scopus 로고
    • Commentary on the paper by Gustavsson et al. entitled Interaction of apolipoprotein e genotype with smoking and physical inactivity on coronary heart disease risk in men and women
    • Talmud P. J., Commentary on the paper by Gustavsson et al. entitled Interaction of apolipoprotein E genotype with smoking and physical inactivity on coronary heart disease risk in men and women Atherosclerosis 2012 220 2 323 324
    • (2012) Atherosclerosis , vol.220 , Issue.2 , pp. 323-324
    • Talmud, P.J.1
  • 30
    • 33745614059 scopus 로고    scopus 로고
    • Apolipoprotein E and coronary disease: A puzzling paradox
    • DOI 10.1371/journal.pmed.0030258
    • Reilly M., Rader D. J., Apolipoprotein E and coronary disease: a puzzling paradox PLoS Medicine 2006 3 6 0736 0738 (Pubitemid 43987810)
    • (2006) PLoS Medicine , vol.3 , Issue.6 , pp. 0736-0738
    • Reilly, M.1    Rader, D.J.2
  • 31
    • 33846007667 scopus 로고    scopus 로고
    • Atherogenic remnant lipoproteins: Role for proteoglycans in trapping, transferring, and internalizing
    • DOI 10.1172/JCI30889
    • Mahley R. W., Huang Y., Atherogenic remnant lipoproteins: role for proteoglycans in trapping, transferring, and internalizing Journal of Clinical Investigation 2007 117 1 94 98 (Pubitemid 46048456)
    • (2007) Journal of Clinical Investigation , vol.117 , Issue.1 , pp. 94-98
    • Mahley, R.W.1    Huang, Y.2
  • 32
    • 66349085616 scopus 로고    scopus 로고
    • Apolipoprotein E: Structure determines function, from atherosclerosis to Alzheimer's disease to AIDS
    • Mahley R. W., Weisgraber K. H., Huang Y., Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS Journal of lipid research 2009 50 S183 188
    • (2009) Journal of Lipid Research , vol.50 , pp. 183-188
    • Mahley, R.W.1    Weisgraber, K.H.2    Huang, Y.3
  • 34
    • 0028871379 scopus 로고
    • Effects of the apolipoprotein e polymorphism on uptake and transfer of cell-derived cholesterol in plasma
    • Huang Y., von Eckardstein A., Wu S., Assmann G., Effects of the apolipoprotein E polymorphism on uptake and transfer of cell-derived cholesterol in plasma Journal of Clinical Investigation 1995 96 6 2693 2701
    • (1995) Journal of Clinical Investigation , vol.96 , Issue.6 , pp. 2693-2701
    • Huang, Y.1    Von Eckardstein, A.2    Wu, S.3    Assmann, G.4
  • 35
    • 0032522990 scopus 로고    scopus 로고
    • Phenotype-dependent differences in apolipoprotein e metabolism and in cholesterol homeostasis in human monocyte-derived macrophages
    • Cullen P., Cignarella A., Brennhausen B., Mohr S., Assmann G., von Eckardstein A., Phenotype-dependent differences in apolipoprotein E metabolism and in cholesterol homeostasis in human monocyte-derived macrophages Journal of Clinical Investigation 1998 101 8 1670 1677 (Pubitemid 28198496)
    • (1998) Journal of Clinical Investigation , vol.101 , Issue.8 , pp. 1670-1677
    • Cullen, P.1    Cignarella, A.2    Brennhausen, B.3    Mohr, S.4    Assmann, G.5    Von Eckardstein, A.6
  • 37
    • 23044470784 scopus 로고    scopus 로고
    • Understanding hyperlipidemia and atherosclerosis: Lessons from genetically modified apoe and ldlr mice
    • DOI 10.1515/CCLM.2005.085
    • Wouters K., Shiri-Sverdlov R., van Gorp P. J., van Bilsen M., Hofker M. H., Understanding hyperlipidemia and atherosclerosis: lessons from genetically modified apoe and ldlr mice Clinical Chemistry and Laboratory Medicine 2005 43 5 470 479 (Pubitemid 41460623)
    • (2005) Clinical Chemistry and Laboratory Medicine , vol.43 , Issue.5 , pp. 470-479
    • Wouters, K.1    Shiri-Sverdlov, R.2    Van Gorp, P.J.3    Van Bilsen, M.4    Hofker, M.H.5
  • 38
    • 0026725757 scopus 로고
    • Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
    • Plump A. S., Smith J. D., Hayek T., Aalto-Setala K., Walsh A., Verstuyft J. G., Rubin E. M., Breslow J. L., Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells Cell 1992 71 2 343 353
    • (1992) Cell , vol.71 , Issue.2 , pp. 343-353
    • Plump, A.S.1    Smith, J.D.2    Hayek, T.3    Aalto-Setala, K.4    Walsh, A.5    Verstuyft, J.G.6    Rubin, E.M.7    Breslow, J.L.8
  • 39
    • 0030741533 scopus 로고    scopus 로고
    • Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis
    • DOI 10.1074/jbc.272.29.17972
    • Sullivan P. M., Mezdour H., Aratani Y., Knouff C., Najib J., Reddick R. L., Quarfordt S. H., Maeda N., Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis The Journal of Biological Chemistry 1997 272 29 17972 17980 (Pubitemid 27306374)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.29 , pp. 17972-17980
    • Sullivan, P.M.1    Mezdour, H.2    Aratani, Y.3    Knouff, C.4    Najib, J.5    Reddick, R.L.6    Quarfordt, S.H.7    Maeda, N.8
  • 40
    • 0032128001 scopus 로고    scopus 로고
    • Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human APOE*2
    • Sullivan P. M., Mezdour H., Quarfordt S. H., Maeda N., Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human APOE2 Journal of Clinical Investigation 1998 102 1 130 135 (Pubitemid 28323839)
    • (1998) Journal of Clinical Investigation , vol.102 , Issue.1 , pp. 130-135
    • Sullivan, P.M.1    Mezdour, H.2    Quarfordt, S.H.3    Maeda, N.4
  • 41
    • 0028339789 scopus 로고
    • Variable heparan sulfate proteoglycan binding of apolipoprotein E variants may modulate the expression of type III hyperlipoproteinemia
    • Ji Z. S., Fazio S., Mahley R. W., Variable heparan sulfate proteoglycan binding of apolipoprotein E variants may modulate the expression of type III hyperlipoproteinemia The Journal of Biological Chemistry 1994 269 18 13421 13428 (Pubitemid 24206115)
    • (1994) Journal of Biological Chemistry , vol.269 , Issue.18 , pp. 13421-13428
    • Ji, Z.-S.1    Fazio, S.2    Mahley, R.W.3
  • 42
    • 0033889707 scopus 로고    scopus 로고
    • ApoE in atherosclerosis: A protein with multiple hats
    • Curtiss L. K., ApoE in atherosclerosis: a protein with multiple hats Arteriosclerosis, Thrombosis, and Vascular Biology 2000 20 8 1852 1853 (Pubitemid 30644632)
    • (2000) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.20 , Issue.8 , pp. 1852-1853
    • Curtiss, L.K.1
  • 43
    • 13244278292 scopus 로고    scopus 로고
    • Apolipoprotein E and atherosclerosis beyond lipid effect
    • DOI 10.1161/01.ATV.0000154570.50696.2c
    • Davignon J., Apolipoprotein E and atherosclerosis beyond lipid effect Arteriosclerosis, Thrombosis, and Vascular Biology 2005 25 2 267 269 (Pubitemid 40189142)
    • (2005) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.25 , Issue.2 , pp. 267-269
    • Davignon, J.1
  • 44
    • 80052659139 scopus 로고    scopus 로고
    • Cross-talk between apolipoprotein e and cytokines
    • Zhang H., Wu L. M., Wu J., Cross-talk between apolipoprotein E and cytokines Mediators of Inflammation 2011 2011 10
    • (2011) Mediators of Inflammation , vol.2011 , pp. 10
    • Zhang, H.1    Wu, L.M.2    Wu, J.3
  • 45
    • 0028135706 scopus 로고
    • Apolipoprotein E inhibition of proliferation of mitogen-activated T lymphocytes: Production of interleukin 2 with reduced biological activity
    • DOI 10.1006/cimm.1994.1302
    • Kelly M. E., Clay M. A., Mistry M. J., Hsieh-Li H. M., Harmony J. A. K., Apolipoprotein E inhibition of proliferation of mitogen-activated T lymphocytes: production of interleukin 2 with reduced biological activity Cellular Immunology 1994 159 2 124 139 (Pubitemid 24381044)
    • (1994) Cellular Immunology , vol.159 , Issue.2 , pp. 124-139
    • Kelly, M.E.1    Clay, M.A.2    Mistry, M.J.3    Hsieh-Li, H.-M.4    Harmony, J.A.K.5
  • 46
    • 0031022828 scopus 로고    scopus 로고
    • Apolipoprotein E inhibits platelet aggregation through the L- arginine:nitric oxide pathway: Implications for vascular disease
    • DOI 10.1074/jbc.272.1.89
    • Riddell D. R., Graham A., Owen J. S., Apolipoprotein E inhibits platelet aggregation through the L- arginine:nitric oxide pathway: implications for vascular disease The Journal of Biological Chemistry 1997 272 1 89 95 (Pubitemid 27021129)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.1 , pp. 89-95
    • Riddell, D.R.1    Graham, A.2    Owen, J.S.3
  • 48
    • 0037430967 scopus 로고    scopus 로고
    • Apolipoprotein E (apoE) isoforms differentially induce nitric oxide production in endothelial cells
    • DOI 10.1016/S0014-5793(03)00261-8
    • Sacre S. M., Stannard A. K., Owen J. S., Apolipoprotein E (apoE) isoforms differentially induce nitric oxide production in endothelial cells FEBS Letters 2003 540 13 181 187 (Pubitemid 36398054)
    • (2003) FEBS Letters , vol.540 , Issue.1-3 , pp. 181-187
    • Sacre, S.M.1    Stannard, A.K.2    Owen, J.S.3
  • 49
    • 11444259796 scopus 로고    scopus 로고
    • Distinct signaling mechanisms for apoE inhibition of cell migration and proliferation
    • DOI 10.1016/j.neurobiolaging.2004.02.030, PII S019745800400274X, Developmental Origins of Aging in the Brain and Blood Vessels
    • Hui D. Y., Basford J. E., Distinct signaling mechanisms for apoE inhibition of cell migration and proliferation Neurobiology of Aging 2005 26 3 317 323 (Pubitemid 40082714)
    • (2005) Neurobiology of Aging , vol.26 , Issue.3 , pp. 317-323
    • Hui, D.Y.1    Basford, J.E.2
  • 50
    • 0037071843 scopus 로고    scopus 로고
    • Subendothelial retention of atherogenic lipoproteins in early atherosclerosis
    • DOI 10.1038/nature00804
    • Sklén K., Gustafsson M., Knutsen Rydberg E., Hultén L. M., Wiklund O., Innerarity T. L., Boren J., Subendothelial retention of atherogenic lipoproteins in early atherosclerosis Nature 2002 417 6890 750 754 (Pubitemid 34640629)
    • (2002) Nature , vol.417 , Issue.6890 , pp. 750-754
    • Skalen, K.1    Gustafsson, M.2    Knutsen Rydberg, E.3    Hulten, L.M.4    Wiklund, O.5    Innerarity, T.L.6    Boren, J.7
  • 52
    • 0029765553 scopus 로고    scopus 로고
    • Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and β-amyloid peptides
    • DOI 10.1038/ng0996-55
    • Miyata M., Smith J. D., Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and -amyloid peptides Nature Genetics 1996 14 1 55 61 (Pubitemid 26301547)
    • (1996) Nature Genetics , vol.14 , Issue.1 , pp. 55-61
    • Miyata, M.1    Smith, J.D.2
  • 53
    • 18844375108 scopus 로고    scopus 로고
    • The receptor binding domain of apolipoprotein E is responsible for its antioxidant activity
    • DOI 10.1021/bi0472696
    • Pham T., Kodvawala A., Hui D. Y., The receptor binding domain of apolipoprotein E is responsible for its antioxidant activity Biochemistry 2005 44 20 7577 7582 (Pubitemid 40696011)
    • (2005) Biochemistry , vol.44 , Issue.20 , pp. 7577-7582
    • Pham, T.1    Kodvawala, A.2    Hui, D.Y.3
  • 55
    • 33947594338 scopus 로고    scopus 로고
    • Apoprotein e isoform-dependent expression and secretion of pro-inflammatory cytokines TNF- and IL-6 in macrophages
    • Tsoi L. M., Wong K. Y., Liu Y. M., Ho Y. Y., Apoprotein E isoform-dependent expression and secretion of pro-inflammatory cytokines TNF- and IL-6 in macrophages Archives of Biochemistry and Biophysics 2007 460 1 33 40
    • (2007) Archives of Biochemistry and Biophysics , vol.460 , Issue.1 , pp. 33-40
    • Tsoi, L.M.1    Wong, K.Y.2    Liu, Y.M.3    Ho, Y.Y.4
  • 56
    • 0028059454 scopus 로고
    • Increased plasma and lipoprotein lipid peroxidation in apo E-deficient mice
    • DOI 10.1006/bbrc.1994.1883
    • Hayek T., Oiknine J., Brook J. G., Aviram M., Increased plasma and lipoprotein lipid peroxidation in apo E-deficient mice Biochemical and Biophysical Research Communications 1994 201 3 1567 1574 (Pubitemid 24234268)
    • (1994) Biochemical and Biophysical Research Communications , vol.201 , Issue.3 , pp. 1567-1574
    • Hayek, T.1    Oiknine, J.2    Brook, J.G.3    Aviram, M.4
  • 57
    • 8444242086 scopus 로고    scopus 로고
    • Apolipoprotein E modulates clearance of apoptotic bodies in vitro and in vivo, resulting in a systemic proinflammatory state in apolipoprotein E-deficient mice
    • Grainger D. J., Reckless J., McKilligin E., Apolipoprotein E modulates clearance of apoptotic bodies in vitro and in vivo, resulting in a systemic proinflammatory state in apolipoprotein E-deficient mice Journal of Immunology 2004 173 10 6366 6375 (Pubitemid 39487796)
    • (2004) Journal of Immunology , vol.173 , Issue.10 , pp. 6366-6375
    • Grainger, D.J.1    Reckless, J.2    McKilligin, E.3
  • 58
    • 27644482670 scopus 로고    scopus 로고
    • Apolipoprotein E suppresses the type I inflammatory response in vivo
    • DOI 10.1161/01.RES.0000187467.67684.43
    • Ali K., Middleton M., Puré E., Rader D. J., Apolipoprotein E suppresses the type I inflammatory response in vivo Circulation Research 2005 97 9 922 927 (Pubitemid 41552678)
    • (2005) Circulation Research , vol.97 , Issue.9 , pp. 922-927
    • Ali, K.1    Middleton, M.2    Pure, E.3    Rader, D.J.4
  • 59
    • 0031687891 scopus 로고    scopus 로고
    • Apolipoprotein E-deficient mice have impaired innate immune responses to Listeria monocytogenes in vivo
    • Roselaar S. E., Daugherty A., Apolipoprotein E-deficient mice have impaired innate immune responses to Listeria monocytogenes in vivo Journal of Lipid Research 1998 39 9 1740 1743 (Pubitemid 28411160)
    • (1998) Journal of Lipid Research , vol.39 , Issue.9 , pp. 1740-1743
    • Roselaar, S.E.1    Daugherty, A.2
  • 62
    • 0033877143 scopus 로고    scopus 로고
    • Low levels of extrahepatic nonmacrophage apoE inhibit atherosclerosis without correcting hypercholesterolemia in apoE-deficient mice
    • Thorngate F. E., Rudel L. L., Walzem R. L., Williams D. L., Low levels of extrahepatic nonmacrophage apoE inhibit atherosclerosis without correcting hypercholesterolemia in apoE-deficient mice Arteriosclerosis, Thrombosis, and Vascular Biology 2000 20 8 1939 1945 (Pubitemid 30644644)
    • (2000) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.20 , Issue.8 , pp. 1939-1945
    • Thorngate, F.E.1    Rudel, L.L.2    Walzem, R.L.3    Williams, D.L.4
  • 63
    • 13244290159 scopus 로고    scopus 로고
    • Apolipoprotein E promotes the regression of atherosclerosis independently of lowering plasma cholesterol levels
    • DOI 10.1161/01.ATV.0000152613.83243.12
    • Raffai R. L., Loeb S. M., Weisgraber K. H., Apolipoprotein E promotes the regression of atherosclerosis independently of lowering plasma cholesterol levels Arteriosclerosis, Thrombosis, and Vascular Biology 2005 25 2 436 441 (Pubitemid 40189170)
    • (2005) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.25 , Issue.2 , pp. 436-441
    • Raffai, R.L.1    Loeb, S.M.2    Weisgraber, K.H.3
  • 65
    • 0031975646 scopus 로고    scopus 로고
    • An apolipoprotein E synthetic peptide targets to lipoproteins in plasma and mediates both cellular lipoprotein interactions in vitro and acute clearance of cholesterol-rich lipoproteins in vivo
    • Nikoulin I. R., Curtiss L. K., An apolipoprotein E synthetic peptide targets to lipoproteins in plasma and mediates both cellular lipoprotein interactions in vitro and acute clearance of cholesterol-rich lipoproteins in vivo Journal of Clinical Investigation 1998 101 1 223 234 (Pubitemid 28058922)
    • (1998) Journal of Clinical Investigation , vol.101 , Issue.1 , pp. 223-234
    • Nikoulin, I.R.1    Curtiss, L.K.2
  • 72
    • 0028883354 scopus 로고
    • Macrophage-specific expression of human apolipoprotein e reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice
    • Bellosta S., Mahley R. W., Sanan D. A., Murata J., Newland D. L., Taylor J. M., Pitas R. E., Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice Journal of Clinical Investigation 1995 96 5 2170 2179
    • (1995) Journal of Clinical Investigation , vol.96 , Issue.5 , pp. 2170-2179
    • Bellosta, S.1    Mahley, R.W.2    Sanan, D.A.3    Murata, J.4    Newland, D.L.5    Taylor, J.M.6    Pitas, R.E.7
  • 73
    • 0028944150 scopus 로고
    • Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation
    • Linton M. F., Atkinson J. B., Fazio S., Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation Science 1995 267 5200 1034 1037
    • (1995) Science , vol.267 , Issue.5200 , pp. 1034-1037
    • Linton, M.F.1    Atkinson, J.B.2    Fazio, S.3
  • 74
    • 0033786210 scopus 로고    scopus 로고
    • Effect of macrophage-derived apolipoprotein e on established atherosclerosis in apolipoprotein E-deficient mice
    • Shi W., Wang X., Wang N. J., McBride W. H., Lusis A. J., Effect of macrophage-derived apolipoprotein E on established atherosclerosis in apolipoprotein E-deficient mice Arteriosclerosis, Thrombosis, and Vascular Biology 2000 20 10 2261 2266
    • (2000) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.20 , Issue.10 , pp. 2261-2266
    • Shi, W.1    Wang, X.2    Wang, N.J.3    McBride, W.H.4    Lusis, A.J.5
  • 76
    • 0030857810 scopus 로고    scopus 로고
    • Liver-directed gene transfer and prolonged expression of three major human apoE isoforms in apoE-deficient mice
    • Tsukamoto K., Smith P., Glick J. M., Rader D. J., Liver-directed gene transfer and prolonged expression of three major human apoE isoforms in apoE-deficient mice Journal of Clinical Investigation 1997 100 1 107 114 (Pubitemid 27311248)
    • (1997) Journal of Clinical Investigation , vol.100 , Issue.1 , pp. 107-114
    • Tsukamoto, K.1    Smith, P.2    Glick, J.M.3    Rader, D.J.4
  • 78
    • 0036151865 scopus 로고    scopus 로고
    • Acute regression of advanced and retardation of early aortic atheroma in immunocompetent apolipoprotein-E (apoE) deficient mice by administration of a second generation [E1-, E3-, polymerase-] adenovirus vector expressing human apoE
    • Harris J. D., Graham I. R., Schepelmann S., Stannard A. K., Roberts M. L., Hodges B. L., Hill V. J., Amalfitano A., Hassall D. G., Owen J. S., Dickson G., Acute regression of advanced and retardation of early aortic atheroma in immunocompetent apolipoprotein-E (apoE) deficient mice by administration of a second generation [E1 -, E31 -, polymerase1 - ] adenovirus vector expressing human apoE Human Molecular Genetics 2002 11 1 43 58 (Pubitemid 34100767)
    • (2002) Human Molecular Genetics , vol.11 , Issue.1 , pp. 43-58
    • Harris, J.D.1    Graham, I.R.2    Schepelmann, S.3    Stannard, A.K.4    Roberts, M.L.5    Hodges, B.L.6    Hill, V.J.7    Amalfitano, A.8    Hassall, D.G.9    Owen, J.S.10    Dickson, G.11
  • 81
    • 6344275675 scopus 로고    scopus 로고
    • Gene therapy with novel adeno-associated virus vectors substantially diminishes atherosclerosis in a murine model of familial hypercholesterolemia
    • DOI 10.1002/jgm.554
    • Lebherz C., Gao G., Louboutin J. P., Millar J., Rader D., Wilson J. M., Gene therapy with novel adeno-associated virus vectors substantially diminishes atherosclerosis in a murine model of familial hypercholesterolemia Journal of Gene Medicine 2004 6 6 663 672 (Pubitemid 40228082)
    • (2004) Journal of Gene Medicine , vol.6 , Issue.6 , pp. 663-672
    • Lebherz, C.1    Gao, G.2    Louboutin, J.-P.3    Millar, J.4    Rader, D.5    Wilson, J.M.6
  • 82
    • 10644289281 scopus 로고    scopus 로고
    • Unrestricted hepatocyte transduction with adeno-associated virus serotype 8 vectors in mice
    • DOI 10.1128/JVI.79.1.214-224.2005
    • Nakai H., Fuess S., Storm T. A., Muramatsu S. I., Nara Y., Kay M. A., Unrestricted hepatocyte transduction with adeno-associated virus serotype 8 vectors in mice Journal of Virology 2005 79 1 214 224 (Pubitemid 39650967)
    • (2005) Journal of Virology , vol.79 , Issue.1 , pp. 214-224
    • Nakai, H.1    Fuess, S.2    Storm, T.A.3    Muramatsu, S.-I.4    Nara, Y.5    Kay, M.A.6
  • 83
    • 0034842912 scopus 로고    scopus 로고
    • Sustained and complete phenotype correction of hemophilia B mice following intramuscular injection of AAV1 serotype vectors
    • DOI 10.1006/mthe.2001.0449
    • Chao H., Monahan P. E., Liu Y., Samulski R. J., Walsh C. E., Sustained and complete phenotype correction of hemophilia B mice following intramuscular injection of AAV1 serotype vectors Molecular Therapy 2001 4 3 217 222 (Pubitemid 32851285)
    • (2001) Molecular Therapy , vol.4 , Issue.3 , pp. 217-222
    • Chao, H.1    Monahan, P.E.2    Liu, Y.3    Samulski R.Jude4    Walsh, C.E.5
  • 84
  • 85
    • 17544383607 scopus 로고    scopus 로고
    • Gene transfer into skeletal muscle using novel AAV serotypes
    • DOI 10.1002/jgm.686
    • Louboutin J. P., Wang L., Wilson J. M., Gene transfer into skeletal muscle using novel AAV serotypes Journal of Gene Medicine 2005 7 4 442 451 (Pubitemid 40553125)
    • (2005) Journal of Gene Medicine , vol.7 , Issue.4 , pp. 442-451
    • Louboutin, J.-P.1    Wang, L.2    Wilson, J.M.3
  • 86
    • 1542347741 scopus 로고    scopus 로고
    • Rapid Uncoating of Vector Genomes Is the Key to Efficient Liver Transduction with Pseudotyped Adeno-Associated Virus Vectors
    • DOI 10.1128/JVI.78.6.3110-3122.2004
    • Thomas C. E., Storm T. A., Huang Z., Kay M. A., Rapid uncoating of vector genomes is the key to efficient liver transduction with pseudotyped adeno-associated virus vectors Journal of Virology 2004 78 6 3110 3122 (Pubitemid 38314369)
    • (2004) Journal of Virology , vol.78 , Issue.6 , pp. 3110-3122
    • Thomas, C.E.1    Storm, T.A.2    Huang, Z.3    Kay, M.A.4
  • 87
    • 0346777307 scopus 로고    scopus 로고
    • Adeno-associated virus terminal repeat (TR) mutant generates self-complementary vectors to overcome the rate-limiting step to transduction in vivo
    • DOI 10.1038/sj.gt.3302134
    • McCarty D. M., Fu H., Monahan P. E., Toulson C. E., Naik P., Samulski R. J., Adeno-associated virus terminal repeat (TR) mutant generates self-complementary vectors to overcome the rate-limiting step to transduction in vivo Gene Therapy 2003 10 26 2112 2118 (Pubitemid 37536760)
    • (2003) Gene Therapy , vol.10 , Issue.26 , pp. 2112-2118
    • McCarty, D.M.1    Fu, H.2    Monahan, P.E.3    Toulson, C.E.4    Naik, P.5    Samulski, R.J.6
  • 88
    • 33645528206 scopus 로고    scopus 로고
    • Self-complementary adeno-associated virus vectors containing a novel liver-specific human factor IX expression cassette enable highly efficient transduction of murine and nonhuman primate liver
    • Nathwani A. C., Gray J. T., Ng C. Y. C., Zhou J., Spence Y., Waddington S. N., Tuddenham E. G. D., Kemball-Cook G., McIntosh J., Boon-Spijker M., Mertens K., Davidoff A. M., Self-complementary adeno-associated virus vectors containing a novel liver-specific human factor IX expression cassette enable highly efficient transduction of murine and nonhuman primate liver Blood 2006 107 7 2653 2661
    • (2006) Blood , vol.107 , Issue.7 , pp. 2653-2661
    • Nathwani, A.C.1    Gray, J.T.2    Ng, C.Y.C.3    Zhou, J.4    Spence, Y.5    Waddington, S.N.6    Tuddenham, E.G.D.7    Kemball-Cook, G.8    McIntosh, J.9    Boon-Spijker, M.10    Mertens, K.11    Davidoff, A.M.12
  • 89
    • 67349236643 scopus 로고    scopus 로고
    • Preliminary evaluation of a self-complementary AAV2/8 vector for hepatic gene transfer of human apoE3 to inhibit atherosclerotic lesion development in apoE-deficient mice
    • Osman E., Evans V., Graham I. R., Athanasopoulos T., McIntosh J., Nathwani A. C., Simons J. P., Dickson G., Owen J. S., Preliminary evaluation of a self-complementary AAV2/8 vector for hepatic gene transfer of human apoE3 to inhibit atherosclerotic lesion development in apoE-deficient mice Atherosclerosis 2009 204 1 121 126
    • (2009) Atherosclerosis , vol.204 , Issue.1 , pp. 121-126
    • Osman, E.1    Evans, V.2    Graham, I.R.3    Athanasopoulos, T.4    McIntosh, J.5    Nathwani, A.C.6    Simons, J.P.7    Dickson, G.8    Owen, J.S.9
  • 92
  • 93
    • 46249124212 scopus 로고    scopus 로고
    • Human apolipoprotein E expression from mouse skeletal muscle by electrotransfer of nonviral DNA (plasmid) and pseudotyped recombinant adeno-associated virus (AAV2/7)
    • DOI 10.1089/hum.2007.169
    • Evans V., Foster H., Graham I. R., Foster K., Athanasopoulos T., Simons J. P., Dickson G., Owen J. S., Human apolipoprotein E expression from mouse skeletal muscle by electrotransfer of nonviral DNA (plasmid) and pseudotyped recombinant adeno-associated virus (AAV2/7) Human Gene Therapy 2008 19 6 569 578 (Pubitemid 351913528)
    • (2008) Human Gene Therapy , vol.19 , Issue.6 , pp. 569-578
    • Evans, V.1    Foster, H.2    Graham, I.R.3    Foster, K.4    Athanasopoulos, T.5    Simons, J.P.6    Dickson, G.7    Owen, J.S.8
  • 94
    • 79952993788 scopus 로고    scopus 로고
    • Adeno-associated virus serotypes 7 and 8 outperform serotype 9 in expressing atheroprotective human apoE3 from mouse skeletal muscle
    • Evans V. C., Graham I. R., Athanasopoulos T., Galley D. J., Jackson C. L., Simons J. P., Dickson G., Owen J. S., Adeno-associated virus serotypes 7 and 8 outperform serotype 9 in expressing atheroprotective human apoE3 from mouse skeletal muscle Metabolism 2011 60 4 491 498
    • (2011) Metabolism , vol.60 , Issue.4 , pp. 491-498
    • Evans, V.C.1    Graham, I.R.2    Athanasopoulos, T.3    Galley, D.J.4    Jackson, C.L.5    Simons, J.P.6    Dickson, G.7    Owen, J.S.8
  • 95
    • 0022389290 scopus 로고
    • Insertion of DNA sequences into the human chromosomal β-globin locus by homologous recombination
    • DOI 10.1038/317230a0
    • Smithies O., Gregg R. G., Boggs S. S., Koralewski M. A., Kucherlapati R. S., Insertion of DNA sequences into the human chromosomal -globin locus by homologous recombination Nature 1985 317 6034 230 234 (Pubitemid 16246494)
    • (1985) Nature , vol.317 , Issue.6034 , pp. 230-234
    • Smithies, O.1    Gregg, R.G.2    Boggs, S.S.3
  • 96
    • 0022542596 scopus 로고
    • High frequency targeting of genes to specific sites in the mammalian genome
    • Thomas K. R., Folger K. R., Capecchi M. R., High frequency targeting of genes to specific sites in the mammalian genome Cell 1986 44 3 419 428 (Pubitemid 16043333)
    • (1986) Cell , vol.44 , Issue.3 , pp. 419-428
    • Thomas, K.R.1    Folger, K.R.2    Capecchi, M.R.3
  • 98
  • 99
    • 0029817766 scopus 로고    scopus 로고
    • Correction of the mutation responsible for sickle cell anemia by an RNA- DNA oligonucleotide
    • Cole-Strauss A., Yoon K., Xiang Y., Byrne B. C., Rice M. C., Gryn J., Holloman W. K., Kmiec E. B., Correction of the mutation responsible for sickle cell anemia by an RNA- DNA oligonucleotide Science 1996 273 5280 1386 1389 (Pubitemid 26296526)
    • (1996) Science , vol.273 , Issue.5280 , pp. 1386-1389
    • Cole-Strauss, A.1    Yoon, K.2    Xiang, Y.3    Byrne, B.C.4    Rice, M.C.5    Gryn, J.6    Holloman, W.K.7    Kmiec, E.B.8
  • 100
    • 0030772320 scopus 로고    scopus 로고
    • +-enriched cell population using a chimeric RNA/DNA oligonucleotide
    • Xiang Y., Cole-Strauss A., Yoon K., Gryn J., Kmiec E. B., Targeted gene conversion in a mammalian CD34+-enriched cell population using a chimeric RNA/DNA oligonucleotide Journal of Molecular Medicine 1997 75 11-12 829 835 (Pubitemid 27511558)
    • (1997) Journal of Molecular Medicine , vol.75 , Issue.11-12 , pp. 829-835
    • Xiang, Y.1    Cole-Strauss, A.2    Yoon, K.3    Gryn, J.4    Kmiec, E.B.5
  • 101
    • 0031047639 scopus 로고    scopus 로고
    • Recombinant DNA technique and sickle cell anemia research [5]
    • Thomas K. R., Capecchi M. R., Recombinant DNA technique and sickle cell anemia research Science 1997 275 5305 1404 1405 (Pubitemid 27111249)
    • (1997) Science , vol.275 , Issue.5305 , pp. 1404-1405
    • Thomas, K.R.1    Capecchi, M.R.2    Kmiec, E.B.3
  • 102
    • 0030913556 scopus 로고    scopus 로고
    • Targeted nucleotide exchange in the alkaline phosphatase gene of HuH-7 cells mediated by a chimeric RNA/DNA oligonucleotide
    • DOI 10.1002/hep.510250626
    • Kren B. T., Cole-Strauss A., Kmiec E. B., Steer C. J., Targeted nucleotide exchange in the alkaline phosphatase gene of HuH-7 cells mediated by a chimeric RNA/DNA oligonucleotide Hepatology 1997 25 6 1462 1468 (Pubitemid 27250770)
    • (1997) Hepatology , vol.25 , Issue.6 , pp. 1462-1468
    • Kren, B.T.1    Cole-Strauss, A.2    Kmiec, E.B.3    Steer, C.J.4
  • 103
    • 0033537836 scopus 로고    scopus 로고
    • Nucleotide exchange in genomic DNA of rat hepatocytes using RNA/DNA oligonucleotides: Targeted delivery of liposomes and polyethyleneimine to the asialoglycoprotein receptor
    • Bandyopadhyay P., Ma Y., Linehan-Stieers C., Kren B. T., Steer C. J., Nucleotide exchange in genomic DNA of rat hepatocytes using RNA/DNA oligonucleotides: targeted delivery of liposomes and polyethyleneimine to the asialoglycoprotein receptor The Journal of Biological Chemistry 1999 274 15 10163 10172
    • (1999) The Journal of Biological Chemistry , vol.274 , Issue.15 , pp. 10163-10172
    • Bandyopadhyay, P.1    Ma, Y.2    Linehan-Stieers, C.3    Kren, B.T.4    Steer, C.J.5
  • 104
    • 0031953132 scopus 로고    scopus 로고
    • In vivo site-directed mutagenesis of the factor IX gene by chimetic RND/DNA oligonucleotides
    • DOI 10.1038/nm0398-285
    • Kren B. T., Banoyopaohyay P., Steer C. J., In vivo site-directed mutagenesis of the factor IX gene by chimetic RND/DNA oligonucleotides Nature Medicine 1998 4 3 285 290 (Pubitemid 28144085)
    • (1998) Nature Medicine , vol.4 , Issue.3 , pp. 285-290
    • Kren, B.T.1    Banoyopaohyay, P.2    Steer, C.J.3
  • 106
    • 0035918314 scopus 로고    scopus 로고
    • Gene correction of the apolipoprotein (apo) E2 phenotype to wild-type apoE3 by in situ chimeraplasty
    • Tagalakis A. D., Graham I. R., Riddell D. R., Dickson J. G., Owen J. S., Gene correction of the apolipoprotein (apo) E2 phenotype to wild-type apoE3 by in situ chimeraplasty The Journal of Biological Chemistry 2001 276 16 13226 13230
    • (2001) The Journal of Biological Chemistry , vol.276 , Issue.16 , pp. 13226-13230
    • Tagalakis, A.D.1    Graham, I.R.2    Riddell, D.R.3    Dickson, J.G.4    Owen, J.S.5
  • 107
    • 25144511563 scopus 로고    scopus 로고
    • Correction of the neuropathogenic human apolipoprotein E4 (APOE4) gene to APOE3 in vitro using synthetic RNA/DNA oligonucleotides (chimeraplasts)
    • Tagalakis A. D., Dickson J. G., Owen J. S., Simons J. P., Correction of the neuropathogenic human apolipoprotein E4 (APOE4) gene to APOE3 in vitro using synthetic RNA/DNA oligonucleotides (chimeraplasts) Journal of Molecular Neuroscience 2005 25 1 95 103 (Pubitemid 41389369)
    • (2005) Journal of Molecular Neuroscience , vol.25 , Issue.1 , pp. 95-103
    • Tagalakis, A.D.1    Dickson, J.G.2    Owen, J.S.3    Simons, J.P.4
  • 109
    • 2342515546 scopus 로고    scopus 로고
    • Failure to generate atheroprotective apolipoprotein AI phenotypes using synthetic RNA/DNA oligonucleotides (chimeraplasts)
    • DOI 10.1002/jgm.403
    • Manzano A., Mohri Z., Sperber G., Ogris M., Graham I., Dickson G., Owen J. S., Failure to generate atheroprotective apolipoprotein AI phenotypes using synthetic RNA/DNA oligonucleotides (chimeraplasts) Journal of Gene Medicine 2003 5 9 795 802 (Pubitemid 40309717)
    • (2003) Journal of Gene Medicine , vol.5 , Issue.9 , pp. 795-802
    • Manzano, A.1    Mohri, Z.2    Sperber, G.3    Ogris, M.4    Graham, I.5    Dickson, G.6    Owen, J.S.7
  • 110
    • 0039594943 scopus 로고    scopus 로고
    • A plausible mechanism for gene correction by chimeric oligonucleotides
    • DOI 10.1021/bi9921891
    • Gamper H. B., Cole-Strauss A., Metz R., Parekh H., Kumar R., Kmiec E. B., A plausible mechanism for gene correction by chimeric oligonucleotides Biochemistry 2000 39 19 5808 5816 (Pubitemid 30307969)
    • (2000) Biochemistry , vol.39 , Issue.19 , pp. 5808-5816
    • Gamper Jr., H.B.1    Cole-Strauss, A.2    Metz, R.3    Parekh, H.4    Kumar, R.5    Kmiec, E.B.6
  • 111
    • 0034327613 scopus 로고    scopus 로고
    • The DNA strand of chimeric RNA/DNA oligonucleotides can direct gene repair/conversion activity in mammalian and plant cell-free extracts
    • Gamper H. B., Parekh H., Rice M. C., Bruner M., Youkey H., Kmiec E. B., The DNA strand of chimeric RNA/DNA oligonucleotides can direct gene repair/conversion activity in mammalian and plant cell-free extracts Nucleic Acids Research 2000 28 21 4332 4339
    • (2000) Nucleic Acids Research , vol.28 , Issue.21 , pp. 4332-4339
    • Gamper, H.B.1    Parekh, H.2    Rice, M.C.3    Bruner, M.4    Youkey, H.5    Kmiec, E.B.6
  • 112
    • 17644372695 scopus 로고    scopus 로고
    • Gene therapy progress and prospects: Targeted gene repair
    • DOI 10.1038/sj.gt.3302511
    • Parekh-Olmedo H., Ferrara L., Brachman E., Kmiec E. B., Gene therapy progress and prospects: targeted gene repair Gene Therapy 2005 12 8 639 646 (Pubitemid 40561502)
    • (2005) Gene Therapy , vol.12 , Issue.8 , pp. 639-646
    • Parekh-Olmedo, H.1    Ferrara, L.2    Brachman, E.3    Kmiec, E.B.4
  • 114
    • 32844470294 scopus 로고    scopus 로고
    • Physical incorporation of a single-stranded oligodeoxynucleotide during targeted repair of a human chromosomal locus
    • DOI 10.1002/jgm.828
    • Radecke S., Radecke F., Peter I., Schwarz K., Physical incorporation of a single-stranded oligodeoxynucleotide during targeted repair of a human chromosomal locus Journal of Gene Medicine 2006 8 2 217 228 (Pubitemid 43250702)
    • (2006) Journal of Gene Medicine , vol.8 , Issue.2 , pp. 217-228
    • Radecke, S.1    Radecke, F.2    Peter, I.3    Schwarz, K.4
  • 115
    • 67349229823 scopus 로고    scopus 로고
    • Validation of oligonucleotide-mediated gene editing
    • Disterer P., Simons J. P., Owen J. S., Validation of oligonucleotide- mediated gene editing Gene Therapy 2009 16 6 824 826
    • (2009) Gene Therapy , vol.16 , Issue.6 , pp. 824-826
    • Disterer, P.1    Simons, J.P.2    Owen, J.S.3
  • 116
    • 65349090679 scopus 로고    scopus 로고
    • Use of internally nuclease-protected single-strand DNA oligonucleotides and silencing of the mismatch repair protein, MSH2, enhances the replication of corrected cells following gene editing
    • Papaioannou I., Disterer P., Owen J. S., Use of internally nuclease-protected single-strand DNA oligonucleotides and silencing of the mismatch repair protein, MSH2, enhances the replication of corrected cells following gene editing Journal of Gene Medicine 2009 11 3 267 274
    • (2009) Journal of Gene Medicine , vol.11 , Issue.3 , pp. 267-274
    • Papaioannou, I.1    Disterer, P.2    Owen, J.S.3
  • 118
    • 79954692758 scopus 로고    scopus 로고
    • Ex vivo gene transfer and correction for cell-based therapies
    • Naldini L., Ex vivo gene transfer and correction for cell-based therapies Nature Reviews Genetics 2011 12 5 301 315
    • (2011) Nature Reviews Genetics , vol.12 , Issue.5 , pp. 301-315
    • Naldini, L.1
  • 121
    • 79961117518 scopus 로고    scopus 로고
    • Liver engraftment potential of hepatic cells derived from patient-specific induced pluripotent stem cells
    • Choi S. M., Kim Y., Liu H., Chaudhari P., Ye Z., Jang Y. Y., Liver engraftment potential of hepatic cells derived from patient-specific induced pluripotent stem cells Cell Cycle 2011 10 15 2423 2427
    • (2011) Cell Cycle , vol.10 , Issue.15 , pp. 2423-2427
    • Choi, S.M.1    Kim, Y.2    Liu, H.3    Chaudhari, P.4    Ye, Z.5    Jang, Y.Y.6
  • 123
    • 72949084251 scopus 로고    scopus 로고
    • Correction of mutant Fanconi anemia gene by homologous recombination in human hematopoietic cells using adeno-associated virus vector
    • Paiboonsukwong K., Ohbayashi F., Shiiba H., Aizawa E., Yamashita T., Mitani K., Correction of mutant Fanconi anemia gene by homologous recombination in human hematopoietic cells using adeno-associated virus vector Journal of Gene Medicine 2009 11 11 1012 1019
    • (2009) Journal of Gene Medicine , vol.11 , Issue.11 , pp. 1012-1019
    • Paiboonsukwong, K.1    Ohbayashi, F.2    Shiiba, H.3    Aizawa, E.4    Yamashita, T.5    Mitani, K.6
  • 126
    • 33746198006 scopus 로고    scopus 로고
    • Homologous recombination is required for AAV-mediated gene targeting
    • Vasileva A., Linden R. M., Jessberger R., Homologous recombination is required for AAV-mediated gene targeting Nucleic acids research. 2006 34 11 3345 3360
    • (2006) Nucleic Acids Research. , vol.34 , Issue.11 , pp. 3345-3360
    • Vasileva, A.1    Linden, R.M.2    Jessberger, R.3
  • 129
    • 84862908002 scopus 로고    scopus 로고
    • Find and replace: Editing human genome in pluripotent stem cells
    • Pan H., Zhang W., Zhang W., Liu G. H., Find and replace: editing human genome in pluripotent stem cells Protein and Cell 2011 2 12 950 956
    • (2011) Protein and Cell , vol.2 , Issue.12 , pp. 950-956
    • Pan, H.1    Zhang, W.2    Zhang, W.3    Liu, G.H.4
  • 130
    • 0026770668 scopus 로고
    • High-fidelity gene targeting in embryonic stem cells by using sequence replacement vectors
    • Thomas K. R., Deng C., Capecchi M. R., High-fidelity gene targeting in embryonic stem cells by using sequence replacement vectors Molecular and Cellular Biology 1992 12 7 2919 2923
    • (1992) Molecular and Cellular Biology , vol.12 , Issue.7 , pp. 2919-2923
    • Thomas, K.R.1    Deng, C.2    Capecchi, M.R.3
  • 131
    • 0029899891 scopus 로고    scopus 로고
    • Genetic manipulation of genomes with rare-cutting endonucleases
    • DOI 10.1016/0168-9525(96)10019-6
    • Jasin M., Genetic manipulation of genomes with rare-cutting endonucleases
    • (1996) Trends in Genetics , vol.12 , Issue.6 , pp. 224-228
    • Jasin, M.1
  • 132
    • 0038523969 scopus 로고    scopus 로고
    • Chimeric nucleases stimulate gene targeting in human cells
    • DOI 10.1126/science.1078395
    • Porteus M. H., Baltimore D., Chimeric nucleases stimulate gene targeting in human cells Science 2003 300 5620 763 (Pubitemid 36532103)
    • (2003) Science , vol.300 , Issue.5620 , pp. 763
    • Porteus, M.H.1    Baltimore, D.2
  • 133
    • 30344473645 scopus 로고    scopus 로고
    • Mammalian gene targeting with designed zinc finger nucleases
    • DOI 10.1016/j.ymthe.2005.08.003, PII S1525001605015558
    • Porteus M. H., Mammalian gene targeting with designed zinc finger nucleases Molecular Therapy 2006 13 2 438 446 (Pubitemid 43056910)
    • (2006) Molecular Therapy , vol.13 , Issue.2 , pp. 438-446
    • Porteus, M.H.1
  • 134
    • 35649010954 scopus 로고    scopus 로고
    • Using homologous recombination to manipulate the genome of human somatic cells
    • Porteus M., Using homologous recombination to manipulate the genome of human somatic cells Biotechnology and Genetic Engineering Reviews 2007 24 195 212 (Pubitemid 350032949)
    • (2007) Biotechnology and Genetic Engineering Reviews , vol.24 , pp. 195-212
    • Porteus, M.1
  • 135
    • 55549129245 scopus 로고    scopus 로고
    • Progress and prospects: Zinc-finger nucleases as gene therapy agents
    • Carroll D., Progress and prospects: zinc-finger nucleases as gene therapy agents Gene Therapy 2008 15 22 1463 1468
    • (2008) Gene Therapy , vol.15 , Issue.22 , pp. 1463-1468
    • Carroll, D.1
  • 136
    • 80051987044 scopus 로고    scopus 로고
    • Zinc-finger nucleases for somatic gene therapy: The next frontier
    • Rahman S. H., Maeder M. L., Joung J. K., Cathomen T., Zinc-finger nucleases for somatic gene therapy: the next frontier Human Gene Therapy 2011 22 8 925 933
    • (2011) Human Gene Therapy , vol.22 , Issue.8 , pp. 925-933
    • Rahman, S.H.1    Maeder, M.L.2    Joung, J.K.3    Cathomen, T.4
  • 137
    • 80052285185 scopus 로고    scopus 로고
    • On target? Tracing zinc-finger-nuclease specificity
    • Mussolino C., Cathomen T., On target? Tracing zinc-finger-nuclease specificity Nature Methods 2011 8 9 725 726
    • (2011) Nature Methods , vol.8 , Issue.9 , pp. 725-726
    • Mussolino, C.1    Cathomen, T.2
  • 138
    • 61449266636 scopus 로고    scopus 로고
    • Attenuation of zinc finger nuclease toxicity by small-molecule regulation of protein levels
    • Pruett-Miller S. M., Reading D. W., Porter S. N., Porteus M. H., Attenuation of zinc finger nuclease toxicity by small-molecule regulation of protein levels PLoS Genetics 2009 5 2
    • (2009) PLoS Genetics , vol.5 , Issue.2
    • Pruett-Miller, S.M.1    Reading, D.W.2    Porter, S.N.3    Porteus, M.H.4
  • 140
    • 84856466896 scopus 로고    scopus 로고
    • Zinc-finger nucleases: How to play two good hands
    • Isalan M., Zinc-finger nucleases: how to play two good hands Nature Methods 2012 9 1 32 34
    • (2012) Nature Methods , vol.9 , Issue.1 , pp. 32-34
    • Isalan, M.1
  • 142
    • 79960034141 scopus 로고    scopus 로고
    • Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes
    • Li T., Huang S., Zhao X., Wright D. A., Carpenter S., Spalding M. H., Weeks D. P., Yang B., Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes Nucleic Acids Research 2011 39 14 6315 6325
    • (2011) Nucleic Acids Research , vol.39 , Issue.14 , pp. 6315-6325
    • Li, T.1    Huang, S.2    Zhao, X.3    Wright, D.A.4    Carpenter, S.5    Spalding, M.H.6    Weeks, D.P.7    Yang, B.8
  • 143
    • 80053039555 scopus 로고    scopus 로고
    • A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity
    • Mussolino C., Morbitzer R., Ltge F., Dannemann N., Lahaye T., Cathomen T., A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity Nucleic Acids Research 2011 39 21 9283 9293
    • (2011) Nucleic Acids Research , vol.39 , Issue.21 , pp. 9283-9293
    • Mussolino, C.1    Morbitzer, R.2    Ltge, F.3    Dannemann, N.4    Lahaye, T.5    Cathomen, T.6
  • 145
    • 79951694132 scopus 로고    scopus 로고
    • Meganucleases and other tools for targeted genome engineering: Perspectives and challenges for gene therapy
    • Silva G., Poirot L., Galetto R., Smith J., Montoya G., Duchateau P., Pques F., Meganucleases and other tools for targeted genome engineering: perspectives and challenges for gene therapy Current Gene Therapy 2011 11 1 11 27
    • (2011) Current Gene Therapy , vol.11 , Issue.1 , pp. 11-27
    • Silva, G.1    Poirot, L.2    Galetto, R.3    Smith, J.4    Montoya, G.5    Duchateau, P.6    Pques, F.7
  • 146
    • 84858023570 scopus 로고    scopus 로고
    • Versatile and efficient genome editing in human cells by combining zinc-finger nucleases with adeno-associated viral vectors
    • Hndel, E. M., Gellhaus K., Khan K., Versatile and efficient genome editing in human cells by combining zinc-finger nucleases with adeno-associated viral vectors Human Gene Therapy 2012 23 3 321 329
    • (2012) Human Gene Therapy , vol.23 , Issue.3 , pp. 321-329
    • Hndel, E.M.1    Gellhaus, K.2    Khan, K.3
  • 147
    • 84856546741 scopus 로고    scopus 로고
    • Directed evolution of adeno-associated virus for enhanced gene delivery and gene targeting in human pluripotent stem cells
    • Asuri P., Bartel M. A., Vazin T., Jang J. H., Wong T. B., Schaffer D. V., Directed evolution of adeno-associated virus for enhanced gene delivery and gene targeting in human pluripotent stem cells Molecular Therapy 2012 20 2 329 338
    • (2012) Molecular Therapy , vol.20 , Issue.2 , pp. 329-338
    • Asuri, P.1    Bartel, M.A.2    Vazin, T.3    Jang, J.H.4    Wong, T.B.5    Schaffer, D.V.6
  • 148
    • 84862304154 scopus 로고    scopus 로고
    • Zinc-finger nuclease-mediated gene correction using single AAV vector transduction and enhancement by Food and Drug Administration-approved drugs
    • Ellis B. L., Hirsch M. L., Porter S. N., Samulski R. J., Porteus M. H., Zinc-finger nuclease-mediated gene correction using single AAV vector transduction and enhancement by Food and Drug Administration-approved drugs. Gene Therapy. In press
    • Gene Therapy. In Press
    • Ellis, B.L.1    Hirsch, M.L.2    Porter, S.N.3    Samulski, R.J.4    Porteus, M.H.5
  • 151
    • 79960034141 scopus 로고    scopus 로고
    • Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes
    • Li T., Huang S., Zhao X., Wright D. A., Carpenter S., Spalding M. H., Weeks D. P., Yang B., Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes Nucleic Acids Research 2011 39 14 6315 6325
    • (2011) Nucleic Acids Research , vol.39 , Issue.14 , pp. 6315-6325
    • Li, T.1    Huang, S.2    Zhao, X.3    Wright, D.A.4    Carpenter, S.5    Spalding, M.H.6    Weeks, D.P.7    Yang, B.8
  • 152
    • 84856479947 scopus 로고    scopus 로고
    • Gene-editing nucleases
    • Baker M., Gene-editing nucleases Nature Methods 2012 9 1 23 26
    • (2012) Nature Methods , vol.9 , Issue.1 , pp. 23-26
    • Baker, M.1
  • 153
    • 0015939409 scopus 로고
    • Heterogeneity of human plasma very low density lipoproteins. Separation of species differing in protein components
    • Shore V. G., Shore B., Heterogeneity of human plasma very low density lipoproteins. Separation of species differing in protein components Biochemistry 1973 12 3 502 507
    • (1973) Biochemistry , vol.12 , Issue.3 , pp. 502-507
    • Shore, V.G.1    Shore, B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.