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Volumn 101, Issue 1, 1998, Pages 223-234

An apolipoprotein E synthetic peptide targets to lipoproteins in plasma and mediates both cellular lipoprotein interactions in vitro and acute clearance of cholesterol-rich lipoproteins in vivo

Author keywords

Apolipoprotein E; Cholesterol; Peptides; Proteoglycans; Receptors

Indexed keywords

APOLIPOPROTEIN E; CHOLESTEROL; LIPOPROTEIN; LIPOPROTEIN RECEPTOR; SYNTHETIC PEPTIDE;

EID: 0031975646     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI1099     Document Type: Article
Times cited : (39)

References (41)
  • 1
    • 0024299370 scopus 로고    scopus 로고
    • Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology
    • Mahley, R.W. 1998. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science. 240:622-630.
    • (1998) Science , vol.240 , pp. 622-630
    • Mahley, R.W.1
  • 5
    • 0026592806 scopus 로고
    • Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E
    • Zhang, S.H., R.L. Reddick, J.A. Piedrahita, and N. Maeda. 1992. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science. 258:468-471.
    • (1992) Science , vol.258 , pp. 468-471
    • Zhang, S.H.1    Reddick, R.L.2    Piedrahita, J.A.3    Maeda, N.4
  • 6
    • 0026536066 scopus 로고
    • Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells
    • Piedrahita, J.A., S.H., Zhang, J.R. Hagaman, P.M. Oliver, and N. Maeda. 1992. Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. Proc. Natl. Acad. Sci. USA. 89:4471-4475.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 4471-4475
    • Piedrahita, J.A.1    Zhang, S.H.2    Hagaman, J.R.3    Oliver, P.M.4    Maeda, N.5
  • 7
    • 0026725757 scopus 로고
    • Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
    • Plump, A.S., J.D. Smith, T. Hayek, K. Aalto-Setälä, A. Walsh, J.G. Verstuyft, E.M. Rubin, and J.L. Breslow. 1992. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell. 71:343-353.
    • (1992) Cell , vol.71 , pp. 343-353
    • Plump, A.S.1    Smith, J.D.2    Hayek, T.3    Aalto-Setälä, K.4    Walsh, A.5    Verstuyft, J.G.6    Rubin, E.M.7    Breslow, J.L.8
  • 8
    • 0029081525 scopus 로고
    • Treatment of severe hypercholesterolemia apolipopotein E-deficient mice by bone marrow transplantation
    • Boisvert, W.A., J. Spangenberg, and L.K. Curtiss. 1995. Treatment of severe hypercholesterolemia apolipopotein E-deficient mice by bone marrow transplantation. J. Clin. Invest. 96:1118-1124.
    • (1995) J. Clin. Invest. , vol.96 , pp. 1118-1124
    • Boisvert, W.A.1    Spangenberg, J.2    Curtiss, L.K.3
  • 9
    • 0026333682 scopus 로고
    • A synthetic peptide mimic of plasma apolipoprotein E that binds the LDL receptor
    • Dyer, C.A., and L.K. Curtiss. 1991. A synthetic peptide mimic of plasma apolipoprotein E that binds the LDL receptor. J. Biol. Chem. 266:22803-22806.
    • (1991) J. Biol. Chem. , vol.266 , pp. 22803-22806
    • Dyer, C.A.1    Curtiss, L.K.2
  • 10
    • 0028819112 scopus 로고
    • Structural features of synthetic peptides apolipoprotein E that bind the LDL receptor
    • Dyer, C.A., D.P. Cistola, G.C. Parry, and L.K. Curtiss. 1995. Structural features of synthetic peptides apolipoprotein E that bind the LDL receptor. J. Lipid Res. 36:80-88.
    • (1995) J. Lipid Res. , vol.36 , pp. 80-88
    • Dyer, C.A.1    Cistola, D.P.2    Parry, G.C.3    Curtiss, L.K.4
  • 11
    • 0025837970 scopus 로고
    • Only multimers of a synthetic peptide of human apolipoprotein E are biologically active
    • Dyer, C.A., R.S. Smith, and L.K. Curtiss. 1991. Only multimers of a synthetic peptide of human apolipoprotein E are biologically active. J. Biol. Chem. 266:15009-15015.
    • (1991) J. Biol. Chem. , vol.266 , pp. 15009-15015
    • Dyer, C.A.1    Smith, R.S.2    Curtiss, L.K.3
  • 12
    • 0001665337 scopus 로고
    • Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor
    • Herz, J., U. Hamann, S. Rogne, O. Myklebost, H. Gausepohl, and K.K. Stanley. 1988. Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor. EMBO J. 7:4119-4127.
    • (1988) EMBO J. , vol.7 , pp. 4119-4127
    • Herz, J.1    Hamann, U.2    Rogne, S.3    Myklebost, O.4    Gausepohl, H.5    Stanley, K.K.6
  • 13
    • 0040177065 scopus 로고
    • Low density lipoprotein receptor related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins
    • Kowal, R.C., J. Herz, J.L. Goldstein, V. Esser, and M.S. Brown. 1989. Low density lipoprotein receptor related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins. Proc. Natl. Acad. Sci. USA. 86: 5810-5814.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 5810-5814
    • Kowal, R.C.1    Herz, J.2    Goldstein, J.L.3    Esser, V.4    Brown, M.S.5
  • 14
    • 0028149980 scopus 로고
    • Role of heparan sulfate proteoglycans and the LDL receptor-related protein in remnant lipoprotein metabolism
    • Mahley, R.W., Z.-S. Ji, W.J. Brecht, R.D. Miranda, and D. He. 1994. Role of heparan sulfate proteoglycans and the LDL receptor-related protein in remnant lipoprotein metabolism. Ann. NY Acad. Sci. 737:39-52.
    • (1994) Ann. NY Acad. Sci. , vol.737 , pp. 39-52
    • Mahley, R.W.1    Ji, Z.-S.2    Brecht, W.J.3    Miranda, R.D.4    He, D.5
  • 15
    • 0024330373 scopus 로고
    • Influence of plaque configuration and stress distribution on fissuring of coronary atherosclerotic plaques
    • Richardson, P.D., M.J. Davies, and G.V.R. Born. 1989. Influence of plaque configuration and stress distribution on fissuring of coronary atherosclerotic plaques. Lancet. 2(8669):941-944.
    • (1989) Lancet , vol.2 , Issue.8669 , pp. 941-944
    • Richardson, P.D.1    Davies, M.J.2    Born, G.V.R.3
  • 16
  • 17
    • 0023795411 scopus 로고
    • Localization of two epitopes of apolipoprotein A-I that are exposed on human high density lipoproteins using monoclonal antibodies and synthetic peptides
    • Curtiss, L.K., and R.S. Smith. 1988. Localization of two epitopes of apolipoprotein A-I that are exposed on human high density lipoproteins using monoclonal antibodies and synthetic peptides. J. Biol. Chem. 263:13779-13785.
    • (1988) J. Biol. Chem. , vol.263 , pp. 13779-13785
    • Curtiss, L.K.1    Smith, R.S.2
  • 18
    • 0018178434 scopus 로고
    • A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples
    • Markwell, M.A.K., S.M. Haas, L.L. Bieber, and N.E.A. Tolbert. 1978. A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Anal. Biochem. 87:206-210.
    • (1978) Anal. Biochem. , vol.87 , pp. 206-210
    • Markwell, M.A.K.1    Haas, S.M.2    Bieber, L.L.3    Tolbert, N.E.A.4
  • 19
    • 0028214529 scopus 로고
    • Oxidized LDL enhances lipopolysaccharide-induced tissue factor expression in human adherent monocytes
    • Brand, K., C.L. Banka, N. Mackman, R.A. Terkeltaub, S.-T. Fan, and L.K. Curtiss. 1994. Oxidized LDL enhances lipopolysaccharide-induced tissue factor expression in human adherent monocytes. Arteriorscler. Thromb. 14: 790-797.
    • (1994) Arteriorscler. Thromb. , vol.14 , pp. 790-797
    • Brand, K.1    Banka, C.L.2    Mackman, N.3    Terkeltaub, R.A.4    Fan, S.-T.5    Curtiss, L.K.6
  • 20
    • 0016241915 scopus 로고
    • Binding and degradation of low density lipoproteins by cultured human fibroblasts
    • Goldstein, J.L., and M.S. Brown. 1974. Binding and degradation of low density lipoproteins by cultured human fibroblasts. J. Biol. Chem. 249:5153-5162.
    • (1974) J. Biol. Chem. , vol.249 , pp. 5153-5162
    • Goldstein, J.L.1    Brown, M.S.2
  • 21
    • 0018161396 scopus 로고
    • Procedure for determination of free and total cholesterol in micro- Or nanogram amounts suitable for studies with cultured cells
    • Gamble, W., M. Voughan, H.S. Kruth, and J. Avigan. 1978. Procedure for determination of free and total cholesterol in micro-or nanogram amounts suitable for studies with cultured cells. J. Lipid Res. 19:1068-1070.
    • (1978) J. Lipid Res. , vol.19 , pp. 1068-1070
    • Gamble, W.1    Voughan, M.2    Kruth, H.S.3    Avigan, J.4
  • 22
    • 0019914963 scopus 로고
    • A direct spectrophotometric microassay for sulfated glycosaminoglycans in cartilage cultures
    • Farndale, R. W., C.A. Sayers, and A.J. Barret. 1982. A direct spectrophotometric microassay for sulfated glycosaminoglycans in cartilage cultures. Connect. Tissue Res. 9:247-248.
    • (1982) Connect. Tissue Res. , vol.9 , pp. 247-248
    • Farndale, R.W.1    Sayers, C.A.2    Barret, A.J.3
  • 23
    • 0022552896 scopus 로고
    • Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue
    • Farndale, R.W., D.J. Buttle, and A.J. Barret. 1986. Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochem. Biophys. Acta. 883:173-177.
    • (1986) Biochem. Biophys. Acta. , vol.883 , pp. 173-177
    • Farndale, R.W.1    Buttle, D.J.2    Barret, A.J.3
  • 24
    • 0022371632 scopus 로고
    • Apolipoprotein E: Phospholipid binding studies with synthetic peptides containing the putative receptor binding region
    • Sparrow, J.T., D.A. Sparrow, A.R. Culwell, and A.M. Gotto. 1985. Apolipoprotein E: Phospholipid binding studies with synthetic peptides containing the putative receptor binding region. Biochemistry. 24:6984-6988.
    • (1985) Biochemistry , vol.24 , pp. 6984-6988
    • Sparrow, J.T.1    Sparrow, D.A.2    Culwell, A.R.3    Gotto, A.M.4
  • 25
    • 0022553387 scopus 로고
    • In vivo interaction of synthetic acetylated apoE peptides with high density lipoprotein in rat
    • Ponsin, G., J.T. Sparrow, A.M. Gotto, Jr., and H.J. Pownall. 1986. In vivo interaction of synthetic acetylated apoE peptides with high density lipoprotein in rat. J. Clin. Invest. 77:559-567.
    • (1986) J. Clin. Invest. , vol.77 , pp. 559-567
    • Ponsin, G.1    Sparrow, J.T.2    Gotto Jr., A.M.3    Pownall, H.J.4
  • 26
    • 0021750396 scopus 로고
    • In vitro binding of synthetic acetylated lipid-associating peptides to high-density lipoproteins: Effect of hydrophobicity
    • Ponsin, G., K. Strong, A.M. Gotto, Jr., J.T. Sparrow, and H.J. Pownall. 1984. In vitro binding of synthetic acetylated lipid-associating peptides to high-density lipoproteins: Effect of hydrophobicity. Biochemistry. 23:5337-5342.
    • (1984) Biochemistry , vol.23 , pp. 5337-5342
    • Ponsin, G.1    Strong, K.2    Gotto Jr., A.M.3    Sparrow, J.T.4    Pownall, H.J.5
  • 27
    • 0027186135 scopus 로고
    • Discrete carboxyl-terminal segments of apolipoprotein E mediate lipoprotein association and protein oligomerization
    • Westerlund, J.A., and K.H. Weisgraber. 1993. Discrete carboxyl-terminal segments of apolipoprotein E mediate lipoprotein association and protein oligomerization. J. Biol. Chem. 268:15745-15750.
    • (1993) J. Biol. Chem. , vol.268 , pp. 15745-15750
    • Westerlund, J.A.1    Weisgraber, K.H.2
  • 28
    • 0023003380 scopus 로고
    • In vivo half-life of a protein is a function of its amino-terminal residue
    • Bachmair, A., D. Finley, and A. Varshavsky. 1986. In vivo half-life of a protein is a function of its amino-terminal residue. Science. 234:179-186.
    • (1986) Science , vol.234 , pp. 179-186
    • Bachmair, A.1    Finley, D.2    Varshavsky, A.3
  • 29
    • 0025786502 scopus 로고
    • 39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor
    • Herz, J., J.L. Goldstein, D.K. Strickland, Y.K. Ho, and M.S. Brown. 1991. 39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. J. Biol. Chem. 266: 21232-21238.
    • (1991) J. Biol. Chem. , vol.266 , pp. 21232-21238
    • Herz, J.1    Goldstein, J.L.2    Strickland, D.K.3    Ho, Y.K.4    Brown, M.S.5
  • 30
    • 0028912587 scopus 로고
    • The 39-kDa receptor associated protein modulates lipoprotein catabolism by binding to LDL receptors
    • Medh, J.D., G.L. Fry, S.L. Bowen, M.W. Pladet, D.K. Strickland, and D.A. Chappel. 1995. The 39-kDa receptor associated protein modulates lipoprotein catabolism by binding to LDL receptors. J. Biol. Chem. 270:536-540.
    • (1995) J. Biol. Chem. , vol.270 , pp. 536-540
    • Medh, J.D.1    Fry, G.L.2    Bowen, S.L.3    Pladet, M.W.4    Strickland, D.K.5    Chappel, D.A.6
  • 31
    • 0027246180 scopus 로고
    • Role of heparan sulfate proteoglycans in the binding and uptake of apolipoprotein E-enriched remnant lipoproteins by cultured cells
    • Ji, Z.-S., W.J. Brecht, R.D. Miranda, M.M. Hussain, T.L. Innerarity, and R.W. Mahley. 1993. Role of heparan sulfate proteoglycans in the binding and uptake of apolipoprotein E-enriched remnant lipoproteins by cultured cells. J. Biol. Chem. 268:10160-10167.
    • (1993) J. Biol. Chem. , vol.268 , pp. 10160-10167
    • Ji, Z.-S.1    Brecht, W.J.2    Miranda, R.D.3    Hussain, M.M.4    Innerarity, T.L.5    Mahley, R.W.6
  • 32
    • 0027990682 scopus 로고
    • Secretion-culture role for apolipoprotein E in remnant lipoprotein metabolism involving cell surface heparan sulfate proteoglycans
    • Ji, Z.-S., S. Fazio, Y.-L. Lee, and R.W. Mahley. 1994. Secretion-culture role for apolipoprotein E in remnant lipoprotein metabolism involving cell surface heparan sulfate proteoglycans. J. Biol. Chem. 269:2764-2772.
    • (1994) J. Biol. Chem. , vol.269 , pp. 2764-2772
    • Ji, Z.-S.1    Fazio, S.2    Lee, Y.-L.3    Mahley, R.W.4
  • 34
    • 3242854520 scopus 로고
    • Rate and equilibrium constants for binding of apo-E HDLc (a cholesterol-induced lipoprotein) and low density lipoproteins to human fibroblasts: Evidence for multiple receptor binding of apo-E HDLc
    • Pitas, R.F., T.L. Innerarity, K.S. Arnold, and R.W. Mahley. 1979. Rate and equilibrium constants for binding of apo-E HDLc (a cholesterol-induced lipoprotein) and low density lipoproteins to human fibroblasts: evidence for multiple receptor binding of apo-E HDLc. Proc. Natl. Acad. Sci. USA. 76:2311-2315.
    • (1979) Proc. Natl. Acad. Sci. USA , vol.76 , pp. 2311-2315
    • Pitas, R.F.1    Innerarity, T.L.2    Arnold, K.S.3    Mahley, R.W.4
  • 35
    • 0018800929 scopus 로고
    • Binding of arginine-rich (E) apoprotein after recombination with phospholipid vesicles to the low density lipoprotein receptors of fibroblasts
    • Innerarity, T.L., R.E. Pitas, and R.W. Mahley. 1979. Binding of arginine-rich (E) apoprotein after recombination with phospholipid vesicles to the low density lipoprotein receptors of fibroblasts. J. Biol. Chem. 254:4186-4190.
    • (1979) J. Biol. Chem. , vol.254 , pp. 4186-4190
    • Innerarity, T.L.1    Pitas, R.E.2    Mahley, R.W.3
  • 36
    • 0019321262 scopus 로고
    • Cell surface receptor binding of phospholipid -protein complexes containing different ratios of receptor-active and -inactive E apoprotein
    • Pitas, R.F., T.L. Innerarity, and R.W. Mahley. 1980. Cell surface receptor binding of phospholipid -protein complexes containing different ratios of receptor-active and -inactive E apoprotein. J. Biol. Chem. 255:5454-5460.
    • (1980) J. Biol. Chem. , vol.255 , pp. 5454-5460
    • Pitas, R.F.1    Innerarity, T.L.2    Mahley, R.W.3
  • 37
    • 0022998825 scopus 로고
    • Human apolipoprotein E. Determination of the heparin binding sites of apolipoprotein E
    • Weisgraber, K.H., S.C. Rall, Jr., R.W. Mahley, Y.L. Marcel, and J.T. Sparrow. 1986. Human apolipoprotein E. Determination of the heparin binding sites of apolipoprotein E. J. Biol. Chem. 261:2068-2076.
    • (1986) J. Biol. Chem. , vol.261 , pp. 2068-2076
    • Weisgraber, K.H.1    Rall Jr., S.C.2    Mahley, R.W.3    Marcel, Y.L.4    Sparrow, J.T.5
  • 39
    • 0028268018 scopus 로고
    • The two-receptor model of lipoprotein clearance: Tests of the hypothesis in "knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E. or both proteins
    • Ishibashi, S., J. Herz, N. Maeda, J.L. Goldstein, and M.S. Brown. 1994. The two-receptor model of lipoprotein clearance: Tests of the hypothesis in "knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E. or both proteins. Proc. Natl. Acad. Sci. USA. 91:4431-4435.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 4431-4435
    • Ishibashi, S.1    Herz, J.2    Maeda, N.3    Goldstein, J.L.4    Brown, M.S.5
  • 40
    • 0026778830 scopus 로고
    • Rabbit very low density lipoprotein receptor: A low density lipoprotein receptor-like protein with distinct ligand specificity
    • Takahashi, S., Y. Kawarabayasi, T. Nakai, J. Sakai, and T. Yamamoto. 1992. Rabbit very low density lipoprotein receptor: A low density lipoprotein receptor-like protein with distinct ligand specificity. Proc. Natl. Acad. Sci. USA. 89:9252-9256.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 9252-9256
    • Takahashi, S.1    Kawarabayasi, Y.2    Nakai, T.3    Sakai, J.4    Yamamoto, T.5
  • 41
    • 0025047522 scopus 로고
    • New methods of drug delivery
    • Langer, R. 1990. New methods of drug delivery. Science. 249:1527-1533.
    • (1990) Science , vol.249 , pp. 1527-1533
    • Langer, R.1


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