Interaction of apolipoprotein E genotype with smoking and physical inactivity on coronary heart disease risk in men and women

Atherosclerosis

Volumn 220, Issue 2, 2012, Pages 486-492

  Gustavsson, Jaana ^a   Mehlig, Kirsten ^a   Leander, Karin ^b   Strandhagen, Elisabeth ^a   Björck, Lena ^a   Thelle, Dag S ^c   Lissner, Lauren ^a   Blennow, Kaj ^a   Zetterberg, Henrik ^a   Nyberg, Fredrik ^a,d  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF OSLO   (Norway)

^d ASTRAZENECA R AND D   (Sweden)

Author keywords

Apolipoprotein E polymorphism; Cardiovascular risk factors; Gene environment interaction; Physical activity; Smoking

Indexed keywords

APOLIPOPROTEIN E; CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; AGED; ARTICLE; BODY MASS; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; DNA POLYMORPHISM; FEMALE; GENE FUNCTION; GENOTYPE; HOMOZYGOSITY; HUMAN; IMMOBILIZATION; ISCHEMIC HEART DISEASE; LIFESTYLE; MAJOR CLINICAL STUDY; MALE; OBESITY; PRIORITY JOURNAL; QUESTIONNAIRE; SELF REPORT; SEX DIFFERENCE; SMOKING HABIT;

ADULT; AGED; APOLIPOPROTEINS E; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; CORONARY DISEASE; FEMALE; GENE FREQUENCY; GENE-ENVIRONMENT INTERACTION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LINEAR MODELS; LOGISTIC MODELS; MALE; MIDDLE AGED; ODDS RATIO; OVERWEIGHT; QUESTIONNAIRES; RISK ASSESSMENT; RISK FACTORS; SEDENTARY LIFESTYLE; SEX FACTORS; SMOKING; SWEDEN;

EID: 84855961434     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2011.10.011     Document Type: Article

References (31)

1. Mahley R.W. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 1988, 240:622-630.
2. Eichner J.E., Dunn S.T., Perveen G., et al. Apolipoprotein E polymorphism and cardiovascular disease: a HuGE review. Am J Epidemiol 2002, 155:487-495.
3. Weisgraber K.H., Rall S.C., Mahley R.W. Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms. J Biol Chem 1981, 256:9077-9083.
4. Jofre-Monseny L., Minihane A., Rimbach G. Impact of apoE genotype on oxidative stress, inflammation and disease risk. Mol Nutr Food Res 2008, 52:131-145.
5. Bennet A.M., Di Angelantonio E., Zheng Y., et al. Association of Apolipoprotein E genotypes with lipid levels and coronary risk. JAMA 2007, 298:1300-1311.
6. Song Y., Stampfer M.J., Liu S. Meta-analysis: apolipoprotein E genotypes and risk for coronary heart disease. Ann Intern Med 2004, 141:137-147.
7. Wilson P.W., Schaefer E.J., Larson M.G., et al. Apolipoprotein E alleles and risk of coronary disease. A meta-analysis. Arterioscler Thromb Vasc Biol 1996, 16:1250-1255.
8. Ward H., Mitrou P.N., Bowman R., et al. APOE genotype, lipids, and coronary heart disease risk. Arch Intern Med 2009, 169:1424-1429.
9. Humphries S.E., Talmud P.J., Hawe E., et al. Apolipoprotein E4 and coronary heart disease in middle-aged men who smoke: a prospective study. Lancet 2001, 358:115-119.
10. Talmud P.J., Stephens J.W., Hawe E., et al. The significant increase in cardiovascular disease risk in ApoE4 carriers is evident only in men who smoke: potential relationship between reduced antioxidant status and ApoE4. Ann Hum Gen 2005, 69:613-622.
11. Humphries S.E., Hawe E., Dhamrait S., et al. In search of genetic precision. Lancet 2003, 361:1908-1909.
12. Keavney B., Parish S., Palmer A., et al. Large-scale evidence that the cardiotoxicity of smoking is not significantly modified by the apolipoprotein E e{open}2/e{open}3/e{open}4 genotype. Lancet 2003, 361:396-398.
13. Talmud P.J. Gene-environment interaction and its impact on coronary heart disease risk. Nutr Metab Cardiovasc Dis 2007, 17:148-152.
14. Bernstein M.S., Costanza M.C., James R.W., et al. Physical activity may modulate effects of ApoE genotype on lipid profile. Arterioscler Thromb Vasc Biol 2002, 22:133-140.
15. Taimela S., Lehtimaki T., Porkka K.V., et al. The effect of physical activity on serum total and low-density lipoprotein cholesterol concentrations varies with apolipoprotein E phenotype in male children and young adults: the cardiovascular risk in young Finns study. Metabolism 1996, 45:797-803.
16. Hagberg J.M., Ferrell R.E., Katzel L.I., et al. Apolipoprotein E genotype and exercise training-induced increases in plasma high-density lipoprotein (HDL)- and HDL2-cholesterol levels in overweight men. Metabolism 1999, 48:943-945.
17. St-Amand J., Prud'homme D., Moorjani S., et al. Apolipoprotein E polymorphism and the relationships of physical fitness to plasma lipoprotein-lipid levels in men and women. Med Sci Sports Exerc 1999, 31:692-697.
18. Boer J.M., Ehnholm C., Menzel H.J., et al. Interactions between lifestyle-related factors and the ApoE polymorphism on plasma lipids and apolipoproteins. Arterioscler Thromb Vasc Biol 1997, 17:1675-1681.
19. Schmitz K.H., Schreiner P.J., Jacobs D.R., et al. Independent and interactive effects of Apolipoprotein E phenotype and cardiorespiratory fitness on plasma lipids. Ann Epidemiol 2001, 11:94-103.
20. Berg C.M., Lissner L., Aires N., et al. Trends in blood lipid levels, blood pressure, alcohol and smoking habits from 1985 to 2002: results from INTERGENE and GOT-MONICA. Eur J Cardiovasc Prev Rehabil 2005, 12:115-125.
21. Strandhagen E., Berg C., Lissner L., et al. Selection bias in a population survey with registry linkage: potential effect on socioeconomic gradient in cardiovascular risk. Eur J Epidemiol 2010, 25:163-172.
22. Reuterwall C., Hallqvist J., Ahlbom A., et al. Higher relative, but lower absolute risks of myocardial infarction in women than in men: analysis of some major risk factors in the SHEEP study. J Intern Med 1999, 246:161-174.
23. Aires N., Selmer R., Thelle D.S. The validity of self-reported leisure time physical activity, and its relationship to serum cholesterol, blood pressure and body mass index. A population based study of 332,182 men and women aged 40-42 years. Eur J Epidemiol 2003, 18:479-485.
24. Friedewald W.T., Levy R.I., Frederickson D.S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1992, 18:499-502.
25. Blennow K., Ricksten A., Prince J.A., et al. No association between the alpha2-macroglobulin (A2M) deletion and Alzheimer's disease, and no change in A2M mRNA, protein, or protein expression. J Neural Transm 2000, 107:1065-1079.
26. Pearce N. What does the odds ratio estimate in a case-control study?. Int J Epidemiol 1993, 22:1189-1192.
27. Björck L., Rosengren A., Bennet K., et al. Modelling the decreasing coronary heart disease mortality in Sweden between 1986 and 2002. Eur Heart J 2009, 30:1046-1056.
28. Talmud P.J., Lewis S.J., Hawe E., et al. No APOEe{open}4 effect on coronary heart disease risk in a cohort with low smoking prevalence: the Whitehall II study. Atherosclerosis 2004, 177:105-112.
29. Ordovas J.M. Gender, a significant factor in the cross talk between genes, environment, and health. Gender Med 2007, 4:111-121.
30. Jolivalt C., Leininger-Muller B., Bertrand P., et al. Differential oxidation of apolipoprotein E isoforms and interaction with phospholipids. Free radic Biol Med 2000, 28:129-140.
31. Laufs U., Wassmann S., Czech T., et al. Physical inactivity increases oxidative stress, endothelial dysfunction, and atherosclerosis. Arterioscler Thromb Vasc Biol 2005, 25:809-814.