Gene therapy with novel adeno-associated virus vectors substantially diminishes atherosclerosis in a murine model of familial hypercholesterolemia

Journal of Gene Medicine

Volumn 6, Issue 6, 2004, Pages 663-672

  Lebherz, Corinna ^a,c   Gao, Guangping ^a,c   Louboutin, Jean Pierre ^a,c   Millar, John ^b   Rader, Daniel ^b   Wilson, James M ^a,c,d  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c WISTAR INSTITUTE   (United States)

^d NONE   (United States)

Author keywords

Adeno associated virus; Atherosclerosis; Gene therapy; Hyperlipidemia; LDL deficient mice

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GAMMA GLUTAMYLTRANSFERASE; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; PARVOVIRUS VECTOR; THYROGLOBULIN; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CONTROLLED STUDY; FAMILIAL HYPERCHOLESTEROLEMIA; GENETIC CODE; LIPID BLOOD LEVEL; LIPID METABOLISM; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PORTAL VEIN; PRIMATE; PRIORITY JOURNAL; SEROTYPE; VIRAL GENE THERAPY;

ANIMALS; ARTERIOSCLEROSIS; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; GENE THERAPY; GENETIC VECTORS; HUMANS; HYPERLIPOPROTEINEMIA TYPE II; LIPID METABOLISM; LIVER; MICE; MICE, INBRED C57BL; RECEPTORS, LDL; TOXICITY TESTS;

ADENO-ASSOCIATED VIRUS; ANIMALIA; MURINAE; PRIMATES;

EID: 6344275675     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.554     Document Type: Article

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