ApoE in atherosclerosis: A protein with multiple hats

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 20, Issue 8, 2000, Pages 1852-1853

  Curtiss, Linda K ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Editorials; Genetically altered mice; Lipid and lipoprotein metabolism; Pathophysiology

Indexed keywords

APOLIPOPROTEIN E; CHOLESTEROL;

ATHEROGENESIS; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL TRANSPORT; EDITORIAL; INFLAMMATION; LIPOPROTEIN METABOLISM; PRIORITY JOURNAL;

EID: 0033889707     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.20.8.1852     Document Type: Editorial

References (21)

1. Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology
2. Hepatic apo E expression is required for remnant lipoprotein clearance in the absence of the low density lipoprotein receptor
3. Mouse models of atherosclerosis
4. Plasma lipoprotein metabolism in transgenic mice overexpressing apolipoprotein E: Accelerated clearance of lipoproteins containing apolipoprotein B
5. An apolipoprotein E synthetic peptide targets to lipoproteins in plasma and mediates both cellular lipoprotein interactions in vitro and acute clearance of cholesterol-rich lipoproteins in vivo
6. Complete atherosclerosis regression after human apoE gene transfer in apoE-deficient/nude mice
7. Treatment of severe hypercholesterolemia in apolipoprotein E-deficient mice by bone marrow transplantation
8. Apolipoprotein E participates in the regulation of very low density lipoprotein-triglyceride secretion by the liver
9. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E
10. Determination of the lower threshold of apolipoprotein E resulting in remnant lipoprotein clearance
11. Low levels of extrahepatic nonmacrophage apoE inhibit atherosclerosis without correcting hypercholesterolemia in apoE-deficient mice
12. Retroviral gene therapy in apoE-deficient mice: ApoE expression in the artery wall reduces early foam cell lesion formation
13. Inhibition of diet-induced atheroma formation in transgenic mice expressing apolipoprotein E in the arterial wall
14. Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides
15. ApoA1 reduces free cholesterol accumulation in atherosclerotic lesions of apoE-deficient mice transplanted with apoE-expressing macrophages
16. Low-dose expression of a human apolipoprotein E transgene in macrophages restores cholesterol efflux capacity of apolipoprotein E-deficient mouse plasma
17. T and B lymphocytes play a minor role in atherosclerotic plaque formation in the apolipoprotein E-deficient mouse
18. Apolipoprotein E is a biologically active constituent Of the normal immunoregulatory lipoprotein, LDL-In
19. Apolipoprotein E inhibition of proliferation of mitogen-activated T lymphocytes: Production of interleukin 2 with reduced biological activity
20. IFN-gamma potentiates atherosclerosis in apoE knock-out mice
21. Apolipoprotein E inhibition of vascular SMC proliferation but not the inhibition of migration is mediated through activation of inducible nitric oxide synthase