Gene Correction of the Apolipoprotein (Apo) E2 Phenotype to Wild-type ApoE3 by in Situ Chimeraplasty

Journal of Biological Chemistry

Volumn 276, Issue 16, 2001, Pages 13226-13230

  Tagalakis, Aristides D ^a,b   Graham, Ian R ^b   Riddell, David R ^a   Dickson, J George ^b   Owen, James S ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOLOGICAL ORGANS; CYTOLOGY; GENES; IMMUNOLOGY; MUTAGENESIS;

CHIMERAPLASTY;

PROTEINS;

APOLIPOPROTEIN E2; APOLIPOPROTEIN E3; APOLIPOPROTEIN E; HYBRID PROTEIN; MESSENGER RNA; OLIGODEOXYRIBONUCLEOTIDE; OLIGORIBONUCLEOTIDE;

ALLELE; ANIMAL CELL; ARTICLE; ATHEROSCLEROSIS; CHIMERAPLASTY; CHO CELL; CONTROLLED STUDY; FEMALE; GENE FUNCTION; GENE OVEREXPRESSION; GENE SEQUENCE; HOMOZYGOSITY; HUMAN; HUMAN CELL; HYPERLIPIDEMIA; IN SITU CHIMERAPLASTY; ISOELECTRIC FOCUSING; LYMPHOCYTE CULTURE; MALE; MOLECULAR CLONING; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN SECRETION; PROTEIN SYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE; WILD TYPE; AMINO ACID SUBSTITUTION; ANIMAL; BIOSYNTHESIS; CHEMISTRY; CROSS BREEDING; CYTOLOGY; GENE LIBRARY; GENE THERAPY; GENETIC TRANSFECTION; GENETICS; GENOTYPE; HAMSTER; LYMPHOCYTE; METABOLISM; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS; MUS MUSCULUS; SYNTHETIC CONSTRUCT;

AMINO ACID SUBSTITUTION; ANIMALS; APOLIPOPROTEIN E2; APOLIPOPROTEIN E3; APOLIPOPROTEINS E; BASE SEQUENCE; CHO CELLS; CRICETINAE; CROSSES, GENETIC; FEMALE; GENE THERAPY; GENOMIC LIBRARY; GENOTYPE; HUMANS; LYMPHOCYTES; MALE; MICE; MICE, TRANSGENIC; OLIGODEOXYRIBONUCLEOTIDES; OLIGORIBONUCLEOTIDES; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; TRANSFECTION;

EID: 0035918314     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C000883200     Document Type: Article

References (43)

1. Weisgraber, K. H. (1994) Adv. Protein Chem. 45, 249-302
2. Mahley, R. W., and Huang, Y. (1999) Curr. Opin. Lipidol. 10, 207-217
3. Huang, Y., von Eckardstein, A., Wu, S., and Assmann, G. (1995) J. Clin. Invest. 96, 2693-2701
4. Riddell, D. R., Graham, A., and Owen, J. S. (1997) J. Biol. Chem. 272, 89-95
5. Genest, J. J., Jr., Bard, J. M., Fruchart, J. C., Ordovas, J. M., Wilson, P. F., and Schaefer, E. J. (1991) Atherosclerosis 90, 149-157
6. Linton, M. F., and Fazio, S. (1997) Curr. Opin. Lipidol. 10, 97-105
7. Linton, M. F., Atkinson, J. B., and Fazio, S. (1999) Science 267, 1034-1037
8. Yamada, N., Inoue, I., Kawamura, M., Harada, K., Watanabe, Y., Shimano, H., Gotoda, T., Shimada, M., Kohzaki, K., and Tsukada, T. (1992) J. Clin. Invest. 89, 706-711
9. Yamamoto, K., Shimano, H., Shimada, M., Kawamura, M., Gotoda, T., Harada, K., Ohsuga, J., Yazaki, Y., and Yamada, N. (1995) Diabetes 44, 580-585
10. Shimano, H., Yamada, N., Katsuki, M., Shimada, M., Gotoda, T., Harada, K., Murase, T., Fukazawa, C., Takaku, F., and Yazaki, Y. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 1750-1754
11. Mahley, R. W., Huang, Y., and Rall, S. C., Jr. (1999) J. Lipid Res. 40, 1933-1949
12. Stevenson, S. C., Marshall-Neff, J., Teng, B., Lee, C. B., Roy, S., and McClelland, A. (1995) Arterioseler. Thromb. Vasc. Biol. 15, 479-484
13. Kashyap, V. S., Santamarina-Fojo, S., Brown, D. R., Parrott, C. L., Applebaum-Bowden, D., Meyn, S., Talley, G., Paigen, B., Maeda, N., and Brewer, H. B., Jr. (1995) J. Clin. Invest. 96, 1612-1620
14. Yoon, K., Cole-Strauss, A., and Kmiec, E. B. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 2071-2076
15. Ye, S., Cole-Strauss, A. C., Frank, B., and Kmiec, E. B. (1998) Mol. Med. Today 4, 431-437
16. Kren, B. T., Metz, R., Kumar, R., and Steer, C. J. (1999) Semin. Liver Dis. 19, 93-104
17. Miloux, B., and Lupker, J. H. (1994) Gene 149, 341-344
18. van Vlijmen, B. J., van Dijk, K. W., van't Hof, H. B., van Gorp, P. J., van der Zee, A., van der Boom, H., Breuer, M. L., Hofker, M. H., and Havekes, L. M. (1996) J. Biol. Chem. 271, 30595-30602
19. van den Maagdenberg, A. M., Weng, W., de Bruijn, I. H., de Knijff, P., Funke, H., Smelt, A. H., Gevers Leuven, J. A., van't Hooft, F. M., Assmann, G., and Hofker, M. H. (1993) Am. J. Hum. Genet. 52, 937-946
20. Negri, C., Chiesa, R., and Ricotti, G. C. (1991) Cytotechnology 7, 173-178
21. Hixson, J. E., and Vernier, D. T. (1990) J. Lipid Res. 31, 545-548
22. Friedmann, T. (1997) Sci. Am. 276, 96-101
23. Alexeev, V., and Yoon, K. (1998) Nat. Biotechnol. 16, 1343-1346
24. Cole-Strauss, A., Yoon, K., Xiang, Y., Byrne, B. C., Rice, M. C., Gryn, J., Holloman, W. K., and Kmiec, E. B. (1996) Science 273, 1386-1389
25. Kren, B. T., Bandyopadhyay, P., and Steer, C. J. (1998) Nat. Med. 4, 285-290
26. Kren, B. T., Parashar, B., Bandyopadhyay, P., Chowdhury, N. R., Chowdhury, J. R., and Steer, C. J. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 10349-10354
27. Rando, T. A., Disatnik, M. H., and Zhou, L. Z. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 5363-5368
28. Bartlett, R. J., Stockinger, S., Denis, M. M., Bartlett, W. T., Inverardi, L., Le, T. T., Man, N., Morris, G. E., Bogan, D. J., Metcalf-Bogan, J., and Kornegay, J. N. (2000) Nat. Biotechnol. 18, 615-622
29. Kmiec, E. B. (1999) Gene Ther. 6, 1-3
30. Zhu, T., Peterson, D. J., Tagliani, L., St Clair, G., Baszczynski, C. L., and Bowen, B. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 8768-8773
31. Fazio, S., Yao, Z., McCarthy, B. J., and Rall, S. C., Jr. (1992) J. Biol. Chem. 267, 6941-6945
32. Banka, C. L., Black, A. S., Dyer, C. A., and Curtiss, L. K. (1991) J. Lipid Res. 32, 35-43
33. Boussif, O., Lezoualc'h, F., Zanta, M. A., Mergny, M. D., Scherman, D., Demeneix, B., and Behr, J. P. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 7297-7301
34. Pollard, H., Remy, J. S., Loussouarn, G., Demolombe, S., Behr, J. P., and Escande, D. (1998) J. Biol. Chem. 273, 7507-7511
35. Boletta, A., Benigni, A., Lutz, J., Remuzzi, G., Soria, M. R., and Monaco, L. (1997) Hum. Gene Ther. 8, 1243-1251
36. Kren, B. T., Cole-Strauss, A., Kmiec, E. B., and Steer, C. J. (1997) Hepatology 25, 1462-1468
37. McDowell, I. F., Wisdom, G. B., and Trimble, E. R. (1989) Clin. Chem. 35, 2070-2073
38. Mahley, R. W. (1988) (1988) Science 240, 622-630
39. Curtiss, L. K., and Boisvert, W. A. (2000) Curr. Opin. Lipidol. 11, 243-251
40. Tsukamoto, K., Tangirala, R., Chun, S. H., Pure, E., and Rader, D. J. (1999) Arterioscler. Thromb. Vasc. Biol. 19, 2162-2170
41. Desurmont, C., Caillaud, J. M., Emmanuel, F., Benoit, P., Fruchart, J. C., Castro, G., Branellec, D., Heard, J. M., and Duverger, N. (2000) Arterioscler. Thromb. Vasc. Biol. 20, 435-442
42. Kowal, R. C., Herz, J., Weisgraber, K. H., Mahley, R. W., Brown, M. S., and Goldstein, J. L. (1990) J. Biol. Chem. 265, 10771-10779
43. Gasparini, L., Racchi, M., Binetti, G., Trabucchi, M., Solerte, S. B., Alkon, D., Etcheberrigaray, R., Gibson, G., Blass, J., Paoletti, R., and Govoni, S. (1998) FASEB J. 12, 17-34