Cross-talk between apolipoprotein e and cytokines

Mediators of Inflammation

Volumn 2011, Issue , 2011, Pages

  Zhang, Hongliang ^a,b   Wu, Li Min ^a   Wu, Jiang ^a  

^a JILIN UNIVERSITY   (China)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; APOLIPOPROTEIN E2; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; ARGININE; CYSTEINE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 23; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MACROPHAGE MIGRATION INHIBITION FACTOR; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VERY LOW DENSITY LIPOPROTEIN; VIRUS FUSION PROTEIN; APOLIPOPROTEIN E; CYTOKINE; ISOPROTEIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ALLERGIC ENCEPHALOMYELITIS; ASTROCYTE; B LYMPHOCYTE ACTIVATION; CENTRAL NERVOUS SYSTEM INFECTION; CYTOKINE PRODUCTION; DNA POLYMORPHISM; ENDOTOXEMIA; GENE FREQUENCY; GENOTYPE; HEPATITIS C; HERPES SIMPLEX VIRUS 1; HOST RESISTANCE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; IMMUNOMODULATION; INFECTION; INFECTION RISK; INFECTION SENSITIVITY; INNATE IMMUNITY; KLEBSIELLA PNEUMONIAE INFECTION; LISTERIA MONOCYTOGENES; MACROPHAGE; MICROGLIA; MOLECULAR BIOLOGY; MOLECULAR INTERACTION; NATURAL KILLER CELL; NERVE CELL; NONHUMAN; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; RECEPTOR BINDING; REVIEW; SCHWANN CELL; SUPERNATANT; TH1 TH2 BALANCE; TH17 CELL; TRANSGENIC MOUSE; ANIMAL; GENETIC POLYMORPHISM; GENETICS; HELPER CELL; IMMUNOLOGY; INFLAMMATION; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; APOLIPOPROTEINS E; CYTOKINES; HUMANS; INFLAMMATION; POLYMORPHISM, GENETIC; PROTEIN ISOFORMS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 80052659139     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2011/949072     Document Type: Review

References (110)

1. Knopman D. S., Roberts R. O., Geda Y. E., Boeve B. F., Pankratz V. S., Cha R. H., Tangalos E. G., Ivnik R. J., Petersen R. C., Association of prior stroke with cognitive function and cognitive impairment: a population-based study Archives of Neurology 2009 66 5 614 619
2. Kim J., Basak J. M., Holtzman D. M., The role of apolipoprotein E in Alzheimer's disease Neuron 2009 63 3 287 303
3. Shi J., Zhao C. B., Vollmer T. L., Tyry T. M., Kuniyoshi S. M., APOE 4 allele is associated with cognitive impairment in patients with multiple sclerosis Neurology 2008 70 3 185 190
4. Coto-Segura P., Coto E., Alvarez V., Morales B., Soto-Snchez J., Corao A. I., Santos-Juanes J., Apolipoprotein 4 allele is associated with psoriasis severity Archives of Dermatological Research 2010 302 2 145 149
5. Mahley R. W., Apolipoprotein E: cholesterol transport protein with expanding role in cell biology Science 1988 240 4852 622 630
6. Refolo L. M., Fillit H. M., Apolipoprotein E4 as a target for developing new therapeutics for Alzheimer's disease Journal of Molecular Neuroscience 2004 23 3 151 155 (Pubitemid 41389381)
7. Corbo R. M., Scacchp R., Apolipoprotein E (APOE) allele distribution in the world. Is APOE4 a 'thrifty' allele? Annals of Human Genetics 1999 63 4 301 310 (Pubitemid 30021229)
8. Takeda M., Martnez R., Kudo T., Tanaka T., Okochi M., Tagami S., Morihara T., Hashimoto R., Cacabelos R., Apolipoprotein E and central nervous system disorders: reviews of clinical findings Psychiatry and Clinical Neurosciences 2010 64 6 592 607
9. Ulrik Gerdes L., The common polymorphism of apolipoprotein E: geographical aspects and new pathophysiological relations Clinical Chemistry and Laboratory Medicine 2003 41 5 628 631 (Pubitemid 36722815)
10. Gong J. S., Morita S. Y., Kobayashi M., Handa T., Fujita S. C., Yanagisawa K., Michikawa M., Novel action of apolipoprotein e (ApoE): ApoE isoform specifically inhibits lipid-particle-mediated cholesterol release from neurons Molecular Neurodegeneration 2007 2 1, article no. 9
11. Hone E., Martins I. J., Jeoung M., Ji T. H., Gandy S. E., Martins R. N., Alzheimer's disease amyloid-beta peptide modulates apolipoprotein E isoform specific receptor binding Journal of Alzheimer's Disease 2005 7 4 303 314 (Pubitemid 41206942)
12. Lauderback C. M., Kanski J., Hackett J. M., Maeda N., Kindy M. S., Butterfield D. A., Apolipoprotein E modulates Alzheimer's A (1-42)-induced oxidative damage to synaptosomes in an allele-specific manner Brain Research 2002 924 1 90 97 (Pubitemid 34017468)
13. Ji Z. S., Mllendorff K., Cheng I. H., Miranda R. D., Huang Y., Mahley R. W., Reactivity of apolipoprotein E4 and amyloid peptide: lysosomal stability and neurodegeneration The Journal of Biological Chemistry 2006 281 5 2683 2692 (Pubitemid 43845731)
14. Zhang H. L., Wu J., Zhu J., The role of apolipoprotein E in Guillain-Barré syndrome and experimental autoimmune neuritis Journal of Biomedicine amp; Biotechnology 2010 2010 12
15. DeKroon R., Robinette J. B., Hjelmeland A. B., Wiggins E., Blackwell M., Mihovilovic M., Fujii M., York J., Hart J., Kontos C., Rich J., Strittmatter W. J., APOE4-VLDL inhibits the HDL-activated phosphatidylinositol 3-kinase/Akt pathway via the phosphoinositol phosphatase SHIP2 Circulation Research 2006 99 8 829 836 (Pubitemid 44556381)
16. Bu G., Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy Nature Reviews Neuroscience 2009 10 5 333 344
17. Yamamoto T., Choi H. W., Ryan R. O., Apolipoprotein E isoform-specific binding to the low-density lipoprotein receptor Analytical Biochemistry 2008 372 2 222 226 (Pubitemid 350116770)
18. Raffa R. L., Dong L. M., Farese R. V., Weisgraber K. H., Introduction of human apolipoprotein E4 domain interaction into mouse apolipoprotein E Proceedings of the National Academy of Sciences of the United States of America 2001 98 20 11587 11591 (Pubitemid 32928772)
19. Herz J., Apolipoprotein E receptors in the nervous system Current Opinion in Lipidology 2009 20 3 190 196
20. Li L., Thompson P. A., Kitchens R. L., Infection induces a positive acute phase apolipoprotein E response from a negative acute phase gene: role of hepatic LDL receptors Journal of Lipid Research 2008 49 8 1782 1793
21. Urosevic N., Martins R. N., Infection and Alzheimer's disease: the APOE 4 connection and lipid metabolism Journal of Alzheimer's Disease 2008 13 4 421 435 (Pubitemid 352039025)
22. Tyor W. R., Glass J. D., Griffin J. W., Becker P. S., McArthur J. C., Bezman L., Griffin D. E., Cytokine expression in the brain during the acquired immunodeficiency syndrome Annals of Neurology 1992 31 4 349 360
23. Polgreen P. M., Fultz S. L., Justice A. C., Wagner J. H., Diekema D. J., Rabeneck L., Weissman S., Stapleton J. T., Association of hypocholesterolaemia with hepatitis C virus infection in HIV-infected people HIV Medicine 2004 5 3 144 150 (Pubitemid 38765280)
24. van Gorp E. C. M., Suharti C., Mairuhu A. T. A., Dolmans W. M. V., van der Ven J. V., Demacker P. N. M., van der Meer J. W. M., Changes in the plasma lipid profile as a potential predictor of clinical outcome in dengue hemorrhagic fever Clinical Infectious Diseases 2002 34 8 1150 1153 (Pubitemid 34289691)
25. Memon R. A., Grunfeld C., Moser A. H., Feingold K. R., Tumor necrosis factor mediates the effects of endotoxin on cholesterol and triglyceride metabolism in mice Endocrinology 1993 132 5 2246 2253 (Pubitemid 23133278)
26. Singh I. P., Chopra A. K., Coppenhaver D. H., Ananatharamaiah G. M., Baron S., Lipoproteins account for part of the broad non-specific antiviral activity of human serum Antiviral Research 1999 42 3 211 218
27. de Bont N., Netea M. G., Demacker P. N. M., Verschueren I., Kullberg B. J., van Dijk KO. W., van der Meer J. W. M., Stalenhoef A. F. H., Apolipoprotein E knock-out mice are highly susceptible to endotoxemia and Klebsiella pneumoniae infection Journal of Lipid Research 1999 40 4 680 685 (Pubitemid 29173771)
28. Lynch J. R., Tang W., Wang H., Vitek M. P., Bennett E. R., Sullivan P. M., Warner D. S., Laskowitz D. T., APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response The Journal of Biological Chemistry 2003 278 49 48529 48533 (Pubitemid 41079490)
29. De Bont N., Netea M. G., Demacker P. N., Kullberg B. J., van der Meer J. W., Stalenhoef A. F., Apolipoprotein E-deficient mice have an impaired immune response to Klebsiella pneumoniae European Journal of Clinical Investigation 2000 30 9 818 822
30. van Oosten M., Rensen P. C. N., van Amersfoort E. S., van Eck M., van Dam A. M., Brevé J. J. P., Vogel T., Panet A., van Berkel T. J. C., Kuiper J., Apolipoprotein E protects against bacterial lipopolysaccharide-induced lethality: a new therapeutic approach to treat Gram-negative sepsis The Journal of Biological Chemistry 2001 276 12 8820 8824
31. Kattan O. M., Kasravi F. B., Elford E. L., Schell M. T., Harris H. W., Apolipoprotein E-mediated immune regulation in sepsis Journal of Immunology 2008 181 2 1399 1408
32. Martens G. W., Arikan M. C., Lee J., Ren F., Vallerskog T., Kornfeld H., Hypercholesterolemia impairs immunity to tuberculosis Infection and Immunity 2008 76 8 3464 3472
33. Burt T. D., Agan B. K., Marconi V. C., He W., Kulkarni H., Mold J. E., Cavrois M., Huang Y., Mahley R. W., Dolan M. J., McCune J. M., Ahuja S. K., Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE 4/ 4 genotype accelerates HIV disease progression Proceedings of the National Academy of Sciences of the United States of America 2008 105 25 8718 8723 (Pubitemid 351987746)
34. Itzhaki R. F., Wozniak M., Dobson C., Lin W. R., ApoE-viral interactions Nature Medicine 1998 4 12 1344
35. Corder E. H., Robertson K., Lannfelt L., Bogdanovic N., Eggertsen G., Wilkins J., Hall C., HIV-infected subjects with the E4 allele for APOE have excess dementia and peripheral neuropathy Nature Medicine 1998 4 10 1182 1184 (Pubitemid 28468833)
36. Itzhaki R. F., Lin W. R., Shang D., Wilcock G. K., Faragher B., Jamieson G. A., Herpes simplex virus type 1 in brain and risk of Alzheimer's disease The Lancet 1997 349 9047 241 244 (Pubitemid 27050990)
37. Itzhaki R. F., Wozniak M. A., Herpes simplex virus type 1, apolipoprotein E, and cholesterol: a dangerous liaison in Alzheimer's disease and other disorders Progress in Lipid Research 2006 45 1 73 90 (Pubitemid 43170805)
38. Price D. A., Bassendine M. F., Norris S. M., Golding C., Toms G. L., Schmid M. L., Morris C. M., Burt A. D., Donaldson P. T., Apolipoprotein 3 allele is associated with persistent hepatitis C virus infection Gut 2006 55 5 715 718
39. Hishiki T., Shimizu Y., Tobita R., Sugiyama K., Ogawa K., Funami K., Ohsaki Y., Fujimoto T., Takaku H., Wakita T., Baumert T. F., Miyanari Y., Shimotohno K., Infectivity of hepatitis C virus is influenced by association with apolipoprotein E isoforms Journal of Virology 2010 84 22 12048 12057
40. Fabris C., Vandelli C., Toniutto P., Minisini R., Colletta C., Falleti E., Smirne C., Pirisi M., Apolipoprotein E genotypes modulate fibrosis progression in patients with chronic hepatitis C and persistently normal transaminases Journal of Gastroenterology and Hepatology 2011 26 2 328 333
41. Yin Z., Xiong C., Wang Y., Zhou X., Yan S.-K., Investigation of the relationship between apolipoprotein E gene polymorphisms and hepatitis B virus infection in northern China Clinical Chemistry and Laboratory Medicine 2010 48 12 1803 1807
42. Baitsch D., Bock H. H., Engel T., Telgmann R., Mller-Tidow C., Varga G., Bot M., Herz J., Robenek H., Von Eckardstein A., Nofer J.-R., Apolipoprotein E induces antiinflammatory phenotype in macrophages Arteriosclerosis, Thrombosis, and Vascular Biology 2011 31 5 1160 1168
43. Zhu Y., Kodvawala A., Hui D. Y., Apolipoprotein E inhibits Toll-like receptor (TLR)-3- and TLR-4-mediated macrophage activation through distinct mechanisms The Biochemical Journal 2010 428 1 47 54
44. Lynch J. R., Morgan D., Mance J., Matthew W. D., Laskowitz D. T., Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response Journal of Neuroimmunology 2001 114 1-2 107 113 (Pubitemid 32184731)
45. Laskowitz D. T., Thekdi A. D., Thekdi S. D., Han S. K. D., Myers J. K., Pizzo S. V., Bennett E. R., Downregulation of microglial activation by apolipoprotein E and apoE-mimetic peptides Experimental Neurology 2001 167 1 74 85 (Pubitemid 32093924)
46. Zhu J., Mix E., Link H., Cytokine production and the pathogenesis of experimental autoimmune neuritis and Gulllain-Barré syndrome Journal of Neuroimmunology 1998 84 1 40 52 (Pubitemid 28210448)
47. Zhu J., Bai X. F., Mix E., Link H., Cytokine dichotomy in peripheral nervous system influences the outcome of experimental allergic neuritis: dynamics of mRNA expression for IL-1, IL-6, IL-10, IL-12, TNF-, TNF-, and cytolysin Clinical Immunology and Immunopathology 1997 84 1 85 94 (Pubitemid 27293547)
48. Zhu J., Bai X. F., Mix E., Link H., Experimental allergic neuritis: cytolysin mRNA expression is upregulated in lymph node cells during convalescence Journal of Neuroimmunology 1997 78 1-2 108 116 (Pubitemid 27394431)
49. Bao L., Lindgren J. U., van der Meide P., Zhu S. W., Ljunggren H. G., Zhu J., The critical role of IL-12p40 in initiating, enhancing, and perpetuating pathogenic events in murine experimental autoimmune neuritis Brain Pathology 2002 12 4 420 429 (Pubitemid 35154929)
50. Nicoletti F., Créange A., Orlikowski D., Bolgert F., Mangano K., Metz C., Di Marco R., Al Abed Y., Macrophage migration inhibitory factor (MIF) seems crucially involved in Guillain-Barré syndrome and experimental allergic neuritis Journal of Neuroimmunology 2005 168 1-2 168 174 (Pubitemid 41396415)
51. Yu S., Chen Z., Mix E., Zhu S. W., Winblad B., Ljunggren H. G., Zhu J., Neutralizing antibodies to IL-18 ameliorate experimental autoimmune neuritis by counter-regulation of autoreactive Th1 responses to peripheral myelin antigen Journal of Neuropathology and Experimental Neurology 2002 61 7 614 622 (Pubitemid 34721466)
52. Deretzi G., Zou L. P., Pelidou S. H., Nennesmo I., Levi M., Wahren B., Mix E., Zhu J., Nasal administration of recombinant rat IL-4 ameliorates ongoing experimental autoimmune neuritis and inhibits demyelination Journal of Autoimmunity 1999 12 2 81 89 (Pubitemid 29130585)
53. Bai X. F., Zhu J., Zhang G. X., Kaponides G., Hjeberg BO., van der Meide P. H., Link H., IL-10 suppresses experimental autoimmune neuritis and down-regulates T(H)1-type immune responses Clinical Immunology and Immunopathology 1997 83 2 117 126 (Pubitemid 27195931)
54. Leipe J., Grunke M., Dechant C., Reindl C., Kerzendorf U., Schulze-Koops H., Skapenko A., Role of Th17 cells in human autoimmune arthritis Arthritis and Rheumatism 2010 62 10 2876 2885
55. Li M. O., Wan Y. Y., Flavell R. A., T cell-produced transforming growth factor- 1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation Immunity 2007 26 5 579 591 (Pubitemid 46756347)
56. Yin M., Zhang L., Sun X. M., Mao L. F., Pan J., Lack of apoE causes alteration of cytokines expression in young mice liver Molecular Biology Reports 2010 37 4 2049 2054
57. Ali K., Middleton M., Puré E., Rader D. J., Apolipoprotein E suppresses the type I inflammatory response in vivo Circulation Research 2005 97 9 922 927 (Pubitemid 41552678)
58. Tenger C., Zhou X., Apolipoprotein E modulates immune activation by acting on the antigen-presenting cell Immunology 2003 109 3 392 397 (Pubitemid 36783265)
59. Zhou X., Paulsson G., Stemme S., Hansson G. K., Hypercholesterolemia is associated with a T helper (Th) 1/Th2 switch of the autoimmune response in atherosclerotic apo E-knockout mice The Journal of Clinical Investigation 1998 101 8 1717 1725 (Pubitemid 28198502)
60. Davenport P., Tipping P. G., The role of interleukin-4 and interleukin-12 in the progression of atherosclerosis in apolipoprotein E-deficient mice American Journal of Pathology 2003 163 3 1117 1125 (Pubitemid 37040147)
61. Kawamura A., Baitsch D., Telgmann R., Feuerborn R., Weissen-Plenz G., Hagedorn C., Saku K., Brand-Herrmann S. M., Von Eckardstein A., Assmann G., Nofer J. R., Apolipoprotein E interrupts interleukin-1 signaling in vascular smooth muscle cells Arteriosclerosis, Thrombosis, and Vascular Biology 2007 27 7 1610 1617 (Pubitemid 46986117)
62. Stuehr D. J., Cho H. J., Nyoun Soo Kwon., Weise M. F., Nathan C. F., Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein Proceedings of the National Academy of Sciences of the United States of America 1991 88 17 7773 7777 (Pubitemid 21915236)
63. Vitek M. P., Snell J., Dawson H., Colton C. A., Modulation of nitric oxide production in human macrophages by apolipoprotein-E and amyloid-beta peptide Biochemical and Biophysical Research Communications 1997 240 2 391 394 (Pubitemid 27523670)
64. Colton C. A., Czapiga M., Snell-Callanan J., Chernyshev O. N., Vitek M. P., Apolipoprotein E acts to increase nitric oxide production in macrophages by stimulating arginine transport Biochimica et Biophysica Acta 2001 1535 2 134 144 (Pubitemid 32112760)
65. Colton C. A., Brown C. M., Cook D., Needham L. K., Xu Q., Czapiga M., Saunders A. M., Schmechel D. E., Rasheed K., Vitek M. P., APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress Neurobiology of Aging 2002 23 5 777 785 (Pubitemid 35217702)
66. Colton C. A., Needham L. K., Brown C., Cook D., Rasheed K., Burke J. R., Strittmatter W. J., Schmechel D. E., Vitek M. P., APOE genotype-specific differences in human and mouse macrophage nitric oxide production Journal of Neuroimmunology 2004 147 1-2 62 67 (Pubitemid 38114948)
67. Maezawa I., Nivison M., Montine K. S., Maeda N., Montine T. J., Neurotoxicity from innate immune response is greatest with targeted replacement of E4 allele of apolipoprotein E gene and is mediated by microglial p38MAPK The FASEB Journal 2006 20 6 797 799 (Pubitemid 46671219)
68. Brown C. M., Xu Q., Okhubo N., Vitek M. P., Colton C. A., Androgen-mediated immune function is altered by the apolipoprotein E gene Endocrinology 2007 148 7 3383 3390 (Pubitemid 46996995)
69. Meyer zu Hrste G., Hu W., Hartung H. P., Lehmann H. C., Kieseier B. C., The immunocompetence of Schwann cells Muscle and Nerve 2008 37 1 3 13
70. Duan R. S., Jin T., Yang X., Mix E., Adem A., Zhu J., Apolipoprotein E deficiency enhances the antigen-presenting capacity of Schwann cells Glia 2007 55 7 772 776 (Pubitemid 46663029)
71. Yu S., Duan R. S., Chen Z., Quezada H. C., Bao L., Nennesmo I., Zhu S. W., Winblad B., Ljunggren H. G., Zhu J., Increased susceptibility to experimental autoimmune neuritis after upregulation of the autoreactive T cell response to peripheral myelin antigen in apolipoprotein E-deficient mice Journal of Neuropathology and Experimental Neurology 2004 63 2 120 128 (Pubitemid 38174777)
72. Xie J. J., Wang J., Tang T. T., Chen J., Gao X. L., Yuan J., Zhou ZI. H., Liao M. Y., Yao R., Yu X., Wang D., Cheng Y., Liao YU. H., Cheng X., The Th17/Treg functional imbalance during atherogenesis in ApoE-/-mice Cytokine 2010 49 2 185 193
73. Smith E., Prasad K. M. R., Butcher M., Dobrian A., Kolls J. K., Ley K., Galkina E., Blockade of interleukin-17A results in reduced atherosclerosis in apolipoprotein E-deficient mice Circulation 2010 121 15 1746 1755
74. Li F. Q., Sempowski G. D., McKenna S. E., Laskowitz D. T., Colton C. A., Vitek M. P., Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis Journal of Pharmacology and Experimental Therapeutics 2006 318 3 956 965 (Pubitemid 44268300)
75. Zhang H. L., Wu J., Zhu J., The immune-modulatory role of apolipoprotein e with emphasis on multiple sclerosis and experimental autoimmune encephalomyelitis Clinical and Developmental Immunology 2010 2010
76. Singh K., Chaturvedi R., Barry D. P., Coburn L. A., Asim M., Lewis N. D., Piazuelo M. B., Washington M. K., Vitek M. P., Wilson K. T., The apolipoprotein E-mimetic peptide COG112 inhibits NF- B signaling, proinflammatory cytokine expression, and disease activity in murine models of colitis The Journal of Biological Chemistry 2011 286 5 3839 3850
77. Schulte S., Sukhova G. K., Libby P., Genetically programmed biases in Th1 and Th2 immune responses modulate atherogenesis American Journal of Pathology 2008 172 6 1500 1508 (Pubitemid 351793344)
78. Jofre-Monseny L., Minihane A. M., Rimbach G., Impact of apoE genotype on oxidative stress, inflammation and disease risk Molecular Nutrition and Food Research 2008 52 1 131 145 (Pubitemid 351211806)
79. Misra U. K., Adlakha C. L., Gawdi G., McMillian M. K., Pizzo S. V., Laskowitz D. T., Apolipoprotein E and mimetic peptide initiate a calcium-dependent signaling response in macrophages Journal of Leukocyte Biology 2001 70 4 677 683 (Pubitemid 32958556)
80. Ruiz J., Kouiavskaia D., Migliorini M., Robinson S., Saenko E. L., Gorlatova N., Li D., Lawrence D., Hyman B. T., Weisgraber K. H., Strickland D. K., The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor Journal of Lipid Research 2005 46 8 1721 1731 (Pubitemid 41099339)
81. Vitek M. P., Brown C. M., Colton C. A., APOE genotype-specific differences in the innate immune response Neurobiology of Aging 2009 30 9 1350 1360
82. Tsoi L. M., Wong K. Y., Liu Y. M., Ho Y. Y., Apoprotein E isoform-dependent expression and secretion of pro-inflammatory cytokines TNF- and IL-6 in macrophages Archives of Biochemistry and Biophysics 2007 460 1 33 40
83. Jofre-Monseny L., Loboda A., Wagner A. E., Huebbe P., Boesch-Saadatmandi C., Jozkowicz A., Minihane A. M., Dulak J., Rimbach G., Effects of apoE genotype on macrophage inflammation and heme oxygenase-1 expression Biochemical and Biophysical Research Communications 2007 357 1 319 324 (Pubitemid 46574533)
84. Laskowitz D. T., Goel S., Bennett E. R., Matthew W. D., Apolipoprotein E suppresses glial cell secretion of TNF Journal of Neuroimmunology 1997 76 1-2 70 74 (Pubitemid 27272630)
85. Barger S. W., Harmon A. D., Microglial activation by alzhelmer amyloid precursor protein and modulation by apolipoprotein E Nature 1997 388 6645 878 881 (Pubitemid 27377060)
86. Guo L., LaDu M. J., van Eldik L. J., A dual role for apolipoprotein e in neuroinflammation: anti- and pro-inflammatory activity Journal of Molecular Neuroscience 2004 23 3 205 212
87. Boesch-Saadatmandi C., Wolffram S., Minihane A. M., Rimbach G., Effect of apoE genotype and dietary quercetin on blood lipids and TNF- levels in apoE3 and apoE4 targeted gene replacement mice British Journal of Nutrition 2009 101 10 1440 1443
88. Chen S., Averett N. T., Manelli A., LaDu M. J., May W., Ard M. D., Isoform-specific effects of apolipoprotein E on secretion of inflammatory mediators in adult rat microglia Journal of Alzheimer's Disease 2005 7 1 25 35 (Pubitemid 40387182)
89. Maezawa I., Maeda N., Montine T. J., Montine K. S., Apolipoprotein E-specific innate immune response in astrocytes from targeted replacement mice Journal of Neuroinflammation 2006 3, article no. 10
90. Tesseur I., Zhang H., Brecht W., Corn J., Gong J. S., Yanagisawa K., Michikawa M., Weisgraber K., Huang Y., Wyss-Coray T., Bioactive TGF- can associate with lipoproteins and is enriched in those containing apolipoprotein E3 Journal of Neurochemistry 2009 110 4 1254 1262
91. Ophir G., Amariglio N., Jacob-Hirsch J., Elkon R., Rechavi G., Michaelson D. M., Apolipoprotein E4 enhances brain inflammation by modulation of the NF- B signaling cascade Neurobiology of Disease 2005 20 3 709 718 (Pubitemid 41619347)
92. Wang H., Christensen D. J., Vitek M. P., Sulivan P. M., Laskowitz D. T., APOE genotype affects outcome in a murine model of sepsis: implications for a new treatment strategy Anaesthesia and Intensive Care 2009 37 1 38 45
93. Olgiati P., Politis A., Malitas P., Albani D., Dusi S., Polito L., De Mauro S., Zisaki A., Piperi C., Stamouli E., Mailis A., Batelli S., Forloni G., De Ronchi D., Kalofoutis A., Liappas I., Serretti A., APOE epsilon-4 allele and cytokine production in Alzheimer's disease International Journal of Geriatric Psychiatry 2010 25 4 338 344
94. Tziakas D. N., Chalikias G. K., Antonoglou C. O., Veletza S., Tentes I. K., Kortsaris A. X., Hatseras D. I., Kaski J. C., Apolipoprotein E genotype and circulating interleukin-10 levels in patients with stable and unstable coronary artery disease Journal of the American College of Cardiology 2006 48 12 2471 2481 (Pubitemid 44881216)
95. Bojanowski C. M., Shen D., Chew E. Y., Ning B., Csaky K. G., Green W. R., Chan C. C., Tuo J., An apolipoprotein E variant may protect against age-related macular degeneration through cytokine regulation Environmental and Molecular Mutagenesis 2006 47 8 594 602 (Pubitemid 44701595)
96. Brown C. M., Choi E., Xu Q., Vitek M. P., Colton C. A., The APOE4 genotype alters the response of microglia and macrophages to 17 -estradiol Neurobiology of Aging 2008 29 12 1783 1794
97. Brand K., Mackman N., Curtiss L. K., Interferon- inhibits macrophage apolipoprotein E production by posttranslational mechanisms The Journal of Clinical Investigation 1993 91 5 2031 2039 (Pubitemid 23141475)
98. Saura J., Petegnief V., Wu X., Liang Y., Paul S. M., Microglial apolipoprotein E and astroglial apolipoprotein J expression in vitro: opposite effects of lipopolysaccharide Journal of Neurochemistry 2003 85 6 1455 1467 (Pubitemid 36702558)
99. Starck M., Bertrand P., Pépin S., Schiele F., Siest G., Galteau M. M., Effects of pro-inflammatory cytokines on apolipoprotein E secretion by a human astrocytoma cell line (CCF-STTG1) Cell Biochemistry and Function 2000 18 1 9 16 (Pubitemid 30105600)
100. Zuckerman S. H., Evans G. F., O'Neal L., Cytokine regulation of macrophage apo E secretion: opposing effects of GM-CSF and TGF- Atherosclerosis 1992 96 2-3 203 214
101. Levin-Allerhand J., McEwen B. S., Lominska C. E., Lubahn D. B., Korach K. S., Smith J. D., Brain region-specific up-regulation of mouse apolipoprotein E by pharmacological estrogen treatments Journal of Neurochemistry 2001 79 4 796 803 (Pubitemid 33086517)
102. Srivastava N., Averna M., Lin R. C., Korach K. S., Lubahn D. B., Schonfeld G., Estrogen up-regulates apolipoprotein E (ApoE) gene expression by increasing ApoE mRNA in the translating pool via the estrogen receptor -mediated pathway The Journal of Biological Chemistry 1997 272 52 33360 33366 (Pubitemid 28023687)
103. Stone D. J., Rozovsky I., Morgan T. E., Anderson C. P., Hajian H., Finch C. E., Astrocytes and microglia respond to estrogen with increased apoE mRNA in vivo and in vitro Experimental Neurology 1997 143 2 313 318 (Pubitemid 27148235)
104. Aleong R., Blain J. F., Poirier J., Pro-inflammatory cytokines modulate glial apolipoprotein E secretion Current Alzheimer Research 2008 5 1 33 37 (Pubitemid 351536352)
105. Hofmann S. M., Perez-Tilve D., Greer T. M., Coburn B. A., Grant E., Basford J. E., Tschp M. H., Hui D. Y., Defective lipid delivery modulates glucose tolerance and metabolic response to diet in apolipoprotein E-deficient mice Diabetes 2008 57 1 5 12
106. Yue L., Rasouli N., Ranganathan G., Kern P. A., Mazzone T., Divergent effects of peroxisome proliferator-activated receptor agonists and tumor necrosis factor on adipocyte ApoE expression The Journal of Biological Chemistry 2004 279 46 47626 47632 (Pubitemid 39540908)
107. Yue L., Christman J. W., Mazzone T., Tumor necrosis factor- -mediated suppression of adipocyte apolipoprotein E gene transcription: primary role for the nuclear factor (NF)- B pathway and NF B p50 Endocrinology 2008 149 8 4051 4058
108. Colton C. A., Brown C. M., Vitek M. P., Sex steroids, APOE genotype and the innate immune system Neurobiology of Aging 2005 26 3 363 372 (Pubitemid 40082720)
109. O'Toole D., Love W. C., Interferon- -1b and interferon- have similar inhibitory effects on apolipoprotein-E production in the monocyte/macrophage Multiple Sclerosis 2002 8 2 124 129 (Pubitemid 34256749)
110. Singh N. N., Ramji D. P., Transforming growth factor- -induced expression of the apolipoprotein E gene requires c-Jun N-terminal kinase, p38 kinase, and casein kinase 2 Arteriosclerosis, Thrombosis, and Vascular Biology 2006 26 6 1323 1329 (Pubitemid 44305377)