Apolipoprotein E-deficient mice have an impaired immune response to Klebsiella pneumoniae

European Journal of Clinical Investigation

Volumn 30, Issue 9, 2000, Pages 818-822

  De Bont, ^a   Netea, ^a   Demacker, ^a   Kullberg, ^a   Van Der Meer, ^a   Stalenhoef, ^a,b  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Apo E deficient mice; Hypercholesterolemia; Klebisiella pneumoniae; Lipoproteins; Survival; TNF

Indexed keywords

APOLIPOPROTEIN E; BACTERIUM LIPOPOLYSACCHARIDE; CYCLOPHOSPHAMIDE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL GROWTH; BLOOD LEVEL; CONTROLLED STUDY; GRAM NEGATIVE INFECTION; GRANULOCYTE; IMMUNE RESPONSE; KIDNEY; KLEBSIELLA PNEUMONIAE; LIVER LEVEL; MORTALITY; MOUSE; NEUTROPENIA; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; SEPSIS; SPLEEN;

ANIMALS; APOLIPOPROTEINS E; CHOLESTEROL; DISEASE MODELS, ANIMAL; IMMUNITY; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEUTROPENIA; PEPTIDE FRAGMENTS; TRIGLYCERIDES;

EID: 0033821562     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.2000.00715.x     Document Type: Article

References (21)

1. Adjunctive therapy for septic shock: A review of experimental approaches
2. The role of lipoproteins and receptor-mediated endocytosis in the transport of bacterial lipopolysaccharide
3. Chylomicrons alter the fate of endotoxin, decreasing tumor necrosis factor release and preventing death
4. Inhibition of endotoxin-induced activation of human monocytes by human lipoproteins
5. Lipoprotein (a) inhibits the lipopolysaccharide-induced tumor necrosis factor-alpha production by human mononuclear cells
6. Cytokine response by monocytes and macrophages to free and lipoprotein-bound lipopolysaccharide
7. Low density lipoproteins inhibit endotoxin activation of monocytes
8. Low-density lipoprotein receptor-deficient mice are protected against lethal endotoxemia and severe gram-negative infections
9. In vivo protection against endotoxin by plasma high density lipoprotein
10. Apolipoprotein E knock-out mice are highly susceptible to endotoxemia and Klebsiella pneumoniae infection
11. Hyperlipoproteinemia enhances susceptibility to acute disseminated Candida albicans infection in low-density-lipoprotein-receptor-deficient mice
12. Infusion of lipoproteins into volunteers enhances the growth of Candida albicans
13. Antimicrobial activity of lipoprotein particles containing apolipoprotein Al
14. Inactivation of penicillin-induced staphylococcal L-forms by human serum high density lipoprotein
15. Diet-induced hypercholesterolemia and atherosclerosis in heterozygous apolipoprotein E-deficient mice
16. Effect of irradiation, cyclophosphamide, and etoposide (VP-16) on number of peripheral blood and peritoneal leukocytes in mice under normal conditions and during acute inflammatory reaction
17. Differential gene expression for IL-1 receptor antagonist, IL-1, and TNF receptors and IL-1 and TNF synthesis may explain IL-1-induced resistance to infection
18. The role of hyperuricemia in the increased cytokine production after lipopolysaccharide challenge in neutropenic mice
19. Human recombinant apolipoprotein E redirects lipopolysaccharide from Kupffer cells to liver parenchymal cells in rats In vivo
20. Human apolipoprotein E protects against the deleterious effects of bacterial lipopolysaccharide in rats in vivo
21. Apolipoprotein E-deficient mice have impaired innate immune responses to Listeria monocytogenes in vivo