메뉴 건너뛰기




Volumn 108, Issue , 2012, Pages 129-158

Genetic and epigenomic footprints of folate

Author keywords

Chromatin; Epigenetics; Evolution; Folate; Folate supplementation; Gene expression; Methylation

Indexed keywords


EID: 84861819063     PISSN: 18771173     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-398397-8.00006-X     Document Type: Chapter
Times cited : (50)

References (152)
  • 4
  • 5
    • 0035906327 scopus 로고    scopus 로고
    • The role of folic acid and Vitamin B12 in genomic stability of human cells
    • M. Fenech The role of folic acid and Vitamin B12 in genomic stability of human cells Mutat Res 475 2001 57 67
    • (2001) Mutat Res , vol.475 , pp. 57-67
    • Fenech, M.1
  • 7
    • 0242610825 scopus 로고    scopus 로고
    • Role of folate in colon cancer development and progression
    • Y.I. Kim Role of folate in colon cancer development and progression J Nutr 133 2003 3731S 3739S
    • (2003) J Nutr , vol.133
    • Kim, Y.I.1
  • 8
    • 79952738916 scopus 로고    scopus 로고
    • The antifolates: Evolution, new agents in the clinic, and how targeting delivery via specific membrane transporters is driving the development of a next generation of folate analogs
    • I.D. Goldman, S. Chattopadhyay, R. Zhao, and R. Moran The antifolates: evolution, new agents in the clinic, and how targeting delivery via specific membrane transporters is driving the development of a next generation of folate analogs Curr Opin Investig Drugs 11 2010 1409 1423
    • (2010) Curr Opin Investig Drugs , vol.11 , pp. 1409-1423
    • Goldman, I.D.1    Chattopadhyay, S.2    Zhao, R.3    Moran, R.4
  • 9
    • 67649849650 scopus 로고    scopus 로고
    • Folate-targeted therapeutic and imaging agents for cancer
    • P.S. Low, and S.A. Kularatne Folate-targeted therapeutic and imaging agents for cancer Curr Opin Chem Biol 13 2009 256 262
    • (2009) Curr Opin Chem Biol , vol.13 , pp. 256-262
    • Low, P.S.1    Kularatne, S.A.2
  • 10
    • 1942535095 scopus 로고    scopus 로고
    • A review of folate receptor alpha cycling and 5-methyltetrahydrofolate accumulation with an emphasis on cell models in vitro
    • B.A. Kamen, and A.K. Smith A review of folate receptor alpha cycling and 5-methyltetrahydrofolate accumulation with an emphasis on cell models in vitro Adv Drug Deliv Rev 56 2004 1085 1097
    • (2004) Adv Drug Deliv Rev , vol.56 , pp. 1085-1097
    • Kamen, B.A.1    Smith, A.K.2
  • 12
    • 1642332919 scopus 로고    scopus 로고
    • Folate concentration dependent transport activity of the Multidrug Resistance Protein 1 (ABCC1)
    • J.H. Hooijberg, G. Jansen, Y.G. Assaraf, I. Kathmann, R. Pieters, and A.C. Laan Folate concentration dependent transport activity of the Multidrug Resistance Protein 1 (ABCC1) Biochem Pharmacol 67 2004 1541 1548
    • (2004) Biochem Pharmacol , vol.67 , pp. 1541-1548
    • Hooijberg, J.H.1    Jansen, G.2    Assaraf, Y.G.3    Kathmann, I.4    Pieters, R.5    Laan, A.C.6
  • 13
    • 54349088976 scopus 로고    scopus 로고
    • Increasing systemic exposure of methotrexate by active efflux mediated by multidrug resistance-associated protein 3 (mrp3/abcc3)
    • Y. Kitamura, M. Hirouchi, H. Kusuhara, J.D. Schuetz, and Y. Sugiyama Increasing systemic exposure of methotrexate by active efflux mediated by multidrug resistance-associated protein 3 (mrp3/abcc3) J Pharmacol Exp Ther 327 2008 465 473
    • (2008) J Pharmacol Exp Ther , vol.327 , pp. 465-473
    • Kitamura, Y.1    Hirouchi, M.2    Kusuhara, H.3    Schuetz, J.D.4    Sugiyama, Y.5
  • 14
    • 0032884078 scopus 로고    scopus 로고
    • Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development
    • J.A. Piedrahita, B. Oetama, G.D. Bennett, J. van Waes, B.A. Kamen, and J. Richardson Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development Nat Genet 23 1999 228 232
    • (1999) Nat Genet , vol.23 , pp. 228-232
    • Piedrahita, J.A.1    Oetama, B.2    Bennett, G.D.3    Van Waes, J.4    Kamen, B.A.5    Richardson, J.6
  • 15
    • 0037217759 scopus 로고    scopus 로고
    • Spatial and temporal expression of folate-binding protein 1 (Fbp1) is closely associated with anterior neural tube closure in mice
    • H. Saitsu, M. Ishibashi, H. Nakano, and K. Shiota Spatial and temporal expression of folate-binding protein 1 (Fbp1) is closely associated with anterior neural tube closure in mice Dev Dyn 226 2003 112 117
    • (2003) Dev Dyn , vol.226 , pp. 112-117
    • Saitsu, H.1    Ishibashi, M.2    Nakano, H.3    Shiota, K.4
  • 16
    • 65349091896 scopus 로고    scopus 로고
    • Regulation of Folate receptor 1 gene expression in the visceral endoderm
    • J. Salbaum, R. Finnell, and C. Kappen Regulation of Folate receptor 1 gene expression in the visceral endoderm Birth Defects Res A Clin Mol Teratol 85 2009 303 313
    • (2009) Birth Defects Res A Clin Mol Teratol , vol.85 , pp. 303-313
    • Salbaum, J.1    Finnell, R.2    Kappen, C.3
  • 17
    • 0031036589 scopus 로고    scopus 로고
    • The divergent 5′ termini of the alpha human folate receptor (hFR) mRNAs originate from two tissue-specific promoters and alternative splicing: Characterization of the alpha hFR gene structure
    • P.C. Elwood, K. Nachmanoff, Y. Saikawa, S.T. Page, P. Pacheco, and S. Roberts The divergent 5′ termini of the alpha human folate receptor (hFR) mRNAs originate from two tissue-specific promoters and alternative splicing: characterization of the alpha hFR gene structure Biochemistry 36 1997 1467 1478
    • (1997) Biochemistry , vol.36 , pp. 1467-1478
    • Elwood, P.C.1    Nachmanoff, K.2    Saikawa, Y.3    Page, S.T.4    Pacheco, P.5    Roberts, S.6
  • 19
    • 0034116765 scopus 로고    scopus 로고
    • Investigation of folate pathway gene polymorphisms and the incidence of neural tube defects in a Texas hispanic population
    • R. Barber, S. Shalat, K. Hendricks, B. Joggerst, R. Larsen, and L. Suarez Investigation of folate pathway gene polymorphisms and the incidence of neural tube defects in a Texas hispanic population Mol Genet Metab 70 2000 45 52
    • (2000) Mol Genet Metab , vol.70 , pp. 45-52
    • Barber, R.1    Shalat, S.2    Hendricks, K.3    Joggerst, B.4    Larsen, R.5    Suarez, L.6
  • 20
    • 0032054038 scopus 로고    scopus 로고
    • Lack of association between mutations in the folate receptor-alpha gene and spina bifida
    • R.C. Barber, G.M. Shaw, E.J. Lammer, K.A. Greer, T.A. Biela, and S.W. Lacey Lack of association between mutations in the folate receptor-alpha gene and spina bifida Am J Med Genet 76 1998 310 317
    • (1998) Am J Med Genet , vol.76 , pp. 310-317
    • Barber, R.C.1    Shaw, G.M.2    Lammer, E.J.3    Greer, K.A.4    Biela, T.A.5    Lacey, S.W.6
  • 21
    • 69449106758 scopus 로고    scopus 로고
    • Folate receptor alpha defect causes cerebral folate transport deficiency: A treatable neurodegenerative disorder associated with disturbed myelin metabolism
    • R. Steinfeld, M. Grapp, R. Kraetzner, S. Dreha-Kulaczewski, G. Helms, and P. Dechent Folate receptor alpha defect causes cerebral folate transport deficiency: a treatable neurodegenerative disorder associated with disturbed myelin metabolism Am J Hum Genet 85 2009 354 363
    • (2009) Am J Hum Genet , vol.85 , pp. 354-363
    • Steinfeld, R.1    Grapp, M.2    Kraetzner, R.3    Dreha-Kulaczewski, S.4    Helms, G.5    Dechent, P.6
  • 22
    • 13444282095 scopus 로고    scopus 로고
    • Developmental consequences of in utero sodium arsenate exposure in mice with folate transport deficiencies
    • O. Spiegelstein, A. Gould, B. Wlodarczyk, M. Tsie, X. Lu, and C. Le Developmental consequences of in utero sodium arsenate exposure in mice with folate transport deficiencies Toxicol Appl Pharmacol 203 2005 18 26
    • (2005) Toxicol Appl Pharmacol , vol.203 , pp. 18-26
    • Spiegelstein, O.1    Gould, A.2    Wlodarczyk, B.3    Tsie, M.4    Lu, X.5    Le, C.6
  • 23
    • 4043172580 scopus 로고    scopus 로고
    • Folate modulates Hox gene-controlled skeletal phenotypes
    • C. Kappen, M.A. Mello, R.H. Finnell, and J.M. Salbaum Folate modulates Hox gene-controlled skeletal phenotypes Genesis 39 2004 155 166
    • (2004) Genesis , vol.39 , pp. 155-166
    • Kappen, C.1    Mello, M.A.2    Finnell, R.H.3    Salbaum, J.M.4
  • 24
    • 0037110469 scopus 로고    scopus 로고
    • Polymorphism G80A in the reduced folate carrier gene and its relationship to methotrexate plasma levels and outcome of childhood acute lymphoblastic leukemia
    • C. Laverdiere, S. Chiasson, I. Costea, A. Moghrabi, and M. Krajinovic Polymorphism G80A in the reduced folate carrier gene and its relationship to methotrexate plasma levels and outcome of childhood acute lymphoblastic leukemia Blood 100 2002 3832 3834
    • (2002) Blood , vol.100 , pp. 3832-3834
    • Laverdiere, C.1    Chiasson, S.2    Costea, I.3    Moghrabi, A.4    Krajinovic, M.5
  • 25
    • 69249211287 scopus 로고    scopus 로고
    • Association of RFC1 A80G and MTHFR C677T polymorphisms with Alzheimer's disease
    • X.H. Bi, H.L. Zhao, Z.X. Zhang, and J.W. Zhang Association of RFC1 A80G and MTHFR C677T polymorphisms with Alzheimer's disease Neurobiol Aging 30 2009 1601 1607
    • (2009) Neurobiol Aging , vol.30 , pp. 1601-1607
    • Bi, X.H.1    Zhao, H.L.2    Zhang, Z.X.3    Zhang, J.W.4
  • 27
    • 0035971190 scopus 로고    scopus 로고
    • Rescue of embryonic lethality in reduced folate carrier-deficient mice by maternal folic acid supplementation reveals early neonatal failure of hematopoietic organs
    • R. Zhao, R.G. Russell, Y. Wang, L. Liu, F. Gao, and B. Kneitz Rescue of embryonic lethality in reduced folate carrier-deficient mice by maternal folic acid supplementation reveals early neonatal failure of hematopoietic organs J Biol Chem 276 2001 10224 10228
    • (2001) J Biol Chem , vol.276 , pp. 10224-10228
    • Zhao, R.1    Russell, R.G.2    Wang, Y.3    Liu, L.4    Gao, F.5    Kneitz, B.6
  • 28
    • 2942752383 scopus 로고    scopus 로고
    • Reduced-folate carrier (RFC) is expressed in placenta and yolk sac, as well as in cells of the developing forebrain, hindbrain, neural tube, craniofacial region, eye, limb buds and heart
    • D.M. Maddox, A. Manlapat, P. Roon, P. Prasad, V. Ganapathy, and S.B. Smith Reduced-folate carrier (RFC) is expressed in placenta and yolk sac, as well as in cells of the developing forebrain, hindbrain, neural tube, craniofacial region, eye, limb buds and heart BMC Dev Biol 3 2003 6
    • (2003) BMC Dev Biol , vol.3 , pp. 6
    • Maddox, D.M.1    Manlapat, A.2    Roon, P.3    Prasad, P.4    Ganapathy, V.5    Smith, S.B.6
  • 29
    • 0027982786 scopus 로고
    • A novel cDNA restores reduced folate carrier activity and methotrexate sensitivity to transport deficient cells
    • K.H. Dixon, B.C. Lanpher, J. Chiu, K. Kelley, and K.H. Cowan A novel cDNA restores reduced folate carrier activity and methotrexate sensitivity to transport deficient cells J Biol Chem 269 1994 17 20
    • (1994) J Biol Chem , vol.269 , pp. 17-20
    • Dixon, K.H.1    Lanpher, B.C.2    Chiu, J.3    Kelley, K.4    Cowan, K.H.5
  • 30
    • 33751244559 scopus 로고    scopus 로고
    • Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption
    • A. Qiu, M. Jansen, A. Sakaris, S.H. Min, S. Chattopadhyay, and E. Tsai Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption Cell 127 2006 917 928
    • (2006) Cell , vol.127 , pp. 917-928
    • Qiu, A.1    Jansen, M.2    Sakaris, A.3    Min, S.H.4    Chattopadhyay, S.5    Tsai, E.6
  • 31
    • 67649371083 scopus 로고    scopus 로고
    • Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice
    • H. Jakubowski, J. Perla-Kajan, R.H. Finnell, R.M. Cabrera, H. Wang, and S. Gupta Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice FASEB J 23 2009 1721 1727
    • (2009) FASEB J , vol.23 , pp. 1721-1727
    • Jakubowski, H.1    Perla-Kajan, J.2    Finnell, R.H.3    Cabrera, R.M.4    Wang, H.5    Gupta, S.6
  • 32
    • 79955963955 scopus 로고    scopus 로고
    • A mouse model of hereditary folate malabsorption: Deletion of the PCFT gene leads to systemic folate deficiency
    • K.V. Salojin, R.M. Cabrera, W. Sun, W.C. Chang, C. Lin, and L. Duncan A mouse model of hereditary folate malabsorption: deletion of the PCFT gene leads to systemic folate deficiency Blood 117 2011 4895 4904
    • (2011) Blood , vol.117 , pp. 4895-4904
    • Salojin, K.V.1    Cabrera, R.M.2    Sun, W.3    Chang, W.C.4    Lin, C.5    Duncan, L.6
  • 33
    • 77958027532 scopus 로고    scopus 로고
    • Mutation of the proton-coupled folate transporter gene (PCFT-SLC46A1) in Turkish siblings with hereditary folate malabsorption
    • B. Atabay, M. Turker, E.A. Ozer, K. Mahadeo, N. Diop-Bove, and I.D. Goldman Mutation of the proton-coupled folate transporter gene (PCFT-SLC46A1) in Turkish siblings with hereditary folate malabsorption Pediatr Hematol Oncol 27 2010 614 619
    • (2010) Pediatr Hematol Oncol , vol.27 , pp. 614-619
    • Atabay, B.1    Turker, M.2    Ozer, E.A.3    Mahadeo, K.4    Diop-Bove, N.5    Goldman, I.D.6
  • 34
    • 70350613227 scopus 로고    scopus 로고
    • Reversible severe combined immunodeficiency phenotype secondary to a mutation of the proton-coupled folate transporter
    • A. Borzutzky, B. Crompton, A.K. Bergmann, S. Giliani, S. Baxi, and M. Martin Reversible severe combined immunodeficiency phenotype secondary to a mutation of the proton-coupled folate transporter Clin Immunol 133 2009 287 294
    • (2009) Clin Immunol , vol.133 , pp. 287-294
    • Borzutzky, A.1    Crompton, B.2    Bergmann, A.K.3    Giliani, S.4    Baxi, S.5    Martin, M.6
  • 35
    • 34548026299 scopus 로고    scopus 로고
    • The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorption
    • R. Zhao, S.H. Min, A. Qiu, A. Sakaris, G.L. Goldberg, and C. Sandoval The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorption Blood 110 2007 1147 1152
    • (2007) Blood , vol.110 , pp. 1147-1152
    • Zhao, R.1    Min, S.H.2    Qiu, A.3    Sakaris, A.4    Goldberg, G.L.5    Sandoval, C.6
  • 36
    • 79851500161 scopus 로고    scopus 로고
    • Dihydrofolate reductase deficiency due to a homozygous DHFR mutation causes megaloblastic anemia and cerebral folate deficiency leading to severe neurologic disease
    • H. Cario, D.E. Smith, H. Blom, N. Blau, H. Bode, and K. Holzmann Dihydrofolate reductase deficiency due to a homozygous DHFR mutation causes megaloblastic anemia and cerebral folate deficiency leading to severe neurologic disease Am J Hum Genet 88 2011 226 231
    • (2011) Am J Hum Genet , vol.88 , pp. 226-231
    • Cario, H.1    Smith, D.E.2    Blom, H.3    Blau, N.4    Bode, H.5    Holzmann, K.6
  • 37
    • 79851503576 scopus 로고    scopus 로고
    • Identification and characterization of an inborn error of metabolism caused by dihydrofolate reductase deficiency
    • S. Banka, H.J. Blom, J. Walter, M. Aziz, J. Urquhart, and C.M. Clouthier Identification and characterization of an inborn error of metabolism caused by dihydrofolate reductase deficiency Am J Hum Genet 88 2011 216 225
    • (2011) Am J Hum Genet , vol.88 , pp. 216-225
    • Banka, S.1    Blom, H.J.2    Walter, J.3    Aziz, M.4    Urquhart, J.5    Clouthier, C.M.6
  • 39
    • 34548059198 scopus 로고    scopus 로고
    • A miR-24 microRNA binding-site polymorphism in dihydrofolate reductase gene leads to methotrexate resistance
    • P.J. Mishra, R. Humeniuk, G.S. Longo-Sorbello, D. Banerjee, and J.R. Bertino A miR-24 microRNA binding-site polymorphism in dihydrofolate reductase gene leads to methotrexate resistance Proc Natl Acad Sci USA 104 2007 13513 13518
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 13513-13518
    • Mishra, P.J.1    Humeniuk, R.2    Longo-Sorbello, G.S.3    Banerjee, D.4    Bertino, J.R.5
  • 40
    • 77956487852 scopus 로고    scopus 로고
    • Anti-folate drug resistance in Africa: Meta-analysis of reported dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant genotype frequencies in African Plasmodium falciparum parasite populations
    • S. Sridaran, S.K. McClintock, L.M. Syphard, K.M. Herman, J.W. Barnwell, and V. Udhayakumar Anti-folate drug resistance in Africa: meta-analysis of reported dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant genotype frequencies in African Plasmodium falciparum parasite populations Malar J 9 2010 247
    • (2010) Malar J , vol.9 , pp. 247
    • Sridaran, S.1    McClintock, S.K.2    Syphard, L.M.3    Herman, K.M.4    Barnwell, J.W.5    Udhayakumar, V.6
  • 41
    • 33744460203 scopus 로고    scopus 로고
    • Confirmation of the R653Q polymorphism of the trifunctional C1-synthase enzyme as a maternal risk for neural tube defects in the Irish population
    • A. Parle-McDermott, P.N. Kirke, J.L. Mills, A.M. Molloy, C. Cox, and V.B. O'Leary Confirmation of the R653Q polymorphism of the trifunctional C1-synthase enzyme as a maternal risk for neural tube defects in the Irish population Eur J Hum Genet 14 2006 768 772
    • (2006) Eur J Hum Genet , vol.14 , pp. 768-772
    • Parle-Mcdermott, A.1    Kirke, P.N.2    Mills, J.L.3    Molloy, A.M.4    Cox, C.5    O'Leary, V.B.6
  • 42
  • 43
    • 59449092734 scopus 로고    scopus 로고
    • Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism
    • A.J. MacFarlane, C.A. Perry, H.H. Girnary, D. Gao, R.H. Allen, and S.P. Stabler Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism J Biol Chem 284 2009 1533 1539
    • (2009) J Biol Chem , vol.284 , pp. 1533-1539
    • MacFarlane, A.J.1    Perry, C.A.2    Girnary, H.H.3    Gao, D.4    Allen, R.H.5    Stabler, S.P.6
  • 44
    • 0036261663 scopus 로고    scopus 로고
    • Mitochondrial NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is essential for embryonic development
    • E. Di Pietro, J. Sirois, M.L. Tremblay, and R.E. MacKenzie Mitochondrial NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is essential for embryonic development Mol Cell Biol 22 2002 4158 4166
    • (2002) Mol Cell Biol , vol.22 , pp. 4158-4166
    • Di Pietro, E.1    Sirois, J.2    Tremblay, M.L.3    MacKenzie, R.E.4
  • 45
    • 0029049553 scopus 로고
    • A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
    • P. Frosst, H.J. Blom, R. Milos, P. Goyette, C.A. Sheppard, and R.G. Matthews A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase Nat Genet 10 1995 111 113
    • (1995) Nat Genet , vol.10 , pp. 111-113
    • Frosst, P.1    Blom, H.J.2    Milos, R.3    Goyette, P.4    Sheppard, C.A.5    Matthews, R.G.6
  • 46
    • 4344575903 scopus 로고    scopus 로고
    • Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease
    • R.C. Austin, S.R. Lentz, and G.H. Werstuck Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease Cell Death Differ 11 Suppl. 1 2004 S56 S64
    • (2004) Cell Death Differ , vol.11 , Issue.SUPPL. 1
    • Austin, R.C.1    Lentz, S.R.2    Werstuck, G.H.3
  • 49
    • 2942754073 scopus 로고    scopus 로고
    • Associations between maternal methylenetetrahydrofolate reductase polymorphisms and adverse outcomes of pregnancy: The Hordaland Homocysteine Study
    • E. Nurk, G.S. Tell, H. Refsum, P.M. Ueland, and S.E. Vollset Associations between maternal methylenetetrahydrofolate reductase polymorphisms and adverse outcomes of pregnancy: the Hordaland Homocysteine Study Am J Med 117 2004 26 31
    • (2004) Am J Med , vol.117 , pp. 26-31
    • Nurk, E.1    Tell, G.S.2    Refsum, H.3    Ueland, P.M.4    Vollset, S.E.5
  • 50
    • 40049103754 scopus 로고    scopus 로고
    • Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk: A huge-GSEC review
    • S. Boccia, R. Hung, G. Ricciardi, F. Gianfagna, M.P. Ebert, and J.Y. Fang Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk: a huge-GSEC review Am J Epidemiol 167 2008 505 516
    • (2008) Am J Epidemiol , vol.167 , pp. 505-516
    • Boccia, S.1    Hung, R.2    Ricciardi, G.3    Gianfagna, F.4    Ebert, M.P.5    Fang, J.Y.6
  • 51
    • 84856812366 scopus 로고    scopus 로고
    • A meta-analysis of MTHFR C677T and A1298C polymorphisms and risk of acute lymphoblastic leukemia in children
    • J. Yan, M. Yin, Z.E. Dreyer, M.E. Scheurer, K. Kamdar, and Q. Wei A meta-analysis of MTHFR C677T and A1298C polymorphisms and risk of acute lymphoblastic leukemia in children Pediatr Blood Cancer 58 2011 513 518
    • (2011) Pediatr Blood Cancer , vol.58 , pp. 513-518
    • Yan, J.1    Yin, M.2    Dreyer, Z.E.3    Scheurer, M.E.4    Kamdar, K.5    Wei, Q.6
  • 53
    • 70349331579 scopus 로고    scopus 로고
    • Association of folate-pathway gene polymorphisms with the risk of prostate cancer: A population-based nested case-control study, systematic review, and meta-analysis
    • S.M. Collin, C. Metcalfe, L. Zuccolo, S.J. Lewis, L. Chen, and A. Cox Association of folate-pathway gene polymorphisms with the risk of prostate cancer: a population-based nested case-control study, systematic review, and meta-analysis Cancer Epidemiol Biomarkers Prev 18 2009 2528 2539
    • (2009) Cancer Epidemiol Biomarkers Prev , vol.18 , pp. 2528-2539
    • Collin, S.M.1    Metcalfe, C.2    Zuccolo, L.3    Lewis, S.J.4    Chen, L.5    Cox, A.6
  • 54
    • 41549094002 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene polymorphisms and lung cancer: A meta-analysis
    • R. Mao, Y. Fan, Y. Jin, J. Bai, and S. Fu Methylenetetrahydrofolate reductase gene polymorphisms and lung cancer: a meta-analysis J Hum Genet 53 2008 340 348
    • (2008) J Hum Genet , vol.53 , pp. 340-348
    • Mao, R.1    Fan, Y.2    Jin, Y.3    Bai, J.4    Fu, S.5
  • 55
    • 78149357320 scopus 로고    scopus 로고
    • MTHFR C677T polymorphisms and childhood acute lymphoblastic leukemia: A meta-analysis
    • J. Wang, P. Zhan, B. Chen, R. Zhou, Y. Yang, and J. Ouyang MTHFR C677T polymorphisms and childhood acute lymphoblastic leukemia: a meta-analysis Leuk Res 34 2010 1596 1600
    • (2010) Leuk Res , vol.34 , pp. 1596-1600
    • Wang, J.1    Zhan, P.2    Chen, B.3    Zhou, R.4    Yang, Y.5    Ouyang, J.6
  • 56
    • 38849089220 scopus 로고    scopus 로고
    • The association of gastric cancer risk with plasma folate, cobalamin, and methylenetetrahydrofolate reductase polymorphisms in the European Prospective Investigation into Cancer and Nutrition
    • S.E. Vollset, J. Igland, M. Jenab, A. Fredriksen, K. Meyer, and S. Eussen The association of gastric cancer risk with plasma folate, cobalamin, and methylenetetrahydrofolate reductase polymorphisms in the European Prospective Investigation into Cancer and Nutrition Cancer Epidemiol Biomarkers Prev 16 2007 2416 2424
    • (2007) Cancer Epidemiol Biomarkers Prev , vol.16 , pp. 2416-2424
    • Vollset, S.E.1    Igland, J.2    Jenab, M.3    Fredriksen, A.4    Meyer, K.5    Eussen, S.6
  • 57
    • 33749428869 scopus 로고    scopus 로고
    • Neural tube defects and folate pathway genes: Family-based association tests of gene-gene and gene-environment interactions
    • A.L. Boyles, A.V. Billups, K.L. Deak, D.G. Siegel, L. Mehltretter, and S.H. Slifer Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions Environ Health Perspect 114 2006 1547 1552
    • (2006) Environ Health Perspect , vol.114 , pp. 1547-1552
    • Boyles, A.L.1    Billups, A.V.2    Deak, K.L.3    Siegel, D.G.4    Mehltretter, L.5    Slifer, S.H.6
  • 58
    • 37549037491 scopus 로고    scopus 로고
    • The MTHFR 677C->T polymorphism and the risk of congenital heart defects: A literature review and meta-analysis
    • I.M. van Beynum, M. den Heijer, H.J. Blom, and L. Kapusta The MTHFR 677C->T polymorphism and the risk of congenital heart defects: a literature review and meta-analysis QJM 100 2007 743 753
    • (2007) QJM , vol.100 , pp. 743-753
    • Van Beynum, I.M.1    Den Heijer, M.2    Blom, H.J.3    Kapusta, L.4
  • 59
    • 0037163849 scopus 로고    scopus 로고
    • MTHFR 677C->T polymorphism and risk of coronary heart disease: A meta-analysis
    • M. Klerk, P. Verhoef, R. Clarke, H.J. Blom, F.J. Kok, and E.G. Schouten MTHFR 677C->T polymorphism and risk of coronary heart disease: a meta-analysis JAMA 288 2002 2023 2031
    • (2002) JAMA , vol.288 , pp. 2023-2031
    • Klerk, M.1    Verhoef, P.2    Clarke, R.3    Blom, H.J.4    Kok, F.J.5    Schouten, E.G.6
  • 60
    • 27744471516 scopus 로고    scopus 로고
    • Meta-analysis of MTHFR 677C->T polymorphism and coronary heart disease: Does totality of evidence support causal role for homocysteine and preventive potential of folate?
    • S.J. Lewis, S. Ebrahim, and G. Davey Smith Meta-analysis of MTHFR 677C->T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate? BMJ 331 2005 1053
    • (2005) BMJ , vol.331 , pp. 1053
    • Lewis, S.J.1    Ebrahim, S.2    Davey Smith, G.3
  • 62
    • 53749101044 scopus 로고    scopus 로고
    • Interrelationships among the MTHFR 677C>T polymorphism, migraine, and cardiovascular disease
    • M. Schurks, R.Y. Zee, J.E. Buring, and T. Kurth Interrelationships among the MTHFR 677C>T polymorphism, migraine, and cardiovascular disease Neurology 71 2008 505 513
    • (2008) Neurology , vol.71 , pp. 505-513
    • Schurks, M.1    Zee, R.Y.2    Buring, J.E.3    Kurth, T.4
  • 63
    • 77449158432 scopus 로고    scopus 로고
    • One carbon metabolism disturbances and the C677T MTHFR gene polymorphism in children with autism spectrum disorders
    • S.P. Pasca, E. Dronca, T. Kaucsar, E.C. Craciun, E. Endreffy, and B.K. Ferencz One carbon metabolism disturbances and the C677T MTHFR gene polymorphism in children with autism spectrum disorders J Cell Mol Med 13 2009 4229 4238
    • (2009) J Cell Mol Med , vol.13 , pp. 4229-4238
    • Pasca, S.P.1    Dronca, E.2    Kaucsar, T.3    Craciun, E.C.4    Endreffy, E.5    Ferencz, B.K.6
  • 64
    • 66349087661 scopus 로고    scopus 로고
    • The MTHFR 677C->T polymorphism and behaviors in children with autism: Exploratory genotype-phenotype correlations
    • R.P. Goin-Kochel, A.E. Porter, S.U. Peters, M. Shinawi, T. Sahoo, and A.L. Beaudet The MTHFR 677C->T polymorphism and behaviors in children with autism: exploratory genotype-phenotype correlations Autism Res 2 2009 98 108
    • (2009) Autism Res , vol.2 , pp. 98-108
    • Goin-Kochel, R.P.1    Porter, A.E.2    Peters, S.U.3    Shinawi, M.4    Sahoo, T.5    Beaudet, A.L.6
  • 65
    • 0035282903 scopus 로고    scopus 로고
    • Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition
    • Z. Chen, A.C. Karaplis, S.L. Ackerman, I.P. Pogribny, S. Melnyk, and S. Lussier-Cacan Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition Hum Mol Genet 10 2001 433 443
    • (2001) Hum Mol Genet , vol.10 , pp. 433-443
    • Chen, Z.1    Karaplis, A.C.2    Ackerman, S.L.3    Pogribny, I.P.4    Melnyk, S.5    Lussier-Cacan, S.6
  • 66
    • 4744373632 scopus 로고    scopus 로고
    • Betaine rescue of an animal model with methylenetetrahydrofolate reductase deficiency
    • B.C. Schwahn, M.D. Laryea, Z. Chen, S. Melnyk, I. Pogribny, and T. Garrow Betaine rescue of an animal model with methylenetetrahydrofolate reductase deficiency Biochem J 382 2004 831 840
    • (2004) Biochem J , vol.382 , pp. 831-840
    • Schwahn, B.C.1    Laryea, M.D.2    Chen, Z.3    Melnyk, S.4    Pogribny, I.5    Garrow, T.6
  • 68
    • 18444365916 scopus 로고    scopus 로고
    • Hyperhomocysteinemia due to methionine synthase deficiency, cblG: Structure of the MTR gene, genotype diversity, and recognition of a common mutation, P1173L
    • D. Watkins, M. Ru, H.Y. Hwang, C.D. Kim, A. Murray, and N.S. Philip Hyperhomocysteinemia due to methionine synthase deficiency, cblG: structure of the MTR gene, genotype diversity, and recognition of a common mutation, P1173L Am J Hum Genet 71 2002 143 153
    • (2002) Am J Hum Genet , vol.71 , pp. 143-153
    • Watkins, D.1    Ru, M.2    Hwang, H.Y.3    Kim, C.D.4    Murray, A.5    Philip, N.S.6
  • 69
    • 12244280859 scopus 로고    scopus 로고
    • CblE type of homocystinuria due to methionine synthase reductase deficiency: Clinical and molecular studies and prenatal diagnosis in two families
    • P. Zavadakova, B. Fowler, J. Zeman, T. Suormala, K. Pristoupilova, and V. Kozich CblE type of homocystinuria due to methionine synthase reductase deficiency: clinical and molecular studies and prenatal diagnosis in two families J Inherit Metab Dis 25 2002 461 476
    • (2002) J Inherit Metab Dis , vol.25 , pp. 461-476
    • Zavadakova, P.1    Fowler, B.2    Zeman, J.3    Suormala, T.4    Pristoupilova, K.5    Kozich, V.6
  • 71
    • 0037341890 scopus 로고    scopus 로고
    • Homocysteine remethylation enzyme polymorphisms and increased risks for neural tube defects
    • H. Zhu, N.J. Wicker, G.M. Shaw, E.J. Lammer, K. Hendricks, and L. Suarez Homocysteine remethylation enzyme polymorphisms and increased risks for neural tube defects Mol Genet Metab 78 2003 216 221
    • (2003) Mol Genet Metab , vol.78 , pp. 216-221
    • Zhu, H.1    Wicker, N.J.2    Shaw, G.M.3    Lammer, E.J.4    Hendricks, K.5    Suarez, L.6
  • 73
    • 33846537961 scopus 로고    scopus 로고
    • Folate metabolic gene polymorphisms and childhood acute lymphoblastic leukemia: A case-control study
    • A. Gast, J.L. Bermejo, T. Flohr, M. Stanulla, B. Burwinkel, and M. Schrappe Folate metabolic gene polymorphisms and childhood acute lymphoblastic leukemia: a case-control study Leukemia 21 2007 320 325
    • (2007) Leukemia , vol.21 , pp. 320-325
    • Gast, A.1    Bermejo, J.L.2    Flohr, T.3    Stanulla, M.4    Burwinkel, B.5    Schrappe, M.6
  • 74
    • 34047265849 scopus 로고    scopus 로고
    • Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase
    • C.L. Elmore, X. Wu, D. Leclerc, E.D. Watson, T. Bottiglieri, and N.I. Krupenko Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase Mol Genet Metab 91 2007 85 97
    • (2007) Mol Genet Metab , vol.91 , pp. 85-97
    • Elmore, C.L.1    Wu, X.2    Leclerc, D.3    Watson, E.D.4    Bottiglieri, T.5    Krupenko, N.I.6
  • 75
    • 77956089407 scopus 로고    scopus 로고
    • Candidate gene association studies and risk of childhood acute lymphoblastic leukemia: A systematic review and meta-analysis
    • J. Vijayakrishnan, and R.S. Houlston Candidate gene association studies and risk of childhood acute lymphoblastic leukemia: a systematic review and meta-analysis Haematologica 95 2010 1405 1414
    • (2010) Haematologica , vol.95 , pp. 1405-1414
    • Vijayakrishnan, J.1    Houlston, R.S.2
  • 76
    • 80455166015 scopus 로고    scopus 로고
    • Identification of miR-193b targets in breast cancer cells and systems biological analysis of their functional impact
    • M110 005322
    • S.K. Leivonen, A. Rokka, P. Ostling, P. Kohonen, G.L. Corthals, and O. Kallioniemi Identification of miR-193b targets in breast cancer cells and systems biological analysis of their functional impact Mol Cell Proteomics 10 2011 M110 005322
    • (2011) Mol Cell Proteomics , vol.10
    • Leivonen, S.K.1    Rokka, A.2    Ostling, P.3    Kohonen, P.4    Corthals, G.L.5    Kallioniemi, O.6
  • 77
    • 54449100192 scopus 로고    scopus 로고
    • Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice
    • A.J. MacFarlane, X. Liu, C.A. Perry, P. Flodby, R.H. Allen, and S.P. Stabler Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice J Biol Chem 283 2008 25846 25853
    • (2008) J Biol Chem , vol.283 , pp. 25846-25853
    • MacFarlane, A.J.1    Liu, X.2    Perry, C.A.3    Flodby, P.4    Allen, R.H.5    Stabler, S.P.6
  • 78
    • 79953186061 scopus 로고    scopus 로고
    • Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice
    • A.E. Beaudin, E.V. Abarinov, D.M. Noden, C.A. Perry, S. Chu, and S.P. Stabler Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice Am J Clin Nutr 93 2011 789 798
    • (2011) Am J Clin Nutr , vol.93 , pp. 789-798
    • Beaudin, A.E.1    Abarinov, E.V.2    Noden, D.M.3    Perry, C.A.4    Chu, S.5    Stabler, S.P.6
  • 79
    • 67649225407 scopus 로고    scopus 로고
    • SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis
    • D.D. Anderson, and P.J. Stover SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis PLoS One 4 2009 e5839
    • (2009) PLoS One , vol.4 , pp. 5839
    • Anderson, D.D.1    Stover, P.J.2
  • 80
    • 0036965325 scopus 로고    scopus 로고
    • From epigenesis to epigenetics: The case of C. H. Waddington
    • L. Van Speybroeck From epigenesis to epigenetics: the case of C. H. Waddington Ann N Y Acad Sci 981 2002 61 81
    • (2002) Ann N y Acad Sci , vol.981 , pp. 61-81
    • Van Speybroeck, L.1
  • 81
    • 77957937011 scopus 로고    scopus 로고
    • Quantitative comparison of genome-wide DNA methylation mapping technologies
    • C. Bock, E.M. Tomazou, A.B. Brinkman, F. Muller, F. Simmer, and H. Gu Quantitative comparison of genome-wide DNA methylation mapping technologies Nat Biotechnol 28 2010 1106 1114
    • (2010) Nat Biotechnol , vol.28 , pp. 1106-1114
    • Bock, C.1    Tomazou, E.M.2    Brinkman, A.B.3    Muller, F.4    Simmer, F.5    Gu, H.6
  • 82
    • 0042736137 scopus 로고    scopus 로고
    • Epigenomic profiling using microarrays
    • 352-344, 356-347
    • B. van Steensel, and S. Henikoff Epigenomic profiling using microarrays Biotechniques 35 2003 346 350 352-344, 356-347
    • (2003) Biotechniques , vol.35 , pp. 346-350
    • Van Steensel, B.1    Henikoff, S.2
  • 83
    • 0025294471 scopus 로고
    • CpG methylation inhibits proenkephalin gene expression and binding of the transcription factor AP-2
    • M. Comb, and H.M. Goodman CpG methylation inhibits proenkephalin gene expression and binding of the transcription factor AP-2 Nucleic Acids Res 18 1990 3975 3982
    • (1990) Nucleic Acids Res , vol.18 , pp. 3975-3982
    • Comb, M.1    Goodman, H.M.2
  • 84
    • 0342437491 scopus 로고    scopus 로고
    • MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin
    • X. Nan, F.J. Campoy, and A. Bird MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin Cell 88 1997 471 481
    • (1997) Cell , vol.88 , pp. 471-481
    • Nan, X.1    Campoy, F.J.2    Bird, A.3
  • 85
    • 15744401773 scopus 로고    scopus 로고
    • Eukaryotic cytosine methyltransferases
    • M.G. Goll, and T.H. Bestor Eukaryotic cytosine methyltransferases Annu Rev Biochem 74 2005 481 514
    • (2005) Annu Rev Biochem , vol.74 , pp. 481-514
    • Goll, M.G.1    Bestor, T.H.2
  • 86
    • 0019318994 scopus 로고
    • DNA methylation and gene function
    • A. Razin, and A.D. Riggs DNA methylation and gene function Science 210 1980 604 610
    • (1980) Science , vol.210 , pp. 604-610
    • Razin, A.1    Riggs, A.D.2
  • 87
    • 77956189495 scopus 로고    scopus 로고
    • Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification
    • S. Ito, A.C. D'Alessio, O.V. Taranova, K. Hong, L.C. Sowers, and Y. Zhang Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification Nature 466 2010 1129 1133
    • (2010) Nature , vol.466 , pp. 1129-1133
    • Ito, S.1    D'Alessio, A.C.2    Taranova, O.V.3    Hong, K.4    Sowers, L.C.5    Zhang, Y.6
  • 88
    • 60749094831 scopus 로고    scopus 로고
    • Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis
    • D.K. Ma, M.H. Jang, J.U. Guo, Y. Kitabatake, M.L. Chang, and N. Pow-Anpongkul Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis Science 323 2009 1074 1077
    • (2009) Science , vol.323 , pp. 1074-1077
    • Ma, D.K.1    Jang, M.H.2    Guo, J.U.3    Kitabatake, Y.4    Chang, M.L.5    Pow-Anpongkul, N.6
  • 89
    • 77954345408 scopus 로고    scopus 로고
    • Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway
    • P. Hajkova, S.J. Jeffries, C. Lee, N. Miller, S.P. Jackson, and M.A. Surani Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway Science 329 2010 78 82
    • (2010) Science , vol.329 , pp. 78-82
    • Hajkova, P.1    Jeffries, S.J.2    Lee, C.3    Miller, N.4    Jackson, S.P.5    Surani, M.A.6
  • 90
    • 0035839136 scopus 로고    scopus 로고
    • Translating the histone code
    • T. Jenuwein, and C.D. Allis Translating the histone code Science 293 2001 1074 1080
    • (2001) Science , vol.293 , pp. 1074-1080
    • Jenuwein, T.1    Allis, C.D.2
  • 91
    • 33646855253 scopus 로고    scopus 로고
    • Histone H3 lysine 9 methyltransferase G9a is a transcriptional coactivator for nuclear receptors
    • D.Y. Lee, J.P. Northrop, M.H. Kuo, and M.R. Stallcup Histone H3 lysine 9 methyltransferase G9a is a transcriptional coactivator for nuclear receptors J Biol Chem 281 2006 8476 8485
    • (2006) J Biol Chem , vol.281 , pp. 8476-8485
    • Lee, D.Y.1    Northrop, J.P.2    Kuo, M.H.3    Stallcup, M.R.4
  • 93
    • 0033119162 scopus 로고    scopus 로고
    • Coactivator and corepressor complexes in nuclear receptor function
    • L. Xu, C.K. Glass, and M.G. Rosenfeld Coactivator and corepressor complexes in nuclear receptor function Curr Opin Genet Dev 9 1999 140 147
    • (1999) Curr Opin Genet Dev , vol.9 , pp. 140-147
    • Xu, L.1    Glass, C.K.2    Rosenfeld, M.G.3
  • 94
    • 76949107741 scopus 로고    scopus 로고
    • Histone H3 lysine 4 (H3K4) methylation in development and differentiation
    • J.C. Eissenberg, and A. Shilatifard Histone H3 lysine 4 (H3K4) methylation in development and differentiation Dev Biol 339 2010 240 249
    • (2010) Dev Biol , vol.339 , pp. 240-249
    • Eissenberg, J.C.1    Shilatifard, A.2
  • 95
    • 44649139771 scopus 로고    scopus 로고
    • Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation
    • A. Shilatifard Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation Curr Opin Cell Biol 20 2008 341 348
    • (2008) Curr Opin Cell Biol , vol.20 , pp. 341-348
    • Shilatifard, A.1
  • 96
    • 65549104157 scopus 로고    scopus 로고
    • Histone modifications at human enhancers reflect global cell-type-specific gene expression
    • N.D. Heintzman, G.C. Hon, R.D. Hawkins, P. Kheradpour, A. Stark, and L.F. Harp Histone modifications at human enhancers reflect global cell-type-specific gene expression Nature 459 2009 108 112
    • (2009) Nature , vol.459 , pp. 108-112
    • Heintzman, N.D.1    Hon, G.C.2    Hawkins, R.D.3    Kheradpour, P.4    Stark, A.5    Harp, L.F.6
  • 97
    • 0037979272 scopus 로고    scopus 로고
    • Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II
    • N.J. Krogan, M. Kim, A. Tong, A. Golshani, G. Cagney, and V. Canadien Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II Mol Cell Biol 23 2003 4207 4218
    • (2003) Mol Cell Biol , vol.23 , pp. 4207-4218
    • Krogan, N.J.1    Kim, M.2    Tong, A.3    Golshani, A.4    Cagney, G.5    Canadien, V.6
  • 100
    • 0035282573 scopus 로고    scopus 로고
    • Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
    • M. Lachner, D. O'Carroll, S. Rea, K. Mechtler, and T. Jenuwein Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins Nature 410 2001 116 120
    • (2001) Nature , vol.410 , pp. 116-120
    • Lachner, M.1    O'Carroll, D.2    Rea, S.3    Mechtler, K.4    Jenuwein, T.5
  • 102
    • 59049105953 scopus 로고    scopus 로고
    • Gestational choline supply regulates methylation of histone H3, expression of histone methyltransferases G9a (Kmt1c) and Suv39h1 (Kmt1a), and DNA methylation of their genes in rat fetal liver and brain
    • J.M. Davison, T.J. Mellott, V.P. Kovacheva, and J.K. Blusztajn Gestational choline supply regulates methylation of histone H3, expression of histone methyltransferases G9a (Kmt1c) and Suv39h1 (Kmt1a), and DNA methylation of their genes in rat fetal liver and brain J Biol Chem 284 2009 1982 1989
    • (2009) J Biol Chem , vol.284 , pp. 1982-1989
    • Davison, J.M.1    Mellott, T.J.2    Kovacheva, V.P.3    Blusztajn, J.K.4
  • 103
    • 77953436400 scopus 로고    scopus 로고
    • Mandatory fortification with folic acid in the United States appears to have adverse effects on histone methylation in women with pre-cancer but not in women free of pre-cancer
    • C.J. Piyathilake, M. Macaluso, J.E. Celedonio, S. Badiga, W.C. Bell, and W.E. Grizzle Mandatory fortification with folic acid in the United States appears to have adverse effects on histone methylation in women with pre-cancer but not in women free of pre-cancer Int J Womens Health 1 2010 131 137
    • (2010) Int J Womens Health , vol.1 , pp. 131-137
    • Piyathilake, C.J.1    MacAluso, M.2    Celedonio, J.E.3    Badiga, S.4    Bell, W.C.5    Grizzle, W.E.6
  • 107
    • 58149156264 scopus 로고    scopus 로고
    • The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation
    • J. Wang, S. Hevi, J.K. Kurash, H. Lei, F. Gay, and J. Bajko The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation Nat Genet 41 2009 125 129
    • (2009) Nat Genet , vol.41 , pp. 125-129
    • Wang, J.1    Hevi, S.2    Kurash, J.K.3    Lei, H.4    Gay, F.5    Bajko, J.6
  • 108
    • 64249166375 scopus 로고    scopus 로고
    • A C. elegans LSD1 demethylase contributes to germline immortality by reprogramming epigenetic memory
    • D.J. Katz, T.M. Edwards, V. Reinke, and W.G. Kelly A C. elegans LSD1 demethylase contributes to germline immortality by reprogramming epigenetic memory Cell 137 2009 308 320
    • (2009) Cell , vol.137 , pp. 308-320
    • Katz, D.J.1    Edwards, T.M.2    Reinke, V.3    Kelly, W.G.4
  • 109
    • 21644434750 scopus 로고    scopus 로고
    • The circuitry of a master switch: Myod and the regulation of skeletal muscle gene transcription
    • S.J. Tapscott The circuitry of a master switch: Myod and the regulation of skeletal muscle gene transcription Development 132 2005 2685 2695
    • (2005) Development , vol.132 , pp. 2685-2695
    • Tapscott, S.J.1
  • 110
    • 53949087832 scopus 로고    scopus 로고
    • Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt
    • K. Yamagata, H. Daitoku, Y. Takahashi, K. Namiki, K. Hisatake, and K. Kako Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt Mol Cell 32 2008 221 231
    • (2008) Mol Cell , vol.32 , pp. 221-231
    • Yamagata, K.1    Daitoku, H.2    Takahashi, Y.3    Namiki, K.4    Hisatake, K.5    Kako, K.6
  • 111
    • 79952538100 scopus 로고    scopus 로고
    • Lysine methylation of promoter-bound transcription factors and relevance to cancer
    • G.R. Stark, Y. Wang, and T. Lu Lysine methylation of promoter-bound transcription factors and relevance to cancer Cell Res 21 2011 375 380
    • (2011) Cell Res , vol.21 , pp. 375-380
    • Stark, G.R.1    Wang, Y.2    Lu, T.3
  • 113
    • 77950841042 scopus 로고    scopus 로고
    • Transcriptional gene silencing through epigenetic changes mediated by non-coding RNAs
    • B. Malecova, and K.V. Morris Transcriptional gene silencing through epigenetic changes mediated by non-coding RNAs Curr Opin Mol Ther 12 2010 214 222
    • (2010) Curr Opin Mol Ther , vol.12 , pp. 214-222
    • Malecova, B.1    Morris, K.V.2
  • 114
    • 79953089167 scopus 로고    scopus 로고
    • PIWI-interacting small RNAs: The vanguard of genome defence
    • M.C. Siomi, K. Sato, D. Pezic, and A.A. Aravin PIWI-interacting small RNAs: the vanguard of genome defence Nat Rev Mol Cell Biol 12 2011 246 258
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 246-258
    • Siomi, M.C.1    Sato, K.2    Pezic, D.3    Aravin, A.A.4
  • 115
    • 70349939426 scopus 로고    scopus 로고
    • Structural insights into mechanisms of the small RNA methyltransferase HEN1
    • Y. Huang, L. Ji, Q. Huang, D.G. Vassylyev, X. Chen, and J.B. Ma Structural insights into mechanisms of the small RNA methyltransferase HEN1 Nature 461 2009 823 827
    • (2009) Nature , vol.461 , pp. 823-827
    • Huang, Y.1    Ji, L.2    Huang, Q.3    Vassylyev, D.G.4    Chen, X.5    Ma, J.B.6
  • 116
    • 41649116098 scopus 로고    scopus 로고
    • DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes
    • S. Kuramochi-Miyagawa, T. Watanabe, K. Gotoh, Y. Totoki, A. Toyoda, and M. Ikawa DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes Genes Dev 22 2008 908 917
    • (2008) Genes Dev , vol.22 , pp. 908-917
    • Kuramochi-Miyagawa, S.1    Watanabe, T.2    Gotoh, K.3    Totoki, Y.4    Toyoda, A.5    Ikawa, M.6
  • 117
    • 79951962109 scopus 로고    scopus 로고
    • Nutritional genomics: Defining the dietary requirement and effects of choline
    • S.H. Zeisel Nutritional genomics: defining the dietary requirement and effects of choline J Nutr 141 2011 531 534
    • (2011) J Nutr , vol.141 , pp. 531-534
    • Zeisel, S.H.1
  • 118
    • 0028073690 scopus 로고
    • Severe folate deficiency causes secondary depletion of choline and phosphocholine in rat liver
    • Y.I. Kim, J.W. Miller, K.A. da Costa, M. Nadeau, D. Smith, and J. Selhub Severe folate deficiency causes secondary depletion of choline and phosphocholine in rat liver J Nutr 124 1994 2197 2203
    • (1994) J Nutr , vol.124 , pp. 2197-2203
    • Kim, Y.I.1    Miller, J.W.2    Da Costa, K.A.3    Nadeau, M.4    Smith, D.5    Selhub, J.6
  • 119
    • 34250303413 scopus 로고    scopus 로고
    • Folate deficiency during pregnancy impacts on methyl metabolism without affecting global DNA methylation in the rat fetus
    • C.A. Maloney, S.M. Hay, and W.D. Rees Folate deficiency during pregnancy impacts on methyl metabolism without affecting global DNA methylation in the rat fetus Br J Nutr 97 2007 1090 1098
    • (2007) Br J Nutr , vol.97 , pp. 1090-1098
    • Maloney, C.A.1    Hay, S.M.2    Rees, W.D.3
  • 120
    • 0031873353 scopus 로고    scopus 로고
    • Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice
    • G.L. Wolff, R.L. Kodell, S.R. Moore, and C.A. Cooney Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice FASEB J 12 1998 949 957
    • (1998) FASEB J , vol.12 , pp. 949-957
    • Wolff, G.L.1    Kodell, R.L.2    Moore, S.R.3    Cooney, C.A.4
  • 121
    • 0043093697 scopus 로고    scopus 로고
    • Transposable elements: Targets for early nutritional effects on epigenetic gene regulation
    • R.A. Waterland, and R.L. Jirtle Transposable elements: targets for early nutritional effects on epigenetic gene regulation Mol Cell Biol 23 2003 5293 5300
    • (2003) Mol Cell Biol , vol.23 , pp. 5293-5300
    • Waterland, R.A.1    Jirtle, R.L.2
  • 122
  • 123
    • 48749119835 scopus 로고    scopus 로고
    • A methyl-deficient diet modifies histone methylation and alters Igf2 and H19 repression in the prostate
    • J.R. Dobosy, V.X. Fu, J.A. Desotelle, R. Srinivasan, M.L. Kenowski, and N. Almassi A methyl-deficient diet modifies histone methylation and alters Igf2 and H19 repression in the prostate Prostate 68 2008 1187 1195
    • (2008) Prostate , vol.68 , pp. 1187-1195
    • Dobosy, J.R.1    Fu, V.X.2    Desotelle, J.A.3    Srinivasan, R.4    Kenowski, M.L.5    Almassi, N.6
  • 124
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • K. Takahashi, and S. Yamanaka Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Cell 126 2006 663 676
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 125
    • 0027326933 scopus 로고
    • DNA methylation in folate deficiency: Use of CpG methylase
    • M. Balaghi, and C. Wagner DNA methylation in folate deficiency: use of CpG methylase Biochem Biophys Res Commun 193 1993 1184 1190
    • (1993) Biochem Biophys Res Commun , vol.193 , pp. 1184-1190
    • Balaghi, M.1    Wagner, C.2
  • 126
    • 0035214369 scopus 로고    scopus 로고
    • Impact of extracellular folate levels on global gene expression
    • M.S. Jhaveri, C. Wagner, and J.B. Trepel Impact of extracellular folate levels on global gene expression Mol Pharmacol 60 2001 1288 1295
    • (2001) Mol Pharmacol , vol.60 , pp. 1288-1295
    • Jhaveri, M.S.1    Wagner, C.2    Trepel, J.B.3
  • 127
    • 0037058663 scopus 로고    scopus 로고
    • De novo methylation of the p16INK4A gene in early preneoplastic liver and tumors induced by folate/methyl deficiency in rats
    • I.P. Pogribny, and S.J. James De novo methylation of the p16INK4A gene in early preneoplastic liver and tumors induced by folate/methyl deficiency in rats Cancer Lett 187 2002 69 75
    • (2002) Cancer Lett , vol.187 , pp. 69-75
    • Pogribny, I.P.1    James, S.J.2
  • 128
    • 0037272902 scopus 로고    scopus 로고
    • The effect of dietary folate on genomic and p53-specific DNA methylation in rat colon
    • K.J. Sohn, J.M. Stempak, S. Reid, S. Shirwadkar, J.B. Mason, and Y.I. Kim The effect of dietary folate on genomic and p53-specific DNA methylation in rat colon Carcinogenesis 24 2003 81 90
    • (2003) Carcinogenesis , vol.24 , pp. 81-90
    • Sohn, K.J.1    Stempak, J.M.2    Reid, S.3    Shirwadkar, S.4    Mason, J.B.5    Kim, Y.I.6
  • 129
    • 0034118587 scopus 로고    scopus 로고
    • Chemopreventive effects of dietary folate on intestinal polyps in Apc +/-Msh2-/- mice
    • J. Song, K.J. Sohn, A. Medline, C. Ash, S. Gallinger, and Y.I. Kim Chemopreventive effects of dietary folate on intestinal polyps in Apc +/-Msh2-/- mice Cancer Res 60 2000 3191 3199
    • (2000) Cancer Res , vol.60 , pp. 3191-3199
    • Song, J.1    Sohn, K.J.2    Medline, A.3    Ash, C.4    Gallinger, S.5    Kim, Y.I.6
  • 130
    • 33646819033 scopus 로고    scopus 로고
    • A folate- and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 rats
    • K. Ghoshal, X. Li, J. Datta, S. Bai, I. Pogribny, and M. Pogribny A folate- and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 rats J Nutr 136 2006 1522 1527
    • (2006) J Nutr , vol.136 , pp. 1522-1527
    • Ghoshal, K.1    Li, X.2    Datta, J.3    Bai, S.4    Pogribny, I.5    Pogribny, M.6
  • 131
    • 59849122714 scopus 로고    scopus 로고
    • Folate deficiency induces genomic uracil misincorporation and hypomethylation but does not increase DNA point mutations
    • e223
    • H.G. Linhart, A. Troen, G.W. Bell, E. Cantu, W.H. Chao, and E. Moran Folate deficiency induces genomic uracil misincorporation and hypomethylation but does not increase DNA point mutations Gastroenterology 136 2009 227 235 e223
    • (2009) Gastroenterology , vol.136 , pp. 227-235
    • Linhart, H.G.1    Troen, A.2    Bell, G.W.3    Cantu, E.4    Chao, W.H.5    Moran, E.6
  • 132
    • 31544467532 scopus 로고    scopus 로고
    • Nutritional epigenetics: Impact of folate deficiency on DNA methylation and colon cancer susceptibility
    • Y.I. Kim Nutritional epigenetics: impact of folate deficiency on DNA methylation and colon cancer susceptibility J Nutr 135 2005 2703 2709
    • (2005) J Nutr , vol.135 , pp. 2703-2709
    • Kim, Y.I.1
  • 133
    • 0033933478 scopus 로고    scopus 로고
    • DNA stability and genomic methylation status in colonocytes isolated from methyl-donor-deficient rats
    • S.J. Duthie, S. Narayanan, G.M. Brand, and G. Grant DNA stability and genomic methylation status in colonocytes isolated from methyl-donor-deficient rats Eur J Nutr 39 2000 106 111
    • (2000) Eur J Nutr , vol.39 , pp. 106-111
    • Duthie, S.J.1    Narayanan, S.2    Brand, G.M.3    Grant, G.4
  • 134
    • 0029062378 scopus 로고
    • Moderate folate deficiency does not cause global hypomethylation of hepatic and colonic DNA or c-myc-specific hypomethylation of colonic DNA in rats
    • Y.I. Kim, J.K. Christman, J.C. Fleet, M.L. Cravo, R.N. Salomon, and D. Smith Moderate folate deficiency does not cause global hypomethylation of hepatic and colonic DNA or c-myc-specific hypomethylation of colonic DNA in rats Am J Clin Nutr 61 1995 1083 1090
    • (1995) Am J Clin Nutr , vol.61 , pp. 1083-1090
    • Kim, Y.I.1    Christman, J.K.2    Fleet, J.C.3    Cravo, M.L.4    Salomon, R.N.5    Smith, D.6
  • 135
    • 79955814807 scopus 로고    scopus 로고
    • Altered folate availability modifies the molecular environment of the human colorectum: Implications for colorectal carcinogenesis
    • P. Protiva, J.B. Mason, Z. Liu, M.E. Hopkins, C. Nelson, and J.R. Marshall Altered folate availability modifies the molecular environment of the human colorectum: implications for colorectal carcinogenesis Cancer Prev Res (Phila) 4 2011 530 543
    • (2011) Cancer Prev Res (Phila) , vol.4 , pp. 530-543
    • Protiva, P.1    Mason, J.B.2    Liu, Z.3    Hopkins, M.E.4    Nelson, C.5    Marshall, J.R.6
  • 136
    • 41849147191 scopus 로고    scopus 로고
    • Moderate folate depletion modulates the expression of selected genes involved in cell cycle, intracellular signaling and folate uptake in human colonic epithelial cell lines
    • J.W. Crott, Z. Liu, M.K. Keyes, S.W. Choi, H. Jang, and M.P. Moyer Moderate folate depletion modulates the expression of selected genes involved in cell cycle, intracellular signaling and folate uptake in human colonic epithelial cell lines J Nutr Biochem 19 2008 328 335
    • (2008) J Nutr Biochem , vol.19 , pp. 328-335
    • Crott, J.W.1    Liu, Z.2    Keyes, M.K.3    Choi, S.W.4    Jang, H.5    Moyer, M.P.6
  • 137
    • 48349133693 scopus 로고    scopus 로고
    • Evidence for dietary regulation of microRNA expression in cancer cells
    • C.D. Davis, and S.A. Ross Evidence for dietary regulation of microRNA expression in cancer cells Nutr Rev 66 2008 477 482
    • (2008) Nutr Rev , vol.66 , pp. 477-482
    • Davis, C.D.1    Ross, S.A.2
  • 138
    • 77952080578 scopus 로고    scopus 로고
    • A new perspective on neural tube defects: Folic acid and microRNA misexpression
    • J.M. Shookhoff, and G.I. Gallicano A new perspective on neural tube defects: folic acid and microRNA misexpression Genesis 48 2010 282 294
    • (2010) Genesis , vol.48 , pp. 282-294
    • Shookhoff, J.M.1    Gallicano, G.I.2
  • 139
    • 78449239095 scopus 로고    scopus 로고
    • Folic acid remodels chromatin on Hes1 and Neurog2 promoters during caudal neural tube development
    • S. Ichi, F.F. Costa, J.M. Bischof, H. Nakazaki, Y.W. Shen, and V. Boshnjaku Folic acid remodels chromatin on Hes1 and Neurog2 promoters during caudal neural tube development J Biol Chem 285 2010 36922 36932
    • (2010) J Biol Chem , vol.285 , pp. 36922-36932
    • Ichi, S.1    Costa, F.F.2    Bischof, J.M.3    Nakazaki, H.4    Shen, Y.W.5    Boshnjaku, V.6
  • 140
    • 0033844302 scopus 로고    scopus 로고
    • Localized folate and vitamin B-12 deficiency in squamous cell lung cancer is associated with global DNA hypomethylation
    • C.J. Piyathilake, G.L. Johanning, M. Macaluso, M. Whiteside, D.K. Oelschlager, and D.C. Heimburger Localized folate and vitamin B-12 deficiency in squamous cell lung cancer is associated with global DNA hypomethylation Nutr Cancer 37 2000 99 107
    • (2000) Nutr Cancer , vol.37 , pp. 99-107
    • Piyathilake, C.J.1    Johanning, G.L.2    MacAluso, M.3    Whiteside, M.4    Oelschlager, D.K.5    Heimburger, D.C.6
  • 141
    • 0028886772 scopus 로고
    • Differential sensitivity to loss of cytosine methyl groups within the hepatic p53 gene of folate/methyl deficient rats
    • I.P. Pogribny, L.A. Poirier, and S.J. James Differential sensitivity to loss of cytosine methyl groups within the hepatic p53 gene of folate/methyl deficient rats Carcinogenesis 16 1995 2863 2867
    • (1995) Carcinogenesis , vol.16 , pp. 2863-2867
    • Pogribny, I.P.1    Poirier, L.A.2    James, S.J.3
  • 142
    • 74249100657 scopus 로고    scopus 로고
    • Intracisternal A particle genes: Distribution in the mouse genome, active subtypes, and potential roles as species-specific mediators of susceptibility to cancer
    • C. Qin, Z. Wang, J. Shang, K. Bekkari, R. Liu, and S. Pacchione Intracisternal A particle genes: distribution in the mouse genome, active subtypes, and potential roles as species-specific mediators of susceptibility to cancer Mol Carcinog 49 2010 54 67
    • (2010) Mol Carcinog , vol.49 , pp. 54-67
    • Qin, C.1    Wang, Z.2    Shang, J.3    Bekkari, K.4    Liu, R.5    Pacchione, S.6
  • 143
    • 77949391388 scopus 로고    scopus 로고
    • CpG methylation of a silent controlling element in the murine Avy allele is incomplete and unresponsive to methyl donor supplementation
    • J.E. Cropley, C.M. Suter, K.B. Beckman, and D.I. Martin CpG methylation of a silent controlling element in the murine Avy allele is incomplete and unresponsive to methyl donor supplementation PLoS One 5 2010 e9055
    • (2010) PLoS One , vol.5 , pp. 9055
    • Cropley, J.E.1    Suter, C.M.2    Beckman, K.B.3    Martin, D.I.4
  • 144
    • 62749097335 scopus 로고    scopus 로고
    • Intestinal neoplasia induced by low dietary folate is associated with altered tumor expression profiles and decreased apoptosis in mouse normal intestine
    • D. Garcia-Crespo, E. Knock, N. Jabado, and R. Rozen Intestinal neoplasia induced by low dietary folate is associated with altered tumor expression profiles and decreased apoptosis in mouse normal intestine J Nutr 139 2009 488 494
    • (2009) J Nutr , vol.139 , pp. 488-494
    • Garcia-Crespo, D.1    Knock, E.2    Jabado, N.3    Rozen, R.4
  • 145
    • 43749104028 scopus 로고    scopus 로고
    • Microarray analysis of E9.5 reduced folate carrier (RFC1; Slc19a1) knockout embryos reveals altered expression of genes in the cubilin-megalin multiligand endocytic receptor complex
    • J. Gelineau-van Waes, J.R. Maddox, L.M. Smith, M. van Waes, J. Wilberding, and J.D. Eudy Microarray analysis of E9.5 reduced folate carrier (RFC1; Slc19a1) knockout embryos reveals altered expression of genes in the cubilin-megalin multiligand endocytic receptor complex BMC Genomics 9 2008 156
    • (2008) BMC Genomics , vol.9 , pp. 156
    • Gelineau-Van Waes, J.1    Maddox, J.R.2    Smith, L.M.3    Van Waes, M.4    Wilberding, J.5    Eudy, J.D.6
  • 146
    • 34447252845 scopus 로고    scopus 로고
    • Folate deficiency in normal human fibroblasts leads to altered expression of genes primarily linked to cell signaling, the cytoskeleton and extracellular matrix
    • K.S. Katula, A.N. Heinloth, and R.S. Paules Folate deficiency in normal human fibroblasts leads to altered expression of genes primarily linked to cell signaling, the cytoskeleton and extracellular matrix J Nutr Biochem 18 2007 541 552
    • (2007) J Nutr Biochem , vol.18 , pp. 541-552
    • Katula, K.S.1    Heinloth, A.N.2    Paules, R.S.3
  • 148
    • 34249026300 scopus 로고    scopus 로고
    • High-resolution profiling of histone methylations in the human genome
    • A. Barski, S. Cuddapah, K. Cui, T.Y. Roh, D.E. Schones, and Z. Wang High-resolution profiling of histone methylations in the human genome Cell 129 2007 823 837
    • (2007) Cell , vol.129 , pp. 823-837
    • Barski, A.1    Cuddapah, S.2    Cui, K.3    Roh, T.Y.4    Schones, D.E.5    Wang, Z.6
  • 149
    • 66149186985 scopus 로고    scopus 로고
    • Genomic location analysis by ChIP-Seq
    • A. Barski, and K. Zhao Genomic location analysis by ChIP-Seq J Cell Biochem 107 2009 11 18
    • (2009) J Cell Biochem , vol.107 , pp. 11-18
    • Barski, A.1    Zhao, K.2
  • 150
    • 34547624303 scopus 로고    scopus 로고
    • Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
    • T.S. Mikkelsen, M. Ku, D.B. Jaffe, B. Issac, E. Lieberman, and G. Giannoukos Genome-wide maps of chromatin state in pluripotent and lineage-committed cells Nature 448 2007 553 560
    • (2007) Nature , vol.448 , pp. 553-560
    • Mikkelsen, T.S.1    Ku, M.2    Jaffe, D.B.3    Issac, B.4    Lieberman, E.5    Giannoukos, G.6
  • 152
    • 77953915915 scopus 로고    scopus 로고
    • Regulation of microRNA expression and abundance during lymphopoiesis
    • S. Kuchen, W. Resch, A. Yamane, N. Kuo, Z. Li, and T. Chakraborty Regulation of microRNA expression and abundance during lymphopoiesis Immunity 32 2010 828 839
    • (2010) Immunity , vol.32 , pp. 828-839
    • Kuchen, S.1    Resch, W.2    Yamane, A.3    Kuo, N.4    Li, Z.5    Chakraborty, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.