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Proceedings of the National Academy of Sciences of the United States of America

Volumn 99, Issue 21, 2002, Pages 13481-13486

Interaction of dihydrofolate reductase with methotrexate: Ensemble and single-molecule kinetics

(6) Rajagopalan, P T Ravi a Zhang, Zhiquan b McCourt, Lynn b Dwyer, Mary b Benkovic, Stephen J a Hammes, Gordon G b

a PENNSYLVANIA STATE UNIVERSITY (United States)

b DUKE UNIVERSITY MEDICAL CENTER (United States)

Author keywords

Enzyme mechanisms; Fluorescence microscopy; Protein dynamics

Indexed keywords

BIOTIN; DIHYDROFOLATE REDUCTASE; FLUORESCENT DYE; METHOTREXATE;

ARTICLE; BINDING KINETICS; CONFORMATIONAL TRANSITION; DISSOCIATION CONSTANT; DRUG BINDING; ENZYME BINDING; ENZYME CONFORMATION; ENZYME MECHANISM; ENZYME MODIFICATION; FLUORESCENCE MICROSCOPY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; THERMODYNAMICS;

BASE SEQUENCE; BIOTIN; DNA, BACTERIAL; ESCHERICHIA COLI; FLUORESCENT DYES; GENES, BACTERIAL; KINETICS; METHOTREXATE; MICROSCOPY, FLUORESCENCE; MODELS, MOLECULAR; MUTATION; PROTEIN CONFORMATION; TETRAHYDROFOLATE DEHYDROGENASE; THERMODYNAMICS;

ALEXA;

EID: 0037108888 PISSN: 00278424 EISSN: None Source Type: Journal
DOI: 10.1073/pnas.172501499 Document Type: Article

Times cited : (241)

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