Mitochondrial NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is essential for embryonic development

Molecular and Cellular Biology

Volumn 22, Issue 12, 2002, Pages 4158-4166

  Di Pietro, E ^a   Sirois, J ^a   Tremblay, M L ^a   MacKenzie, R E ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; TRANSFER RNA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CATALYSIS; CELL COMPARTMENTALIZATION; CELL CULTURE; CELL LINE; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; EMBRYO; EMBRYO DEATH; EMBRYO DEVELOPMENT; ENZYME MECHANISM; FOLATE METABOLISM; HETEROZYGOSITY; HOMOZYGOTE; KNOCKOUT MOUSE; LETHALITY; LIVER CELL; MAMMAL CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; TRANSCRIPTION REGULATION;

AMINOHYDROLASES; ANIMALS; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; FETAL DEATH; FIBROBLASTS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HOMOZYGOTE; LIVER; MALE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP); MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MITOCHONDRIA; MULTIENZYME COMPLEXES; PROTEIN BIOSYNTHESIS;

ANIMALIA; EUKARYOTA; MAMMALIA;

EID: 0036261663     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.12.4158-4166.2002     Document Type: Article

References (32)

1. Isolation and characterization of cDNA clones encoding the murine NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase
2. Reversion of a Chinese hamster cell auxotrophic mutant
3. Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition
4. In vitro genetic transfer of protein synthesis and respiration defects to mitochondrial DNA-less cells with myopathy-patient mitochondria
5. Expression cloning of a human cDNA encoding folylpoly-γ-glutamate synthetase and determination of its primary structure
6. The pseudogene on the X chromosome for the human trifunctional enzyme MTHFD (methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase)
7. Role of mitochondrial and cytoplasmic serine hydroxymethyltransferase isozymes in de novo purine synthesis in Saccharomyces cerevisiae
8. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
9. Initiation of protein synthesis in Saccharomyces cerevisiae mitochondria without formylation of the initiator tRNA
10. Regulation of folate and one-carbon metabolism in mammalian cells. 3. Role of mitochondrial folylpoly-γ-glutamate synthetase
11. Expression of Escherichia coli folylpolyglutamate synthetase in the Chinese hamster ovary cell mitochondrion
12. Folic acid: Nutritional biochemistry, molecular biology and role in disease processes
13. Biogenesis and interconversion of substituted folates
14. NAD-dependent methylenetetrahydrofolate dehydrogenase is expressed by immortal cells
15. NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase from ascites tumor cells
16. NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase in transformed cells is a mitochondrial enzyme
17. 13C NMR analysis of intercompartmental flow of one-carbon units into cholines and purines in Saccharomyces cerevisiae
18. Binding and interconversion of tetrahydrofolates at a single site in the bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase
19. Transcriptional regulation of the murine NADP-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase-synthetase
20. +-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase: Detection of the mRNA in normal murine tissues and transcriptional regulation of the gene in cell lines
21. Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development
22. Regulation of the balance of one-carbon metabolism in Saccharomyces cerevisiae
23. Guide to techniques in mouse development
24. Occurrence of a DPN- linked, N5, N10-methylenetetrahydrofolic dehydrogenase in Ehrlich ascites tumor cells
25. Purification and characterization of mitochondrial isozyme of C1-tetrahydrofolate synthase from Saccharomyces cerevisiae
26. Activity of an NAD-dependent 5,10-methylenetetrahydrofolate dehydrogenase in normal tissue, neoplastic cells and oncogene transformed cells
27. Targeted disruption of the methionine synthase gene in mice
28. 1-tetrahydrofolate synthase
29. Metabolic role of cytoplasmic isozymes of 5,10-methylenetetrahydrofolate dehydrogenase in Saccharomyces cerevisiae
30. NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is the mammalian homolog of the mitochondrial enzyme encoded by the yeast MISI gene
31. Rescue of embryonic lethality in reduced folate carrier-deficient mice by maternal folic acid supplementation reveals early neonatal failure of hematopoietic organs