A miR-24 microRNA binding-site polymorphism in dihydrofolate reductase gene leads to methotrexate resistance

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 33, 2007, Pages 13513-13518

  Mishra, Prasun J ^a   Humeniuk, Rita ^b   Mishra, Pravin J ^b   Longo Sorbello, Giuseppe S A ^b,c   Banerjee, Debabrata ^b   Bertino, Joseph R ^b  

^a UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^b RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

^c CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

Author keywords

3 UTR; Drug resistance; mRNA stability; Single nucleotide polymorphism; Translational regulation

Indexed keywords

DIHYDROFOLATE REDUCTASE; METHOTREXATE; MICRORNA; MUTANT PROTEIN;

3' UNTRANSLATED REGION; ARTICLE; BINDING SITE; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENE MUTATION; GENE OVEREXPRESSION; GENE SEQUENCE; GENETIC POLYMORPHISM; HALF LIFE TIME; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE NUCLEOTIDE POLYMORPHISM; UPREGULATION;

ANIMALS; BASE SEQUENCE; BINDING SITES; CHO CELLS; CRICETINAE; CRICETULUS; MICRORNAS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; POLYMORPHISM, SINGLE NUCLEOTIDE; RNA, MESSENGER; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 34548059198     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0706217104     Document Type: Article

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