Maternal methyl supplements increase offspring DNA methylation at Axin fused

Genesis (United States)

Volumn 44, Issue 9, 2006, Pages 401-406

  Waterland, Robert A ^a   Dolinoy, Dana C ^b   Lin, Juan Ru ^a   Smith, Charlotte A ^a   Shi, Xin ^a   Tahiliani, Kajal G ^a  

^a CHILDREN S NUTRITION RESEARCH CENTER   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Developmental origins; Epigenetic; Metastable epiallele; Nutrition

Indexed keywords

AGOUTI PROTEIN; AXIN; DNA; METHYL GROUP;

ALLELE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AXIN FUSED MOUSE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DNA METHYLATION; EMBRYO DEVELOPMENT; ENVIRONMENTAL EXPOSURE; EPIGENETICS; FEMALE; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE LOCUS; GENETIC STABILITY; GENOTYPE; MALE; MATERNAL NUTRITION; METABOLISM; MOUSE; MOUSE STRAIN; NEWBORN; NONHUMAN; PHENOTYPE; PREGNANCY; PRIORITY JOURNAL; PROGENY; TAIL; VIABLE YELLOW AGOUTI MOUSE;

AGOUTI; MAMMALIA; MURINAE;

EID: 33749026098     PISSN: 1526954X     EISSN: 1526968X     Source Type: Journal    
DOI: 10.1002/dvg.20230     Document Type: Article

References (24)

1. Baron RM, Kenny DA. 1986. The moderator-mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations. J Pers Soc Psychol 51:1173-1182.
2. Bateson P, Barker D, Clutton-Brock T, Deb D, D'Udine B, Foley RA, Gluckman P, Godfrey K, Kirkwood T, Lahr MM, McNamara J, Metcalfe NB, Monaghan P, Spencer HG, Sultan SE. 2004. Developmental plasticity and human health. Nature 430:419-421.
3. Fraga MF, Ballestar E, Paz MF, Ropero S, Setien F, Ballestar ML, Heine-Suner D, Cigudosa JC, Urioste M, Benitez J, Boix-Chornet M, Sanchez-Aguilera A, Ling C, Carlsson E, Poulsen P, Vaag A, Stephan Z, Spector TD, Wu YZ, Plass C, Esteller M. 2005. Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci USA 102:10604-10609.
4. Jaenisch R, Bird A. 2003. Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals. Nat Genet 33 (Suppl):245-254.
5. Kazazian HH Jr, Moran JV. 1998. The impact of L1 retrotransposons on the human genome. Nat Genet 19:19-24.
6. Lane N, Dean W, Erhardt S, Hajkova P, Surani A, Walter J, Reik W 2003. Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse. Genesis 35:88-93.
7. Lucas A. 1991. Programming by early nutrition in man. Ciba Found Symp 156:38-50.
8. McMillen IC, Robinson JS. 2005. Developmental origins of the metabolic syndrome: Prediction, plasticity, and programming. Physiol Rev 85:571-633.
9. Nagy A, Gertsenstein M, Vintersten K, Beringer B. 2003. Manipulating the mouse embryo; A laboratory manual, 3rd ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
10. Nekrutenko A, Li WH. 2001. Transposable elements are found in a large number of human protein- coding genes. Trends Genet 17:619-621.
11. Nigumann P, Redik K, Matlik K, Speek M. 2002. Many human genes are transcribed from the antisense promoter of L1 retrotransposon. Genomics 79:628-634.
12. Rakyan VK, Blewitt ME, Druker R, Preis JI, Whitelaw E. 2002. Metastable epialleles in mammals. Trends Genet 18:348-351.
13. Rakyan VK, Chong S, Champ ME, Cuthbert PC, Morgan HD, Luu KV, Whitelaw E. 2003. Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission. Proc Natl Acad Sci USA 100:2538-2543.
14. Rakyan VK, Hildmann T, Novik KL, Lewin J, Tost J, Cox AV, Andrews TD, Howe KL, Otto T, Olek A, Fischer J, Gut IG, Berlin K, Beck S. 2004. DNA methylation profiling of the human major histocompatibility complex: A pilot study for the human epigenome project. PLoS Biol 2:e405.
15. Reik W, Dean W, Walter J. 2001. Epigenetic reprogramming in mammalian development. Science 293:1089-1093.
16. Strauss WM. 2001. Preparation of genomic DNA from mammalian tissue. In: Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K, editors. Current protocols in molecular biology. New York: Wiley. pp 2.2.1-2.2.3.
17. Van den Veyver I. 2002. Genetic effects of methylation diets. Annu Rev Nutr 22:255-282.
18. Vasicek TJ, Zeng L, Guan XJ, Zhang T, Costantini F, Tilghman SM. 1997. Two dominant mutations in the mouse fused gene are the result of transposon insertions. Genetics 147:777-786.
19. Waterland RA, Garza C. 1999. Potential mechanisms of metabolic imprinting that lead to chronic disease. Am J Clin Nutr 69:179-197.
20. Waterland RA, Jirtle RL. 2003. Transposable elements: Targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol 23:5293-5300.
21. Waterland RA, Jirtle RL. 2004. Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases. Nutrition 20:63-68.
22. Waterland RA, Lin JR, Smith CA, Jirtle RL. 2006. Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus. Hum Mol Genet 15:705-716.
23. Wolff GL, Kodell RL, Moore SR, Cooney CA. 1998. Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice. FASEB J 12:949-957.
24. Zeng L, Fagotto F, Zhang T, Hsu W Vasicek TJ, Perry WL III, Lee JJ, Tilghman SM, Gumbiner BM, Costantini F. 1997. The mouse fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. Cell 90:181-192.