Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition

Human Molecular Genetics

Volumn 10, Issue 5, 2001, Pages 433-443

  Chen, Zhoutao ^a   Karaplis, Andrew C ^a   Ackerman, Susan L ^b   Pogribny, Igor P ^c   Melnyk, Stepan ^c   Lussier Cacan, Suzanne ^d   Chen, Moy Fong ^a   Pai, Aditya ^a   John, Simon W M ^b   Smith, Richard S ^b   Bottiglieri, Teodoro ^e   Bagley, Pamela ^f   Selhub, Jacob ^f   Rudnicki, Michael A ^g   James, S Jill ^c   Rozen, Rima ^a,h  

^a MCGILL UNIVERSITY   (Canada)

^b JACKSON LABORATORY   (United States)

^c NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^d CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^e BAYLOR UNIVERSITY MEDICAL CENTER   (United States)

^f TUFTS UNIVERSITY   (United States)

^g MCMASTER UNIVERSITY   (Canada)

^h MONTREAL CHILDREN S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); DNA; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE;

AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; AORTA ATHEROSCLEROSIS; ARTICLE; CANCER RISK; CARDIOVASCULAR DISEASE; CEREBELLUM DISEASE; COLON CANCER; CONTROLLED STUDY; DNA METHYLATION; ENZYME DEFICIENCY; FEMALE; GENE MUTATION; GENETICS; GROWTH RETARDATION; HETEROZYGOSITY; HOMOZYGOSITY; HYPERHOMOCYSTEINEMIA; IN VIVO STUDY; INBORN ERROR OF METABOLISM; KNOCKOUT MOUSE; LEUKEMIA; LIPID STORAGE; MALE; MOUSE; NEURAL TUBE DEFECT; NEUROPATHOLOGY; NONHUMAN; NUTRITION; PATHOGENESIS; PREGNANCY COMPLICATION; PRIORITY JOURNAL; RISK FACTOR; VASCULAR DISEASE;

ANIMALIA;

EID: 0035282903     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/10.5.433     Document Type: Article

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