A review of folate receptor alpha cycling and 5-methyltetrahydrofolate accumulation with an emphasis on cell models in vitro

Advanced Drug Delivery Reviews

Volumn 56, Issue 8, 2004, Pages 1085-1097

  Kamen, Barton A ^a   Smith, Angel K ^a  

^a ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

5 Methyltetrahydratefolate uptake; Function of folate receptor; Regulation of folate receptor recycling

Indexed keywords

ALCOHOLS; BIOLOGICAL MEMBRANES; CARCINOGENS; CELLS; LIPIDS; PROTEINS;

ACTIN CYTOSKELETON; CELL SURFACE; EPITHELIAL CELLS; FOLATE RECEPTOR ALPHA CYCLING;

BIOCHEMISTRY;

5 METHYLTETRAHYDROFOLIC ACID; CHOLESTEROL; FOLATE RECEPTOR; FOLATE RECEPTOR ALPHA; FOLIC ACID; PHORBOL 12 ACETATE 13 MYRISTATE; PROTEIN KINASE C INHIBITOR; RECEPTOR PROTEIN; UNCLASSIFIED DRUG;

CELL ACTIVITY; CELL DENSITY; CELL DISRUPTION; CELL GROWTH; CELL SURFACE; CLUSTER ANALYSIS; CYTOSKELETON; DRUG EFFECT; DRUG SELECTIVITY; EXPERIMENTAL MODEL; HUMAN; INTERNALIZATION; KIDNEY CELL; LIPID MEMBRANE; MEMBRANE RESISTANCE; MONKEY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; REVIEW;

EID: 1942535095     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.addr.2004.01.002     Document Type: Article

References (63)

1. Weitman S., Anderson R.G.W., Kamen B.A. Folate binding proteins. Dakshinamurti K. Vitamin Receptors: Vitamins as Ligands in Cell Communication. 1994;106-136 Cambridge University Press.
2. Piedrahita J.A., Oetama B., Bemmett G.D., Van Waes J., Lacey S.W., Kamen B.A., Richardson J., Lark R.H., Finnell R.H. Inactivation of the folate binding protein genes disrupts neural tube closure. Nat. Genet. 23:1999;228-232.
3. Leamon C.P., Low P. Delivery of macromolecules into living cells: a method that exploits folate receptor endocytosis. Proc. Natl. Acad. Sci. USA. 88:1991;5572-5576.
4. Lee R.J., Low P. Delivery of liposomes into cultured KB cells via folate receptor-mediated endocytosis. J. Biol. Chem. 269:1994;3198-3204.
5. Leamon C.P., Cooper S.R., Hardee G.E. Folate-liposome-mediated antisense oligodeoxynucleotide targeting to cancer cells: evaluation in vitro and in vivo. Bioconjug. Chem. 14:(4):2003;738-747.
6. Zhu W.Y., Alliegro M.A., Melera P. The rate of FRα synthesis in folate depleted CHL cells is regulated by a translational mechanism sensitive to media folate levels, while stable overexpression if its mRNA is mediated by gene amplification and an increase in transcript half-life. J. Cell Biochem. 81:2001;205-219.
7. Kim C.H., Park Y.S., Chung K.N., Elwood P.C. Sorting and function of the human folate receptor is independent of the caveolin expression in fisher rat thyroid epithelial cells. J. Biochem. Mol. Biol. 35:2002;395-402.
8. Bridges C., El-Sherneny A., Ola S., Ganapathy V., Smith S. Transcellular transfer of folate across the retinal pigment epithelium. Curr. Eye Res. 24:2002;129-138.
9. Chatterjee S., Smith E.R., Hanada K., Stevens V.L., Mayor S. GPI anchoring leads to sphingolipid-dependent retention of endocytosed proteins in the recycling endosomal compartment. EMBO J. 20:2001;1583-1592.
10. da Costa M., Rothenberg S.P., Sadasivan E., Regec A., Qian L. Folate deficiency reduces the GPI-anchored folate-binding protein in rat renal tubules. Am. J. Physiol. Cell Physiol. 278:2000;C812-C821.
11. Hsueh C.T., Dolnick B.J. Regulation of folate-binding protein gene expression by DNA methylation in methotrexate-resistant KB cells. Biochem. Pharmacol. 47:1994;1019-1027.
12. Mattson M.P., Shea T.B. Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci. 26:2003;137-146.
13. Ulrich C.M., Robien K., Sparks R. Pharmacogenetics and folate metabolism - a promising direction. Pharmacogenomics. 3:2002;299-313.
14. Lamprecht S.A., Lipkin M. Chemoprevention of colon cancer by calcium, vitamin D and folate: molecular mechanisms. Nat. Rev. 3:2003;601-614.
15. Kamen B.A. Folate receptor α, a review. Massaro E., Rogers J.M. Symposium on Folates and Human Development. 2002;117-135 Humana Press, New Jersey.
16. Antony A.C. Folate receptors. Annu. Rev. Nutr. 16:1996;501-521.
17. Matherly L.H., Goldman D.I. Membrane transport of folates. Vitam. Horm. 66:2003;403-456.
18. Antony A.C. The biological chemistry of folate receptors. Blood. 79:1992;2807-2820.
19. Christensen E.I., Birn H., Verroust P., Moestrup S.K. Membrane receptors for endocytosis in the renal proximal tubule. Int. Rev. Cytol. 180:1998;237-284.
20. Suleiman S.A., Spector R. Purification and characterization of a folate binding protein from porcine choroid plexus. Arch. Biochem. Biophys. 208:1981;87-94.
21. da Costa M., Rothenberg S.P. Purification and characterization of folate binding proteins from rat placenta. Biochim. Biophys. Acta. 1292:1996;23-30.
22. Ratnam M., Marquardt H., Duhring J.L., Freisheim J.H. Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA. Biochemistry. 28:1989;8249-8254.
23. Elwood P.C. Molecular cloning and characterization of the human folate-binding protein cDNA from placenta and malignant tissue culture (KB) cells. J. Biol. Chem. 264:1989;4893-4901.
24. Sikka P.K., McMartin K.E. Determination of folate transport pathways in cultured rat proximal tubule cells. Chem. Biol. Interact. 114:1998;15-31.
25. Morshed K.M., Ross D.M., McMartin K.E. Folate transport proteins mediate the bidirectional transport of 5-methyltetrahydrofolate in cultured human proximal tubule cells. J. Nutr. 127:1997;1137-1147.
26. Birn H., Selhub J., Christensen E.I. Internalization and intracellular transport of folate-binding protein in rat kidney proximal tubule. Am. J. Physiol. 264:1993;C302-C310.
27. Muldoon R.T., Ross D.M., McMartin K.E. Folate transport pathways regulate urinary excretion of 5-methyltetrahydrofolate in isolated perfused rat kidney. J. Nutr. 126:1996;242-250.
28. Chancey C.D., Kekuda R., Huang W., Prasad P.D., Kuhnel J.-M., Sirotnak F.M., Roon P., Ganapathy V., Smith S.B. Expression and differential polarization of the reduced-folate transporter-1 and the folate receptor α in mammalian retinal pigment epithelium. J. Biol. Chem. 275:2000;20676-20684.
29. Serot J.M., Christmann D., Dubost T., Bene M.C. Faure GC CSF-folate levels are decreased in late-onset AD patients. J. Neural Transm. 108:2001;93-99.
30. Wells D.G., Casey H.J. Lactobacillus casei C.S.F. folate activity. Br. Med. J. 30:1967;834-837.
31. Kamen B.A., Caston J.D. Purification of a folate binding factor in normal human umbilical cord serum. Proc. Natl. Acad. Sci. 72:1975;4261-4264.
32. Gross S., Kamen B.A., Fanaroff A., Caston J.D. Folate compartmentation during developmental maturation. J. Pediatr. 96:1980;842-844.
33. Lark R.H., Smith A.K., Kamen B.A. Should patients receiving anti-folates be treated with folic acid first? A rationale based upon studies of folylpolyglutamate synthetase. Cancer Res. Ther. Control. 4:1994;11-16.
34. Doucette M.M., Stevens V.L. Folate receptor function is regulated in response to different cellular growth rates in cultured mammalian cells. J. Nutr. 131:2001;2819-2825.
35. Orr R.B., Kamen B.A. Similarity of folate receptor expression in UMSCC 38 cells to squamous cell carcinoma differentiation markers. J. Natl. Cancer Inst. 87:1995;299-303.
36. Willis S.A., Lacey S.W., Weitman S.D., Kamen B.A., Nisen P.D. Folate receptor gene expression is tissue-specific and temporally-regulated. Cancer Ther. Control. 2:1992;223-230.
37. Matsue H., Rothberg K.G., Takashima A., Kamen B.A., Anderson R.G.W., Lacey S.W. Potocytosis of folate selects cells for growth in physiologic concentrations of the vitamin. Proc. Natl. Acad. Sci. 89:1992;6006-6009.
38. Orr R.B., Kamen B.A. UMSCC38 cells amplified at 11q13 for the folate receptor synthesize nonfunctional folate receptor antigen. Cancer Res. 54:1994;3905-3911.
39. Kamen B.A., Caston J.D. Properties of a folate binding protein (FBP) isolated from porcine kidney. Biochem. Pharmacol. 35:1986;2323-2329.
40. Cha S. Tight-binding inhibitors - III. A new approach for the determination of competition between tight-binding inhibitors and substrates - inhibition of adenosine deaminase by coformycin. Biochem. Pharmacol. 25:1976;2695-2702.
41. Westerhof G.R., Jansen G., van Emmerik N., Kathmann I., Rijksen G., Jackman A.L., Schornagel J.H. Membrane transport of natural folates and antifolate compounds in murine L1210 leukemia cells: role of carrier- and receptor-mediated transport systems. Cancer Res. 51:1991;5507-5513.
42. Kamen B.A., Smith A.K., Anderson R.G. The folate receptor works in tandem with a probenecid-sensitive carrier in MA104 cells in vitro. J. Clin. Invest. 87:1991;1442-1449.
43. Kamen B.A., Wang M.T., Streckfuss A.J., Peryea X., Anderson R.G.W. Delivery of folates to the cytoplasm of MA104 cells is mediated by a surface membrane receptor that recycles. J. Biol. Chem. 263:1988;13602-13609.
44. Carver L.A., Schnitzer J.E. Caveolae: mining little caves for new cancer targets. Nat. Rev. Cancer. 8:2003;571-581.
45. Wu M., Fan J., Gunning W., Ratnam M. Clustering of GPI-anchored folate receptor independent of both cross-linking and association with caveolin. J. Membr. Biol. 159:1997;137-147.
46. Wang J., Gunning W., Kelley K.M., Ratnam M. Evidence for segregation of heterologous GPI-anchored proteins into separate lipid rafts within the plasma membrane. J. Membr. Biol. 189:2002;35-43.
47. Kamen B.A., Capdevilla A. Receptor-mediated folate accumulation is regulated by the cellular folate content. Proc. Natl. Acad. Sci. USA. 83:1986;5983-5987.
48. Kamen B.A., Johnson C.A., Wang M.T., Anderson R.G. Regulation of the cytoplasmic accumulation of 5-methyltetrahydrofolate in MA104 cells is independent of folate receptor regulation. J. Clin. Invest. 84:1989;1379-1386.
49. McHugh M., Cheng Y.C. Demonstration of high affinity folate binder in human cell membranes and its characterization in cultured human KB cells. J. Biol. Chem. 254:1979;11312-11318.
50. Fan J., Vitols K.S., Huennekens F.M. Biotin derivatives of methotrexate and folate. Synthesis and utilization for affinity purification of two membrane-associated folate transporters from L1210 cells. J. Biol. Chem. 266:1991;14862-14865.
51. Lark R.H., Smith A.S., Kamen B.A. Folylpolyglutamate synthetase but not folate receptor correlates with MA104 cell growth in vitro. Cancer Res. Ther. Control. 5:1996;1-10.
52. Orr R., Kreisler A.R., Kamen B.A. Similarity of folate receptor expression in UMSCC 38 cells to squamous cell carcinoma differentiation markers. J. Natl. Cancer Inst. 87:1995;299-303.
53. Kelley K.M., Rowan B.G., Ratnam M. Modulation of the folate receptor alpha gene by the estrogen receptor: mechanism and implications in tumor targeting. Cancer Res. 63:2003;2820-2828.
54. Hao H., Qi H., Ratnam M. Modulation of the folate receptor type beta gene by coordinate actions of retinoic acid receptors at activator Sp1/ets and repressor AP-1 sites. Blood. 101:2003;4551-4560.
55. Wang H., Zheng X., Behm F.G., Ratnam M. Differentiation-independent retinoid induction of folate receptor type beta, a potential tumor target in myeloid leukemia. Blood. 96:2000;3529-3536.
56. Chang W.J., Rothberg K.G., Kamen B.A., Anderson R.W.J. Lowering the cholesterol content of MA104 cells inhibits receptor-mediated transport of folate. J. Cell Biol. 118:1992;63-69.
57. Rothberg K.G., Ying Y.S., Kamen B.A., Anderson R.W.J. Cholesterol controls the clustering of the glycophospholipid-anchored membrane receptor for 5-methyltetrahydrofolate. J. Cell Biol. 111:1990;2931-2938.
58. Hao M., Mukherjee S., Maxfield F.R. Cholesterol depletion induces large scale domain segregation in living cell membranes. Proc. Natl. Acad. Sci. USA. 98:2001;13072-13077.
59. Smart E.J., Foster D.C., Ying Y.S., Kamen B.A., Anderson R.G. Protein kinase C activators inhibit receptor-mediated potocytosis by preventing internalization of caveolae. J. Cell Biol. 124:1994;307-313.
60. Lewis C.M., Smith A.K., Nguyen C., Kamen B.A. PMA alters folate receptor distribution in the plasma membrane and increases the rate of 5-methyltetrahydrofolate delivery in mature MA104 cells. Biochim. Biophys. Acta. 1401:1998;157-169.
61. Caloca M.J., Fernandez N., Lewin N.E., Ching D., Modali R., Blumberg P.M., Kazanietz M.G. Beta2-chimaerin is a high affinity receptor for the phorbol ester tumor promoters. J. Biol. Chem. 272:1997;26488-26496.
62. Lewis C.M., Smith A.K., Kamen B.A. Cytochalasin D induced F-actin disruption increases receptor mediated folate delivery. Cancer Res. 58:1998;2592-2956.
63. Zwiener R.J., Johnson C.A., Anderson R.G.W., Kamen B.A. Purified folate receptor-5-methyltetrahydrofolic acid interaction at neutral and acid pH. Cancer Res. Ther. Control. 3:1993;37-42.