Localized folate and vitamin B-12 deficiency in squamous cell lung cancer is associated with global DNA hypomethylation

Nutrition and Cancer

Volumn 37, Issue 1, 2000, Pages 99-107

  Piyathilake, C J ^a   Johanning, G L ^a   Macaluso, M ^a   Whiteside, M ^a   Oelschlager, D K ^a   Heimburger, D C ^a   Grizzle, W E ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYANOCOBALAMIN; DNA; FOLIC ACID; METHYL GROUP;

ADULT; AGED; ARTICLE; BRONCHUS MUCOSA; CANCER RISK; CANCER SUSCEPTIBILITY; CIGARETTE SMOKING; CYANOCOBALAMIN DEFICIENCY; DNA METHYLATION; FOLIC ACID DEFICIENCY; HUMAN; HUMAN TISSUE; ISOTOPE LABELING; LUNG SQUAMOUS CELL CARCINOMA; PROTEIN EXPRESSION;

BRONCHUS;

EID: 0033844302     PISSN: 01635581     EISSN: None     Source Type: Journal    
DOI: 10.1207/S15327914NC3701_13     Document Type: Article

References (66)

1. Folic acid
2. The chemical composition of tobacco and tobacco smoke
3. Reaction of tetrahydrofolic acid with cyanate from urea solutions. Formation of an inactive folate derivative
4. Effect of vegetarianism and smoking on vitamin B-12, thiocyanate, and folate levels in the blood of normal subjects
5. Effects of smoking on metabolism and excretion of vitamin B-12
6. Chemical agents in cigarette smoke
7. Nitrous oxide has multiple deleterious effects on cobalamin metabolism and causes decreases in activities of both mammalian cobalamin-dependent enzymes in rats
8. In vitro inactivation of methionine synthase by nitrous oxide
9. Polyglutamation as a factor in the trapping of 5-methyl-tetrahydrofolate by cobalamin-deficient L1210 cells
10. Inactivation of B-12 and folate coenzymes by butyl nitrite as observed by NMR: Implications on one-carbon transfer mechanism
11. Folate, carotene, and smoking
12. Serum folic acid levels and antipyrine clearance rates in smokers and non-smokers
13. Increased chromosome fragility as a consequence of blood folate levels. Smoking status and coffee consumption
14. Local and systemic effects of cigarette smoking on folate and vitamin B-12
15. Localized folic acid deficiency and bronchial metaplasia in smokers: Hypothesis and preliminary report
16. Improvement in bronchial squamous metaplasia in smokers treated with folate and vitamin B-12
17. Chemoprevention effects on bronchial squamous metaplasia by folate and vitamin B-12 in heavy smokers
18. Effect of smoking on folate levels in buccal mucosal cells
19. Microbiological assay of folates
20. Trouble-free microbiologic serum and red cell folate assays
21. Global DNA hypomethylation increases progressively in cervical dysplasia and carcinoma
22. The role of DNA methylation in cancer genetics and epigenetics
23. DNA hypomethylation leads to elevated mutation rates
24. DNA methylation and chromatin structure
25. Hypomethylation of ras oncogenes in primary human cancers
26. Hypomethylation distinguishes genes of some human cancers from their normal counterparts
27. Alterations in DNA methylation: A fundamental aspect of neoplasia
28. DNA Methylation and gene expression
29. Eukaryotic DNA methylation and gene expression
30. The 5-methylcytosine content of DNA from human tumors
31. Hypomethylation of DNA from benign and malignant human colon neoplasms
32. Reduced genomic 5-methylcytosine content in human colonic neoplasia
33. DNA methylation in human lung tumors
34. Global DNA hypomethylation occurs in the early stages of intestinal-type gastric carcinoma
35. Global DNA hypomethylation increases progressively in cervical dysplasia and carcinoma
36. Global DNA hypomethylation in breast carcinoma - Correlation with prognostic factors and tumor progression
37. Folate-deficiency-induced homocysteinaemia in rats: Disruption of S-adenosylmethionine's co-ordinate regulation of homocysteine metabolism
38. Hepatic one-carbon metabolism in early folate deficiency in rats
39. DNA Methylation in folate deficiency: Use of CpG methylase
40. Folate deficiency in rats causes hypomethylation of liver DNA
41. Brain folates and DNA methylation in rats fed a choline-deficient diet or treated with low doses of methotrexate
42. Moderate folate deficiency does not cause global hypomethylation of hepatic and colonic DNA or c-myc-specific hypomethylation of colonic DNA in rats
43. Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene
44. DNA Methylation as an intermediate biomarker in colorectal cancer: Modulation by folic acid supplementation
45. Epithelial cell folate depletion occurs in neoplastic but not adjacent normal colon mucosa
46. Colonic mucosal concentrations of folate correlate well with blood measurements of folate status in persons with colorectal polyps
47. Hypomethylation: An early event in cervical carcinogenesis
48. Smoking-attributable cancer mortality in 1991: Is lung cancer now the leading cause of death among smokers in the United States?
49. Non small cell lung cancer. 1. Biology, diagnosis and staging
50. Cigarette smoking and changes in the histopathology of lung cancer
51. Food and nutrient intake differences between smokers and non smokers in the US
52. Alcohol and folate interactions: Clinical implications
53. Diet and alcohol consumption and lung cancer risk in the New York State Cohort (United States)
54. A cross-sectional study of vitamin intake in postoperative non-small cell lung cancer patients
55. Experimental study of antitumor effect of methyl-B-12
56. Quantitative determination of water- and lipid-soluble antioxidants in neoplastic and nonneoplastic human breast tissue
57. Concentrations of carotenoids, tocopherols, and retinol in paired plasma and cervical tissue of patients with cervical cancer, precancer, and non-cancerous diseases
58. Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications
59. New anti-lung-cancer antibody cluster 12 reacts with human folate receptors present on adenocarcinoma
60. Expansion of bronchial epithelial cell populations by in vitro culture of explants from dysplastic and histologically normal sites
61. Inhibition of cellular uptake of folate by blocking synthesis of the membrane folate receptor
62. Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer
63. Germ line polymorphisms in cytochrome P-450 1A1 (C4887 CYP1A1) and methylenetetrahydrofolate reductase (MTHFR) genes and endometrial cancer susceptibility
64. Loss of heterozygosity at the 5,10-methylenetetrahydrofolate reductase locus in human ovarian carcinomas
65. Correlation between methylation status of the p16/CDKN2 gene and the expression of p16 and Rb proteins in primary non-small cell lung cancers