MTHFR C677T polymorphisms and childhood acute lymphoblastic leukemia: A meta-analysis

Leukemia Research

Volumn 34, Issue 12, 2010, Pages 1596-1600

  Wang, Jing ^a   Zhan, Ping ^b   Chen, Bing ^a   Zhou, Rongfu ^a   Yang, Yonggong ^a   Ouyang, Jian ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^b NANJING CHEST HOSPITAL   (China)

Author keywords

Acute lymphoblastic leukemia; Meta analysis; MTHFR polymorphisms

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2);

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CANCER RISK; CASE CONTROL STUDY; CHILD; CHILDHOOD LEUKEMIA; ETHNICITY; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HOMOZYGOTE; HUMAN; LEUKEMOGENESIS; PRIORITY JOURNAL;

ADOLESCENT; ALLELES; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; COLORECTAL NEOPLASMS; FEMALE; HOMOZYGOTE; HUMANS; MALE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP); MODELS, BIOLOGICAL; POLYMORPHISM, GENETIC; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PREDICTIVE VALUE OF TESTS; RISK FACTORS; STOMACH NEOPLASMS;

EID: 78149357320     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2010.03.034     Document Type: Article

References (38)

1. Chen C.L., Liu Q., Pui C.H., Rivera G.K., Sandlund J.T., Ribeiro R., et al. Higher frequency of glutathione Stransferase deletions in black children with acute lymphoblastic leukemia. Blood 1997, 89(5):1701-1707.
2. Sinnett D., Krajinovic M., Labuda D. Genetic susceptibility to childhood acute lymphoblastic leukemia. Leuk Lymphoma 2000, 38(5-6):447-462.
3. Gilliland D.G. Molecular genetics of human leukemia. Leukemia 1998, 12(Suppl. 1):S7-12.
4. Smith M.T., McHale C.M., Wiemels J.L., Zhang L., Wiencke J.K., Zheng S., et al. Molecular biomarkers for the study of childhood leukemia. Toxicol Appl Pharmacol 2005, 206(2):237-245.
5. Cnattingius S., Zack M.M., Ekbom A., Gunnarskog J., Kreuger A., Linet M., et al. Prenatal and neonatal risk factors for childhood lymphatic leukemia. J Natl Cancer Inst 1995, 87(12):908-914.
6. Frosst P., Blom H.J., Milos R., Goyette P., Sheppard C.A., Matthews R.G., et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995, 10(1):111-113.
7. Dong L.M., Potter J.D., White E., Ulrich C.M., Cardon L.R., Peters U. Genetic susceptibility to cancer: the role of polymorphisms in candidate genes. JAMA 2008, 299(20):2423-2436.
8. Franco R.F., Simões B.P., Tone L.G., Gabellini S.M., Zago M.A., Falcão R.P. The methylenetetrahydrofolate reductase C677T gene polymorphism decreases the risk of childhood acute lymphocytic leukaemia. Br J Haematol 2001, 115(3):616-618.
9. Jiang H., Gu L.J., Xue H.L. Methylenetetrahydrofolate reductase gene polymorphism of childhood acute lymphocytic leukaemia. Zhonghua Xue Ye Xue Za Zhi 2004, 25(7):439-440.
10. Wiemels J.L., Smith R.N., Taylor G.M., Eden O.B., Alexander F.E., Greaves M.F. Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia. Proc Natl Acad Sci USA 2001, 98(7):4004-4009.
11. Balta G., Yuksek N., Ozyurek E., Ertem U., Hicsonmez G., Altay C., et al. Characterization of MTHFR, GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes in childhood acute leukemia. Am J Hematol 2003, 73(3):154-160.
12. Zintzaras E., Koufakis T., Ziakas P.D., Rodopoulou P., Giannouli S., Voulgarelis M. A meta-analysis of genotypes and haplotypes of methylenetetrahydrofolate reductase gene polymorphisms in acute lymphoblastic leukemia. Eur J Epidemiol 2006, 21(7):501-510.
13. Pereira T.V., Rudnicki M., Pereira A.C., Pombo-de-Oliveira M.S., Franco R.F. 5,10-Methylenetetrahydrofolate reductase polymorphisms and acute lymphoblastic leukemia risk: a meta-analysis. Cancer Epidemiol Biomark Prev 2006, 15(10):1956-1963.
14. Krajinovic M., Lamothe S., Labuda D., Lemieux-Blanchard E., Theoret Y., Moghrabi A., et al. Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Blood 2004, 103(1):252-257.
15. Thirumaran R.K., Gast A., Flohr T., Burwinkel B., Bartram C., Hemminki K., et al. MTHFR genetic polymorphisms and susceptibility to childhood acute lymphoblastic leukemia. Blood 2005, 106(7):2590-2591.
16. Oliveira E., Alves S., Quental S., Ferreira F., Norton L., Costa V., et al. The MTHFR C677T and A1298C polymorphisms and susceptibility to childhood acute lymphoblastic leukemia in Portugal. J Pediatr Hematol Oncol 2005, 27(8):425-429.
17. Schnakenberg E., Mehles A., Cario G., Rehe K., Seidemann K., Schlegelberger B., et al. Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and susceptibility to pediatric acute lymphoblastic leukemia in a German study population. BMC Med Genet 2005, 6:23.
18. Chatzidakis K., Goulas A., Athanassiadou-Piperopoulou F., Fidani L., Koliouskas D., Mirtsou V. Methylenetetrahydrofolate reductase C677T polymorphism: association with risk for childhood acute lymphoblastic leukemia and response during the initial phase of chemotherapy in Greek patients. Pediatr Blood Cancer 2006, 47(2):147-151.
19. Zanrosso C.W., Hatagima A., Emerenciano M., Ramos F., Figueiredo A., Félix T.M., et al. The role of methylenetetrahydrofolate reductase in acute lymphoblastic leukemia in a Brazilian mixed population. Leuk Res 2006, 30(4):477-481.
20. Yu H., Jin R.M., Bai Y. The relationship between the methylenetetrahydrofolate reductase C677T gene polymorphism and acute lymphocytic leukemia in children. Lin Chuang Xue Ye Xue Za Zhi 2006, 19(4):205-209.
21. Reddy H., Jamil K. Polymorphisms in the MTHFR gene and their possible association with susceptibility to childhood acute lymphocytic leukemia in an Indian population. Leuk Lymphoma 2006, 47(7):1333-1339.
22. Kim N.K., Chong S.Y., Jang M.J., Hong S.H., Kim H.S., Cho E.K., et al. Association of the methylenetetrahydrofolate reductase polymorphism in Korean patients with childhood acute lymphoblastic leukemia. Anticancer Res 2006, 26(4B):2879-2881.
23. Kamel A.M., Moussa H.S., Ebid G.T., Bu R.R., Bhatia K.G. Synergistic effect of methyltetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphism as risk modifiers of pediatric acute lymphoblastic leukemia. J Egypt Natl Canc Inst 2007, 19(2):96-105.
24. Petra B.G., Janez J., Vita D. Gene-gene interactions in the folate metabolic pathway influence the risk for acute lymphoblastic leukemia in children. Leuk Lymphoma 2007, 48(4):786-792.
25. Giovannetti E., Ugrasena D.G., Supriyadi E., Vroling L., Azzarello A., de Lange D., et al. Methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase promoter (TSER) polymorphisms in Indonesian children with and without leukemia. Leuk Res 2008, 32(1):19-24.
26. Alcasabas P., Ravindranath Y., Goyette G., Haller A., Del Rosario L., Lesaca-Medina M.Y., et al. 5,10-Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and the risk of acute lymphoblastic leukemia (ALL) in Filipino children. Pediatr Blood Cancer 2008, 51(2):178-182.
27. Liu J.X., Chen J.P., Lin D.X. Polymorphisms in the MTHFR gene and their possible association with susceptibility to acute lymphocytic leukemia. Jie Fang Jun Za Zhi 2008, 33(11):1291-1293.
28. de Jonge R., Tissing W.J., Hooijberg J.H., Jansen G., Kaspers G.J., Lindemans J., et al. Polymorphisms in folate-related genes and risk of pediatric acute lymphoblastic leukemia. Blood 2009, 113(10):2284-2289.
29. Kim H.N., Kim Y.K., Lee I.K., Yang D.H., Lee J.J., Shin M.H., et al. Association between polymorphisms of folate-metabolizing enzymes and hematological malignancies. Leuk Res 2009, 33(1):82-87.
30. Yeoh A.E., Lu Y., Chan J.Y., Chan Y.H., Ariffin H., Kham S.K., et al. Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: results from the Malaysia-Singapore ALL Study Group. Leuk Res 2010, 34(3):276-283.
31. Hirschhorn J.N., Lohmueller K., Byrne E. A comprehensive review of genetic association studies. Genet Med 2002, 4:45-61.
32. Deligezer U., Akisik E., Dalay N. Genotyping of the MTHFR gene polymorphism, C677T in patients with leukemia by melting curve analysis. Mol Diagn 2003, 7(3-4):181-185.
33. Gemmati D., Ongaro A., Scapoli G.L., Della Porta M., Tognazzo S., Serino M.L., et al. Common gene polymorphisms in the metabolic folate and methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkin's lymphoma in adults. Cancer Epidemiol Biomarkers Prev 2004, 13(5):787-794.
34. Shuman A.L. For literature searches, is Medline enough? Perception of an adequate literature search. Lab Anim (NY) 2004, 33(2):15-16.
35. Brand-de Heer D.L. A comparison of the coverage of clinical medicine provided by PASCAL BIOMED and MEDLINE. Health Info Libr J 2001, 18(2):110-116.
36. Chiusolo P., Reddiconto G., Cimino G., Sica S., Fiorini A., Farina G., et al. Methylenetetrahydrofolate reductase genotypes do not play a role in acute lymphoblastic leukemia pathogenesis in the Italian population. Haematologica 2004, 89(2):139-144.
37. Chen J., Gammon M.D., Chan W., Palomeque C., Wetmur J.G., Kabat G.C., et al. One-carbon metabolism, MTHFR polymorphisms, and risk of breast cancer. Cancer Res 2005, 65(4):1606-1614.
38. Shrubsole M.J., Gao Y.T., Cai Q., Shu X.O., Dai Q., Hébert J.R., et al. MTHFR polymorphisms, dietary folate intake, and breast cancer risk: results from the Shanghai Breast Cancer Study. Cancer Epidemiol Biomark Prev 2004, 13(2):190-196.