Betaine rescue of an animal model with methylenetetrahydrofolate reductase deficiency

Biochemical Journal

Volumn 382, Issue 3, 2004, Pages 831-840

  Schwahn, Bernd C ^a,b   Laryea, Maurice D ^b   Chen, Zhoutao ^a   Melnyk, Stepan ^c   Pogribny, Igor ^d   Garrow, Timothy ^e   James, S Jill ^c   Rozen, Rima ^a  

^a MONTREAL CHILDREN S HOSPITAL   (Canada)

^b UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^d NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^e UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Betaine supplementation; Brain development; Hyperhomocysteinaemia; Methylenetetrahydrofolate reductase (MTHFR); Remethylation

Indexed keywords

BIOCHEMISTRY; DERIVATIVES; ENZYMES; MEDICAL IMAGING; PATHOLOGY;

BETAINE SUPPLEMENTATION; FOLATE DERIVATIVES; HOMOCYSTINURIA; METHIONINE;

ORGANIC COMPOUNDS;

5 METHYLTETRAHYDROFOLIC ACID; 5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); BETAINE; CHOLINE; HOMOCYSTEINE; METHIONINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN; CATALYSIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CEREBELLUM; CONTROLLED STUDY; DISEASE COURSE; ENZYME DEFICIENCY; FETUS; HIPPOCAMPUS; HOMOCYSTINURIA; HYPERHOMOCYSTEINEMIA; KNOCKOUT MOUSE; LACTATION; LIVER; METHYLATION; METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY; MOUSE; NEWBORN; NONHUMAN; PHYSICAL DEVELOPMENT; PREGNANCY; PRIORITY JOURNAL; SURVIVAL;

ANIMALS; ANIMALS, SUCKLING; BETAINE; BODY WEIGHT; BRAIN; DISEASE MODELS, ANIMAL; FEMALE; GENOTYPE; HOMOCYSTEINE; HOMOCYSTINURIA; LACTATION; LIVER; MALE; MATERNAL-FETAL EXCHANGE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MICE; MICE, KNOCKOUT; ORGAN SIZE; PREGNANCY;

ANIMALIA;

EID: 4744373632     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20040822     Document Type: Article

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