Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism

Journal of Biological Chemistry

Volumn 284, Issue 3, 2009, Pages 1533-1539

  MacFarlane, Amanda J ^a,d   Perry, Cheryll A ^a   Girnary, Hussein H ^a   Gao, Dacao ^b   Allen, Robert H ^c   Stabler, Sally P ^c   Shane, Barry ^b   Stover, Patrick J ^a  

^a Department of Obstetrics Gynecology   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d HEALTH CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON METABOLISMS; COFACTORS; DE NOVO SYNTHESIS; EMBRYONIC LETHALITIES; ENTRY POINTS; ESSENTIAL GENES; GENE TRAPS; HOMOCYSTEINE; METHYLATION REACTIONS; SYNTHETASE; TETRAHYDROFOLATE;

AMINO ACIDS; BIOCHEMISTRY; CESIUM; NUCLEIC ACIDS; ORGANIC ACIDS;

METABOLISM;

10 FORMYL TETRAHYDROFOLATE; ADENOSINE TRIPHOSPHATE; BIOLOGICAL MARKER; C1 TETRAHYDROFOLATE SYNTHASE; CARBON; CELL NUCLEUS DNA; FOLIC ACID; FORMATE TETRAHYDROFOLATE LIGASE; FORMIC ACID; GLYCINE HYDROXYMETHYLTRANSFERASE; HOMOCYSTEINE; METHIONINE; PURINE; S ADENOSYLMETHIONINE; TETRAHYDROFOLIC ACID; THYMIDINE PHOSPHATE; UNCLASSIFIED DRUG; URACIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CARBON METABOLISM; CONTROLLED STUDY; CYTOPLASM; EMBRYO; ENZYME ACTIVITY; ENZYME DEGRADATION; ESSENTIAL GENE; FEMALE; FOLATE METABOLISM; GENE EXPRESSION; GENE FUNCTION; GENE INSERTION; GENE VECTOR; LETHALITY; LIVER LEVEL; LIVER METABOLISM; MALE; MOUSE; MTHFD1 GENE; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN METHYLATION; PURINE SYNTHESIS;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BIOLOGICAL MARKERS; DNA; FOLIC ACID; FORMATE-TETRAHYDROFOLATE LIGASE; FORMIC ACIDS; GLYCINE HYDROXYMETHYLTRANSFERASE; HOMOCYSTEINE; METHYLATION; MICE; THYMIDINE MONOPHOSPHATE; URACIL;

MUS;

EID: 59449092734     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M808281200     Document Type: Article

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