메뉴 건너뛰기




Volumn 13, Issue 10, 2009, Pages 4229-4238

One carbon metabolism disturbances and the C677T MTHFR gene polymorphism in children with autism spectrum disorders

Author keywords

Autism; Methionine cycle; MTHFR; Transsulphuration; Vitamins

Indexed keywords

AMINOBUTYRIC ACID DERIVATIVE; BUTYRINE; CARBON; GLUTATHIONE; HOMOCYSTEINE; METHIONINE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); ALPHA-AMINOBUTYRIC ACID;

EID: 77449158432     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2008.00463.x     Document Type: Article
Times cited : (100)

References (50)
  • 2
    • 0013139395 scopus 로고    scopus 로고
    • American Psychiatric Association, 4th ed., Washington, DC, American Psychiatric Association
    • Diagnostic and Statistical Manual-Text Revision 2000, American Psychiatric Association, 4th ed., Washington, DC, American Psychiatric Association
    • (2000) Diagnostic and Statistical Manual-Text Revision
  • 3
    • 33846969944 scopus 로고    scopus 로고
    • Prevalence of autism spectrum disorders-autism and developmental disabilities monitoring network, 14 sites, United States, 2002
    • Autism and Developmental Disabilities Monitoring Network Surveillance Year 2002 Principal Investigators, Centers for Disease Control and Prevention
    • Prevalence of autism spectrum disorders-autism and developmental disabilities monitoring network, 14 sites, United States, 2002. MMWR Surveill Summ. 2007, 56:12-28. Autism and Developmental Disabilities Monitoring Network Surveillance Year 2002 Principal Investigators, Centers for Disease Control and Prevention
    • (2007) MMWR Surveill Summ. , vol.56 , pp. 12-28
  • 4
    • 33745818375 scopus 로고    scopus 로고
    • Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP)
    • Baird G, Simonoff E, Pickles A. Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP). Lancet. 2006, 368:210-5.
    • (2006) Lancet. , vol.368 , pp. 210-215
    • Baird, G.1    Simonoff, E.2    Pickles, A.3    et al4
  • 5
    • 33846614076 scopus 로고    scopus 로고
    • Recent advances in the genetics of autism
    • Gupta AR, State MW. Recent advances in the genetics of autism. Biol Psychiatry. 2007, 61:429-37.
    • (2007) Biol Psychiatry. , vol.61 , pp. 429-437
    • Gupta, A.R.1    State, M.W.2
  • 6
    • 33746314832 scopus 로고    scopus 로고
    • Searching for ways out of the autism maze: genetic, epigenetic and environmental clues
    • Persico AM, Bourgeron T. Searching for ways out of the autism maze: genetic, epigenetic and environmental clues. Trends Neurosci. 2006, 29:349-58.
    • (2006) Trends Neurosci. , vol.29 , pp. 349-358
    • Persico, A.M.1    Bourgeron, T.2
  • 7
    • 33846921789 scopus 로고    scopus 로고
    • Autism spectrum disorders: developmental disconnection syndromes
    • Geschwind DH, Levitt P. Autism spectrum disorders: developmental disconnection syndromes. Curr Opin Neurobiol. 2007, 17:103-11.
    • (2007) Curr Opin Neurobiol. , vol.17 , pp. 103-111
    • Geschwind, D.H.1    Levitt, P.2
  • 8
    • 33749032127 scopus 로고    scopus 로고
    • Time to give up on a single explanation for autism
    • Happe F, Ronald A, Plomin R. Time to give up on a single explanation for autism. Nat Neurosci. 2006, 9:1218-20.
    • (2006) Nat Neurosci. , vol.9 , pp. 1218-1220
    • Happe, F.1    Ronald, A.2    Plomin, R.3
  • 10
    • 15244348759 scopus 로고    scopus 로고
    • Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism
    • James SJ, Cutler P, Melnyk S. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. Am J Clin Nutr. 2004, 80:1611-7.
    • (2004) Am J Clin Nutr. , vol.80 , pp. 1611-1617
    • James, S.J.1    Cutler, P.2    Melnyk, S.3    et al4
  • 11
    • 33845438146 scopus 로고    scopus 로고
    • Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism
    • James SJ, Melnyk S, Jernigan S. Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism. Am J Med Genet B Neuropsychiatr Genet. 2006, 141:947-56.
    • (2006) Am J Med Genet B Neuropsychiatr Genet. , vol.141 , pp. 947-956
    • James, S.J.1    Melnyk, S.2    Jernigan, S.3    et al4
  • 12
    • 33645238117 scopus 로고    scopus 로고
    • High levels of homocysteine and low serum paraoxonase 1 arylesterase activity in children with autism
    • Paüsca SP, Nemes B, Vlase L. High levels of homocysteine and low serum paraoxonase 1 arylesterase activity in children with autism. Life Sci. 2006, 78:2244-8.
    • (2006) Life Sci. , vol.78 , pp. 2244-2248
    • Paüsca, S.P.1    Nemes, B.2    Vlase, L.3    et al4
  • 13
    • 33748774908 scopus 로고    scopus 로고
    • A clinical and laboratory evaluation of methionine cycle-transsulfuration and androgen pathway markers in children with autistic disorders
    • Geier DA, Geier MR. A clinical and laboratory evaluation of methionine cycle-transsulfuration and androgen pathway markers in children with autistic disorders. Horm Res. 2006, 66:182-8.
    • (2006) Horm Res. , vol.66 , pp. 182-188
    • Geier, D.A.1    Geier, M.R.2
  • 14
    • 49949152394 scopus 로고    scopus 로고
    • Brief report: autistic symptoms, developmental regression, mental retardation, epilepsy, and dyskinesias in CNS folate deficiency
    • Moretti P, Peters SU, Del Gaudio D. Brief report: autistic symptoms, developmental regression, mental retardation, epilepsy, and dyskinesias in CNS folate deficiency. J Autism Dev Disord. 2008, 38:1170-7.
    • (2008) J Autism Dev Disord. , vol.38 , pp. 1170-1177
    • Moretti, P.1    Peters, S.U.2    Del Gaudio, D.3    et al4
  • 16
    • 37849037738 scopus 로고    scopus 로고
    • How environmental and genetic factors combine to cause autism: A redox/ methylation hypothesis
    • Deth R, Muratore C, Benzecry J. How environmental and genetic factors combine to cause autism: A redox/ methylation hypothesis. Neurotoxicology. 2008, 29:190-201.
    • (2008) Neurotoxicology. , vol.29 , pp. 190-201
    • Deth, R.1    Muratore, C.2    Benzecry, J.3    et al4
  • 17
    • 42449129108 scopus 로고    scopus 로고
    • Altered sulfur amino acid metabolism in immune cells of children diagnosed with autism
    • Suh J, Walsh W, McGinnis W. Altered sulfur amino acid metabolism in immune cells of children diagnosed with autism. Am J Biochem Biotech. 2008, 4:105-13.
    • (2008) Am J Biochem Biotech. , vol.4 , pp. 105-113
    • Suh, J.1    Walsh, W.2    McGinnis, W.3    et al4
  • 18
    • 34447643277 scopus 로고    scopus 로고
    • Preliminary evidence for involvement of the folate gene polymorphism 19bp deletion-DHFR in occurrence of autism
    • Adams M, Lucock M, Stuart J. Preliminary evidence for involvement of the folate gene polymorphism 19bp deletion-DHFR in occurrence of autism. Neurosci Lett. 2007, 422:24-9.
    • (2007) Neurosci Lett. , vol.422 , pp. 24-29
    • Adams, M.1    Lucock, M.2    Stuart, J.3    et al4
  • 19
    • 58849106335 scopus 로고    scopus 로고
    • A prospective study of transsulfuration biomarkers in autistic disorders
    • Geier DA, Kern JK, Garver CR. A prospective study of transsulfuration biomarkers in autistic disorders. Neurochem Res 2009, 34:394.
    • (2009) Neurochem Res , vol.34 , pp. 394
    • Geier, D.A.1    Kern, J.K.2    Garver, C.R.3    et al4
  • 20
  • 21
    • 0027160548 scopus 로고
    • Elevation of serum cystathionine levels in patients with cobalamin and folate deficiency
    • Stabler SP, Lindenbaum J, Savage DG. Elevation of serum cystathionine levels in patients with cobalamin and folate deficiency. Blood. 1993, 81:3404-13.
    • (1993) Blood. , vol.81 , pp. 3404-3413
    • Stabler, S.P.1    Lindenbaum, J.2    Savage, D.G.3    et al4
  • 22
    • 0023870112 scopus 로고
    • Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry
    • Stabler SP, Marcell PD, Podell ER. Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry. J Clin Invest. 1988, 81:466-74.
    • (1988) J Clin Invest. , vol.81 , pp. 466-474
    • Stabler, S.P.1    Marcell, P.D.2    Podell, E.R.3    et al4
  • 23
    • 0032791267 scopus 로고    scopus 로고
    • High-speed prothrombin G->A 20210 and methylenetetrahydrofolate reductase C->T 677 mutation detection using real-time fluorescence PCR and melting curves
    • Aslanidis C, Nauck M, Schmitz G. High-speed prothrombin G->A 20210 and methylenetetrahydrofolate reductase C->T 677 mutation detection using real-time fluorescence PCR and melting curves. Biotechniques. 1999, 27:8-6.
    • (1999) Biotechniques. , vol.27 , pp. 8-16
    • Aslanidis, C.1    Nauck, M.2    Schmitz, G.3
  • 24
    • 40349091422 scopus 로고    scopus 로고
    • Folate metabolism genes, vegetable intake and renal cancer risk in central Europe
    • Moore LE, Hung R, Karami S. Folate metabolism genes, vegetable intake and renal cancer risk in central Europe. Int J Cancer. 2008, 122:1710-5.
    • (2008) Int J Cancer. , vol.122 , pp. 1710-1715
    • Moore, L.E.1    Hung, R.2    Karami, S.3    et al4
  • 26
    • 33749007122 scopus 로고    scopus 로고
    • Epigenetics of autism spectrum disorders
    • Schanen NC. Epigenetics of autism spectrum disorders. Hum Mol Genet 2006, 2:R138-50.
    • (2006) Hum Mol Genet , vol.2
    • Schanen, N.C.1
  • 27
    • 33746845341 scopus 로고    scopus 로고
    • One-carbon metabolism in psychiatric illness
    • Sugden C. One-carbon metabolism in psychiatric illness. Nutr Res Rev. 2006, 19:117-36.
    • (2006) Nutr Res Rev. , vol.19 , pp. 117-136
    • Sugden, C.1
  • 28
    • 33749681965 scopus 로고    scopus 로고
    • Folate and long-chain polyunsaturated fatty acids in psychiatric disease
    • Muskiet FA, Kemperman RF. Folate and long-chain polyunsaturated fatty acids in psychiatric disease. J Nutr Biochem. 2006, 17:717-27.
    • (2006) J Nutr Biochem. , vol.17 , pp. 717-727
    • Muskiet, F.A.1    Kemperman, R.F.2
  • 29
    • 0035495690 scopus 로고    scopus 로고
    • An assessment of food acceptance in children with autism or pervasive developmental disorder-not otherwise specified
    • Ahearn WH, Castine T, Nault K. An assessment of food acceptance in children with autism or pervasive developmental disorder-not otherwise specified. J Autism Dev Disord. 2001, 31:505-11.
    • (2001) J Autism Dev Disord. , vol.31 , pp. 505-511
    • Ahearn, W.H.1    Castine, T.2    Nault, K.3    et al4
  • 30
    • 0141427890 scopus 로고    scopus 로고
    • Plasma amino acids profiles in children with autism: potential risk of nutritional deficiencies
    • Arnold GL, Hyman SL, Mooney RA. Plasma amino acids profiles in children with autism: potential risk of nutritional deficiencies. J Autism Dev Disord. 2003, 33:449-54.
    • (2003) J Autism Dev Disord. , vol.33 , pp. 449-454
    • Arnold, G.L.1    Hyman, S.L.2    Mooney, R.A.3    et al4
  • 31
    • 33846627653 scopus 로고    scopus 로고
    • Relationship of dietary intake to gastrointestinal symptoms in children with autistic spectrum disorders
    • Levy SE, Souders MC, Ittenbach RF. Relationship of dietary intake to gastrointestinal symptoms in children with autistic spectrum disorders. Biol Psychiatry. 2007, 61:492-7.
    • (2007) Biol Psychiatry. , vol.61 , pp. 492-497
    • Levy, S.E.1    Souders, M.C.2    Ittenbach, R.F.3    et al4
  • 32
    • 0030811925 scopus 로고    scopus 로고
    • Genetic predisposition to hyperhomocysteinemia: deficiency of methylenetetrahydrofolate reductase (MTHFR)
    • Rozen R. Genetic predisposition to hyperhomocysteinemia: deficiency of methylenetetrahydrofolate reductase (MTHFR). Thromb Haemost. 1997, 78:523-6.
    • (1997) Thromb Haemost. , vol.78 , pp. 523-526
    • Rozen, R.1
  • 33
    • 0036185195 scopus 로고    scopus 로고
    • Iron deficiency in autism and Asperger syndrome
    • Latif A, Heinz P, Cook R. Iron deficiency in autism and Asperger syndrome. Autism. 2002, 6:103-14.
    • (2002) Autism. , vol.6 , pp. 103-114
    • Latif, A.1    Heinz, P.2    Cook, R.3
  • 34
    • 34247159476 scopus 로고    scopus 로고
    • Aberrant amino acid transport in fibroblasts from children with autism
    • Fernell E, Karagiannakis A, Edman G. Aberrant amino acid transport in fibroblasts from children with autism. Neurosci Lett. 2007, 418:82-6.
    • (2007) Neurosci Lett. , vol.418 , pp. 82-86
    • Fernell, E.1    Karagiannakis, A.2    Edman, G.3    et al4
  • 35
    • 0018755254 scopus 로고
    • Plasma levels of folates, riboflavin, vitamin B6, and ascorbate in severely disturbed children
    • Siva Sankar DV. Plasma levels of folates, riboflavin, vitamin B6, and ascorbate in severely disturbed children. J Autism Dev Disord. 1979, 9:73-82.
    • (1979) J Autism Dev Disord. , vol.9 , pp. 73-82
    • Siva Sankar, D.V.1
  • 36
    • 33644782771 scopus 로고    scopus 로고
    • Abnormally high plasma levels of vitamin B6 in children with autism not taking supplements compared to controls not taking supplements
    • Adams JB, George F, Audhya T. Abnormally high plasma levels of vitamin B6 in children with autism not taking supplements compared to controls not taking supplements. J Altern Complement Med. 2006, 12:59-63.
    • (2006) J Altern Complement Med. , vol.12 , pp. 59-63
    • Adams, J.B.1    George, F.2    Audhya, T.3
  • 37
    • 13144293996 scopus 로고    scopus 로고
    • Pilot study of a moderate dose multivitamin/mineral supplement for children with autistic spectrum disorder
    • Adams JB, Holloway C. Pilot study of a moderate dose multivitamin/mineral supplement for children with autistic spectrum disorder. J Altern Complement Med. 2004, 10:1033-9.
    • (2004) J Altern Complement Med. , vol.10 , pp. 1033-1039
    • Adams, J.B.1    Holloway, C.2
  • 38
    • 37849023607 scopus 로고    scopus 로고
    • A prospective assessment of androgen levels in patients with autistic spectrum disorders: biochemical underpinnings and suggested therapies
    • Geier DA, Geier MR. A prospective assessment of androgen levels in patients with autistic spectrum disorders: biochemical underpinnings and suggested therapies. Neuro Endocrinol Lett. 2007, 28:565-73.
    • (2007) Neuro Endocrinol Lett. , vol.28 , pp. 565-573
    • Geier, D.A.1    Geier, M.R.2
  • 39
    • 35449005301 scopus 로고    scopus 로고
    • Testosterone regulation of homocysteine metabolism modulates redox status in human prostate cancer cells
    • Prudova A, Albin M, Bauman Z. Testosterone regulation of homocysteine metabolism modulates redox status in human prostate cancer cells. Antioxid Redox Signal. 2007, 9:1875-81.
    • (2007) Antioxid Redox Signal. , vol.9 , pp. 1875-1881
    • Prudova, A.1    Albin, M.2    Bauman, Z.3    et al4
  • 40
    • 34548431842 scopus 로고    scopus 로고
    • Testosterone regulation of renal cystathionine beta-synthase: implications for sex-dependent differences in plasma homocysteine levels
    • Vitvitsky V, Prudova A, Stabler S. Testosterone regulation of renal cystathionine beta-synthase: implications for sex-dependent differences in plasma homocysteine levels. Am J Physiol Renal Physiol 2007, 293:F594-600.
    • (2007) Am J Physiol Renal Physiol , vol.293
    • Vitvitsky, V.1    Prudova, A.2    Stabler, S.3    et al4
  • 41
    • 0032785673 scopus 로고    scopus 로고
    • Sulphation deficit in " low-functioning" autistic children: a pilot study
    • Alberti A, Pirrone P, Elia M. Sulphation deficit in " low-functioning" autistic children: a pilot study. Biol Psychiatry. 1999, 46:420-4.
    • (1999) Biol Psychiatry. , vol.46 , pp. 420-424
    • Alberti, A.1    Pirrone, P.2    Elia, M.3    et al4
  • 43
    • 33745712154 scopus 로고    scopus 로고
    • Porphyrinuria in childhood autistic disorder: implications for environmental toxicity
    • Nataf R, Skorupka C, Amet L. Porphyrinuria in childhood autistic disorder: implications for environmental toxicity. Toxicol Appl Pharmacol. 2006, 214:99-108.
    • (2006) Toxicol Appl Pharmacol. , vol.214 , pp. 99-108
    • Nataf, R.1    Skorupka, C.2    Amet, L.3    et al4
  • 44
    • 34548850634 scopus 로고    scopus 로고
    • A prospective study of mercury toxicity biomarkers in autistic spectrum disorders
    • Geier DA, Geier MR. A prospective study of mercury toxicity biomarkers in autistic spectrum disorders. J Toxicol Environ Health A. 2007, 70:1723-30.
    • (2007) J Toxicol Environ Health A. , vol.70 , pp. 1723-1730
    • Geier, D.A.1    Geier, M.R.2
  • 45
    • 33750605792 scopus 로고    scopus 로고
    • A prospective assessment of porphyrins in autistic disorders: a potential marker for heavy metal exposure
    • Geier DA, Geier MR. A prospective assessment of porphyrins in autistic disorders: a potential marker for heavy metal exposure. Neurotox Res. 2006, 10:57-64.
    • (2006) Neurotox Res. , vol.10 , pp. 57-64
    • Geier, D.A.1    Geier, M.R.2
  • 46
    • 33746639780 scopus 로고    scopus 로고
    • Corpus callosum morphometrics in young children with autism spectrum disorder
    • Boger-Megiddo I, Shaw DW, Friedman SD. Corpus callosum morphometrics in young children with autism spectrum disorder. J Autism Dev Disord. 2006, 36:733-9.
    • (2006) J Autism Dev Disord. , vol.36 , pp. 733-739
    • Boger-Megiddo, I.1    Shaw, D.W.2    Friedman, S.D.3    et al4
  • 47
    • 32544434349 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor and autoantibodies to neural antigens in sera of children with autistic spectrum disorders, Landau-Kleffner syndrome, and epilepsy
    • Connolly AM, Chez M, Streif EM. Brain-derived neurotrophic factor and autoantibodies to neural antigens in sera of children with autistic spectrum disorders, Landau-Kleffner syndrome, and epilepsy. Biol Psychiatry. 2006, 59:354-63.
    • (2006) Biol Psychiatry. , vol.59 , pp. 354-363
    • Connolly, A.M.1    Chez, M.2    Streif, E.M.3    et al4
  • 48
    • 0036403334 scopus 로고    scopus 로고
    • Genetic effects of methylation diets
    • Van den Veyver IB. Genetic effects of methylation diets. Annu Rev Nutr. 2002, 22:255-82.
    • (2002) Annu Rev Nutr. , vol.22 , pp. 255-282
    • Van den Veyver, I.B.1
  • 49
    • 33745234245 scopus 로고    scopus 로고
    • Imbalanced genomic imprinting in brain development: an evolutionary basis for the aetiology of autism
    • Badcock C, Crespi B. Imbalanced genomic imprinting in brain development: an evolutionary basis for the aetiology of autism. J Evol Biol. 2006, 19:1007-32.
    • (2006) J Evol Biol. , vol.19 , pp. 1007-1032
    • Badcock, C.1    Crespi, B.2
  • 50
    • 34447324944 scopus 로고    scopus 로고
    • What do disturbances in neural synchrony tell us about autism
    • Uhlhaas PJ, Singer W. What do disturbances in neural synchrony tell us about autism. Biol Psychiatry. 2007, 62:190-1.
    • (2007) Biol Psychiatry. , vol.62 , pp. 190-191
    • Uhlhaas, P.J.1    Singer, W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.