Increasing systemic exposure of methotrexate by active efflux mediated by multidrug resistance-associated protein 3 (Mrp3/Abcc3)

Journal of Pharmacology and Experimental Therapeutics

Volumn 327, Issue 2, 2008, Pages 465-473

  Kitamura, Yoshiaki ^a   Hirouchi, Masakazu ^a   Kusuhara, Hiroyuki ^a   Schuetz, John D ^b   Sugiyama, Yuichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHOTREXATE; MULTIDRUG RESISTANCE PROTEIN 3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG PROTEIN BINDING; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BIOLOGICAL AVAILABILITY; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; INTESTINES; KIDNEY; LIVER; MALE; METHOTREXATE; MICE; MICE, INBRED C57BL; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; RECEPTORS, CELL SURFACE; RNA, MESSENGER;

EID: 54349088976     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.108.140475     Document Type: Article

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