-
1
-
-
0035128723
-
beta-cell apoptosis: stimuli and signaling
-
Mandrup-Poulsen T, (2001) beta-cell apoptosis: stimuli and signaling. Diabetes 50 (Suppl 1): S58-S63.
-
(2001)
Diabetes
, vol.50
, Issue.SUPPL. 1
-
-
Mandrup-Poulsen, T.1
-
2
-
-
33644747390
-
Mechanisms of {beta}-Cell Death in Type 2 Diabetes
-
Donath MY, Ehses JA, Maedler K, Schumann DM, Ellingsgaard H, et al. (2005) Mechanisms of {beta}-Cell Death in Type 2 Diabetes. Diabetes 54 (Suppl 2): S108-S113.
-
(2005)
Diabetes
, vol.54
, Issue.SUPPL. 2
-
-
Donath, M.Y.1
Ehses, J.A.2
Maedler, K.3
Schumann, D.M.4
Ellingsgaard, H.5
-
3
-
-
0035668779
-
A choice of death-the signal-transduction of immune-mediated beta-cell apoptosis
-
Eizirik DL, Mandrup-Poulsen T, (2001) A choice of death-the signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia 44: 2115-2133.
-
(2001)
Diabetologia
, vol.44
, pp. 2115-2133
-
-
Eizirik, D.L.1
Mandrup-Poulsen, T.2
-
4
-
-
67649364114
-
The role of inflammation in insulitis and beta-cell loss in type 1 diabetes
-
10.1038/nrendo.2009.21
-
Eizirik DL, Colli ML, Ortis F, (2009) The role of inflammation in insulitis and beta-cell loss in type 1 diabetes. Nat Rev Endocrinol 5: 219-226 10.1038/nrendo.2009.21.
-
(2009)
Nat Rev Endocrinol
, vol.5
, pp. 219-226
-
-
Eizirik, D.L.1
Colli, M.L.2
Ortis, F.3
-
5
-
-
0022596377
-
Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans
-
Mandrup-Poulsen T, Bendtzen K, Nerup J, Dinarello CA, Svenson M, et al. (1986) Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans. Diabetologia 29: 63-67.
-
(1986)
Diabetologia
, vol.29
, pp. 63-67
-
-
Mandrup-Poulsen, T.1
Bendtzen, K.2
Nerup, J.3
Dinarello, C.A.4
Svenson, M.5
-
6
-
-
0029817047
-
The role of interleukin-1 in the pathogenesis of IDDM
-
Mandrup-Poulsen T, (1996) The role of interleukin-1 in the pathogenesis of IDDM. Diabetologia 39: 1005-1029.
-
(1996)
Diabetologia
, vol.39
, pp. 1005-1029
-
-
Mandrup-Poulsen, T.1
-
7
-
-
0033850451
-
The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells
-
Ammendrup A, Maillard A, Nielsen K, Aabenhus AN, Serup P, et al. (2000) The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells. Diabetes 49: 1468-1476.
-
(2000)
Diabetes
, vol.49
, pp. 1468-1476
-
-
Ammendrup, A.1
Maillard, A.2
Nielsen, K.3
Aabenhus, A.N.4
Serup, P.5
-
8
-
-
0035152487
-
Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death
-
Bonny C, Oberson A, Negri S, Sauser C, Schorderet DF, (2001) Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death. Diabetes 50: 77-82.
-
(2001)
Diabetes
, vol.50
, pp. 77-82
-
-
Bonny, C.1
Oberson, A.2
Negri, S.3
Sauser, C.4
Schorderet, D.F.5
-
9
-
-
34447128361
-
The c-Jun N-terminal kinase JNK participates in cytokine- and isolation stress-induced rat pancreatic islet apoptosis
-
10.1007/s00125-007-0704-2
-
Abdelli S, Abderrahmani A, Hering BJ, Beckmann JS, Bonny C, (2007) The c-Jun N-terminal kinase JNK participates in cytokine- and isolation stress-induced rat pancreatic islet apoptosis. Diabetologia 50: 1660-1669 10.1007/s00125-007-0704-2.
-
(2007)
Diabetologia
, vol.50
, pp. 1660-1669
-
-
Abdelli, S.1
Abderrahmani, A.2
Hering, B.J.3
Beckmann, J.S.4
Bonny, C.5
-
10
-
-
0034644522
-
Signal transduction by the JNK group of MAP kinases
-
Davis RJ, (2000) Signal transduction by the JNK group of MAP kinases. Cell 103: 239-252.
-
(2000)
Cell
, vol.103
, pp. 239-252
-
-
Davis, R.J.1
-
11
-
-
0029885419
-
Selective interaction of JNK protein kinase isoforms with transcription factors
-
Gupta S, Barrett T, Whitmarsh AJ, Cavanagh J, Sluss HK, et al. (1996) Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J 15: 2760-2770.
-
(1996)
EMBO J
, vol.15
, pp. 2760-2770
-
-
Gupta, S.1
Barrett, T.2
Whitmarsh, A.J.3
Cavanagh, J.4
Sluss, H.K.5
-
12
-
-
68449084306
-
JNK3 is abundant in insulin-secreting cells and protects against cytokine-induced apoptosis
-
10.1007/s00125-009-1431-7
-
Abdelli S, Puyal J, Bielmann C, Buchillier V, Abderrahmani A, et al. (2009) JNK3 is abundant in insulin-secreting cells and protects against cytokine-induced apoptosis. Diabetologia 52: 1871-1880 10.1007/s00125-009-1431-7.
-
(2009)
Diabetologia
, vol.52
, pp. 1871-1880
-
-
Abdelli, S.1
Puyal, J.2
Bielmann, C.3
Buchillier, V.4
Abderrahmani, A.5
-
13
-
-
0037153158
-
A central role for JNK in obesity and insulin resistance
-
Hirosumi J, Tuncman G, Chang L, Gorgun CZ, Uysal KT, et al. (2002) A central role for JNK in obesity and insulin resistance. Nature 420: 333-336.
-
(2002)
Nature
, vol.420
, pp. 333-336
-
-
Hirosumi, J.1
Tuncman, G.2
Chang, L.3
Gorgun, C.Z.4
Uysal, K.T.5
-
14
-
-
21044453408
-
Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes
-
10.1073/pnas.0502143102
-
Jaeschke A, Rincon M, Doran B, Reilly J, Neuberg D, et al. (2005) Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes. Proc Natl Acad Sci U S A 102: 6931-6935 10.1073/pnas.0502143102.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 6931-6935
-
-
Jaeschke, A.1
Rincon, M.2
Doran, B.3
Reilly, J.4
Neuberg, D.5
-
15
-
-
4644333142
-
Cross-talk between phosphatidylinositol 3-kinase/AKT and c-jun NH2-terminal kinase mediates survival of isolated human islets
-
Aikin R, Maysinger D, Rosenberg L, (2004) Cross-talk between phosphatidylinositol 3-kinase/AKT and c-jun NH2-terminal kinase mediates survival of isolated human islets. Endocrinology 145: 4522-4531.
-
(2004)
Endocrinology
, vol.145
, pp. 4522-4531
-
-
Aikin, R.1
Maysinger, D.2
Rosenberg, L.3
-
16
-
-
9644270397
-
Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells
-
10.1172/JCI20016
-
Bernal-Mizrachi E, Fatrai S, Johnson JD, Ohsugi M, Otani K, et al. (2004) Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells. J Clin Invest 114: 928-936 10.1172/JCI20016.
-
(2004)
J Clin Invest
, vol.114
, pp. 928-936
-
-
Bernal-Mizrachi, E.1
Fatrai, S.2
Johnson, J.D.3
Ohsugi, M.4
Otani, K.5
-
17
-
-
37549027687
-
Inhibition of c-jun N terminal kinase (JNK) improves functional beta cell mass in human islets and leads to AKT and glycogen synthase kinase-3 (GSK-3) phosphorylation
-
Fornoni A, Pileggi A, Molano RD, Sanabria NY, Tejada T, et al. (2008) Inhibition of c-jun N terminal kinase (JNK) improves functional beta cell mass in human islets and leads to AKT and glycogen synthase kinase-3 (GSK-3) phosphorylation. Diabetologia 51: 298-308.
-
(2008)
Diabetologia
, vol.51
, pp. 298-308
-
-
Fornoni, A.1
Pileggi, A.2
Molano, R.D.3
Sanabria, N.Y.4
Tejada, T.5
-
18
-
-
0037474274
-
c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade
-
Lee YH, Giraud J, Davis RJ, White MF, (2003) c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade. J Biol Chem 278: 2896-2902.
-
(2003)
J Biol Chem
, vol.278
, pp. 2896-2902
-
-
Lee, Y.H.1
Giraud, J.2
Davis, R.J.3
White, M.F.4
-
19
-
-
15044363028
-
Recent advances in the protein kinase B signaling pathway
-
10.1016/j.ceb.2005.02.010
-
Woodgett JR, (2005) Recent advances in the protein kinase B signaling pathway. Curr Opin Cell Biol 17: 150-157 10.1016/j.ceb.2005.02.010.
-
(2005)
Curr Opin Cell Biol
, vol.17
, pp. 150-157
-
-
Woodgett, J.R.1
-
20
-
-
34247116441
-
Physiological roles of PKB/Akt isoforms in development and disease
-
10.1042/BST0350231
-
Dummler B, Hemmings BA, (2007) Physiological roles of PKB/Akt isoforms in development and disease. Biochem Soc Trans 35: 231-235 10.1042/BST0350231.
-
(2007)
Biochem Soc Trans
, vol.35
, pp. 231-235
-
-
Dummler, B.1
Hemmings, B.A.2
-
21
-
-
2342466109
-
Physiological functions of protein kinase B/Akt
-
10.1042/
-
Yang ZZ, Tschopp O, Baudry A, Dummler B, Hynx D, et al. (2004) Physiological functions of protein kinase B/Akt. Biochem Soc Trans 32: 350-354 10.1042/.
-
(2004)
Biochem Soc Trans
, vol.32
, pp. 350-354
-
-
Yang, Z.Z.1
Tschopp, O.2
Baudry, A.3
Dummler, B.4
Hynx, D.5
-
22
-
-
0028826421
-
Cloning, chromosomal localization and expression analysis of the mouse Akt2 oncogene
-
Altomare DA, Guo K, Cheng JQ, Sonoda G, Walsh K, et al. (1995) Cloning, chromosomal localization and expression analysis of the mouse Akt2 oncogene. Oncogene 11: 1055-1060.
-
(1995)
Oncogene
, vol.11
, pp. 1055-1060
-
-
Altomare, D.A.1
Guo, K.2
Cheng, J.Q.3
Sonoda, G.4
Walsh, K.5
-
23
-
-
0032493105
-
Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin
-
10.1038/sj.onc.1201750
-
Altomare DA, Lyons GE, Mitsuuchi Y, Cheng JQ, Testa JR, (1998) Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin. Oncogene 16: 2407-2411 10.1038/sj.onc.1201750.
-
(1998)
Oncogene
, vol.16
, pp. 2407-2411
-
-
Altomare, D.A.1
Lyons, G.E.2
Mitsuuchi, Y.3
Cheng, J.Q.4
Testa, J.R.5
-
24
-
-
0032497288
-
Protein kinase B is expressed in pancreatic beta cells and activated upon stimulation with insulin-like growth factor I. Biochem Biophys Res Commun
-
10.1006/bbrc.1998.9166
-
Holst LS, Mulder H, Manganiello V, Sundler F, Ahren B, et al. (1998) Protein kinase B is expressed in pancreatic beta cells and activated upon stimulation with insulin-like growth factor I. Biochem Biophys Res Commun 250: 181-186 10.1006/bbrc.1998.9166.
-
(1998)
, vol.250
, pp. 181-186
-
-
Holst, L.S.1
Mulder, H.2
Manganiello, V.3
Sundler, F.4
Ahren, B.5
-
25
-
-
0037352170
-
Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy
-
10.1038/sj.leu.2402824
-
Chang F, Lee JT, Navolanic PM, Steelman LS, Shelton JG, et al. (2003) Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy. Leukemia 17: 590-603 10.1038/sj.leu.2402824.
-
(2003)
Leukemia
, vol.17
, pp. 590-603
-
-
Chang, F.1
Lee, J.T.2
Navolanic, P.M.3
Steelman, L.S.4
Shelton, J.G.5
-
26
-
-
3242656480
-
Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?
-
10.1152/ajpendo.00031.2004
-
Dickson LM, Rhodes CJ, (2004) Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt? Am J Physiol Endocrinol Metab 287: E192-E198 10.1152/ajpendo.00031.2004.
-
(2004)
Am J Physiol Endocrinol Metab
, vol.287
-
-
Dickson, L.M.1
Rhodes, C.J.2
-
27
-
-
0035448879
-
Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene
-
10.1101/gad.913901
-
Chen WS, Xu PZ, Gottlob K, Chen ML, Sokol K, et al. (2001) Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev 15: 2203-2208 10.1101/gad.913901.
-
(2001)
Genes Dev
, vol.15
, pp. 2203-2208
-
-
Chen, W.S.1
Xu, P.Z.2
Gottlob, K.3
Chen, M.L.4
Sokol, K.5
-
28
-
-
0035368548
-
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)
-
10.1126/science.292.5522.1728
-
Cho H, Mu J, Kim JK, Thorvaldsen JL, Chu Q, et al. (2001) Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science 292: 1728-1731 10.1126/science.292.5522.1728.
-
(2001)
Science
, vol.292
, pp. 1728-1731
-
-
Cho, H.1
Mu, J.2
Kim, J.K.3
Thorvaldsen, J.L.4
Chu, Q.5
-
29
-
-
85047693348
-
Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta
-
10.1172/JCI16885
-
Garofalo RS, Orena SJ, Rafidi K, Torchia AJ, Stock JL, et al. (2003) Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta. J Clin Invest 112: 197-208 10.1172/JCI16885.
-
(2003)
J Clin Invest
, vol.112
, pp. 197-208
-
-
Garofalo, R.S.1
Orena, S.J.2
Rafidi, K.3
Torchia, A.J.4
Stock, J.L.5
-
30
-
-
0344305782
-
Insulin signaling in health and disease
-
White MF, (2003) Insulin signaling in health and disease. Science 302: 1710-1711.
-
(2003)
Science
, vol.302
, pp. 1710-1711
-
-
White, M.F.1
-
31
-
-
0030780254
-
The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action
-
White MF, Yenush L, (1998) The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action. Curr Top Microbiol Immunol 228: 179-208.
-
(1998)
Curr Top Microbiol Immunol
, vol.228
, pp. 179-208
-
-
White, M.F.1
Yenush, L.2
-
32
-
-
0035125526
-
IRS proteins and beta-cell function
-
Burks DJ, White MF, (2001) IRS proteins and beta-cell function. Diabetes 50 (Suppl 1): S140-S145.
-
(2001)
Diabetes
, vol.50
, Issue.SUPPL. 1
-
-
Burks, D.J.1
White, M.F.2
-
33
-
-
0034644523
-
Cellular signaling: pivoting around PDK-1
-
Toker A, Newton AC, (2000) Cellular signaling: pivoting around PDK-1. Cell 103: 185-188.
-
(2000)
Cell
, vol.103
, pp. 185-188
-
-
Toker, A.1
Newton, A.C.2
-
34
-
-
0031127305
-
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
-
Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, et al. (1997) Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr Biol 7: 261-269.
-
(1997)
Curr Biol
, vol.7
, pp. 261-269
-
-
Alessi, D.R.1
James, S.R.2
Downes, C.P.3
Holmes, A.B.4
Gaffney, P.R.5
-
35
-
-
0030841793
-
PDK1, one of the missing links in insulin signal transduction?
-
Cohen P, Alessi DR, Cross DA, (1997) PDK1, one of the missing links in insulin signal transduction? FEBS Lett 410: 3-10.
-
(1997)
FEBS Lett
, vol.410
, pp. 3-10
-
-
Cohen, P.1
Alessi, D.R.2
Cross, D.A.3
-
36
-
-
0037310664
-
Physiological functions of Pten in mouse tissues
-
Kishimoto H, Hamada K, Saunders M, Backman S, Sasaki T, et al. (2003) Physiological functions of Pten in mouse tissues. Cell Struct Funct 28: 11-21.
-
(2003)
Cell Struct Funct
, vol.28
, pp. 11-21
-
-
Kishimoto, H.1
Hamada, K.2
Saunders, M.3
Backman, S.4
Sasaki, T.5
-
37
-
-
0032577699
-
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
-
Maehama T, Dixon JE, (1998) The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 273: 13375-13378.
-
(1998)
J Biol Chem
, vol.273
, pp. 13375-13378
-
-
Maehama, T.1
Dixon, J.E.2
-
38
-
-
33947203621
-
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms
-
10.1016/j.molcel.2007.02.017
-
Brognard J, Sierecki E, Gao T, Newton AC, (2007) PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Mol Cell 25: 917-931 10.1016/j.molcel.2007.02.017.
-
(2007)
Mol Cell
, vol.25
, pp. 917-931
-
-
Brognard, J.1
Sierecki, E.2
Gao, T.3
Newton, A.C.4
-
39
-
-
7044249212
-
PTEN regulatory functions in tumor suppression and cell biology
-
Chu EC, Tarnawski AS, (2004) PTEN regulatory functions in tumor suppression and cell biology. Med Sci Monit 10: RA235-RA241.
-
(2004)
Med Sci Monit
, vol.10
-
-
Chu, E.C.1
Tarnawski, A.S.2
-
40
-
-
15944406764
-
PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth
-
10.1016/j.molcel.2005.03.008
-
Gao T, Furnari F, Newton AC, (2005) PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell 18: 13-24 10.1016/j.molcel.2005.03.008.
-
(2005)
Mol Cell
, vol.18
, pp. 13-24
-
-
Gao, T.1
Furnari, F.2
Newton, A.C.3
-
41
-
-
0033595011
-
Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
-
Biggs WH, III, Meisenhelder J, Hunter T, Cavenee WK, Arden KC, (1999) Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc Natl Acad Sci U S A 96: 7421-7426.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 7421-7426
-
-
Biggs III, W.H.1
Meisenhelder, J.2
Hunter, T.3
Cavenee, W.K.4
Arden, K.C.5
-
42
-
-
0442276554
-
The glamour and gloom of glycogen synthase kinase-3
-
10.1016/j.tibs.2003.12.004
-
Jope RS, Johnson GV, (2004) The glamour and gloom of glycogen synthase kinase-3. Trends Biochem Sci 29: 95-102 10.1016/j.tibs.2003.12.004.
-
(2004)
Trends Biochem Sci
, vol.29
, pp. 95-102
-
-
Jope, R.S.1
Johnson, G.V.2
-
43
-
-
78649335126
-
Conditional ablation of Gsk-3beta in islet beta cells results in expanded mass and resistance to fat feeding-induced diabetes in mice
-
10.1007/s00125-010-1882-x
-
Liu Y, Tanabe K, Baronnier D, Patel S, Woodgett J, et al. (2010) Conditional ablation of Gsk-3beta in islet beta cells results in expanded mass and resistance to fat feeding-induced diabetes in mice. Diabetologia 53: 2600-2610 10.1007/s00125-010-1882-x.
-
(2010)
Diabetologia
, vol.53
, pp. 2600-2610
-
-
Liu, Y.1
Tanabe, K.2
Baronnier, D.3
Patel, S.4
Woodgett, J.5
-
44
-
-
78449267308
-
Exendin-4 protects oxidative stress-induced beta-cell apoptosis through reduced JNK and GSK3beta activity
-
10.3346/jkms.2010.25.11.1626
-
Kim JY, Lim DM, Moon CI, Jo KJ, Lee SK, et al. (2010) Exendin-4 protects oxidative stress-induced beta-cell apoptosis through reduced JNK and GSK3beta activity. J Korean Med Sci 25: 1626-1632 10.3346/jkms.2010.25.11.1626.
-
(2010)
J Korean Med Sci
, vol.25
, pp. 1626-1632
-
-
Kim, J.Y.1
Lim, D.M.2
Moon, C.I.3
Jo, K.J.4
Lee, S.K.5
-
45
-
-
79955625843
-
Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3beta independent of JNK activation
-
10.1371/journal.pone.0018146
-
Tanabe K, Liu Y, Hasan SD, Martinez SC, Cras-Meneur C, et al. (2011) Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3beta independent of JNK activation. PLoS One 6: e18146 10.1371/journal.pone.0018146.
-
(2011)
PLoS One
, vol.6
-
-
Tanabe, K.1
Liu, Y.2
Hasan, S.D.3
Martinez, S.C.4
Cras-Meneur, C.5
-
46
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
-
Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, et al. (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96: 857-868.
-
(1999)
Cell
, vol.96
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
Lin, M.Z.4
Juo, P.5
-
47
-
-
0036950665
-
The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth
-
10.1172/JCI16857
-
Kitamura T, Nakae J, Kitamura Y, Kido Y, Biggs WH, et al. (2002) The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest 110: 1839-1847 10.1172/JCI16857.
-
(2002)
J Clin Invest
, vol.110
, pp. 1839-1847
-
-
Kitamura, T.1
Nakae, J.2
Kitamura, Y.3
Kido, Y.4
Biggs, W.H.5
-
48
-
-
0036651790
-
A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR
-
Ramaswamy S, Nakamura N, Sansal I, Bergeron L, Sellers WR, (2002) A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR. Cancer Cell 2: 81-91.
-
(2002)
Cancer Cell
, vol.2
, pp. 81-91
-
-
Ramaswamy, S.1
Nakamura, N.2
Sansal, I.3
Bergeron, L.4
Sellers, W.R.5
-
49
-
-
80755168893
-
FoxO feedback control of basal IRS-2 expression in pancreatic beta-cells is distinct from that in hepatocytes
-
10.2337/db11-0340
-
Tsunekawa S, Demozay D, Briaud I, McCuaig J, Accili D, et al. (2011) FoxO feedback control of basal IRS-2 expression in pancreatic beta-cells is distinct from that in hepatocytes. Diabetes 60: 2883-2891 10.2337/db11-0340.
-
(2011)
Diabetes
, vol.60
, pp. 2883-2891
-
-
Tsunekawa, S.1
Demozay, D.2
Briaud, I.3
McCuaig, J.4
Accili, D.5
-
50
-
-
0026550830
-
Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines
-
Asfari M, Janjic D, Meda P, Li G, Halban PA, et al. (1992) Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology 130: 167-178.
-
(1992)
Endocrinology
, vol.130
, pp. 167-178
-
-
Asfari, M.1
Janjic, D.2
Meda, P.3
Li, G.4
Halban, P.A.5
-
51
-
-
7044249537
-
Intracellular stress signaling pathways activated during human islet preparation and following acute cytokine exposure
-
Abdelli S, Ansite J, Roduit R, Borsello T, Matsumoto I, et al. (2004) Intracellular stress signaling pathways activated during human islet preparation and following acute cytokine exposure. Diabetes 53: 2815-2823.
-
(2004)
Diabetes
, vol.53
, pp. 2815-2823
-
-
Abdelli, S.1
Ansite, J.2
Roduit, R.3
Borsello, T.4
Matsumoto, I.5
-
52
-
-
0034708832
-
The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)
-
Aguirre V, Uchida T, Yenush L, Davis R, White MF, (2000) The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J Biol Chem 275: 9047-9054.
-
(2000)
J Biol Chem
, vol.275
, pp. 9047-9054
-
-
Aguirre, V.1
Uchida, T.2
Yenush, L.3
Davis, R.4
White, M.F.5
-
53
-
-
0032567937
-
Disruption of IRS-2 causes type 2 diabetes in mice
-
Withers DJ, Gutierrez JS, Towery H, Burks DJ, Ren JM, et al. (1998) Disruption of IRS-2 causes type 2 diabetes in mice. Nature 391: 900-904.
-
(1998)
Nature
, vol.391
, pp. 900-904
-
-
Withers, D.J.1
Gutierrez, J.S.2
Towery, H.3
Burks, D.J.4
Ren, J.M.5
-
54
-
-
34247849262
-
Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice
-
10.1007/s00125-007-0637-9
-
Cantley J, Choudhury AI, Asare-Anane H, Selman C, Lingard S, et al. (2007) Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice. Diabetologia 50: 1248-1256 10.1007/s00125-007-0637-9.
-
(2007)
Diabetologia
, vol.50
, pp. 1248-1256
-
-
Cantley, J.1
Choudhury, A.I.2
Asare-Anane, H.3
Selman, C.4
Lingard, S.5
-
55
-
-
0033966768
-
Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2
-
10.1172/JCI7917
-
Kido Y, Burks DJ, Withers D, Bruning JC, Kahn CR, et al. (2000) Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. J Clin Invest 105: 199-205 10.1172/JCI7917.
-
(2000)
J Clin Invest
, vol.105
, pp. 199-205
-
-
Kido, Y.1
Burks, D.J.2
Withers, D.3
Bruning, J.C.4
Kahn, C.R.5
-
56
-
-
40149099886
-
Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance
-
10.1371/journal.pbio.0060037
-
Tanabe K, Liu Z, Patel S, Doble BW, Li L, et al. (2008) Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance. PLoS Biol 6: e37 10.1371/journal.pbio.0060037.
-
(2008)
PLoS Biol
, vol.6
-
-
Tanabe, K.1
Liu, Z.2
Patel, S.3
Doble, B.W.4
Li, L.5
-
57
-
-
33646549635
-
Phosphorylation marks IPF1/PDX1 protein for degradation by glycogen synthase kinase 3-dependent mechanisms
-
10.1074/jbc.M511597200
-
Boucher MJ, Selander L, Carlsson L, Edlund H, (2006) Phosphorylation marks IPF1/PDX1 protein for degradation by glycogen synthase kinase 3-dependent mechanisms. J Biol Chem 281: 6395-6403 10.1074/jbc.M511597200.
-
(2006)
J Biol Chem
, vol.281
, pp. 6395-6403
-
-
Boucher, M.J.1
Selander, L.2
Carlsson, L.3
Edlund, H.4
-
58
-
-
34250326302
-
The emerging role of FOXO transcription factors in pancreatic beta cells
-
10.1677/JOE-06-0191
-
Glauser DA, Schlegel W, (2007) The emerging role of FOXO transcription factors in pancreatic beta cells. J Endocrinol 193: 195-207 10.1677/JOE-06-0191.
-
(2007)
J Endocrinol
, vol.193
, pp. 195-207
-
-
Glauser, D.A.1
Schlegel, W.2
-
59
-
-
10744227975
-
Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH(2)-terminal kinase
-
Kawamori D, Kajimoto Y, Kaneto H, Umayahara Y, Fujitani Y, et al. (2003) Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH(2)-terminal kinase. Diabetes 52: 2896-2904.
-
(2003)
Diabetes
, vol.52
, pp. 2896-2904
-
-
Kawamori, D.1
Kajimoto, Y.2
Kaneto, H.3
Umayahara, Y.4
Fujitani, Y.5
-
60
-
-
0028838079
-
c-jun inhibits insulin control element-mediated transcription by affecting the transactivation potential of the E2A gene products
-
Robinson GL, Henderson E, Massari ME, Murre C, Stein R, (1995) c-jun inhibits insulin control element-mediated transcription by affecting the transactivation potential of the E2A gene products. Mol Cell Biol 15: 1398-1404.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 1398-1404
-
-
Robinson, G.L.1
Henderson, E.2
Massari, M.E.3
Murre, C.4
Stein, R.5
-
61
-
-
33744932973
-
Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta-cells
-
10.1074/jbc.M600356200
-
Lingohr MK, Briaud I, Dickson LM, McCuaig JF, Alarcon C, et al. (2006) Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta-cells. J Biol Chem 281: 15884-15892 10.1074/jbc.M600356200.
-
(2006)
J Biol Chem
, vol.281
, pp. 15884-15892
-
-
Lingohr, M.K.1
Briaud, I.2
Dickson, L.M.3
McCuaig, J.F.4
Alarcon, C.5
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