Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type 1 diabetes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 19, 2005, Pages 6931-6935

  Jaeschke, Anja ^a   Rincón, Mercedes ^b   Doran, Beth ^a   Reilly, Judith ^a   Neuberg, Donna ^c   Greiner, Dale L ^a   Shultz, Leonard D ^d   Rossini, Aldo A ^a   Flavell, Richard A ^e   Davis, Roger J ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d JACKSON LABORATORY   (United States)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Insulitis; Nonobese diabetic mouse; Stress activated protein kinase; T cell differentiation

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 4; INTERLEUKIN 5; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ACTIVITY; DISEASE COURSE; GENE; GENE DISRUPTION; IMMUNE RESPONSE; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; MAPK9 GENE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; T LYMPHOCYTE; TH1 CELL; TH2 CELL;

ANIMALS; APOPTOSIS; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; DIABETES MELLITUS, EXPERIMENTAL; FEMALE; GENE EXPRESSION REGULATION; IMMUNE SYSTEM; IMMUNOHISTOCHEMISTRY; INSULIN; MALE; MICE; MICE, INBRED NOD; MICE, SCID; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; MITOGEN-ACTIVATED PROTEIN KINASE 9; PHENOTYPE; PROTEIN ISOFORMS; TH1 CELLS; TH2 CELLS; TIME FACTORS;

EID: 21044453408     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0502143102     Document Type: Article

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