-
1
-
-
12344323484
-
Type 2 diabetes - A matter of beta-cell life and death?
-
DOI 10.1126/science.1104345
-
Rhodes CJ. Type 2 diabetes-a matter of β-cell life and death? Science 2005; 307:380-384 (Pubitemid 40139973)
-
(2005)
Science
, vol.307
, Issue.5708
, pp. 380-384
-
-
Rhodes, C.J.1
-
2
-
-
0032567937
-
Disruption of IRS-2 causes type 2 diabetes in mice
-
DOI 10.1038/36116
-
Withers DJ, Gutierrez JS, Towery H, et al. Disruption of IRS-2 causes type 2 diabetes in mice. Nature 1998;391:900-904 (Pubitemid 28157668)
-
(1998)
Nature
, vol.391
, Issue.6670
, pp. 900-904
-
-
Withers, D.J.1
Gutierrez, J.S.2
Towery, H.3
Burks, D.J.4
Ren, J.-M.5
Previs, S.6
Zhang, Y.7
Bernal, D.8
Pons, S.9
Shulman, G.I.10
Bonner-Weir, S.11
White, M.F.12
-
3
-
-
0032841435
-
Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling
-
DOI 10.1038/12631
-
Withers DJ, Burks DJ, Towery HH, Altamuro SL, Flint CL, White MF. Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling. Nat Genet 1999;23:32-40 (Pubitemid 29418784)
-
(1999)
Nature Genetics
, vol.23
, Issue.1
, pp. 32-40
-
-
Withers, D.J.1
Burks, D.J.2
Towery, H.H.3
Altamuro, S.L.4
Flint, C.L.5
White, M.F.6
-
4
-
-
0033755408
-
Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia
-
Kubota N, Tobe K, Terauchi Y, et al. Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia. Diabetes 2000;49:1880-1889
-
(2000)
Diabetes
, vol.49
, pp. 1880-1889
-
-
Kubota, N.1
Tobe, K.2
Terauchi, Y.3
-
5
-
-
0242329748
-
Decreasing IRS-2 expression in pancreatic beta-cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression
-
DOI 10.1016/j.mce.2003.08.003
-
Lingohr MK, Dickson LM, Wrede CE, et al. Decreasing IRS-2 expression in pancreatic beta-cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression. Mol Cell Endocrinol 2003;209:17-31 (Pubitemid 37353079)
-
(2003)
Molecular and Cellular Endocrinology
, vol.209
, Issue.1-2
, pp. 17-31
-
-
Lingohr, M.K.1
Dickson, L.M.2
Wrede, C.E.3
Briaud, I.4
McCuaig, J.F.5
Myers Jr., M.G.6
Rhodes, C.J.7
-
6
-
-
0036224165
-
Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation
-
Lingohr MK, Dickson LM, McCuaig JF, Hügl SR, Twardzik DR, Rhodes CJ. Activation of IRS-2-mediated signal transduction by IGF-1, but not TGFalpha or EGF, augments pancreatic β-cell proliferation. Diabetes 2002;51: 966-976 (Pubitemid 34438338)
-
(2002)
Diabetes
, vol.51
, Issue.4
, pp. 966-976
-
-
Lingohr, M.K.1
Dickson, L.M.2
McCuaig, J.F.3
Hugl, S.R.4
Twardzik, D.R.5
Rhodes, C.J.6
-
7
-
-
0345618266
-
Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes
-
DOI 10.1172/JCI200318581
-
Hennige AM, Burks DJ, Ozcan U, et al. Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes. J Clin Invest 2003; 112:1521-1532 (Pubitemid 38056278)
-
(2003)
Journal of Clinical Investigation
, vol.112
, Issue.10
, pp. 1521-1532
-
-
Hennige, A.M.1
Burks, D.J.2
Ozcan, U.3
Kulkarni, R.N.4
Ye, J.5
Park, S.6
Schubert, M.7
Fisher, T.L.8
Dow, M.A.9
Leshan, R.10
Zakaria, M.11
Mossa-Basha, M.12
White, M.F.13
-
9
-
-
0035779997
-
Surfing the insulin signaling web
-
DOI 10.1046/j.1365-2362.2001.00896.x
-
Van Obberghen E, Baron V, Delahaye L, et al. Surfing the insulin signaling web. Eur J Clin Invest 2001;31:966-977 (Pubitemid 35300666)
-
(2001)
European Journal of Clinical Investigation
, vol.31
, Issue.11
, pp. 966-977
-
-
Van Obberghen, E.1
Baron, V.2
Delahaye, L.3
Emanuelli, B.4
Filippa, N.5
Giorgetti-Peraldi, S.6
Lebrun, P.7
Mothe-Satney, I.8
Peraldi, P.9
Rocchi, S.10
Sawka-Verhelle, D.11
Tartare-Deckert, S.12
Giudicelli, J.13
-
10
-
-
33744932973
-
Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta-cells
-
DOI 10.1074/jbc.M600356200
-
Lingohr MK, Briaud I, Dickson LM, et al. Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta-cells. J Biol Chem 2006;281:15884-15892 (Pubitemid 43848480)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.23
, pp. 15884-15892
-
-
Lingohr, M.K.1
Briaud, I.2
Dickson, L.M.3
McCuaig, J.F.4
Alarcon, C.5
Wicksteed, B.L.6
Rhodes, C.J.7
-
11
-
-
25444507156
-
The metabolisable hexoses D-glucose and D-mannose enhance the expression of IRS-2 but not of IRS-1 in pancreatic beta-cells
-
DOI 10.1055/s-2005-865803
-
Amacker-Françoys I, Mohanty S, Niessen M, Spinas GA, Trüb T. The metabolisable hexoses D-glucose and D-mannose enhance the expression of IRS-2 but not of IRS-1 in pancreatic beta-cells. Exp Clin Endocrinol Diabetes 2005;113:423-429 (Pubitemid 41360747)
-
(2005)
Experimental and Clinical Endocrinology and Diabetes
, vol.113
, Issue.8
, pp. 423-429
-
-
Amacker-Francoys, I.1
Mohanty, S.2
Niessen, M.3
Spinas, G.A.4
Trub, T.5
-
12
-
-
0038339191
-
cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2
-
DOI 10.1101/gad.1097103
-
Jhala US, Canettieri G, Screaton RA, et al. cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. Genes Dev 2003;17:1575-1580 (Pubitemid 36828785)
-
(2003)
Genes and Development
, vol.17
, Issue.13
, pp. 1575-1580
-
-
Jhala, U.S.1
Canettieri, G.2
Screaton, R.A.3
Kulkarni, R.N.4
Krajewski, S.5
Reed, J.6
Walker, J.7
Lin, X.8
White, M.9
Montminy, M.10
-
13
-
-
0035957414
-
Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulin-repressed genes
-
DOI 10.1073/pnas.071054598
-
Zhang J, Ou J, Bashmakov Y, Horton JD, Brown MS, Goldstein JL. Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulin-repressed genes. Proc Natl Acad Sci USA 2001;98:3756-3761 (Pubitemid 32249844)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.7
, pp. 3756-3761
-
-
Zhang, J.1
Ou, J.2
Bashmakov, Y.3
Horton, J.D.4
Brown, M.S.5
Goldstein, J.L.6
-
14
-
-
2342483040
-
SREBPs suppress IRS-2-mediated insulin signalling in the liver
-
DOI 10.1038/ncb1111
-
Ide T, Shimano H, Yahagi N, et al. SREBPs suppress IRS-2-mediated insulin signalling in the liver. Nat Cell Biol 2004;6:351-357 (Pubitemid 38584825)
-
(2004)
Nature Cell Biology
, vol.6
, Issue.4
, pp. 351-357
-
-
Ide, T.1
Shimano, H.2
Yahagi, N.3
Matsuzaka, T.4
Nakakuki, M.5
Yamamoto, T.6
Nakagawa, Y.7
Takahashi, A.8
Suzuki, H.9
Sone, H.10
Toyoshima, H.11
Fukamizu, A.12
Yamada, N.13
-
15
-
-
30044437308
-
TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes
-
DOI 10.1038/nm1334
-
Nakagawa Y, Shimano H, Yoshikawa T, et al. TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes. Nat Med 2006;12:107-113 (Pubitemid 43050084)
-
(2006)
Nature Medicine
, vol.12
, Issue.1
, pp. 107-113
-
-
Nakagawa, Y.1
Shimano, H.2
Yoshikawa, T.3
Ide, T.4
Tamura, M.5
Furusawa, M.6
Yamamoto, T.7
Inoue, N.8
Matsuzaka, T.9
Takahashi, A.10
Hasty, A.H.11
Suzuki, H.12
Sone, H.13
Toyoshima, H.14
Yahagi, N.15
Yamada, N.16
-
16
-
-
74949111272
-
The Fox genes in the liver: From organogenesis to functional integration
-
Le Lay J, Kaestner KH. The Fox genes in the liver: from organogenesis to functional integration. Physiol Rev 2010;90:1-22
-
(2010)
Physiol Rev
, vol.90
, pp. 1-22
-
-
Le Lay, J.1
Kaestner, K.H.2
-
17
-
-
0027418977
-
The biosynthesis of the subtilisin-related proprotein convertase PC3, but not that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets
-
Alarcón C, Lincoln B, Rhodes CJ. The biosynthesis of the subtilisin-related proprotein convertase PC3, but no that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets. J Biol Chem 1993;268:4276-4280 (Pubitemid 23072968)
-
(1993)
Journal of Biological Chemistry
, vol.268
, Issue.6
, pp. 4276-4280
-
-
Alarcon, C.1
Lincoln, B.2
Rhodes, C.J.3
-
18
-
-
0026550830
-
Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines
-
Asfari M, Janjic D, Meda P, Li G, Halban PA, Wollheim CB. Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology 1992;130:167-178
-
(1992)
Endocrinology
, vol.130
, pp. 167-178
-
-
Asfari, M.1
Janjic, D.2
Meda, P.3
Li, G.4
Halban, P.A.5
Wollheim, C.B.6
-
19
-
-
0037147215
-
Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1)
-
DOI 10.1074/jbc.M208756200
-
Wrede CE, Dickson LM, Lingohr MK, Briaud I, Rhodes CJ. Protein kinase B/ Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1). J Biol Chem 2002;277:49676-49684 (Pubitemid 36014411)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.51
, pp. 49676-49684
-
-
Wrede, C.E.1
Dickson, L.M.2
Lingohr, M.K.3
Briaud, I.4
Rhodes, C.J.5
-
20
-
-
0042531617
-
Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis
-
DOI 10.1074/jbc.M302548200
-
Kelpe CL, Moore PC, Parazzoli SD, Wicksteed BL, Rhodes CJ, Poitout V. Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis. J Biol Chem 2003;278:30015-30021 (Pubitemid 36962391)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.32
, pp. 30015-30021
-
-
Kelpe, C.L.1
Moore, P.C.2
Parazzoli, S.D.3
Wicksteed, B.4
Rhodes, C.J.5
Poitout, V.6
-
21
-
-
0033524937
-
Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes
-
DOI 10.1016/S0092-8674(00)80546-2
-
Kulkarni RN, Brüning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR. Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 1999;96:329-339 (Pubitemid 29077587)
-
(1999)
Cell
, vol.96
, Issue.3
, pp. 329-339
-
-
Kulkarni, R.N.1
Bruning, J.C.2
Winnay, J.N.3
Postic, C.4
Magnuson, M.A.5
Ronald, K.C.6
-
22
-
-
78049446505
-
Conditional gene targeting in mouse pancreatic β-cells: Analysis of ectopic Cre transgene expression in the brain
-
Wicksteed B, Brissova M, Yan W, et al. Conditional gene targeting in mouse pancreatic β-cells: analysis of ectopic Cre transgene expression in the brain. Diabetes 2010;59:3090-3098
-
(2010)
Diabetes
, vol.59
, pp. 3090-3098
-
-
Wicksteed, B.1
Brissova, M.2
Yan, W.3
-
23
-
-
78650039585
-
The hypothalamus and β-cell connection in the gene-targeting era
-
Schwartz MW, Guyenet SJ, Cirulli V. The hypothalamus and β-cell connection in the gene-targeting era. Diabetes 2010;59:2991-2993
-
(2010)
Diabetes
, vol.59
, pp. 2991-2993
-
-
Schwartz, M.W.1
Guyenet, S.J.2
Cirulli, V.3
-
24
-
-
0034730756
-
Glucose-stimulated insulin biosynthesis depends on insulin-stimulated insulin gene transcription
-
Leibiger B, Wahlander K, Berggren PO, Leibiger IB. Glucose-stimulated insulin biosynthesis depends on insulin-stimulated insulin gene transcription. J Biol Chem 2000;275:30153-30156
-
(2000)
J Biol Chem
, vol.275
, pp. 30153-30156
-
-
Leibiger, B.1
Wahlander, K.2
Berggren, P.O.3
Leibiger, I.B.4
-
25
-
-
0142149134
-
Glucose-induced Translational Control of Proinsulin Biosynthesis is Proportional to Preproinsulin mRNA Levels in Islet beta-Cells but Not Regulated via a Positive Feedback of Secreted Insulin
-
DOI 10.1074/jbc.M303509200
-
Wicksteed BL, Alarcón C, Briaud I, Dickson L, Lingohr MK, Rhodes CJ. Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin. J Biol Chem 2003; 278:42080-42090 (Pubitemid 37310474)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.43
, pp. 42080-42090
-
-
Wicksteed, B.1
Alarcon, C.2
Briaud, I.3
Lingohr, M.K.4
Rhodes, C.J.5
-
26
-
-
0036578921
-
Beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass
-
Kulkarni RN, Holzenberger M, Shih DQ, et al. Beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. Nat Genet 2002;31:111-115
-
(2002)
Nat Genet
, vol.31
, pp. 111-115
-
-
Kulkarni, R.N.1
Holzenberger, M.2
Shih, D.Q.3
-
27
-
-
23744439083
-
Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes
-
DOI 10.1016/j.cell.2005.05.027, PII S0092867405005416
-
Gunton JE, Kulkarni RN, Yim S, et al. Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell 2005;122:337-349 (Pubitemid 41127137)
-
(2005)
Cell
, vol.122
, Issue.3
, pp. 337-349
-
-
Gunton, J.E.1
Kulkarni, R.N.2
Yim, S.3
Okada, T.4
Hawthorne, W.J.5
Tseng, Y.-H.6
Roberson, R.S.7
Ricordi, C.8
O'Connell, P.J.9
Gonzalez, F.J.10
Kahn, C.R.11
-
28
-
-
41849093037
-
The role of FoxO in the regulation of metabolism
-
DOI 10.1038/onc.2008.25, PII ONC200825
-
Gross DN, van den Heuvel AP, Birnbaum MJ. The role of FoxO in the regulation of metabolism. Oncogene 2008;27:2320-2336 (Pubitemid 351501783)
-
(2008)
Oncogene
, vol.27
, Issue.16
, pp. 2320-2336
-
-
Gross, D.N.1
Van Den, H.A.P.J.2
Birnbaum, M.J.3
-
29
-
-
45849104555
-
14-3-3 proteins: A family of versatile molecular regulators
-
Obsilová V, Silhan J, Boura E, Teisinger J, Obsil T. 14-3-3 proteins: a family of versatile molecular regulators. Physiol Res 2008;57(Suppl. 3):S11-S21
-
(2008)
Physiol Res
, vol.57
, Issue.SUPPL. 3
-
-
Obsilová, V.1
Silhan, J.2
Boura, E.3
Teisinger, J.4
Obsil, T.5
-
30
-
-
79953840839
-
Nucleo-cytosolic shuttling of FoxO1 directly regulates mouse Ins2 but not Ins1 gene expression in pancreatic beta cells (MIN6)
-
Meur G, Qian Q, da Silva Xavier G, et al. Nucleo-cytosolic shuttling of FoxO1 directly regulates mouse Ins2 but not Ins1 gene expression in pancreatic beta cells (MIN6). J Biol Chem 2011;286:13647-13656
-
(2011)
J Biol Chem
, vol.286
, pp. 13647-13656
-
-
Meur, G.1
Qian, Q.2
Da Silva Xavier, G.3
-
31
-
-
14144251157
-
Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1c
-
DOI 10.1073/pnas.0405067102
-
Hegarty BD, Bobard A, Hainault I, Ferré P, Bossard P, Foufelle F. Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1c. Proc Natl Acad Sci USA 2005;102: 791-796 (Pubitemid 40282744)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.3
, pp. 791-796
-
-
Hegarty, B.D.1
Bobard, A.2
Hainault, I.3
Ferre, P.4
Bossard, P.5
Foufelle, F.6
-
32
-
-
34548670709
-
Role of FoxO proteins in pancreatic beta cells
-
DOI 10.1507/endocrj.KR-109
-
Kitamura T, Ido Kitamura Y. Role of FoxO proteins in pancreatic beta cells. Endocr J 2007;54:507-515 (Pubitemid 47414596)
-
(2007)
Endocrine Journal
, vol.54
, Issue.4
, pp. 507-515
-
-
Kitamura, T.1
Ido, K.Y.2
-
33
-
-
0036950665
-
The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth
-
DOI 10.1172/JCI200216857
-
Kitamura T, Nakae J, Kitamura Y, et al. The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest 2002;110:1839-1847 (Pubitemid 36076491)
-
(2002)
Journal of Clinical Investigation
, vol.110
, Issue.12
, pp. 1839-1847
-
-
Kitamura, T.1
Nakae, J.2
Kitamura, Y.3
Kido, Y.4
Biggs III, W.H.5
Wright, C.V.E.6
White, M.F.7
Arden, K.C.8
Accili, D.9
-
34
-
-
0038152845
-
Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a
-
DOI 10.1126/science.1086336
-
Castrillon DH, Miao L, Kollipara R, Horner JW, DePinho RA. Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science 2003;301:215-218 (Pubitemid 36858475)
-
(2003)
Science
, vol.301
, Issue.5630
, pp. 215-218
-
-
Castrillon, D.H.1
Miao, L.2
Kollipara, R.3
Horner, J.W.4
DePinho, R.A.5
-
35
-
-
55849111942
-
Constitutively active Akt1 expression in mouse pancreas requires S6 kinase 1 for insulinoma formation
-
Alliouachene S, Tuttle RL, Boumard S, et al. Constitutively active Akt1 expression in mouse pancreas requires S6 kinase 1 for insulinoma formation. J Clin Invest 2008;118:3629-3638
-
(2008)
J Clin Invest
, vol.118
, pp. 3629-3638
-
-
Alliouachene, S.1
Tuttle, R.L.2
Boumard, S.3
-
36
-
-
0001582482
-
Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: Amplification of AKT1 in a primary human gastric adenocarcinoma
-
DOI 10.1073/pnas.84.14.5034
-
Staal SP. Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma. Proc Natl Acad Sci USA 1987;84:5034-5037 (Pubitemid 17095859)
-
(1987)
Proceedings of the National Academy of Sciences of the United States of America
, vol.84
, Issue.14
, pp. 5034-5037
-
-
Staal, S.P.1
|