Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3β independent of JNK activation

PLoS ONE

Volumn 6, Issue 4, 2011, Pages

  Tanabe, Katsuya ^a   Liu, Yang ^a   Hasan, Syed D ^a   Martinez, Sara C ^a   Cras Méneur, Corentin ^a   Welling, Cris M ^a   Bernal Mizrachi, Ernesto ^a   Tanizawa, Yukio ^b   Rhodes, Christopher J ^c   Zmuda, Erik ^d   Hai, Tsonwin ^d   Abumrad, Nada A ^a   Permutt, M Alan ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c University of Chicago ^*  (United States)

^d OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; FATTY ACID; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3BETA; INSULIN RECEPTOR SUBSTRATE; PALMITIC ACID; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STRESS ACTIVATED PROTEIN KINASE; ACTIVATING TRANSCRIPTION FACTOR 3; ATF3 PROTEIN, MOUSE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; INSULIN; IRS2 PROTEIN, MOUSE; SREBF1 PROTEIN, MOUSE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL NUCLEUS; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME ACTIVITY; HYPERGLYCEMIA; HYPERLIPIDEMIA; INSULINOMA; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN SYNTHESIS INHIBITION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TUMOR CELL; ANIMAL; C57BL MOUSE; CELL LINE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENDOPLASMIC RETICULUM; ENZYMOLOGY; METABOLISM; PATHOLOGY; PHYSIOLOGICAL STRESS;

ADENOVIRIDAE;

ACTIVATING TRANSCRIPTION FACTOR 3; ANIMALS; APOPTOSIS; CELL LINE; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN-SECRETING CELLS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MICE; MICE, INBRED C57BL; PALMITIC ACID; SIGNAL TRANSDUCTION; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STRESS, PHYSIOLOGICAL;

EID: 79955625843     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0018146     Document Type: Article

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