메뉴 건너뛰기




Volumn 36, Issue 3, 2012, Pages 663-683

Failure of innate and adaptive immune responses in controlling hepatitis C virus infection

Author keywords

HCV; Immune escape; Interferon; MAVS; Persistence; T cell failure

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CLAUDIN 1; EPITOPE; GAMMA INTERFERON; HLA A3 ANTIGEN; HLA B27 ANTIGEN; INTERFERON; INTERFERON REGULATORY FACTOR 3; JANUS KINASE 1; MYELOID DIFFERENTIATION FACTOR 88; OCCLUDIN; PROTEIN KINASE R; RETINOIC ACID INDUCIBLE PROTEIN I; STAT PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR;

EID: 84859432807     PISSN: 01686445     EISSN: 15746976     Source Type: Journal    
DOI: 10.1111/j.1574-6976.2011.00319.x     Document Type: Review
Times cited : (109)

References (209)
  • 1
    • 33845650186 scopus 로고    scopus 로고
    • Intrahepatic virus-specific IL-10-producing CD8 T cells prevent liver damage during chronic hepatitis C virus infection
    • Abel M, Sene D, Pol S, Bourliere M, Poynard T, Charlotte F, Cacoub P & Caillat-Zucman S (2006) Intrahepatic virus-specific IL-10-producing CD8 T cells prevent liver damage during chronic hepatitis C virus infection. Hepatology 44: 1607-1616.
    • (2006) Hepatology , vol.44 , pp. 1607-1616
    • Abel, M.1    Sene, D.2    Pol, S.3    Bourliere, M.4    Poynard, T.5    Charlotte, F.6    Cacoub, P.7    Caillat-Zucman, S.8
  • 3
    • 72549104093 scopus 로고    scopus 로고
    • Natural killer cells are polarized toward cytotoxicity in chronic hepatitis C in an interferon-alfa-dependent manner
    • Ahlenstiel G, Titerence RH, Koh C et al. (2010) Natural killer cells are polarized toward cytotoxicity in chronic hepatitis C in an interferon-alfa-dependent manner. Gastroenterology 138: 325-335.
    • (2010) Gastroenterology , vol.138 , pp. 325-335
    • Ahlenstiel, G.1    Titerence, R.H.2    Koh, C.3
  • 6
    • 77956400067 scopus 로고    scopus 로고
    • Hepatitis C virus controls interferon production through PKR activation
    • Arnaud Nl, Dabo SP, Maillard P et al. (2010) Hepatitis C virus controls interferon production through PKR activation. PLoS ONE 5: e10575.
    • (2010) PLoS ONE , vol.5
    • Arnaud, N.1    Dabo, S.P.2    Maillard, P.3
  • 8
    • 77951990633 scopus 로고    scopus 로고
    • Hepatitis C virus hypervariable region 1 modulates receptor interactions, conceals the CD81 binding site, and protects conserved neutralizing epitopes
    • Bankwitz D, Steinmann E, Bitzegeio J et al. (2010) Hepatitis C virus hypervariable region 1 modulates receptor interactions, conceals the CD81 binding site, and protects conserved neutralizing epitopes. J Virol 84: 5751-5763.
    • (2010) J Virol , vol.84 , pp. 5751-5763
    • Bankwitz, D.1    Steinmann, E.2    Bitzegeio, J.3
  • 10
    • 77950603105 scopus 로고    scopus 로고
    • Cleavage of mitochondrial antiviral signaling protein in the liver of patients with chronic hepatitis C correlates with a reduced activation of the endogenous interferon system
    • Bellecave P, Sarasin-Filipowicz M, Donze O et al. (2010) Cleavage of mitochondrial antiviral signaling protein in the liver of patients with chronic hepatitis C correlates with a reduced activation of the endogenous interferon system. Hepatology 51: 1127-1136.
    • (2010) Hepatology , vol.51 , pp. 1127-1136
    • Bellecave, P.1    Sarasin-Filipowicz, M.2    Donze, O.3
  • 11
    • 33846090225 scopus 로고    scopus 로고
    • Analysis of CD127 and KLRG1 expression on hepatitis C virus-specific CD8+ T cells reveals the existence of different memory T-cell subsets in the peripheral blood and liver
    • Bengsch B, Spangenberg HC, Kersting N, Neumann-Haefelin C, Panther E, von Weizsacker F, Blum HE, Pircher H & Thimme R (2007) Analysis of CD127 and KLRG1 expression on hepatitis C virus-specific CD8+ T cells reveals the existence of different memory T-cell subsets in the peripheral blood and liver. J Virol 81: 945-953.
    • (2007) J Virol , vol.81 , pp. 945-953
    • Bengsch, B.1    Spangenberg, H.C.2    Kersting, N.3    Neumann-Haefelin, C.4    Panther, E.5    von Weizsacker, F.6    Blum, H.E.7    Pircher, H.8    Thimme, R.9
  • 12
    • 77954674575 scopus 로고    scopus 로고
    • Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation
    • Bengsch B, Seigel B, Ruhl M, Timm J, Kuntz M, Blum HE, Pircher H & Thimme R (2010) Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation. PLoS Pathog 6: e1000947.
    • (2010) PLoS Pathog , vol.6
    • Bengsch, B.1    Seigel, B.2    Ruhl, M.3    Timm, J.4    Kuntz, M.5    Blum, H.E.6    Pircher, H.7    Thimme, R.8
  • 13
    • 0034948009 scopus 로고    scopus 로고
    • DNA microarray analysis of chimpanzee liver during acute resolving hepatitis C virus infection
    • Bigger CB, Brasky KM & Lanford RE (2001) DNA microarray analysis of chimpanzee liver during acute resolving hepatitis C virus infection. J Virol 75: 7059-7066.
    • (2001) J Virol , vol.75 , pp. 7059-7066
    • Bigger, C.B.1    Brasky, K.M.2    Lanford, R.E.3
  • 15
    • 77649253219 scopus 로고    scopus 로고
    • Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties
    • Billerbeck E, Kang YH, Walker L et al. (2010) Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties. P Natl Acad Sci USA 107: 3006-3011.
    • (2010) P Natl Acad Sci USA , vol.107 , pp. 3006-3011
    • Billerbeck, E.1    Kang, Y.H.2    Walker, L.3
  • 16
    • 36348936640 scopus 로고    scopus 로고
    • Hepatitis C virus escape from the interferon regulatory factor 3 pathway by a passive and active evasion strategy
    • Binder M, Kochs G, Bartenschlager R & Lohmann V (2007) Hepatitis C virus escape from the interferon regulatory factor 3 pathway by a passive and active evasion strategy. Hepatology 46: 1365-1374.
    • (2007) Hepatology , vol.46 , pp. 1365-1374
    • Binder, M.1    Kochs, G.2    Bartenschlager, R.3    Lohmann, V.4
  • 19
    • 0037621934 scopus 로고    scopus 로고
    • Expression of hepatitis C virus proteins inhibits interferon alpha signaling in the liver of transgenic mice
    • Blindenbacher A, Duong FH, Hunziker L et al. (2003) Expression of hepatitis C virus proteins inhibits interferon alpha signaling in the liver of transgenic mice. Gastroenterology 124: 1465-1475.
    • (2003) Gastroenterology , vol.124 , pp. 1465-1475
    • Blindenbacher, A.1    Duong, F.H.2    Hunziker, L.3
  • 21
    • 19944370822 scopus 로고    scopus 로고
    • T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection
    • Boettler T, Spangenberg HC, Neumann-Haefelin C, Panther E, Urbani S, Ferrari C, Blum HE, von Weizsacker F & Thimme R (2005) T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection. J Virol 79: 7860-7867.
    • (2005) J Virol , vol.79 , pp. 7860-7867
    • Boettler, T.1    Spangenberg, H.C.2    Neumann-Haefelin, C.3    Panther, E.4    Urbani, S.5    Ferrari, C.6    Blum, H.E.7    von Weizsacker, F.8    Thimme, R.9
  • 22
    • 22344448015 scopus 로고    scopus 로고
    • Mutational escape from CD8+ T cell immunity: HCV evolution, from chimpanzees to man
    • Bowen DG & Walker CM (2005) Mutational escape from CD8+ T cell immunity: HCV evolution, from chimpanzees to man. J Exp Med 201: 1709-1714.
    • (2005) J Exp Med , vol.201 , pp. 1709-1714
    • Bowen, D.G.1    Walker, C.M.2
  • 23
    • 43249095801 scopus 로고    scopus 로고
    • Variable patterns of programmed death-1 expression on fully functional memory T cells after spontaneous resolution of hepatitis C virus infection
    • Bowen DG, Shoukry NH, Grakoui A et al. (2008) Variable patterns of programmed death-1 expression on fully functional memory T cells after spontaneous resolution of hepatitis C virus infection. J Virol 82: 5109-5114.
    • (2008) J Virol , vol.82 , pp. 5109-5114
    • Bowen, D.G.1    Shoukry, N.H.2    Grakoui, A.3
  • 24
    • 78650048403 scopus 로고    scopus 로고
    • Neutralizing antibody-resistant hepatitis C virus cell-to-cell transmission
    • Brimacombe CL, Grove J, Meredith LW et al. (2011) Neutralizing antibody-resistant hepatitis C virus cell-to-cell transmission. J Virol 85: 596-605.
    • (2011) J Virol , vol.85 , pp. 596-605
    • Brimacombe, C.L.1    Grove, J.2    Meredith, L.W.3
  • 25
    • 0026674719 scopus 로고
    • Secondary structure of the 5′ nontranslated regions of hepatitis C virus and pestivirus genomic RNAs
    • Brown EA, Zhang H, Ping LH & Lemon SM (1992) Secondary structure of the 5′ nontranslated regions of hepatitis C virus and pestivirus genomic RNAs. Nucleic Acids Res 20: 5041-5045.
    • (1992) Nucleic Acids Res , vol.20 , pp. 5041-5045
    • Brown, E.A.1    Zhang, H.2    Ping, L.H.3    Lemon, S.M.4
  • 26
    • 0034987467 scopus 로고    scopus 로고
    • Failure to infect rhesus monkeys with hepatitis C virus strains of genotypes 1a, 2a or 3a
    • Bukh J, Apgar CL, Govindarajan S, Emerson SU & Purcell RH (2001) Failure to infect rhesus monkeys with hepatitis C virus strains of genotypes 1a, 2a or 3a. J Viral Hepat 8: 228-231.
    • (2001) J Viral Hepat , vol.8 , pp. 228-231
    • Bukh, J.1    Apgar, C.L.2    Govindarajan, S.3    Emerson, S.U.4    Purcell, R.H.5
  • 27
    • 7044247947 scopus 로고    scopus 로고
    • An immunomodulatory role for CD4(+)CD25(+) regulatory T lymphocytes in hepatitis C virus infection
    • Cabrera R, Tu Z, Xu Y, Firpi RJ, Rosen HR, Liu C & Nelson DR (2004) An immunomodulatory role for CD4(+)CD25(+) regulatory T lymphocytes in hepatitis C virus infection. Hepatology 40: 1062-1071.
    • (2004) Hepatology , vol.40 , pp. 1062-1071
    • Cabrera, R.1    Tu, Z.2    Xu, Y.3    Firpi, R.J.4    Rosen, H.R.5    Liu, C.6    Nelson, D.R.7
  • 28
    • 79952397756 scopus 로고    scopus 로고
    • A siege of hepatitis: immune boost for viral hepatitis
    • Callendret B & Walker C (2011) A siege of hepatitis: immune boost for viral hepatitis. Nat Med 17: 252-253.
    • (2011) Nat Med , vol.17 , pp. 252-253
    • Callendret, B.1    Walker, C.2
  • 29
    • 0030671121 scopus 로고    scopus 로고
    • Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus
    • Chang KM, Rehermann B, McHutchison JG, Pasquinelli C, Southwood S, Sette A & Chisari FV (1997) Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus. J Clin Invest 100: 2376-2385.
    • (1997) J Clin Invest , vol.100 , pp. 2376-2385
    • Chang, K.M.1    Rehermann, B.2    McHutchison, J.G.3    Pasquinelli, C.4    Southwood, S.5    Sette, A.6    Chisari, F.V.7
  • 30
    • 78651083396 scopus 로고    scopus 로고
    • Natural killer cells and hepatitis C: action and reaction
    • Cheent K & Khakoo SI (2011) Natural killer cells and hepatitis C: action and reaction. Gut 60: 268-278.
    • (2011) Gut , vol.60 , pp. 268-278
    • Cheent, K.1    Khakoo, S.I.2
  • 32
    • 33744828747 scopus 로고    scopus 로고
    • Inhibition of dsRNA-induced signaling in hepatitis C virus-infected cells by NS3 protease-dependent and -independent mechanisms
    • Cheng G, Zhong J & Chisari FV (2006) Inhibition of dsRNA-induced signaling in hepatitis C virus-infected cells by NS3 protease-dependent and -independent mechanisms. P Natl Acad Sci USA 103: 8499-8504.
    • (2006) P Natl Acad Sci USA , vol.103 , pp. 8499-8504
    • Cheng, G.1    Zhong, J.2    Chisari, F.V.3
  • 33
    • 23944481107 scopus 로고    scopus 로고
    • Unscrambling hepatitis C virus-host interactions
    • Chisari FV (2005) Unscrambling hepatitis C virus-host interactions. Nature 436: 930-932.
    • (2005) Nature , vol.436 , pp. 930-932
    • Chisari, F.V.1
  • 35
    • 21344442371 scopus 로고    scopus 로고
    • Comprehensive analyses of CD8+ T cell responses during longitudinal study of acute human hepatitis C
    • Cox AL, Mosbruger T, Lauer GM, Pardoll D, Thomas DL & Ray SC (2005a) Comprehensive analyses of CD8+ T cell responses during longitudinal study of acute human hepatitis C. Hepatology 42: 104-112.
    • (2005) Hepatology , vol.42 , pp. 104-112
    • Cox, A.L.1    Mosbruger, T.2    Lauer, G.M.3    Pardoll, D.4    Thomas, D.L.5    Ray, S.C.6
  • 36
    • 21344442507 scopus 로고    scopus 로고
    • Cellular immune selection with hepatitis C virus persistence in humans
    • Cox AL, Mosbruger T, Mao Q et al. (2005b) Cellular immune selection with hepatitis C virus persistence in humans. J Exp Med 201: 1741-1752.
    • (2005) J Exp Med , vol.201 , pp. 1741-1752
    • Cox, A.L.1    Mosbruger, T.2    Mao, Q.3
  • 37
    • 78751576088 scopus 로고    scopus 로고
    • Liver antigen-presenting cells
    • Crispe IN (2011) Liver antigen-presenting cells. J Hepatol 54: 357-365.
    • (2011) J Hepatol , vol.54 , pp. 357-365
    • Crispe, I.N.1
  • 38
    • 0037033359 scopus 로고    scopus 로고
    • Inhibition of natural killer cells through engagement of CD81 by the major hepatitis C virus envelope protein
    • Crotta S, Stilla A, Wack A et al. (2002) Inhibition of natural killer cells through engagement of CD81 by the major hepatitis C virus envelope protein. J Exp Med 195: 35-41.
    • (2002) J Exp Med , vol.195 , pp. 35-41
    • Crotta, S.1    Stilla, A.2    Wack, A.3
  • 39
    • 75549090719 scopus 로고    scopus 로고
    • Hepatitis C virions subvert natural killer cell activation to generate a cytokine environment permissive for infection
    • Crotta S, Brazzoli M, Piccioli D, Valiante NM & Wack A (2010) Hepatitis C virions subvert natural killer cell activation to generate a cytokine environment permissive for infection. J Hepatol 52: 183-190.
    • (2010) J Hepatol , vol.52 , pp. 183-190
    • Crotta, S.1    Brazzoli, M.2    Piccioli, D.3    Valiante, N.M.4    Wack, A.5
  • 40
    • 78149323060 scopus 로고    scopus 로고
    • Interferons and microRNAs
    • David M (2010) Interferons and microRNAs. J Interferon Cytokine Res 30: 825-828.
    • (2010) J Interferon Cytokine Res , vol.30 , pp. 825-828
    • David, M.1
  • 42
    • 61749103383 scopus 로고    scopus 로고
    • Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response
    • Dazert E, Neumann-Haefelin C, Bressanelli S et al. (2009) Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response. J Clin Invest 119: 376-386.
    • (2009) J Clin Invest , vol.119 , pp. 376-386
    • Dazert, E.1    Neumann-Haefelin, C.2    Bressanelli, S.3
  • 43
    • 78650149393 scopus 로고    scopus 로고
    • Comparative analysis of the lambda-interferons IL-28A and IL-29 regarding their transcriptome and their antiviral properties against hepatitis C virus
    • Diegelmann J, Beigel F, Zitzmann K, Kaul A, Goke B, Auernhammer CJ, Bartenschlager R, Diepolder HM & Brand S (2010) Comparative analysis of the lambda-interferons IL-28A and IL-29 regarding their transcriptome and their antiviral properties against hepatitis C virus. PLoS ONE 5: e15200.
    • (2010) PLoS ONE , vol.5
    • Diegelmann, J.1    Beigel, F.2    Zitzmann, K.3    Kaul, A.4    Goke, B.5    Auernhammer, C.J.6    Bartenschlager, R.7    Diepolder, H.M.8    Brand, S.9
  • 44
    • 0029151623 scopus 로고
    • Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection
    • Diepolder HM, Zachoval R, Hoffmann RM, Wierenga EA, Santantonio T, Jung MC, Eichenlaub D & Pape GR (1995) Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection. Lancet 346: 1006-1007.
    • (1995) Lancet , vol.346 , pp. 1006-1007
    • Diepolder, H.M.1    Zachoval, R.2    Hoffmann, R.M.3    Wierenga, E.A.4    Santantonio, T.5    Jung, M.C.6    Eichenlaub, D.7    Pape, G.R.8
  • 45
    • 0030790664 scopus 로고    scopus 로고
    • Immunodominant CD4(+) T-cell epitope within nonstructural protein 3 in acute hepatitis C virus infection
    • Diepolder HM, Gerlach JT, Zachoval R et al. (1997) Immunodominant CD4(+) T-cell epitope within nonstructural protein 3 in acute hepatitis C virus infection. J Virol 71: 6011-6019.
    • (1997) J Virol , vol.71 , pp. 6011-6019
    • Diepolder, H.M.1    Gerlach, J.T.2    Zachoval, R.3
  • 46
    • 66149119738 scopus 로고    scopus 로고
    • Selection pressure from neutralizing antibodies drives sequence evolution during acute infection with hepatitis C virus
    • Dowd KA, Netski DM, Wang XH, Cox AL & Ray SC (2009) Selection pressure from neutralizing antibodies drives sequence evolution during acute infection with hepatitis C virus. Gastroenterology 136: 2377-2386.
    • (2009) Gastroenterology , vol.136 , pp. 2377-2386
    • Dowd, K.A.1    Netski, D.M.2    Wang, X.H.3    Cox, A.L.4    Ray, S.C.5
  • 47
    • 69549135689 scopus 로고    scopus 로고
    • The autophagy machinery is required to initiate hepatitis C virus replication
    • Dreux MN, Gastaminza P, Wieland SF & Chisari FV (2009) The autophagy machinery is required to initiate hepatitis C virus replication. P Natl Acad Sci USA 106: 14046-14051.
    • (2009) P Natl Acad Sci USA , vol.106 , pp. 14046-14051
    • Dreux, M.N.1    Gastaminza, P.2    Wieland, S.F.3    Chisari, F.V.4
  • 48
    • 0346100572 scopus 로고    scopus 로고
    • Hepatitis C virus inhibits interferon signaling through up-regulation of protein phosphatase 2A
    • Duong FH, Filipowicz M, Tripodi M, La Monica N & Heim MH. (2004) Hepatitis C virus inhibits interferon signaling through up-regulation of protein phosphatase 2A. Gastroenterology 126: 263-277.
    • (2004) Gastroenterology , vol.126 , pp. 263-277
    • Duong, F.H.1    Filipowicz, M.2    Tripodi, M.3    La Monica, N.4    Heim, M.H.5
  • 49
    • 0037371835 scopus 로고    scopus 로고
    • Impaired response to interferon-alpha/beta and lethal viral disease in human STAT1 deficiency
    • Dupuis SP, Jouanguy E, Al Hajjar S et al. (2003) Impaired response to interferon-alpha/beta and lethal viral disease in human STAT1 deficiency. Nat Genet 33: 388-391.
    • (2003) Nat Genet , vol.33 , pp. 388-391
    • Dupuis, S.P.1    Jouanguy, E.2    Al Hajjar, S.3
  • 51
    • 34547098811 scopus 로고    scopus 로고
    • Hepatitis C virus envelope glycoprotein E2 glycans modulate entry, CD81 binding, and neutralization
    • Falkowska E, Kajumo F, Garcia E, Reinus J & Dragic T (2007) Hepatitis C virus envelope glycoprotein E2 glycans modulate entry, CD81 binding, and neutralization. J Virol 81: 8072-8079.
    • (2007) J Virol , vol.81 , pp. 8072-8079
    • Falkowska, E.1    Kajumo, F.2    Garcia, E.3    Reinus, J.4    Dragic, T.5
  • 52
    • 79960975003 scopus 로고    scopus 로고
    • Activation of natural killer cells by hepatitis C virus particles in vitro
    • Farag MMS, Weigand K, Encke J & Momburg F (2011) Activation of natural killer cells by hepatitis C virus particles in vitro. Clin Exp Immunol 163: 352-362.
    • (2011) Clin Exp Immunol , vol.163 , pp. 352-362
    • Farag, M.M.S.1    Weigand, K.2    Encke, J.3    Momburg, F.4
  • 55
    • 80053566559 scopus 로고    scopus 로고
    • Molecular footprints reveal the impact of the protective HLA-A*03 allele in hepatitis C virus infection
    • Fitzmaurice K, Petrovic D, Ramamurthy N et al. (2011) Molecular footprints reveal the impact of the protective HLA-A7*03 allele in hepatitis C virus infection. Gut 60: 1563-1571.
    • (2011) Gut , vol.60 , pp. 1563-1571
    • Fitzmaurice, K.1    Petrovic, D.2    Ramamurthy, N.3
  • 56
    • 77952720377 scopus 로고    scopus 로고
    • Virological footprint of CD4+ T-cell responses during chronic hepatitis C virus infection
    • Fleming VM, Harcourt G, Barnes E & Klenerman P (2010) Virological footprint of CD4+ T-cell responses during chronic hepatitis C virus infection. J Gen Virol 91: 1396-1406.
    • (2010) J Gen Virol , vol.91 , pp. 1396-1406
    • Fleming, V.M.1    Harcourt, G.2    Barnes, E.3    Klenerman, P.4
  • 57
    • 77956455659 scopus 로고    scopus 로고
    • Hepatitis C virus infection of neuroepithelioma cell lines
    • Fletcher NF, Yang JP, Farquhar MJ et al. (2010) Hepatitis C virus infection of neuroepithelioma cell lines. Gastroenterology 139: 1365-1374.
    • (2010) Gastroenterology , vol.139 , pp. 1365-1374
    • Fletcher, N.F.1    Yang, J.P.2    Farquhar, M.J.3
  • 58
    • 0037687422 scopus 로고    scopus 로고
    • Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease
    • Foy E, Li K, Wang C, Sumpter Jr R, Ikeda M, Lemon SM & Gale Jr M (2003) Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease. Science 300: 1145-1148.
    • (2003) Science , vol.300 , pp. 1145-1148
    • Foy, E.1    Li, K.2    Wang, C.3    Sumpter Jr, R.4    Ikeda, M.5    Lemon, S.M.6    Gale Jr, M.7
  • 60
    • 0035065277 scopus 로고    scopus 로고
    • Interferon-alpha inhibits hepatitis C virus subgenomic RNA replication by an MxA-independent pathway
    • Frese M, Pietschmann T, Moradpour D, Haller O & Bartenschlager R (2001) Interferon-alpha inhibits hepatitis C virus subgenomic RNA replication by an MxA-independent pathway. J Gen Virol 82: 723-733.
    • (2001) J Gen Virol , vol.82 , pp. 723-733
    • Frese, M.1    Pietschmann, T.2    Moradpour, D.3    Haller, O.4    Bartenschlager, R.5
  • 63
    • 0345164384 scopus 로고    scopus 로고
    • Molecular mechanisms of interferon resistance mediated by viral-directed inhibition of PKR, the interferon-induced protein kinase
    • Gale M & Katze MG (1998) Molecular mechanisms of interferon resistance mediated by viral-directed inhibition of PKR, the interferon-induced protein kinase. Pharmacol Ther 78: 29-46.
    • (1998) Pharmacol Ther , vol.78 , pp. 29-46
    • Gale, M.1    Katze, M.G.2
  • 64
    • 75149139029 scopus 로고    scopus 로고
    • Hepatitis C virus blocks interferon effector function by inducing protein kinase R phosphorylation
    • Garaigorta U & Chisari FV (2009) Hepatitis C virus blocks interferon effector function by inducing protein kinase R phosphorylation. Cell Host Microbe 6: 513-522.
    • (2009) Cell Host Microbe , vol.6 , pp. 513-522
    • Garaigorta, U.1    Chisari, F.V.2
  • 65
    • 33750735455 scopus 로고    scopus 로고
    • Evidence of viral adaptation to HLA class I-restricted immune pressure in chronic hepatitis C virus infection
    • Gaudieri S, Rauch A, Park LP et al. (2006) Evidence of viral adaptation to HLA class I-restricted immune pressure in chronic hepatitis C virus infection. J Virol 80: 11094-11104.
    • (2006) J Virol , vol.80 , pp. 11094-11104
    • Gaudieri, S.1    Rauch, A.2    Park, L.P.3
  • 66
    • 70349292099 scopus 로고    scopus 로고
    • Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
    • Ge D, Fellay J, Thompson AJ et al. (2009) Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 461: 399-401.
    • (2009) Nature , vol.461 , pp. 399-401
    • Ge, D.1    Fellay, J.2    Thompson, A.J.3
  • 68
    • 34548191951 scopus 로고    scopus 로고
    • Upregulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific CD8+ T cells associated with reversible immune dysfunction
    • Golden-Mason L, Palmer B, Klarquist J, Mengshol JA, Castelblanco N & Rosen HR (2007) Upregulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific CD8+ T cells associated with reversible immune dysfunction. J Virol 81: 9249-9258.
    • (2007) J Virol , vol.81 , pp. 9249-9258
    • Golden-Mason, L.1    Palmer, B.2    Klarquist, J.3    Mengshol, J.A.4    Castelblanco, N.5    Rosen, H.R.6
  • 69
    • 48249137638 scopus 로고    scopus 로고
    • Altered natural killer cell subset distributions in resolved and persistent hepatitis C virus infection following single source exposure
    • Golden-Mason L, Madrigal-Estebas L, McGrath E, Conroy MJ, Ryan EJ, Hegarty JE, O'Farrelly C & Doherty DG (2008) Altered natural killer cell subset distributions in resolved and persistent hepatitis C virus infection following single source exposure. Gut 57: 1121-1128.
    • (2008) Gut , vol.57 , pp. 1121-1128
    • Golden-Mason, L.1    Madrigal-Estebas, L.2    McGrath, E.3    Conroy, M.J.4    Ryan, E.J.5    Hegarty, J.E.6    O'Farrelly, C.7    Doherty, D.G.8
  • 71
    • 84859425214 scopus 로고    scopus 로고
    • Differential antigen-specificity of hepatitis C virus specific IL-17- and IFN-γ-producing CD8+ T cells during chronic infection
    • in press.
    • Grafmüller S, Billerbeck E, Blum HE, Neumann-Haefelin C & Thimme R (2011) Differential antigen-specificity of hepatitis C virus specific IL-17- and IFN-γ-producing CD8+ T cells during chronic infection. J Inf Dis in press.
    • (2011) J Inf Dis
    • Grafmüller, S.1    Billerbeck, E.2    Blum, H.E.3    Neumann-Haefelin, C.4    Thimme, R.5
  • 73
    • 0034129951 scopus 로고    scopus 로고
    • Association of hepatitis C virus-specific CD8+ T cells with viral clearance in acute hepatitis C
    • Gruner NH, Gerlach TJ, Jung MC et al. (2000) Association of hepatitis C virus-specific CD8+ T cells with viral clearance in acute hepatitis C. J Infect Dis 181: 1528-1536.
    • (2000) J Infect Dis , vol.181 , pp. 1528-1536
    • Gruner, N.H.1    Gerlach, T.J.2    Jung, M.C.3
  • 74
    • 3042660285 scopus 로고    scopus 로고
    • Mechanism of the interferon alpha response against hepatitis C virus replicons
    • Guo JT, Sohn JA, Zhu Q & Seeger C (2004) Mechanism of the interferon alpha response against hepatitis C virus replicons. Virology 325: 71-81.
    • (2004) Virology , vol.325 , pp. 71-81
    • Guo, J.T.1    Sohn, J.A.2    Zhu, Q.3    Seeger, C.4
  • 75
    • 33847015308 scopus 로고    scopus 로고
    • Hepatitis C virus continuously escapes from neutralizing antibody and T-cell responses during chronic infection in vivo
    • von Hahn T, Yoon JC, Alter H, Rice CM, Rehermann B, Balfe P & McKeating JA (2007) Hepatitis C virus continuously escapes from neutralizing antibody and T-cell responses during chronic infection in vivo. Gastroenterology 132: 667-678.
    • (2007) Gastroenterology , vol.132 , pp. 667-678
    • von Hahn, T.1    Yoon, J.C.2    Alter, H.3    Rice, C.M.4    Rehermann, B.5    Balfe, P.6    McKeating, J.A.7
  • 76
    • 38449090489 scopus 로고    scopus 로고
    • Pathogenic viruses: smart manipulators of the interferon system
    • Haller O & Weber F (2007) Pathogenic viruses: smart manipulators of the interferon system. Curr Top Microbiol Immunol 316: 315-334.
    • (2007) Curr Top Microbiol Immunol , vol.316 , pp. 315-334
    • Haller, O.1    Weber, F.2
  • 77
    • 70349429634 scopus 로고    scopus 로고
    • FOXP3 expression in hepatitis C virus-specific CD4+ T cells during acute hepatitis C
    • Heeg MH, Ulsenheimer A, Gruner NH et al. (2009) FOXP3 expression in hepatitis C virus-specific CD4+ T cells during acute hepatitis C. Gastroenterology 137: 1280-1288.
    • (2009) Gastroenterology , vol.137 , pp. 1280-1288
    • Heeg, M.H.1    Ulsenheimer, A.2    Gruner, N.H.3
  • 78
    • 0032824134 scopus 로고    scopus 로고
    • Expression of hepatitis C virus proteins inhibits signal transduction through the Jak-STAT pathway
    • Heim MH, Moradpour D & Blum HE (1999) Expression of hepatitis C virus proteins inhibits signal transduction through the Jak-STAT pathway. J Virol 73: 8469-8475.
    • (1999) J Virol , vol.73 , pp. 8469-8475
    • Heim, M.H.1    Moradpour, D.2    Blum, H.E.3
  • 79
    • 24144487496 scopus 로고    scopus 로고
    • Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector
    • Helbig KJ, Lau DT, Semendric L, Harley HA & Beard MR (2005) Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector. Hepatology 42: 702-710.
    • (2005) Hepatology , vol.42 , pp. 702-710
    • Helbig, K.J.1    Lau, D.T.2    Semendric, L.3    Harley, H.A.4    Beard, M.R.5
  • 81
    • 31344474524 scopus 로고    scopus 로고
    • Human leukocyte antigen class II DQB1*0301, DRB1*1101 alleles and spontaneous clearance of hepatitis C virus infection: a meta-analysis
    • Hong X, Yu RB, Sun NX, Wang B, Xu YC & Wu GL (2005) Human leukocyte antigen class II DQB1*0301, DRB1*1101 alleles and spontaneous clearance of hepatitis C virus infection: a meta-analysis. World J Gastroenterol 11: 7302-7307.
    • (2005) World J Gastroenterol , vol.11 , pp. 7302-7307
    • Hong, X.1    Yu, R.B.2    Sun, N.X.3    Wang, B.4    Xu, Y.C.5    Wu, G.L.6
  • 82
    • 62949087170 scopus 로고    scopus 로고
    • Analysis of CD8+ T-cell-mediated inhibition of hepatitis C virus replication using a novel immunological model
    • Jo J, Aichele U, Kersting N et al. (2009) Analysis of CD8+ T-cell-mediated inhibition of hepatitis C virus replication using a novel immunological model. Gastroenterology 136: 1391-1401.
    • (2009) Gastroenterology , vol.136 , pp. 1391-1401
    • Jo, J.1    Aichele, U.2    Kersting, N.3
  • 83
    • 79951796190 scopus 로고    scopus 로고
    • Experimental models to study the immunobiology of hepatitis C virus
    • Jo J, Lohmann V, Bartenschlager R & Thimme R (2011) Experimental models to study the immunobiology of hepatitis C virus. J Gen Virol 92: 477-493.
    • (2011) J Gen Virol , vol.92 , pp. 477-493
    • Jo, J.1    Lohmann, V.2    Bartenschlager, R.3    Thimme, R.4
  • 84
    • 24644483623 scopus 로고    scopus 로고
    • Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA
    • Jopling CL, Yi M, Lancaster AM, Lemon SM & Sarnow P (2005) Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA. Science 309: 1577-1581.
    • (2005) Science , vol.309 , pp. 1577-1581
    • Jopling, C.L.1    Yi, M.2    Lancaster, A.M.3    Lemon, S.M.4    Sarnow, P.5
  • 85
    • 67349265228 scopus 로고    scopus 로고
    • PKR protein kinase is activated by hepatitis C virus and inhibits viral replication through translational control
    • Kang JI, Kwon SN, Park SH, Kim YK, Choi SY, Kim JP & Ahn BY (2009) PKR protein kinase is activated by hepatitis C virus and inhibits viral replication through translational control. Virus Res 142: 51-56.
    • (2009) Virus Res , vol.142 , pp. 51-56
    • Kang, J.I.1    Kwon, S.N.2    Park, S.H.3    Kim, Y.K.4    Choi, S.Y.5    Kim, J.P.6    Ahn, B.Y.7
  • 86
    • 33847067210 scopus 로고    scopus 로고
    • Discordant role of CD4 T-cell response relative to neutralizing antibody and CD8 T-cell responses in acute hepatitis C
    • Kaplan DE, Sugimoto K, Newton K et al. (2007) Discordant role of CD4 T-cell response relative to neutralizing antibody and CD8 T-cell responses in acute hepatitis C. Gastroenterology 132: 654-666.
    • (2007) Gastroenterology , vol.132 , pp. 654-666
    • Kaplan, D.E.1    Sugimoto, K.2    Newton, K.3
  • 87
    • 40149094779 scopus 로고    scopus 로고
    • High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome
    • Kasprowicz V, Schulze Zur Wiesch J, Kuntzen T et al. (2008) High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome. J Virol 82: 3154-3160.
    • (2008) J Virol , vol.82 , pp. 3154-3160
    • Kasprowicz, V.1    Schulze Zur Wiesch, J.2    Kuntzen, T.3
  • 88
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
    • Kawai T & Akira S (2010) The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 11: 373-384.
    • (2010) Nat Immunol , vol.11 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 89
    • 78650961487 scopus 로고    scopus 로고
    • Activation of the unfolded protein response and autophagy after hepatitis C virus infection suppresses innate antiviral immunity in vitro
    • Ke PY & Chen SS (2011) Activation of the unfolded protein response and autophagy after hepatitis C virus infection suppresses innate antiviral immunity in vitro. J Clin Invest 121: 37-56.
    • (2011) J Clin Invest , vol.121 , pp. 37-56
    • Ke, P.Y.1    Chen, S.S.2
  • 90
    • 3843075120 scopus 로고    scopus 로고
    • HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection
    • Khakoo SI, Thio CL, Martin MP et al. (2004) HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection. Science 305: 872-874.
    • (2004) Science , vol.305 , pp. 872-874
    • Khakoo, S.I.1    Thio, C.L.2    Martin, M.P.3
  • 91
    • 79251547401 scopus 로고    scopus 로고
    • Spontaneous control of HCV is associated with expression of HLA-B 57 and preservation of targeted epitopes
    • Kim AY, Kuntzen T, Timm J et al. (2011) Spontaneous control of HCV is associated with expression of HLA-B 57 and preservation of targeted epitopes. Gastroenterology 140: 686-696.
    • (2011) Gastroenterology , vol.140 , pp. 686-696
    • Kim, A.Y.1    Kuntzen, T.2    Timm, J.3
  • 92
    • 16244377751 scopus 로고    scopus 로고
    • Escape mutations alter proteasome processing of major histocompatibility complex class I-restricted epitopes in persistent hepatitis C virus infection
    • Kimura Y, Gushima T, Rawale S, Kaumaya P & Walker CM (2005) Escape mutations alter proteasome processing of major histocompatibility complex class I-restricted epitopes in persistent hepatitis C virus infection. J Virol 79: 4870-4876.
    • (2005) J Virol , vol.79 , pp. 4870-4876
    • Kimura, Y.1    Gushima, T.2    Rawale, S.3    Kaumaya, P.4    Walker, C.M.5
  • 93
    • 77950626070 scopus 로고    scopus 로고
    • Consistent beneficial effects of killer cell immunoglobulin-like receptor 2DL3 and group 1 human leukocyte antigen-C following exposure to hepatitis C virus
    • Knapp S, Warshow U, Hegazy D et al. (2010) Consistent beneficial effects of killer cell immunoglobulin-like receptor 2DL3 and group 1 human leukocyte antigen-C following exposure to hepatitis C virus. Hepatology 51: 1168-1175.
    • (2010) Hepatology , vol.51 , pp. 1168-1175
    • Knapp, S.1    Warshow, U.2    Hegazy, D.3
  • 94
    • 77951466879 scopus 로고    scopus 로고
    • Specific human leukocyte antigen class I and II alleles associated with hepatitis C virus viremia
    • Kuniholm MH, Kovacs A, Gao X et al. (2010) Specific human leukocyte antigen class I and II alleles associated with hepatitis C virus viremia. Hepatology 51: 1514-1522.
    • (2010) Hepatology , vol.51 , pp. 1514-1522
    • Kuniholm, M.H.1    Kovacs, A.2    Gao, X.3
  • 95
    • 75749138095 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells: key players in the initiation and regulation of immune responses
    • Lande R & Gilliet M (2010) Plasmacytoid dendritic cells: key players in the initiation and regulation of immune responses. Ann NY Acad Sci 1183: 89-103.
    • (2010) Ann NY Acad Sci , vol.1183 , pp. 89-103
    • Lande, R.1    Gilliet, M.2
  • 96
    • 33845897090 scopus 로고    scopus 로고
    • Cytokine-activated natural killer cells exert direct killing of hepatoma cells harboring hepatitis C virus replicons
    • Larkin J, Bost A, Glass JI & Tan SL (2006) Cytokine-activated natural killer cells exert direct killing of hepatoma cells harboring hepatitis C virus replicons. J Interferon Cytokine Res 26: 854-865.
    • (2006) J Interferon Cytokine Res , vol.26 , pp. 854-865
    • Larkin, J.1    Bost, A.2    Glass, J.I.3    Tan, S.L.4
  • 97
    • 0035811625 scopus 로고    scopus 로고
    • Hepatitis C virus infection
    • Lauer GM & Walker BD (2001) Hepatitis C virus infection. N Engl J Med 345: 41-52.
    • (2001) N Engl J Med , vol.345 , pp. 41-52
    • Lauer, G.M.1    Walker, B.D.2
  • 98
    • 0036116355 scopus 로고    scopus 로고
    • Comprehensive analysis of CD8(+)-T-cell responses against hepatitis C virus reveals multiple unpredicted specificities
    • Lauer GM, Ouchi K, Chung RT et al. (2002) Comprehensive analysis of CD8(+)-T-cell responses against hepatitis C virus reveals multiple unpredicted specificities. J Virol 76: 6104-6113.
    • (2002) J Virol , vol.76 , pp. 6104-6113
    • Lauer, G.M.1    Ouchi, K.2    Chung, R.T.3
  • 100
    • 33947134377 scopus 로고    scopus 로고
    • Autophagy-dependent viral recognition by plasmacytoid dendritic cells
    • Lee HK, Lund JM, Ramanathan B, Mizushima N & Iwasaki A (2007) Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science 315: 1398-1401.
    • (2007) Science , vol.315 , pp. 1398-1401
    • Lee, H.K.1    Lund, J.M.2    Ramanathan, B.3    Mizushima, N.4    Iwasaki, A.5
  • 104
    • 34548648264 scopus 로고    scopus 로고
    • HCV structural proteins interfere with interferon-alpha Jak/STAT signalling pathway
    • Luquin E, Larrea E, Civeira MP, Prieto Js & Aldabe R (2007) HCV structural proteins interfere with interferon-alpha Jak/STAT signalling pathway. Antiviral Res 76: 194-197.
    • (2007) Antiviral Res , vol.76 , pp. 194-197
    • Luquin, E.1    Larrea, E.2    Civeira, M.P.3    Prieto, J.4    Aldabe, R.5
  • 105
    • 2542577112 scopus 로고    scopus 로고
    • Hepatitis C virus kinetics and host responses associated with disease and outcome of infection in chimpanzees
    • Major ME, Dahari H, Mihalik K, Puig M, Rice CM, Neumann AU & Feinstone SM (2004) Hepatitis C virus kinetics and host responses associated with disease and outcome of infection in chimpanzees. Hepatology 39: 1709-1720.
    • (2004) Hepatology , vol.39 , pp. 1709-1720
    • Major, M.E.1    Dahari, H.2    Mihalik, K.3    Puig, M.4    Rice, C.M.5    Neumann, A.U.6    Feinstone, S.M.7
  • 106
    • 34547960175 scopus 로고    scopus 로고
    • Small self-RNA generated by RNase L amplifies antiviral innate immunity
    • Malathi K, Dong B, Gale Jr M & Silverman RH (2007) Small self-RNA generated by RNase L amplifies antiviral innate immunity. Nature 448: 816-819.
    • (2007) Nature , vol.448 , pp. 816-819
    • Malathi, K.1    Dong, B.2    Gale Jr, M.3    Silverman, R.H.4
  • 107
    • 33845605155 scopus 로고    scopus 로고
    • Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics
    • Marcello T, Grakoui A, Barba-Spaeth G, Machlin ES, Kotenko SV, MacDonald MR & Rice CM (2006) Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics. Gastroenterology 131: 1887-1898.
    • (2006) Gastroenterology , vol.131 , pp. 1887-1898
    • Marcello, T.1    Grakoui, A.2    Barba-Spaeth, G.3    Machlin, E.S.4    Kotenko, S.V.5    MacDonald, M.R.6    Rice, C.M.7
  • 109
    • 0027971622 scopus 로고
    • CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection
    • Matloubian M, Concepcion RJ & Ahmed R (1994) CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection. J Virol 68: 8056-8063.
    • (1994) J Virol , vol.68 , pp. 8056-8063
    • Matloubian, M.1    Concepcion, R.J.2    Ahmed, R.3
  • 111
    • 78649903057 scopus 로고    scopus 로고
    • Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity
    • McMahan RH, Golden-Mason L, Nishimura MI, McMahon BJ, Kemper M, Allen TM, Gretch DR & Rosen HR (2010) Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity. J Clin Invest 120: 4546-4557.
    • (2010) J Clin Invest , vol.120 , pp. 4546-4557
    • McMahan, R.H.1    Golden-Mason, L.2    Nishimura, M.I.3    McMahon, B.J.4    Kemper, M.5    Allen, T.M.6    Gretch, D.R.7    Rosen, H.R.8
  • 112
    • 79151474495 scopus 로고    scopus 로고
    • Effect of immune pressure on hepatitis C virus evolution: insights from a single-source outbreak
    • Merani S, Petrovic D, James I et al. (2011) Effect of immune pressure on hepatitis C virus evolution: insights from a single-source outbreak. Hepatology 53: 396-405.
    • (2011) Hepatology , vol.53 , pp. 396-405
    • Merani, S.1    Petrovic, D.2    James, I.3
  • 114
    • 27144440476 scopus 로고    scopus 로고
    • Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
    • Meylan E, Curran J, Hofmann K, Moradpour D, Binder M, Bartenschlager R & Tschopp J (2005) Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437: 1167-1172.
    • (2005) Nature , vol.437 , pp. 1167-1172
    • Meylan, E.1    Curran, J.2    Hofmann, K.3    Moradpour, D.4    Binder, M.5    Bartenschlager, R.6    Tschopp, J.7
  • 115
    • 10244225383 scopus 로고    scopus 로고
    • Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response
    • Missale G, Bertoni R, Lamonaca V, Valli A, Massari M, Mori C, Rumi MG, Houghton M, Fiaccadori F & Ferrari C (1996) Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response. J Clin Invest 98: 706-714.
    • (1996) J Clin Invest , vol.98 , pp. 706-714
    • Missale, G.1    Bertoni, R.2    Lamonaca, V.3    Valli, A.4    Massari, M.5    Mori, C.6    Rumi, M.G.7    Houghton, M.8    Fiaccadori, F.9    Ferrari, C.10
  • 117
    • 44649188658 scopus 로고    scopus 로고
    • Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization
    • Nakamoto N, Kaplan DE, Coleclough J et al. (2008) Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization. Gastroenterology 134: 1927-1937.
    • (2008) Gastroenterology , vol.134 , pp. 1927-1937
    • Nakamoto, N.1    Kaplan, D.E.2    Coleclough, J.3
  • 118
    • 61449181280 scopus 로고    scopus 로고
    • Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade
    • Nakamoto N, Cho H, Shaked A et al. (2009) Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade. PLoS Pathog 5: e1000313.
    • (2009) PLoS Pathog , vol.5
    • Nakamoto, N.1    Cho, H.2    Shaked, A.3
  • 121
    • 33645229492 scopus 로고    scopus 로고
    • Dominant influence of an HLA-B27 restricted CD8+ T cell response in mediating HCV clearance and evolution
    • Neumann-Haefelin C, McKiernan S, Ward S et al. (2006) Dominant influence of an HLA-B27 restricted CD8+ T cell response in mediating HCV clearance and evolution. Hepatology 43: 563-572.
    • (2006) Hepatology , vol.43 , pp. 563-572
    • Neumann-Haefelin, C.1    McKiernan, S.2    Ward, S.3
  • 123
    • 73449106806 scopus 로고    scopus 로고
    • Protective effect of human leukocyte antigen B27 in hepatitis C virus infection requires the presence of a genotype-specific immunodominant CD8+ T-cell epitope
    • Neumann-Haefelin C, Timm J, Schmidt J et al. (2010) Protective effect of human leukocyte antigen B27 in hepatitis C virus infection requires the presence of a genotype-specific immunodominant CD8+ T-cell epitope. Hepatology 51: 54-62.
    • (2010) Hepatology , vol.51 , pp. 54-62
    • Neumann-Haefelin, C.1    Timm, J.2    Schmidt, J.3
  • 124
    • 39549087674 scopus 로고    scopus 로고
    • CD161 expression on hepatitis C virus-specific CD8+ T cells suggests a distinct pathway of T cell differentiation
    • Northfield JW, Kasprowicz V, Lucas M et al. (2008) CD161 expression on hepatitis C virus-specific CD8+ T cells suggests a distinct pathway of T cell differentiation. Hepatology 47: 396-406.
    • (2008) Hepatology , vol.47 , pp. 396-406
    • Northfield, J.W.1    Kasprowicz, V.2    Lucas, M.3
  • 127
    • 35748976569 scopus 로고    scopus 로고
    • IFN regulatory factor family members differentially regulate the expression of type III IFN (IFN-lambda) genes
    • Osterlund PI, Pietil+ñ TE, Veckman V, Kotenko SV & Julkunen I (2007) IFN regulatory factor family members differentially regulate the expression of type III IFN (IFN-lambda) genes. J Immunol 179: 3434-3442.
    • (2007) J Immunol , vol.179 , pp. 3434-3442
    • Osterlund, P.I.1    Pietil+ñ, T.E.2    Veckman, V.3    Kotenko, S.V.4    Julkunen, I.5
  • 129
    • 34347230939 scopus 로고    scopus 로고
    • Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C
    • Pestka JM, Zeisel MB, Blaser E et al. (2007) Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C. P Natl Acad Sci USA 104: 6025-6030.
    • (2007) P Natl Acad Sci USA , vol.104 , pp. 6025-6030
    • Pestka, J.M.1    Zeisel, M.B.2    Blaser, E.3
  • 131
    • 60149090028 scopus 로고    scopus 로고
    • Human occludin is a hepatitis C virus entry factor required for infection of mouse cells
    • Ploss A, Evans MJ, Gaysinskaya VA, Panis M, You H, de Jong YP & Rice CM (2009) Human occludin is a hepatitis C virus entry factor required for infection of mouse cells. Nature 457: 882-886.
    • (2009) Nature , vol.457 , pp. 882-886
    • Ploss, A.1    Evans, M.J.2    Gaysinskaya, V.A.3    Panis, M.4    You, H.5    de Jong, Y.P.6    Rice, C.M.7
  • 132
    • 77958487999 scopus 로고    scopus 로고
    • New insights into structure and replication of the hepatitis C virus and clinical implications
    • Poenisch M & Bartenschlager R (2010) New insights into structure and replication of the hepatitis C virus and clinical implications. Semin Liver Dis 30: 333-347.
    • (2010) Semin Liver Dis , vol.30 , pp. 333-347
    • Poenisch, M.1    Bartenschlager, R.2
  • 133
    • 27144513392 scopus 로고    scopus 로고
    • Quantitative analysis of the hepatitis C virus replication complex
    • Quinkert D, Bartenschlager R & Lohmann V (2005) Quantitative analysis of the hepatitis C virus replication complex. J Virol 79: 13594-13605.
    • (2005) J Virol , vol.79 , pp. 13594-13605
    • Quinkert, D.1    Bartenschlager, R.2    Lohmann, V.3
  • 134
    • 33947407689 scopus 로고    scopus 로고
    • Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression
    • Radziewicz H, Ibegbu CC, Fernandez ML et al. (2007) Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression. J Virol 81: 2545-2553.
    • (2007) J Virol , vol.81 , pp. 2545-2553
    • Radziewicz, H.1    Ibegbu, C.C.2    Fernandez, M.L.3
  • 135
    • 53749083074 scopus 로고    scopus 로고
    • Impaired hepatitis C virus (HCV)-specific effector CD8+ T cells undergo massive apoptosis in the peripheral blood during acute HCV infection and in the liver during the chronic phase of infection
    • Radziewicz H, Ibegbu CC, Hon H et al. (2008) Impaired hepatitis C virus (HCV)-specific effector CD8+ T cells undergo massive apoptosis in the peripheral blood during acute HCV infection and in the liver during the chronic phase of infection. J Virol 82: 9808-9822.
    • (2008) J Virol , vol.82 , pp. 9808-9822
    • Radziewicz, H.1    Ibegbu, C.C.2    Hon, H.3
  • 136
    • 36348940608 scopus 로고    scopus 로고
    • Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures
    • Randall RE & Goodbourn S (2008) Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. J Gen Virol 89: 1-47.
    • (2008) J Gen Virol , vol.89 , pp. 1-47
    • Randall, R.E.1    Goodbourn, S.2
  • 137
    • 34247256105 scopus 로고    scopus 로고
    • Influence of inhibitory killer immunoglobulin-like receptors and their HLA-C ligands on resolving hepatitis C virus infection
    • Rauch A, Laird R, McKinnon E, Telenti A, Furrer H, Weber R, Smillie D, Gaudieri S & Swiss HIV CS (2007) Influence of inhibitory killer immunoglobulin-like receptors and their HLA-C ligands on resolving hepatitis C virus infection. Tissue Antigens 69(Suppl 1): 237-240.
    • (2007) Tissue Antigens , vol.69 , Issue.SUPPL. 1 , pp. 237-240
    • Rauch, A.1    Laird, R.2    McKinnon, E.3    Telenti, A.4    Furrer, H.5    Weber, R.6    Smillie, D.7    Gaudieri, S.8    Swiss HIV, C.S.9
  • 138
    • 70350048559 scopus 로고    scopus 로고
    • Divergent adaptation of hepatitis C virus genotypes 1 and 3 to human leukocyte antigen-restricted immune pressure
    • Rauch A, James I, Pfafferott K et al. (2009) Divergent adaptation of hepatitis C virus genotypes 1 and 3 to human leukocyte antigen-restricted immune pressure. Hepatology 50: 1017-1029.
    • (2009) Hepatology , vol.50 , pp. 1017-1029
    • Rauch, A.1    James, I.2    Pfafferott, K.3
  • 139
    • 22344447485 scopus 로고    scopus 로고
    • Divergent and convergent evolution after a common-source outbreak of hepatitis C virus
    • Ray SC, Fanning L, Wang XH, Netski DM, Kenny-Walsh E & Thomas DL (2005) Divergent and convergent evolution after a common-source outbreak of hepatitis C virus. J Exp Med 201: 1753-1759.
    • (2005) J Exp Med , vol.201 , pp. 1753-1759
    • Ray, S.C.1    Fanning, L.2    Wang, X.H.3    Netski, D.M.4    Kenny-Walsh, E.5    Thomas, D.L.6
  • 140
    • 68849111675 scopus 로고    scopus 로고
    • Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence
    • Rehermann B (2009) Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence. J Clin Invest 119: 1745-1754.
    • (2009) J Clin Invest , vol.119 , pp. 1745-1754
    • Rehermann, B.1
  • 143
    • 79958121692 scopus 로고    scopus 로고
    • CD8(+)T-cell response promotes evolution of hepatitis C virus nonstructural proteins
    • Ruhl M, Knuschke T, Schewior K et al. (2011) CD8(+)T-cell response promotes evolution of hepatitis C virus nonstructural proteins. Gastroenterology 140: 2064-2073.
    • (2011) Gastroenterology , vol.140 , pp. 2064-2073
    • Ruhl, M.1    Knuschke, T.2    Schewior, K.3
  • 144
    • 19944366276 scopus 로고    scopus 로고
    • Regulatory T cells suppress in vitro proliferation of virus-specific CD8+ T cells during persistent hepatitis C virus infection
    • Rushbrook SM, Ward SM, Unitt E, Vowler SL, Lucas M, Klenerman P & Alexander GJ (2005) Regulatory T cells suppress in vitro proliferation of virus-specific CD8+ T cells during persistent hepatitis C virus infection. J Virol 79: 7852-7859.
    • (2005) J Virol , vol.79 , pp. 7852-7859
    • Rushbrook, S.M.1    Ward, S.M.2    Unitt, E.3    Vowler, S.L.4    Lucas, M.5    Klenerman, P.6    Alexander, G.J.7
  • 145
    • 79960485199 scopus 로고    scopus 로고
    • Neutralizing monoclonal antibodies against hepatitis C virus E2 protein bind discontinuous epitopes and inhibit infection at a postattachment step
    • Sabo MC, Luca VC, Prentoe J et al. (2011) Neutralizing monoclonal antibodies against hepatitis C virus E2 protein bind discontinuous epitopes and inhibit infection at a postattachment step. J Virol 85: 7005-7019.
    • (2011) J Virol , vol.85 , pp. 7005-7019
    • Sabo, M.C.1    Luca, V.C.2    Prentoe, J.3
  • 146
    • 47949092573 scopus 로고    scopus 로고
    • Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA
    • Saito T, Owen DM, Jiang F, Marcotrigiano J & Gale Jr M (2008) Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA. Nature 454: 523-527.
    • (2008) Nature , vol.454 , pp. 523-527
    • Saito, T.1    Owen, D.M.2    Jiang, F.3    Marcotrigiano, J.4    Gale Jr, M.5
  • 147
    • 77953601881 scopus 로고    scopus 로고
    • Regulation of innate immune responses by autophagy-related proteins
    • Saitoh T & Akira S (2010) Regulation of innate immune responses by autophagy-related proteins. J Cell Biol 189: 925-935.
    • (2010) J Cell Biol , vol.189 , pp. 925-935
    • Saitoh, T.1    Akira, S.2
  • 149
    • 58149333128 scopus 로고    scopus 로고
    • Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy
    • Sarasin-Filipowicz M, Krol J, Markiewicz I, Heim MH & Filipowicz W (2009) Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy. Nat Med 15: 31-33.
    • (2009) Nat Med , vol.15 , pp. 31-33
    • Sarasin-Filipowicz, M.1    Krol, J.2    Markiewicz, I.3    Heim, M.H.4    Filipowicz, W.5
  • 150
    • 52949111844 scopus 로고    scopus 로고
    • Inteferons pen the JAK-STAT pathway
    • Schindler C & Plumlee C (2008) Inteferons pen the JAK-STAT pathway. Semin Cell Dev Biol 19: 311-318.
    • (2008) Semin Cell Dev Biol , vol.19 , pp. 311-318
    • Schindler, C.1    Plumlee, C.2
  • 151
    • 79958076040 scopus 로고    scopus 로고
    • Dual function of the NK cell receptor 2B4 (CD244) in the regulation of HCV-specific CD8+ T cells
    • Schlaphoff V, Lunemann S, Suneetha PV et al. (2011) Dual function of the NK cell receptor 2B4 (CD244) in the regulation of HCV-specific CD8+ T cells. PLoS Pathog 7: e1002045.
    • (2011) PLoS Pathog , vol.7
    • Schlaphoff, V.1    Lunemann, S.2    Suneetha, P.V.3
  • 152
    • 68049089651 scopus 로고    scopus 로고
    • Recognition of 5′ triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus
    • Schlee M, Roth A, Hornung V et al. (2009) Recognition of 5′ triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus. Immunity 31: 25-34.
    • (2009) Immunity , vol.31 , pp. 25-34
    • Schlee, M.1    Roth, A.2    Hornung, V.3
  • 153
    • 67749133995 scopus 로고    scopus 로고
    • 5′-Triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I
    • Schmidt A, Schwerd T, Hamm W et al. (2009) 5′-Triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I. P Natl Acad Sci USA 106: 12067-12072.
    • (2009) P Natl Acad Sci USA , vol.106 , pp. 12067-12072
    • Schmidt, A.1    Schwerd, T.2    Hamm, W.3
  • 154
    • 79953858550 scopus 로고    scopus 로고
    • Host genetics in immune-mediated hepatitis C virus clearance
    • Schmidt J, Thimme R & Neumann-Haefelin C (2011) Host genetics in immune-mediated hepatitis C virus clearance. Biomark Med 5: 155-169.
    • (2011) Biomark Med , vol.5 , pp. 155-169
    • Schmidt, J.1    Thimme, R.2    Neumann-Haefelin, C.3
  • 156
    • 24744453723 scopus 로고    scopus 로고
    • Broad repertoire of the CD4+ Th cell response in spontaneously controlled hepatitis C virus infection includes dominant and highly promiscuous epitopes
    • Schulze Zur Wiesch J, Lauer GM, Day CL et al. (2005) Broad repertoire of the CD4+ Th cell response in spontaneously controlled hepatitis C virus infection includes dominant and highly promiscuous epitopes. J Immunol 175: 3603-3613.
    • (2005) J Immunol , vol.175 , pp. 3603-3613
    • Schulze Zur Wiesch, J.1    Lauer, G.M.2    Day, C.L.3
  • 157
    • 4043148744 scopus 로고    scopus 로고
    • Hepatitis C virus mutation affects proteasomal epitope processing
    • Seifert U, Liermann H, Racanelli V et al. (2004) Hepatitis C virus mutation affects proteasomal epitope processing. J Clin Invest 114: 250-259.
    • (2004) J Clin Invest , vol.114 , pp. 250-259
    • Seifert, U.1    Liermann, H.2    Racanelli, V.3
  • 159
    • 79251522151 scopus 로고    scopus 로고
    • Hepatitis C virus (HCV) evades NKG2D-dependent NK cell responses through NS5A-mediated imbalance of inflammatory cytokines
    • Sene D, Levasseur F, Abel M et al. (2010) Hepatitis C virus (HCV) evades NKG2D-dependent NK cell responses through NS5A-mediated imbalance of inflammatory cytokines. PLoS Pathog 6: e1001184.
    • (2010) PLoS Pathog , vol.6
    • Sene, D.1    Levasseur, F.2    Abel, M.3
  • 160
    • 23944506014 scopus 로고    scopus 로고
    • Global epidemiology of hepatitis C virus infection
    • Shepard CW, Finelli L & Alter MJ (2005) Global epidemiology of hepatitis C virus infection. Lancet Infect Dis 5: 558-567.
    • (2005) Lancet Infect Dis , vol.5 , pp. 558-567
    • Shepard, C.W.1    Finelli, L.2    Alter, M.J.3
  • 161
    • 0037236826 scopus 로고    scopus 로고
    • IL-28, IL-29 and their class II cytokine receptor IL-28R
    • Sheppard P, Kindsvogel W, Xu W et al. (2003) IL-28, IL-29 and their class II cytokine receptor IL-28R. Nat Immunol 4: 63-68.
    • (2003) Nat Immunol , vol.4 , pp. 63-68
    • Sheppard, P.1    Kindsvogel, W.2    Xu, W.3
  • 162
    • 80051521537 scopus 로고    scopus 로고
    • Delayed induction, not impaired recruitment of specific CD8(+) T cells, causes the late onset of acute hepatitis C
    • Shin EC, Park SH, Demino M et al. (2011) Delayed induction, not impaired recruitment of specific CD8(+) T cells, causes the late onset of acute hepatitis C. Gastroenterology 141: 686-695.
    • (2011) Gastroenterology , vol.141 , pp. 686-695
    • Shin, E.C.1    Park, S.H.2    Demino, M.3
  • 164
    • 79251512287 scopus 로고    scopus 로고
    • Knockdown of autophagy enhances the innate immune response in hepatitis C virus-infected hepatocytes
    • Shrivastava S, Raychoudhuri A, Steele R, Ray R & Ray RB (2011) Knockdown of autophagy enhances the innate immune response in hepatitis C virus-infected hepatocytes. Hepatology 53: 406-414.
    • (2011) Hepatology , vol.53 , pp. 406-414
    • Shrivastava, S.1    Raychoudhuri, A.2    Steele, R.3    Ray, R.4    Ray, R.B.5
  • 165
    • 23444461182 scopus 로고    scopus 로고
    • Regulation of gene-activation pathways by PIAS proteins in the immune system
    • Shuai K & Liu B (2005) Regulation of gene-activation pathways by PIAS proteins in the immune system. Nat Rev Immunol 5: 593-605.
    • (2005) Nat Rev Immunol , vol.5 , pp. 593-605
    • Shuai, K.1    Liu, B.2
  • 166
    • 73849087396 scopus 로고    scopus 로고
    • Autophagy in viral replication and pathogenesis
    • Sir D & Ou JH (2010) Autophagy in viral replication and pathogenesis. Mol Cells 29: 1-7.
    • (2010) Mol Cells , vol.29 , pp. 1-7
    • Sir, D.1    Ou, J.H.2
  • 167
    • 54449101892 scopus 로고    scopus 로고
    • Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein response
    • Sir D, Chen WL, Choi J, Wakita T, Yen TS & Ou JH (2008) Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein response. Hepatology 48: 1054-1061.
    • (2008) Hepatology , vol.48 , pp. 1054-1061
    • Sir, D.1    Chen, W.L.2    Choi, J.3    Wakita, T.4    Yen, T.S.5    Ou, J.H.6
  • 169
    • 30944431676 scopus 로고    scopus 로고
    • Relation between viral fitness and immune escape within the hepatitis C virus protease
    • Soderholm J, Ahlen G, Kaul A et al. (2006) Relation between viral fitness and immune escape within the hepatitis C virus protease. Gut 55: 266-274.
    • (2006) Gut , vol.55 , pp. 266-274
    • Soderholm, J.1    Ahlen, G.2    Kaul, A.3
  • 170
    • 42949160129 scopus 로고    scopus 로고
    • IFN-lambda (IFN-lambda) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo
    • Sommereyns C, Paul S, Staeheli P & Michiels T (2008) IFN-lambda (IFN-lambda) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo. PLoS Pathog 4: e1000017.
    • (2008) PLoS Pathog , vol.4
    • Sommereyns, C.1    Paul, S.2    Staeheli, P.3    Michiels, T.4
  • 172
    • 77951861128 scopus 로고    scopus 로고
    • Interferon-alpha-induced TRAIL on natural killer cells is associated with control of hepatitis C virus infection
    • Stegmann KA, Björkström NK, Veber H et al. (2010) Interferon-alpha-induced TRAIL on natural killer cells is associated with control of hepatitis C virus infection. Gastroenterology 138: 1885-1897.
    • (2010) Gastroenterology , vol.138 , pp. 1885-1897
    • Stegmann, K.A.1    Björkström, N.K.2    Veber, H.3
  • 173
    • 0037180553 scopus 로고    scopus 로고
    • Genomic analysis of the host response to hepatitis C virus infection
    • Su AI, Pezacki JP, Wodicka L et al. (2002) Genomic analysis of the host response to hepatitis C virus infection. P Natl Acad Sci USA 99: 15669-15674.
    • (2002) P Natl Acad Sci USA , vol.99 , pp. 15669-15674
    • Su, A.I.1    Pezacki, J.P.2    Wodicka, L.3
  • 174
    • 0345017746 scopus 로고    scopus 로고
    • Suppression of HCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection
    • Sugimoto K, Ikeda F, Stadanlick J, Nunes FA, Alter HJ & Chang KM (2003) Suppression of HCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection. Hepatology 38: 1437-1448.
    • (2003) Hepatology , vol.38 , pp. 1437-1448
    • Sugimoto, K.1    Ikeda, F.2    Stadanlick, J.3    Nunes, F.A.4    Alter, H.J.5    Chang, K.M.6
  • 175
    • 70349548852 scopus 로고    scopus 로고
    • IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy
    • Suppiah V, Moldovan M, Ahlenstiel G et al. (2009) IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy. Nat Genet 41: 1100-1104.
    • (2009) Nat Genet , vol.41 , pp. 1100-1104
    • Suppiah, V.1    Moldovan, M.2    Ahlenstiel, G.3
  • 176
    • 84859433654 scopus 로고    scopus 로고
    • Myeloid suppressor cells induced by hepatitis C virus suppress T cell responses through the production of reactive oxygen species
    • in press.
    • Tacke R, Lee HC, Goh C, Courtney J, Polyak SJ, Rosen HR & Hahn YS (2011) Myeloid suppressor cells induced by hepatitis C virus suppress T cell responses through the production of reactive oxygen species. Hepatology in press.
    • (2011) Hepatology
    • Tacke, R.1    Lee, H.C.2    Goh, C.3    Courtney, J.4    Polyak, S.J.5    Rosen, H.R.6    Hahn, Y.S.7
  • 178
    • 0034030136 scopus 로고    scopus 로고
    • Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C
    • Takaki A, Wiese M, Maertens G, Depla E, Seifert U, Liebetrau A, Miller JL, Manns MP & Rehermann B (2000) Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C. Nat Med 6: 578-582.
    • (2000) Nat Med , vol.6 , pp. 578-582
    • Takaki, A.1    Wiese, M.2    Maertens, G.3    Depla, E.4    Seifert, U.5    Liebetrau, A.6    Miller, J.L.7    Manns, M.P.8    Rehermann, B.9
  • 179
    • 70349533037 scopus 로고    scopus 로고
    • Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C
    • Tanaka Y, Nishida N, Sugiyama M et al. (2009) Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. Nat Genet 41: 1105-1109.
    • (2009) Nat Genet , vol.41 , pp. 1105-1109
    • Tanaka, Y.1    Nishida, N.2    Sugiyama, M.3
  • 180
    • 0036314483 scopus 로고    scopus 로고
    • Hepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathway
    • Tardif KD, Mori K & Siddiqui A (2002) Hepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathway. J Virol 76: 7453-7459.
    • (2002) J Virol , vol.76 , pp. 7453-7459
    • Tardif, K.D.1    Mori, K.2    Siddiqui, A.3
  • 181
    • 0033516497 scopus 로고    scopus 로고
    • Inhibition of the interferon-inducible protein kinase PKR by HCV E protein
    • Taylor DR, Shi ST, Romano PR, Barber GN & Lai MC (1999) Inhibition of the interferon-inducible protein kinase PKR by HCV E protein. Science 285: 107-110.
    • (1999) Science , vol.285 , pp. 107-110
    • Taylor, D.R.1    Shi, S.T.2    Romano, P.R.3    Barber, G.N.4    Lai, M.C.5
  • 182
    • 18144401994 scopus 로고    scopus 로고
    • New antiviral pathway that mediates hepatitis C virus replicon interferon sensitivity through ADAR1
    • Taylor DR, Puig M, Darnell ME, Mihalik K & Feinstone SM (2005) New antiviral pathway that mediates hepatitis C virus replicon interferon sensitivity through ADAR1. J Virol 79: 6291-6298.
    • (2005) J Virol , vol.79 , pp. 6291-6298
    • Taylor, D.R.1    Puig, M.2    Darnell, M.E.3    Mihalik, K.4    Feinstone, S.M.5
  • 184
    • 0035914925 scopus 로고    scopus 로고
    • Determinants of viral clearance and persistence during acute hepatitis C virus infection
    • Thimme R, Oldach D, Chang KM, Steiger C, Ray SC & Chisari FV (2001) Determinants of viral clearance and persistence during acute hepatitis C virus infection. J Exp Med 194: 1395-1406.
    • (2001) J Exp Med , vol.194 , pp. 1395-1406
    • Thimme, R.1    Oldach, D.2    Chang, K.M.3    Steiger, C.4    Ray, S.C.5    Chisari, F.V.6
  • 186
    • 0036010981 scopus 로고    scopus 로고
    • HLA-Cw*04 and hepatitis C virus persistence
    • Thio CL, Gao X, Goedert JJ et al. (2002) HLA-Cw*04 and hepatitis C virus persistence. J Virol 76: 4792-4797.
    • (2002) J Virol , vol.76 , pp. 4792-4797
    • Thio, C.L.1    Gao, X.2    Goedert, J.J.3
  • 187
    • 70349966196 scopus 로고    scopus 로고
    • Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
    • Thomas DL, Thio CL, Martin MP et al. (2009) Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature 461: 798-801.
    • (2009) Nature , vol.461 , pp. 798-801
    • Thomas, D.L.1    Thio, C.L.2    Martin, M.P.3
  • 188
    • 19944428565 scopus 로고    scopus 로고
    • CD8 epitope escape and reversion in acute HCV infection
    • Timm J, Lauer GM, Kavanagh DG et al. (2004) CD8 epitope escape and reversion in acute HCV infection. J Exp Med 200: 1593-1604.
    • (2004) J Exp Med , vol.200 , pp. 1593-1604
    • Timm, J.1    Lauer, G.M.2    Kavanagh, D.G.3
  • 189
    • 34548304730 scopus 로고    scopus 로고
    • Human leukocyte antigen-associated sequence polymorphisms in hepatitis C virus reveal reproducible immune responses and constraints on viral evolution
    • Timm J, Li B, Daniels MG et al. (2007) Human leukocyte antigen-associated sequence polymorphisms in hepatitis C virus reveal reproducible immune responses and constraints on viral evolution. Hepatology 46: 339-349.
    • (2007) Hepatology , vol.46 , pp. 339-349
    • Timm, J.1    Li, B.2    Daniels, M.G.3
  • 190
    • 38649100951 scopus 로고    scopus 로고
    • Hepatitis C virus cell-cell transmission in hepatoma cells in the presence of neutralizing antibodies
    • Timpe JM, Stamataki Z, Jennings A et al. (2008) Hepatitis C virus cell-cell transmission in hepatoma cells in the presence of neutralizing antibodies. Hepatology 47: 17-24.
    • (2008) Hepatology , vol.47 , pp. 17-24
    • Timpe, J.M.1    Stamataki, Z.2    Jennings, A.3
  • 191
    • 0037033363 scopus 로고    scopus 로고
    • Binding of the hepatitis C virus envelope protein E2 to CD81 inhibits natural killer cell functions
    • Tseng CT & Klimpel GR (2002) Binding of the hepatitis C virus envelope protein E2 to CD81 inhibits natural killer cell functions. J Exp Med 195: 43-49.
    • (2002) J Exp Med , vol.195 , pp. 43-49
    • Tseng, C.T.1    Klimpel, G.R.2
  • 192
    • 28244493685 scopus 로고    scopus 로고
    • The impairment of CD8 responses limits the selection of escape mutations in acute hepatitis C virus infection
    • Urbani S, Amadei B, Cariani E, Fisicaro P, Orlandini A, Missale G & Ferrari C (2005) The impairment of CD8 responses limits the selection of escape mutations in acute hepatitis C virus infection. J Immunol 175: 7519-7529.
    • (2005) J Immunol , vol.175 , pp. 7519-7529
    • Urbani, S.1    Amadei, B.2    Cariani, E.3    Fisicaro, P.4    Orlandini, A.5    Missale, G.6    Ferrari, C.7
  • 193
    • 66149114745 scopus 로고    scopus 로고
    • Nucleotide sequences and modifications that determine RIG-I/RNA binding and signaling activities
    • Uzri D & Gehrke L (2009) Nucleotide sequences and modifications that determine RIG-I/RNA binding and signaling activities. J Virol 83: 4174-4184.
    • (2009) J Virol , vol.83 , pp. 4174-4184
    • Uzri, D.1    Gehrke, L.2
  • 194
    • 78049393044 scopus 로고    scopus 로고
    • Adaptive immunity to the hepatitis C virus
    • Walker CM (2010) Adaptive immunity to the hepatitis C virus. Adv Virus Res 78: 43-86.
    • (2010) Adv Virus Res , vol.78 , pp. 43-86
    • Walker, C.M.1
  • 195
    • 0037379437 scopus 로고    scopus 로고
    • Alpha interferon induces distinct translational control programs to suppress hepatitis C virus RNA replication
    • Wang C, Pflugheber J, Sumpter Jr R, Sodora DL, Hui D, Sen GC & Gale Jr M (2003) Alpha interferon induces distinct translational control programs to suppress hepatitis C virus RNA replication. J Virol 77: 3898-3912.
    • (2003) J Virol , vol.77 , pp. 3898-3912
    • Wang, C.1    Pflugheber, J.2    Sumpter Jr, R.3    Sodora, D.L.4    Hui, D.5    Sen, G.C.6    Gale Jr, M.7
  • 199
    • 79957597757 scopus 로고    scopus 로고
    • Mitochondria in innate immune responses
    • West AP, Shadel GS & Ghosh S (2011) Mitochondria in innate immune responses. Nat Rev Immunol 11: 389-402.
    • (2011) Nat Rev Immunol , vol.11 , pp. 389-402
    • West, A.P.1    Shadel, G.S.2    Ghosh, S.3
  • 200
    • 59849121683 scopus 로고    scopus 로고
    • CD81 is dispensable for hepatitis C virus cell-to-cell transmission in hepatoma cells
    • Witteveldt J, Evans MJ, Bitzegeio J et al. (2009) CD81 is dispensable for hepatitis C virus cell-to-cell transmission in hepatoma cells. J Gen Virol 90: 48-58.
    • (2009) J Gen Virol , vol.90 , pp. 48-58
    • Witteveldt, J.1    Evans, M.J.2    Bitzegeio, J.3
  • 202
    • 34548277125 scopus 로고    scopus 로고
    • Efficient infection of tree shrew (Tupaia belangeri) with hepatitis C virus grown in cell culture or from patient plasma
    • Xu X, Chen H, Cao X & Ben K (2007) Efficient infection of tree shrew (Tupaia belangeri) with hepatitis C virus grown in cell culture or from patient plasma. J Gen Virol 88: 2504-2512.
    • (2007) J Gen Virol , vol.88 , pp. 2504-2512
    • Xu, X.1    Chen, H.2    Cao, X.3    Ben, K.4
  • 203
    • 58049217490 scopus 로고    scopus 로고
    • RNA recognition and signal transduction by RIG-I-like receptors
    • Yoneyama M & Fujita T (2009) RNA recognition and signal transduction by RIG-I-like receptors. Immunol Rev 227: 54-65.
    • (2009) Immunol Rev , vol.227 , pp. 54-65
    • Yoneyama, M.1    Fujita, T.2
  • 204
    • 58949091314 scopus 로고    scopus 로고
    • Natural killer cell function is intact after direct exposure to infectious hepatitis C virions
    • Yoon JC, Shiina M, Ahlenstiel G & Rehermann B (2009) Natural killer cell function is intact after direct exposure to infectious hepatitis C virions. Hepatology 49: 12-21.
    • (2009) Hepatology , vol.49 , pp. 12-21
    • Yoon, J.C.1    Shiina, M.2    Ahlenstiel, G.3    Rehermann, B.4
  • 205
    • 34249660614 scopus 로고    scopus 로고
    • SOCS proteins, cytokine signalling and immune regulation
    • Yoshimura A, Naka T & Kubo M (2007) SOCS proteins, cytokine signalling and immune regulation. Nat Rev Immunol 7: 454-465.
    • (2007) Nat Rev Immunol , vol.7 , pp. 454-465
    • Yoshimura, A.1    Naka, T.2    Kubo, M.3
  • 206
    • 47149098765 scopus 로고    scopus 로고
    • Host neutralizing responses and pathogenesis of hepatitis C virus infection
    • Zeisel MB, Cosset FL & Baumert TF (2008) Host neutralizing responses and pathogenesis of hepatitis C virus infection. Hepatology 48: 299-307.
    • (2008) Hepatology , vol.48 , pp. 299-307
    • Zeisel, M.B.1    Cosset, F.L.2    Baumert, T.F.3
  • 207
    • 79951669627 scopus 로고    scopus 로고
    • Hepatitis C virus entry into hepatocytes: molecular mechanisms and targets for antiviral therapies
    • Zeisel MB, Fofana I, Fafi-Kremer S & Baumert TF (2011) Hepatitis C virus entry into hepatocytes: molecular mechanisms and targets for antiviral therapies. J Hepatol 54: 566-576.
    • (2011) J Hepatol , vol.54 , pp. 566-576
    • Zeisel, M.B.1    Fofana, I.2    Fafi-Kremer, S.3    Baumert, T.F.4
  • 209
    • 34948827431 scopus 로고    scopus 로고
    • Hepatitis C virus lymphotropism: lessons from a decade of studies
    • Zignego AL, Giannini C, Monti M & Gragnani L (2007) Hepatitis C virus lymphotropism: lessons from a decade of studies. Dig Liver Dis 39(Suppl 1): S38-S45.
    • (2007) Dig Liver Dis , vol.39 , Issue.SUPPL. 1
    • Zignego, A.L.1    Giannini, C.2    Monti, M.3    Gragnani, L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.