Expression of hepatitis C virus proteins inhibits signal transduction through the Jak-STAT pathway

Journal of Virology

Volumn 73, Issue 10, 1999, Pages 8469-8475

  Heim, Markus H ^a,b   Moradpour, Darius ^b   Blum, Hubert E ^b  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; VIRUS PROTEIN;

ARTICLE; CHRONIC LIVER DISEASE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 0032824134     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.10.8469-8475.1999     Document Type: Article

References (51)

1. Alter, M. J. 1997. Epidemiology of hepatitis C. Hepatology 26(SuppI. 1): 62S-65S.
2. Alter, M. J., H. S. Margolis, K. Krawczynski, F. N. Judson, A. Mares, W. J. Alexander, P. Y. Hu, J. K. Miller, M. A. Gerber, R. E. Sampliner, E. L. Meeks, and M. J. Beach. 1992. The natural history of community-acquired hepatitis C in the United States. The Sentinel Counties Chronic non-A, non-B Hepatitis Study Team. N. Engl. J. Med. 327:1899-1905.
3. Baeuerle, P. A., and T. Henkel. 1994. Function and activation of NF-kappaB in the immune system. Annu. Rev. Immunol. 12:141-179.
4. Choo, Q. L., G. Kuo, A. J. Weiner, L. R. Overby, D. W. Bradley, and M. Houghton. 1989. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 244:359-362.
5. Chung, C. D., J. Liao, B. Liu, X. Rao, P. Jay, P. Berta, and K. Shuai. 1997. Specific inhibition of Stat3 signal transduction by PIAS3. Science 278:1803-1805.
6. Darnell, J. E., Jr., I. M. Kerr, and G. R. Stark. 1994. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415-1421.
7. Endo, T. A., M. Masuhara, M. Yokouchi, R. Suzuki, H. Sakamoto, K. Mitsui, A. Matsumoto, S. Tanimura, M. Ohtsubo, H. Misawa, T. Miyazaki, N. Leonor, T. Taniguchi, T. Fujita, Y. Kanakura, S. Komlya, and A. Yoshimura. 1997. A new protein containing an SH2 domain that inhibits JAK kinases. Nature 387:921-924.
8. Englert, C., X. Hou, S. Maheswaran, P. Bennett, C. Ngwu, G. G. Re, A. J. Garvin, M. R. Rosner, and D. A. Haber. 1995. WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis. EMBO J. 14: 4662-4675.
9. Foster, G. R., A. M. Ackrill, R. D. Goldin, I. M. Kerr, H. C. Thomas, and G. R. Stark. 1991. Expression of the terminal protein region of hepatitis B virus inhibits cellular responses to interferons alpha and gamma and double-stranded RNA. Proc. Natl. Acad. Sci. USA 88:2888-2892. (Erratum, 92: 3632, 1995.)
10. Fu, X. Y., C. Schindler, T. Improta, R. Aebersold, and J. E. Darnell, Jr. 1992. The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction. Proc. Natl. Acad. Sci. USA 89:7840-7843.
11. Gale, M. J., Jr., M. J. Korth, N. M. Tang, S.-L. Tan, D. A. Hopkins, T. E. Dever, S. J. Polyak, D. R. Gretch, and M. G. Katze. 1997. Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein. Virology 230:217-227.
12. Gale, M. J., Jr., C. M. Blakely, B. Kwiecisztwski, S. L. Tan, M. Dossett, N. M. Tang, M. J. Korth, S. J. Polyak, D. R Gretch, and M. G. Katze. 1998. Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation. Mol. Cell. Biol. 18:5208-5218.
13. Gossen, M., and H. Bujard. 1992. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. USA 89:5547-5551.
14. Grakoui, A., C. Wychowski, C. Lin, S. M. Feinstone, and C. M. Rice. 1993. Expression and identification of hepatitis C virus polyprotein cleavage products. J. Virol. 67:1385-1395.
15. Haspel, R. L., M. Saldittgeorgieff, and J. E. Darnell, Jr. 1996. The rapid inactivation of nuclear tyrosine phosphorylated Stal1 depends upon a protein tyrosine phosphatase. EMBO J. 15:6262-6268.
16. Heim, M. H. 1996. The Jak-Stat pathway - specific signal transduction from the cell membrane to the nucleus. Eur. J. Clin. Invest. 26:1-12.
17. Heim, M. H., I. M. Kerr, G. R. Stark, and J. E. Darnell, Jr. 1995. Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway. Science 267:1347-1349.
18. Hoofnagle, J. H., and A. M. di Bisceglie. 1997. The treatment of chronic viral hepatitis. N. Engl. J. Med. 336:347-356.
19. Ihle, J. N. 1996. Stats - signal transducers and activators of transcription. Cell 84:331-334.
20. Kim, T. K., and T. Maniatis. 1996. Regulation of interferon-gamrna-activated Stat1 by the ubiquitin-proteasome pathway. Science 273:1717-1719.
21. Krawczynski, K., M. J. Beach, D. W. Bradley, G. Kuo, A. M. Di Bisceglie, M. Houghton, G. R. Reyes, J. P. Kim, Q. L. Choo, and M. J. Alter. 1992. Hepatitis C virus antigen in hepalocytes: immunomorphological detection and identification. Gastroenterology 103:622-629.
22. Kuo, G., Q. L. Choo, H. J. Alter, G. L. Gitnick, A. G. Redeker, R. H. Purcell, T. Miyamura, J. L. Dienstag, M. J. Alter, and C. E. Stevens. 1989. An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science 244:362-364.
23. Lehtonen, A., S. Maitikainen, and I. Julkunen. 1997. Interferons up-regulate STAT1, STAT2, and IRF family transcription factor gene expression in human peripheral blood mononuclear cells and macrophages. J. Immunol. 159:794-803.
24. Lutfalla, G., S. J. Holland, E. Cinato, D. Monneron, J. Reboul, N. C. Rogers, J. M. Smith, G. R. Stark, K. Gardiner, K. E. Mogensen, I. M. Kerr, and G. Uź. 1995. Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster. EMBO J. 14:5100-5108.
25. Meurs, E., K. Chong, J. Galabru, N. S. Thomas, I. M. Kerr, B. R. Williams, and A. G. Hovanessian. 1990. Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon. Cell 62:379-390.
26. Miller, D. M., B. M. Rahill, J. M. Boss, M. D. Lairmore, J. E. Durbin, J. W. Waldman, and D. D. Sedmak. 1998. Human cytomegalovirus inhibits major histocompatibility complex class II expression by disruption of the Jak/Stat pathway. J. Exp. Med. 187:675-683.
27. Moradpour, D., C. Englert, T. Wakita, and J. R. Wands. 1996. Characterization of cell lines allowing tightly regulated expression of hepatitis C virus core protein. Virology 222:51-63.
28. Moradpour, D., P. Kary, C. M. Rice, and H. E. Blum. 1998. Continuous human cell lines inducibly expressing hepatitis C virus structural and non-structural proteins. Hepatology 28:192-201.
29. Moradpour, D., and H. E. Blum. 1999. Current and evolving therapies for hepatitis C. Eur. J. Gastroenterol. Hepatol. 11:1-3.
30. Moradpour, D., and H. E. Blum. Unpublished data.
31. Naka, T., M. Narazaki, M. Hirata, T. Matsumoto, S. Minamoto, A. Aono, N. Nishimoto, T. Kajita, T. Taga, K. Yoshizaki, S. Akira, and T. Kishimoto. 1997. Structure and function of a new STAT-induced STAT inhibitor. Nature 387:924-929.
32. Podevin, P., J. Guechot, L. Serfaty, L. Monrand-Joubert, C. Veyrunes, M. T. Bonnefis, and R. Poupon. 1997. Evidence for a deficiency of interferon response in mononuclear cells from hepatitis C viremic patients. J. Hepatol. 27:265-271.
33. Poynard, T., V. Leroy, M. Cohard, T. Thevenot, P. Mathurin, P. Opolon, and J. P. Zarski. 1996. Meta-analysis of interferon randomized trials in the treatment of viral hepatitis C: effects of dose and duration. Hepatology 24:778-789.
34. Qureshi, S. A., M. Salditt-Georgieff, and J. E. Darnell, Jr. 1995. Tyrosine-phosphorylated Stat1 and Stat2 plus a 48-kDa protein all contact DNA in forming interferon-stimulated-gene factor 3. Proc. Natl. Acad. Sci. USA 92:3829-3833.
35. Reich, N., B. Evans, D. Levy, D. Fahey, E. J. Knight, and J. E. Darnell. Jr. 1987. Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element. Proc. Natl. Acad. Sci. USA 84:6394-6398.
36. Sansonno, D., and F. Dammacco. 1993. Hepatitis C virus C100 antigen in liver tissue from patients with acute and chronic infection. Hepatology 18: 240-245.
37. Schindler, C., K. Shuai, V. R. Prezioso, and J. E. Darnell, Jr. 1992. Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science 257:809-813.
38. Schmit, M. L., A. Indorf, F. P. Limbourg, H. Stadtler, E. B. Traenckner, and P. A. Baeuerle. 1996. The dual effect of adenovirus type 5 E1A 13S protein on NF-κB activation is antagonized by E1B 19K. Mol. Cell. Biol. 16:4052-4063.
39. Sen, G. C., and P. Lengyel. 1992. The interferon system. A bird's eye view of its biochemistry. J. Biol. Chem. 267:5017-5020.
40. Shual, K., C. M. Horvath, L. H. Huang, S. A. Qureshi, D. Cowburn, and J. E. Darnell, Jr. 1994. Interferon activation of the transcription factor Stat1 involves dimerization through SH2-phosphotyrosyl peptide interactions. Cell 76:821-828.
41. Shuai, K., G. R. Stark, I. M. Kerr, and J. E. Darnell Jr. 1993. A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma. Science 161:1744-1746.
42. Silvennoinen, O., C. Schindler, J. Schlessinger, and D. E. Levy. 1993. Rasindependent growth factor signaling by transcription factor tyrosine phosphorylation. Science 261:1736-1739.
43. Starr, R., T. A. Willson, E. M. Viney, L. J. Murray, J. R. Rayner, B. J. Jenkins, T. J. Gonda, W. S. Alexander, D. Metcalf, N. A. Nicola, and D. J. Hilton. 1997. A family of cytokine-inducibie inhibitors of signalling. Nature 387:917-921.
44. Symons, J. A., A. Alcami, and G. L. Smith. 1995. Vaccinia virus encodes a soluble type I interferon receptor of novel structure and broad species specificity. Cell 81:551-560.
45. Tong, M. J., N. S. el-Farra, A. R. Reikes, and R. L. Co. 1995. Clinical outcomes after transfusion-associated hepatitis C. N. Engl. J. Med. 332: 1463-1466.
46. Velazquez, L., M. Fellous, G. R. Stark, and S. Pellegrini. 1992. A protein tyrosine kinase in the interferon alpha/beta signaling pathway. Cell 70:313-322.
47. Verma, I. M., J. K. Stevenson, E. M. Schwarz, D. Van Antwerp, and S. Miyamoto. 1995. Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev. 9:2723-2735.
48. Wagner, B. J., T. E. Hayes, C. J. Hoban, and B. H. Cochran. 1990. The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter. EMBO J. 9:4477-4484.
49. Yan, H., K. Krishnan, A. C. Greenlund, S. Gupta, J. T. E. Lim, R. D. Schreiber, C. W. Schindler, and J. J. Krolewski. 1996. Phosphorated interferon-alpha receptor 1 subunit (IFNAR1) acts as a docking site for the latent form of the 113 kDa Stat2 protein. EMBO J. 15:1064-1074.
50. Yi, T., and J. N. Ihle. 1993. Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand. Mol. Cell. Biol. 13:3350-3358.
51. Zhong, Z., Z. Wen, and J. E. Darnell, Jr. 1994. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 264:95-98.