메뉴 건너뛰기




Volumn 76, Issue 2, 2007, Pages 194-197

HCV structural proteins interfere with interferon-alpha Jak/STAT signalling pathway

Author keywords

HCV; Interferon; Interferon stimulated genes; Replicon; STAT phosphorylation

Indexed keywords

ALPHA INTERFERON; ALPHA2B INTERFERON; GAMMA INTERFERON; JANUS KINASE; RIBAVIRIN; STAT PROTEIN; STAT1 PROTEIN; STAT2 PROTEIN; STAT3 PROTEIN; STRUCTURAL PROTEIN; VIRUS PROTEIN;

EID: 34548648264     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.antiviral.2007.06.004     Document Type: Article
Times cited : (27)

References (23)
  • 3
    • 15244346528 scopus 로고    scopus 로고
    • Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon
    • Breiman A., Grandvaux N., Lin R., Ottone C., Akira S., Yoneyama M., Fujita T., Hiscott J., and Meurs E.F. Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon. J. Virol. 79 (2005) 3969-3978
    • (2005) J. Virol. , vol.79 , pp. 3969-3978
    • Breiman, A.1    Grandvaux, N.2    Lin, R.3    Ottone, C.4    Akira, S.5    Yoneyama, M.6    Fujita, T.7    Hiscott, J.8    Meurs, E.F.9
  • 5
    • 11144342298 scopus 로고    scopus 로고
    • Hepatitis C virus core protein down-regulates transcription of interferon-induced antiviral genes
    • de Lucas S., Bartolomé J., and Carreño C. Hepatitis C virus core protein down-regulates transcription of interferon-induced antiviral genes. J. Infect. Dis. 191 (2005) 93-99
    • (2005) J. Infect. Dis. , vol.191 , pp. 93-99
    • de Lucas, S.1    Bartolomé, J.2    Carreño, C.3
  • 6
    • 29744450126 scopus 로고    scopus 로고
    • Upregulation of protein phosphatase 2Ac by hepatitis C virus modulates NS3 helicase activity through inhibition of protein arginine methyltransferase 1
    • Duong F.H.T., Christen V., Berke J.M., Penna S.H., Moradpour D., and Heim M.H. Upregulation of protein phosphatase 2Ac by hepatitis C virus modulates NS3 helicase activity through inhibition of protein arginine methyltransferase 1. J. Virol. 79 (2005) 15342-15350
    • (2005) J. Virol. , vol.79 , pp. 15342-15350
    • Duong, F.H.T.1    Christen, V.2    Berke, J.M.3    Penna, S.H.4    Moradpour, D.5    Heim, M.H.6
  • 7
    • 0346100572 scopus 로고    scopus 로고
    • Hepatitis C virus inhibits interferon signaling through up-regulation of protein phosphatase 2A
    • Duong F.H.T., Filipowicz M., Tripodi M., La Monica N., and Heim M.H. Hepatitis C virus inhibits interferon signaling through up-regulation of protein phosphatase 2A. Gastroenterology 126 (2004) 263-277
    • (2004) Gastroenterology , vol.126 , pp. 263-277
    • Duong, F.H.T.1    Filipowicz, M.2    Tripodi, M.3    La Monica, N.4    Heim, M.H.5
  • 8
    • 0343924357 scopus 로고    scopus 로고
    • Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein
    • Gale J.M.J., Korth M.J., Tang N.M., Tan S.-L., Hopkins D.A., Dever T.E., Polyak S.J., Gretch D.R., and Katze M.G. Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein. Virology 230 (1997) 217-227
    • (1997) Virology , vol.230 , pp. 217-227
    • Gale, J.M.J.1    Korth, M.J.2    Tang, N.M.3    Tan, S.-L.4    Hopkins, D.A.5    Dever, T.E.6    Polyak, S.J.7    Gretch, D.R.8    Katze, M.G.9
  • 9
    • 1842480410 scopus 로고    scopus 로고
    • Host factors and failure of interferon-α treatment in hepatitis C virus
    • Gao B., Hong F., and Radaeva S. Host factors and failure of interferon-α treatment in hepatitis C virus. Hepatology 39 (2004) 880-890
    • (2004) Hepatology , vol.39 , pp. 880-890
    • Gao, B.1    Hong, F.2    Radaeva, S.3
  • 11
    • 0032824134 scopus 로고    scopus 로고
    • Expression of hepatitis C virus proteins inhibits signal transduction through the Jak-STAT pathway
    • Heim M.H., Moradpour D., and Blum H.E. Expression of hepatitis C virus proteins inhibits signal transduction through the Jak-STAT pathway. J. Virol. 73 (1999) 8469-8475
    • (1999) J. Virol. , vol.73 , pp. 8469-8475
    • Heim, M.H.1    Moradpour, D.2    Blum, H.E.3
  • 12
    • 33746139034 scopus 로고    scopus 로고
    • Altered expression and activation of signal transducers and activators of transcription (STATs) in hepatitis C virus infection: in vivo and in vitro studies
    • Larrea E., Aldabe R., Molano E., Fernandez-Rodriguez C.M., Ametzazurra A., Civeira M.P., and Prieto J. Altered expression and activation of signal transducers and activators of transcription (STATs) in hepatitis C virus infection: in vivo and in vitro studies. Gut 55 (2006) 1188-1196
    • (2006) Gut , vol.55 , pp. 1188-1196
    • Larrea, E.1    Aldabe, R.2    Molano, E.3    Fernandez-Rodriguez, C.M.4    Ametzazurra, A.5    Civeira, M.P.6    Prieto, J.7
  • 15
    • 33748488244 scopus 로고    scopus 로고
    • Hepatitis C virus core protein blocks interferon signaling by interaction with the STAT1 SH2 domain
    • Lin W., Kim S.S., Yeung E., Kamegaya Y., Blackard J.T., Kim K.A., Holtzman M.J., and Chung R.T. Hepatitis C virus core protein blocks interferon signaling by interaction with the STAT1 SH2 domain. J. Virol. 80 (2006) 9226-9235
    • (2006) J. Virol. , vol.80 , pp. 9226-9235
    • Lin, W.1    Kim, S.S.2    Yeung, E.3    Kamegaya, Y.4    Blackard, J.T.5    Kim, K.A.6    Holtzman, M.J.7    Chung, R.T.8
  • 17
    • 33747797031 scopus 로고    scopus 로고
    • Treating viral hepatitis C: efficacy, side effects, and complications
    • Manns M.P., Wedemeyer H., and Cornberg M. Treating viral hepatitis C: efficacy, side effects, and complications. Gut 55 (2006) 1350-1359
    • (2006) Gut , vol.55 , pp. 1350-1359
    • Manns, M.P.1    Wedemeyer, H.2    Cornberg, M.3
  • 18
    • 27144440476 scopus 로고    scopus 로고
    • Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
    • Meylan E., Curran J., Hofmann K., Moradpour D., Binder M., Bartenschlager R., and Tschopp J. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437 (2005) 1167-1172
    • (2005) Nature , vol.437 , pp. 1167-1172
    • Meylan, E.1    Curran, J.2    Hofmann, K.3    Moradpour, D.4    Binder, M.5    Bartenschlager, R.6    Tschopp, J.7
  • 19
    • 18844457095 scopus 로고    scopus 로고
    • Mechanisms of type-I and type-II-interferon-mediated signalling
    • Platanias L.C. Mechanisms of type-I and type-II-interferon-mediated signalling. Nat. Rev. Immunol. 5 (2005) 375-386
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 375-386
    • Platanias, L.C.1
  • 20
    • 0032951754 scopus 로고    scopus 로고
    • The human 2′,5′-oligoadenylate synthetase family: interferon-induced proteins with unique enzymatic properties
    • Rebouillat D., and Hovanessian A.G. The human 2′,5′-oligoadenylate synthetase family: interferon-induced proteins with unique enzymatic properties. J. Interferon Cytokine Res. 19 (1999) 295-308
    • (1999) J. Interferon Cytokine Res. , vol.19 , pp. 295-308
    • Rebouillat, D.1    Hovanessian, A.G.2
  • 21
    • 23944506014 scopus 로고    scopus 로고
    • Global epidemiology of hepatitis C virus infection
    • Shepard C.W., Finelli L., and Alter M.J. Global epidemiology of hepatitis C virus infection. Lancet Infect. Dis. 5 (2005) 558-567
    • (2005) Lancet Infect. Dis. , vol.5 , pp. 558-567
    • Shepard, C.W.1    Finelli, L.2    Alter, M.J.3
  • 22
    • 0033516497 scopus 로고    scopus 로고
    • Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein
    • Taylor D.R., Shi S.T., Romano P.R., Barber G.N., and Lai M.M. Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein. Science 285 (1999) 107-110
    • (1999) Science , vol.285 , pp. 107-110
    • Taylor, D.R.1    Shi, S.T.2    Romano, P.R.3    Barber, G.N.4    Lai, M.M.5
  • 23
    • 32644490562 scopus 로고    scopus 로고
    • A target on the move: innate and adaptive immune escape strategies of hepatitis C virus
    • Thimme R., Lohmann V., and Weber F. A target on the move: innate and adaptive immune escape strategies of hepatitis C virus. Antiviral Res. 69 (2006) 129-141
    • (2006) Antiviral Res. , vol.69 , pp. 129-141
    • Thimme, R.1    Lohmann, V.2    Weber, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.