Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease

Science

Volumn 300, Issue 5622, 2003, Pages 1145-1148

  Foy, Eileen ^a   Li, Kui ^b   Wang, Chunfu ^a   Sumpter Jr , Rhea ^a   Ikeda, Masanori ^b   Lemon, Stanley M ^b   Gale Jr , Michael ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; ENZYME INHIBITION; INTERFERONS; MOLECULES;

PHOSPHORYLATION;

VIRUSES;

AMINOKETONE; ENZYME INHIBITOR; INTERFERON REGULATORY FACTOR 3; SERINE PROTEINASE; VIRUS ENZYME; VIRUS RNA;

DEFENSE MECHANISM; HEPATITIS; HOST;

ARTICLE; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; HEPATITIS C; HEPATITIS C VIRUS; HEPATOMA CELL; HUMAN; HUMAN CELL; MUTATION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; VIRUS REPLICATION;

DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, VIRAL; HEPACIVIRUS; HEPATITIS C; HUMANS; INTERFERON REGULATORY FACTOR-3; INTERFERONS; MUTATION; PHOSPHORYLATION; PROTEASE INHIBITORS; RNA, VIRAL; RNA-BINDING PROTEINS; SERINE ENDOPEPTIDASES; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

HEPATITIS C VIRUS; RNA VIRUSES;

EID: 0037687422     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1082604     Document Type: Article

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30. Supported by NIH grants U01-AI48235 (M.G.) and U19-AI40035 (S.M.L.), the Ellison Medical Foundation (ID-NS-0032), a gift from Mr. and Mrs. R. Batcheldor (M.G.), and a research grant from Schering-Plough (S.M.L.). M.G. is the Nancy C. and Jeffrey A. Marcus Scholar in Medical Research in Honor of Dr. Bill S. VowelL K.L. was supported by the J. W. McLaughlin Fellowship. We thank S. Bogen, M. Murray, and B. Malcolm of the Schering-Plough Research Institute for kindly providing SCH6, and B. Fredericksen, W. Bresnahan, G. Klimpel, and L. Soong for critical review of the manuscript.