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Volumn 47, Issue 6, 2008, Pages 1824-1836

Virological and immunological determinants of intrahepatic virus-specific CD8+ T-cell failure in chronic hepatitis C virus infection

Author keywords

[No Author keywords available]

Indexed keywords

HLA B ANTIGEN; VIRUS PROTEIN; EPITOPE; GAMMA INTERFERON; HLA ANTIGEN;

EID: 46249090636     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.22242     Document Type: Article
Times cited : (103)

References (41)
  • 1
    • 34247612265 scopus 로고    scopus 로고
    • Flying under the radar: The immunobiology of hepatitis C
    • Dustin LB, Rice CM. Flying under the radar: the immunobiology of hepatitis C. Annu Rev Immunol 2007;25:71-99.
    • (2007) Annu Rev Immunol , vol.25 , pp. 71-99
    • Dustin, L.B.1    Rice, C.M.2
  • 3
    • 21344442371 scopus 로고    scopus 로고
    • Comprehensive analyses of CD8+ T cell responses during longitudinal study of acute human hepatitis C
    • Cox AL, Mosbruger T, Lauer GM, Pardoll D, Thomas DL, Ray SC. Comprehensive analyses of CD8+ T cell responses during longitudinal study of acute human hepatitis C. HEPATOLOGY 2005;42:104-112.
    • (2005) HEPATOLOGY , vol.42 , pp. 104-112
    • Cox, A.L.1    Mosbruger, T.2    Lauer, G.M.3    Pardoll, D.4    Thomas, D.L.5    Ray, S.C.6
  • 4
    • 33847067210 scopus 로고    scopus 로고
    • Discordant role of CD4 T-cell response relative to neutralizing antibody and CD8 T-cell responses in acute hepatitis C
    • Kaplan DE, Sugimoto K, Newton K, Valiga ME, Ikeda F, Aytaman A, et al. Discordant role of CD4 T-cell response relative to neutralizing antibody and CD8 T-cell responses in acute hepatitis C. Gastroenterology 2007; 132:654-666.
    • (2007) Gastroenterology , vol.132 , pp. 654-666
    • Kaplan, D.E.1    Sugimoto, K.2    Newton, K.3    Valiga, M.E.4    Ikeda, F.5    Aytaman, A.6
  • 5
    • 17644444485 scopus 로고    scopus 로고
    • Analysis of successful immune responses in persons infected with hepatitis C virus
    • Lechner F, Wong DK, Dunbar PR, Chapman R, Chung RT, Dohrenwend P, et al. Analysis of successful immune responses in persons infected with hepatitis C virus. J Exp Med 2000;191:1499-1512.
    • (2000) J Exp Med , vol.191 , pp. 1499-1512
    • Lechner, F.1    Wong, D.K.2    Dunbar, P.R.3    Chapman, R.4    Chung, R.T.5    Dohrenwend, P.6
  • 7
    • 0035914925 scopus 로고    scopus 로고
    • Determinants of Viral Clearance and Persistence during Acute Hepatitis C Virus Infection
    • Thimme R, Oldach D, Chang KM, Steiger C, Ray SC, Chisari FV. Determinants of Viral Clearance and Persistence during Acute Hepatitis C Virus Infection. J Exp Med 2001;194:1395-1406.
    • (2001) J Exp Med , vol.194 , pp. 1395-1406
    • Thimme, R.1    Oldach, D.2    Chang, K.M.3    Steiger, C.4    Ray, S.C.5    Chisari, F.V.6
  • 8
    • 0038543543 scopus 로고    scopus 로고
    • Memory CD8+ T cells are required for protection from persistent hepatitis C virus infection
    • Shoukry NH, Grakoui A, Houghton M, Chien DY, Ghrayeb J, Reimann KA, et al. Memory CD8+ T cells are required for protection from persistent hepatitis C virus infection. J Exp Med 2003;197:1645-1655.
    • (2003) J Exp Med , vol.197 , pp. 1645-1655
    • Shoukry, N.H.1    Grakoui, A.2    Houghton, M.3    Chien, D.Y.4    Ghrayeb, J.5    Reimann, K.A.6
  • 9
    • 33645229492 scopus 로고    scopus 로고
    • Dominant influence of an HLA-B27 restricted CD8+ T cell response in mediating HCV clearance and evolution
    • Neumann-Haefelin C, McKiernan S, Ward S, Viazov S, Spangenberg HC, Killinger T, et al. Dominant influence of an HLA-B27 restricted CD8+ T cell response in mediating HCV clearance and evolution. HEPATOLOGY 2006;43:563-572.
    • (2006) HEPATOLOGY , vol.43 , pp. 563-572
    • Neumann-Haefelin, C.1    McKiernan, S.2    Ward, S.3    Viazov, S.4    Spangenberg, H.C.5    Killinger, T.6
  • 10
    • 0034858270 scopus 로고    scopus 로고
    • Direct ex vivo comparison of the breadth and specificity of the T cells in the liver and peripheral blood of patients with chronic HCV infection
    • Grabowska AM, Lechner F, Klenerman P, Tighe PJ, Ryder S, Ball JK, et al. Direct ex vivo comparison of the breadth and specificity of the T cells in the liver and peripheral blood of patients with chronic HCV infection. Eur J Immunol 2001;31:2388-2394.
    • (2001) Eur J Immunol , vol.31 , pp. 2388-2394
    • Grabowska, A.M.1    Lechner, F.2    Klenerman, P.3    Tighe, P.J.4    Ryder, S.5    Ball, J.K.6
  • 11
    • 13044313467 scopus 로고    scopus 로고
    • Quantitative analysis of hepatitis C virus-specific CD8(+) T cells in peripheral blood and liver using peptide-MHC tetramers
    • He XS, Rehermann B, Lopez-Labrador FX, Boisvert J, Cheung R, Mumm J, et al. Quantitative analysis of hepatitis C virus-specific CD8(+) T cells in peripheral blood and liver using peptide-MHC tetramers. Proc Natl Acad Sci U S A 1999;96:5692-5697.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 5692-5697
    • He, X.S.1    Rehermann, B.2    Lopez-Labrador, F.X.3    Boisvert, J.4    Cheung, R.5    Mumm, J.6
  • 12
    • 0027443147 scopus 로고
    • Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV
    • Koziel MJ, Dudley D, Afdhal N, Choo QL, Houghton M, Ralston R, et al. Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV. J Virol 1993;67:7522-7532.
    • (1993) J Virol , vol.67 , pp. 7522-7532
    • Koziel, M.J.1    Dudley, D.2    Afdhal, N.3    Choo, Q.L.4    Houghton, M.5    Ralston, R.6
  • 13
    • 0026486418 scopus 로고
    • Intrahepatic cytotoxic T lymphocytes specific for hepatitis C virus in persons with chronic hepatitis
    • Koziel MJ, Dudley D, Wong JT, Dienstag J, Houghton M, Ralston R, et al. Intrahepatic cytotoxic T lymphocytes specific for hepatitis C virus in persons with chronic hepatitis. J Immunol 1992;149:3339-3344.
    • (1992) J Immunol , vol.149 , pp. 3339-3344
    • Koziel, M.J.1    Dudley, D.2    Wong, J.T.3    Dienstag, J.4    Houghton, M.5    Ralston, R.6
  • 14
    • 0031915132 scopus 로고    scopus 로고
    • Liver-derived CTL in hepatitis C virus infection: Breadth and specificity of responses in a cohort of persons with chronic infection
    • Wong DK, Dudley DD, Afdhal NH, Dienstag J, Rice CM, Wang L, et al. Liver-derived CTL in hepatitis C virus infection: breadth and specificity of responses in a cohort of persons with chronic infection. J Immunol 1998; 160:1479-1488.
    • (1998) J Immunol , vol.160 , pp. 1479-1488
    • Wong, D.K.1    Dudley, D.D.2    Afdhal, N.H.3    Dienstag, J.4    Rice, C.M.5    Wang, L.6
  • 16
    • 0030671121 scopus 로고    scopus 로고
    • Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus
    • Chang KM, Rehermann B, McHutchison JG, Pasquinelli C, Southwood S, Sette A, et al. Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus. J Clin Invest 1997;100:2376-2385.
    • (1997) J Clin Invest , vol.100 , pp. 2376-2385
    • Chang, K.M.1    Rehermann, B.2    McHutchison, J.G.3    Pasquinelli, C.4    Southwood, S.5    Sette, A.6
  • 17
    • 22344440368 scopus 로고    scopus 로고
    • Immune evasion versus recovery after acute hepatitis C virus infection from a shared source
    • Tester I, Smyk-Pearson S, Wang P, Wertheimer A, Yao E, Lewinsohn DM, et al. Immune evasion versus recovery after acute hepatitis C virus infection from a shared source. J Exp Med 2005;201:1725-1731.
    • (2005) J Exp Med , vol.201 , pp. 1725-1731
    • Tester, I.1    Smyk-Pearson, S.2    Wang, P.3    Wertheimer, A.4    Yao, E.5    Lewinsohn, D.M.6
  • 18
    • 21344442507 scopus 로고    scopus 로고
    • Cellular immune selection with hepatitis C virus persistence in humans
    • Cox AL, Mosbruger T, Mao Q, Liu Z, Wang XH, Yang HC, et al. Cellular immune selection with hepatitis C virus persistence in humans. J Exp Med 2005;201:1741-1752.
    • (2005) J Exp Med , vol.201 , pp. 1741-1752
    • Cox, A.L.1    Mosbruger, T.2    Mao, Q.3    Liu, Z.4    Wang, X.H.5    Yang, H.C.6
  • 19
    • 28244493685 scopus 로고    scopus 로고
    • The impairment of CD8 responses limits the selection of escape mutations in acute hepatitis C virus infection
    • Urbani S, Amadei B, Cariani E, Fisicaro P, Orlandini A, Missale G, et al. The impairment of CD8 responses limits the selection of escape mutations in acute hepatitis C virus infection. J Immunol 2005;175:7519-7529.
    • (2005) J Immunol , vol.175 , pp. 7519-7529
    • Urbani, S.1    Amadei, B.2    Cariani, E.3    Fisicaro, P.4    Orlandini, A.5    Missale, G.6
  • 21
    • 34548304730 scopus 로고    scopus 로고
    • Human leukocyte antigen-associated sequence polymorphisms in hepatitis C virus reveal reproducible immune responses and constraints on viral evolution
    • Timm J, Li B, Daniels MG, Bhattacharya T, Reyor LL, Allgaier R, et al. Human leukocyte antigen-associated sequence polymorphisms in hepatitis C virus reveal reproducible immune responses and constraints on viral evolution. HEPATOLOGY 2007;46:339-349.
    • (2007) HEPATOLOGY , vol.46 , pp. 339-349
    • Timm, J.1    Li, B.2    Daniels, M.G.3    Bhattacharya, T.4    Reyor, L.L.5    Allgaier, R.6
  • 22
    • 22344447485 scopus 로고    scopus 로고
    • Divergent and convergent evolution after a common-source outbreak of hepatitis C virus
    • Ray SC, Fanning L, Wang XH, Netski DM, Kenny-Walsh E, Thomas DL. Divergent and convergent evolution after a common-source outbreak of hepatitis C virus. J Exp Med 2005;201:1753-1759.
    • (2005) J Exp Med , vol.201 , pp. 1753-1759
    • Ray, S.C.1    Fanning, L.2    Wang, X.H.3    Netski, D.M.4    Kenny-Walsh, E.5    Thomas, D.L.6
  • 23
    • 18244397979 scopus 로고    scopus 로고
    • The outcome of hepatitis C virus infection is predicted by escape mutations in epitopes targeted by cytotoxic T lymphocytes
    • Erickson AL, Kimura Y, Igarashi S, Eichelberger J, Houghton M, Sidney J, et al. The outcome of hepatitis C virus infection is predicted by escape mutations in epitopes targeted by cytotoxic T lymphocytes. Immunity 2001;15:885-895.
    • (2001) Immunity , vol.15 , pp. 885-895
    • Erickson, A.L.1    Kimura, Y.2    Igarashi, S.3    Eichelberger, J.4    Houghton, M.5    Sidney, J.6
  • 24
    • 0036116355 scopus 로고    scopus 로고
    • Comprehensive analysis of CD8(+)-T-cell responses against hepatitis C virus reveals multiple unpredicted specificities
    • Lauer GM, Ouchi K, Chung RT, Nguyen TN, Day CL, Purkis DR, et al. Comprehensive analysis of CD8(+)-T-cell responses against hepatitis C virus reveals multiple unpredicted specificities. J Virol 2002;76:6104-6113.
    • (2002) J Virol , vol.76 , pp. 6104-6113
    • Lauer, G.M.1    Ouchi, K.2    Chung, R.T.3    Nguyen, T.N.4    Day, C.L.5    Purkis, D.R.6
  • 25
    • 4444354594 scopus 로고    scopus 로고
    • High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection
    • Lauer GM, Barnes E, Lucas M, Timm J, Ouchi K, Kim AY, et al. High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection. Gastroenterology 2004;127:924-936.
    • (2004) Gastroenterology , vol.127 , pp. 924-936
    • Lauer, G.M.1    Barnes, E.2    Lucas, M.3    Timm, J.4    Ouchi, K.5    Kim, A.Y.6
  • 26
    • 33846090225 scopus 로고    scopus 로고
    • Analysis of CD127 and KLRG1 expression on hepatitis C virus-specific CD8+ T cells reveals the existence of different memory T-cell subsets in the peripheral blood and liver
    • Bengsch B, Spangenberg HC, Kersting N, Neumann-Haefelin C, Panther E, von Weizsacker F, et al. Analysis of CD127 and KLRG1 expression on hepatitis C virus-specific CD8+ T cells reveals the existence of different memory T-cell subsets in the peripheral blood and liver. J Virol 2007;81: 945-953.
    • (2007) J Virol , vol.81 , pp. 945-953
    • Bengsch, B.1    Spangenberg, H.C.2    Kersting, N.3    Neumann-Haefelin, C.4    Panther, E.5    von Weizsacker, F.6
  • 28
    • 0036109159 scopus 로고    scopus 로고
    • Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections
    • Appay V, Dunbar PR, Callan M, Klenerman P, Gillespie GM, Papagno L, et al. Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Nat Med 2002;8:379-385.
    • (2002) Nat Med , vol.8 , pp. 379-385
    • Appay, V.1    Dunbar, P.R.2    Callan, M.3    Klenerman, P.4    Gillespie, G.M.5    Papagno, L.6
  • 29
    • 0035148471 scopus 로고    scopus 로고
    • Detection of diverse hepatitis C virus (HCV)-specific cytotoxic T lymphocytes in peripheral blood of infected persons by screening for responses to all translated proteins of HCV
    • Wong DK, Dudley DD, Dohrenwend PB, Lauer GM, Chung RT, Thomas DL, et al. Detection of diverse hepatitis C virus (HCV)-specific cytotoxic T lymphocytes in peripheral blood of infected persons by screening for responses to all translated proteins of HCV. J Virol 2001;75:1229-1235.
    • (2001) J Virol , vol.75 , pp. 1229-1235
    • Wong, D.K.1    Dudley, D.D.2    Dohrenwend, P.B.3    Lauer, G.M.4    Chung, R.T.5    Thomas, D.L.6
  • 30
    • 0028832184 scopus 로고
    • HLA class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus: Identification of multiple epitopes and characterization of patterns of cytokine release
    • Koziel MJ, Dudley D, Afdhal N, Grakoui A, Rice CM, Choo QL, et al. HLA class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus: identification of multiple epitopes and characterization of patterns of cytokine release. J Clin Invest 1995;96:2311-2321.
    • (1995) J Clin Invest , vol.96 , pp. 2311-2321
    • Koziel, M.J.1    Dudley, D.2    Afdhal, N.3    Grakoui, A.4    Rice, C.M.5    Choo, Q.L.6
  • 31
    • 0345017746 scopus 로고    scopus 로고
    • Suppression of HCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection
    • Sugimoto K, Ikeda F, Stadanlick J, Nunes FA, Alter HJ, Chang KM. Suppression of HCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection. HEPATOLOGY 2003;38:1437-1448.
    • (2003) HEPATOLOGY , vol.38 , pp. 1437-1448
    • Sugimoto, K.1    Ikeda, F.2    Stadanlick, J.3    Nunes, F.A.4    Alter, H.J.5    Chang, K.M.6
  • 32
    • 33750735455 scopus 로고    scopus 로고
    • Evidence of viral adaptation to HLA class I-restricted immune pressure in chronic hepatitis C virus infection
    • Gaudieri S, Rauch A, Park LP, Freitas E, Herrmann S, Jeffrey G, et al. Evidence of viral adaptation to HLA class I-restricted immune pressure in chronic hepatitis C virus infection. J Virol 2006;80:11094-11104.
    • (2006) J Virol , vol.80 , pp. 11094-11104
    • Gaudieri, S.1    Rauch, A.2    Park, L.P.3    Freitas, E.4    Herrmann, S.5    Jeffrey, G.6
  • 33
    • 10644267588 scopus 로고    scopus 로고
    • Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA
    • Kiepiela P, Leslie AJ, Honeyborne I, Ramduth D, Thobakgale C, Chetty S, et al. Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA. Nature 2004;432:769-775.
    • (2004) Nature , vol.432 , pp. 769-775
    • Kiepiela, P.1    Leslie, A.J.2    Honeyborne, I.3    Ramduth, D.4    Thobakgale, C.5    Chetty, S.6
  • 34
    • 3042715432 scopus 로고    scopus 로고
    • Distinct MHC class I and II alleles are associated with hepatitis C viral clearance, originating from a single source
    • McKiernan SM, Hagan R, Curry M, McDonald GS, Kelly A, Nolan N, et al. Distinct MHC class I and II alleles are associated with hepatitis C viral clearance, originating from a single source. HEPATOLOGY 2004;40:108-114.
    • (2004) HEPATOLOGY , vol.40 , pp. 108-114
    • McKiernan, S.M.1    Hagan, R.2    Curry, M.3    McDonald, G.S.4    Kelly, A.5    Nolan, N.6
  • 36
    • 2342540480 scopus 로고    scopus 로고
    • HIV escape: There and back again
    • Airman JD, Feinberg MB. HIV escape: there and back again. Nat Med 2004;10:229-230.
    • (2004) Nat Med , vol.10 , pp. 229-230
    • Airman, J.D.1    Feinberg, M.B.2
  • 37
    • 34347336641 scopus 로고    scopus 로고
    • Absence of viral escape within a frequently recognized HLA-A26-restricted CD8+ T-cell epitope targeting the functionally constrained hepatitis C virus NS5A/5B cleavage site
    • Neumann-Haefelin C, Killinger T, Timm J, Southwood S, McKinney D, Blum HE, et al. Absence of viral escape within a frequently recognized HLA-A26-restricted CD8+ T-cell epitope targeting the functionally constrained hepatitis C virus NS5A/5B cleavage site. J Gen Virol 2007;88: 1986-1991.
    • (2007) J Gen Virol , vol.88 , pp. 1986-1991
    • Neumann-Haefelin, C.1    Killinger, T.2    Timm, J.3    Southwood, S.4    McKinney, D.5    Blum, H.E.6
  • 38
    • 30944431676 scopus 로고    scopus 로고
    • Relation between viral fitness and immune escape within the hepatitis C virus protease
    • Soderholm J, Ahlen G, Kaul A, Frelin L, Alheim M, Barnfield C, et al. Relation between viral fitness and immune escape within the hepatitis C virus protease. Gut 2006;55:266-274.
    • (2006) Gut , vol.55 , pp. 266-274
    • Soderholm, J.1    Ahlen, G.2    Kaul, A.3    Frelin, L.4    Alheim, M.5    Barnfield, C.6
  • 40
    • 3543151385 scopus 로고    scopus 로고
    • Limited T cell receptor diversity of HCV-specific T cell responses is associated with CTL escape
    • Meyer-Olson D, Shoukry NH, Brady KW, Kim H, Olson DP, Hartman K, et al. Limited T cell receptor diversity of HCV-specific T cell responses is associated with CTL escape. J Exp Med 2004;200:307-319.
    • (2004) J Exp Med , vol.200 , pp. 307-319
    • Meyer-Olson, D.1    Shoukry, N.H.2    Brady, K.W.3    Kim, H.4    Olson, D.P.5    Hartman, K.6
  • 41
    • 33947407689 scopus 로고    scopus 로고
    • Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression
    • Radziewicz H, Ibegbu CC, Fernandez ML, Workowski KA, Obideen K, Wehbi M, et al. Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression. J Virol 2007;81: 2545-2553.
    • (2007) J Virol , vol.81 , pp. 2545-2553
    • Radziewicz, H.1    Ibegbu, C.C.2    Fernandez, M.L.3    Workowski, K.A.4    Obideen, K.5    Wehbi, M.6


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