Impaired hepatitis C virus (HCV)-specific effector CD8+ T cells undergo massive apoptosis in the peripheral blood during acute HCV infection and in the liver during the chronic phase of infection

Journal of Virology

Volumn 82, Issue 20, 2008, Pages 9808-9822

  Radziewicz, Henry ^a   Ibegbu, Chris C ^a   Hon, Huiming ^a   Osborn, Melissa K ^a   Obideen, Kamil ^a   Wehbi, Mohammad ^a   Freeman, Gordon J ^b   Lennox, Jeffrey L ^a   Workowski, Kimberly A ^a   Hanson, Holly L ^a   Grakoui, Arash ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CASPASE 9; CYTOKINE; DEATH RECEPTOR; INTERFERON; INTERLEUKIN 7 RECEPTOR; PROGRAMMED DEATH 1 PROTEIN; RIBAVIRIN; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; CD27 ANTIGEN; LEUKOCYTE ANTIGEN; PDCD1 PROTEIN, HUMAN;

ADULT; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CHRONIC HEPATITIS; CLINICAL ARTICLE; ENZYME ACTIVATION; FEMALE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOMODULATION; LIVER; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION; MALE; MEMORY T LYMPHOCYTE; PERIPHERAL CIRCULATION; PHENOTYPE; PRIORITY JOURNAL; VIRUS LOAD; CHRONIC DISEASE; IMMUNOLOGY; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; VIROLOGY;

HEPATITIS C VIRUS;

ADULT; ANTIGENS, CD; ANTIGENS, CD27; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CASPASE 9; CD8-POSITIVE T-LYMPHOCYTES; CHRONIC DISEASE; CYTOKINES; FEMALE; HEPACIVIRUS; HEPATITIS C; HUMANS; LIVER; MALE; MIDDLE AGED; VIRAL LOAD;

EID: 53749083074     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.01075-08     Document Type: Article

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